All Outputs (5)

TAp73 transcriptionally represses BNIP3 expression (2015)
Journal Article
Petrova, V., Mancini, M., Agostini, M., Knight, R. A., Annicchiarico-Petruzzelli, M., Barlev, N. A., …Amelio, I. (2015). TAp73 transcriptionally represses BNIP3 expression. Cell Cycle, 14(15), 2484-2493. https://doi.org/10.1080/15384101.2015.1044178

TAp73 is a tumor suppressor transcriptional factor, belonging to p53 family. Alteration of TAp73 in tumors might lead to reduced DNA damage response, cell cycle arrest and apoptosis. Carcinogen-induced TAp73?/? tumors display also increased angiogene... Read More about TAp73 transcriptionally represses BNIP3 expression.

The p53 family and the hypoxia-inducible factors (HIFs): determinants of cancer progression (2015)
Journal Article
Melino, G., & Amelio, I. (2015). The p53 family and the hypoxia-inducible factors (HIFs): determinants of cancer progression. Trends in Biochemical Sciences, 40(8), 425-434. https://doi.org/10.1016/j.tibs.2015.04.007

HIFs have long been associated with resistance to therapy, metastasis, and poor survival rates in cancer patients. In parallel, although the tumor-suppressor p53 acts as the first barrier against tumor transformation, its inactivation also appears to... Read More about The p53 family and the hypoxia-inducible factors (HIFs): determinants of cancer progression.

Perspective on Multi-Target Antiplatelet Therapies: High Content Phenotypic Screening as an Unbiased Source of Novel Polypharmacological Strategies (2015)
Journal Article
Landre, V., Amelio, I., Barlev, N., Knight, R., Lisitsa, A., Melino, G., & Antonov, A. (2015). Perspective on Multi-Target Antiplatelet Therapies: High Content Phenotypic Screening as an Unbiased Source of Novel Polypharmacological Strategies. Mini-Reviews in Medicinal Chemistry, 15(8), 622-629. https://doi.org/10.2174/1389557515666150219124018

Platelets play an important role in cardiovascular thrombosis as well as in many other pathological conditions such as inflammation, atherosclerosis and cancer. While multi-target strategies to treat complex diseases are gaining considerable attenti... Read More about Perspective on Multi-Target Antiplatelet Therapies: High Content Phenotypic Screening as an Unbiased Source of Novel Polypharmacological Strategies.

Polypharmacology of small molecules targeting the ubiquitin–proteasome and ubiquitin-like systems (2015)
Journal Article
Amelio, I., Landré, V., Knight, R. A., Lisitsa, A., Melino, G., & Antonov, A. V. (2015). Polypharmacology of small molecules targeting the ubiquitin–proteasome and ubiquitin-like systems. Oncotarget, 6(12), 9646-9656. https://doi.org/10.18632/oncotarget.3917

Targeting the ubiquitin–proteasome system (UPS) and ubiquitin-like signalling systems (UBL) has been considered a promising therapeutic strategy to treat cancer, neurodegenerative and immunological disorders. There have been multiple efforts recently... Read More about Polypharmacology of small molecules targeting the ubiquitin–proteasome and ubiquitin-like systems.

Peritoneal expression of Matrilysin helps identify early post-operative recurrence of colorectal cancer (2015)
Journal Article
Gaspari, A. L., Sica, G. S., Iaculli, E., Fiorani, C., Tema, G., Stolfi, C., …Amelio, I. (2015). Peritoneal expression of Matrilysin helps identify early post-operative recurrence of colorectal cancer. Oncotarget, 6(15), 13402-13415. https://doi.org/10.18632/oncotarget.2830

Recurrence of colorectal cancer (CRC) following a potentially curative resection is a challenging clinical problem. Matrix metalloproteinase-7 (MMP-7) is over-expressed by CRC cells and supposed to play a major role in CRC cell diffusion and metastas... Read More about Peritoneal expression of Matrilysin helps identify early post-operative recurrence of colorectal cancer.