All Outputs (665)

Regulation of Anopheles gambiae male accessory gland genes influences postmating response in female (2012)
Journal Article

In Drosophila, the accessory gland proteins (Acps) secreted from the male accessory glands (MAGs) and transferred along with sperm into the female reproductive tract have been implicated in triggering postmating behavioral changes, including refracto... Read More about Regulation of Anopheles gambiae male accessory gland genes influences postmating response in female.

A unique protein phosphatase with kelch-like domains (PPKL) in plasmodium modulates ookinete differentiation, motility and invasion (2012)
Journal Article

Protein phosphorylation and dephosphorylation (catalysed by kinases and phosphatases, respectively) are post-translational modifications that play key roles in many eukaryotic signalling pathways, and are often deregulated in a number of pathological... Read More about A unique protein phosphatase with kelch-like domains (PPKL) in plasmodium modulates ookinete differentiation, motility and invasion.

A cooperative instinct (2012)
Journal Article

Acting on a gut feeling may sometimes lead to poor decisions, but it will usually support the common good, according to a study showing that human intuition favours cooperative, rather than selfish, behaviour.

Coping with and factors impacting upon the experience of lung cancer in patients and primary carers (2012)
Journal Article

There is a paucity of research exploring patients' and their informal carers' experience of coping with and factors impacting on the lung cancer experience. This study aims to explore how patients and their informal carers cope with a diagnosis of lu... Read More about Coping with and factors impacting upon the experience of lung cancer in patients and primary carers.

A Bayesian elicitation of veterinary beliefs regarding systemic dry cow therapy: variation and importance for clinical trial design (2012)
Journal Article

The two key aims of this research were: (i) to conduct a probabilistic elicitation to quantify the variation in veterinarians’ beliefs regarding the efficacy of systemic antibiotics when used as an adjunct to intra-mammary dry cow therapy and (ii) to... Read More about A Bayesian elicitation of veterinary beliefs regarding systemic dry cow therapy: variation and importance for clinical trial design.

The essential iron-sulfur protein Rli1 is an important target accounting for inhibition of cell growth by reactive oxygen species (2012)
Journal Article

Oxidative stress mediated by reactive oxygen species (ROS) is linked to degenerative conditions in humans and damage to an array of cellular components. However, it is unclear which molecular target(s) may be the primary “Achilles’ heel” of organisms... Read More about The essential iron-sulfur protein Rli1 is an important target accounting for inhibition of cell growth by reactive oxygen species.

The impact of individual budgets on the targeting of support: Findings from a national evaluation of pilot projects in England (2012)
Journal Article

Individual or personal budgets are part of a growing international trend to encourage greater choice and control over social care services at a time of financial austerity. The authors' evaluation of individual budgets found that levels of allocated... Read More about The impact of individual budgets on the targeting of support: Findings from a national evaluation of pilot projects in England.

The linear spin-up of a stratified, rotating fluid in a square cylinder (2012)
Journal Article

Here we present experimental and theoretical results for how a stratified fluid, initially rotating as a solid body with constant angular velocity, , within a closed cylinder of square cross-section, is spun up when subject to a small, impulsive incr... Read More about The linear spin-up of a stratified, rotating fluid in a square cylinder.

Demographics and economic burden of un-owned cats and dogs in the UK: results of a 2010 census (2012)
Journal Article

Background The population of dogs and cats passing through rescue shelters may be subject to compromised welfare and increased susceptibility to disease. Little information exists to describe this population, its dynamics and associated management... Read More about Demographics and economic burden of un-owned cats and dogs in the UK: results of a 2010 census.

Protocol evaluating the effectiveness of a school-based group programme for parents of children at risk of ADHD: the ‘PArents, Teachers and CHildren WORKing Together (PATCHWORK)’ cluster RCT protocol (2012)
Journal Article

Introduction Early intervention for childhood behavioural problems may help improve health and educational outcomes in affected children and reduce the likelihood of developing additional difficulties. The National Institute for Health and Clinical... Read More about Protocol evaluating the effectiveness of a school-based group programme for parents of children at risk of ADHD: the ‘PArents, Teachers and CHildren WORKing Together (PATCHWORK)’ cluster RCT protocol.

Identity and public realm (2012)
Journal Article

In a very general sense, Identities materialise space to create significance, meaning and spatial relations. In urban design terms, identity is considered to be a fixed point of thought and being or ground of actions. However, as Hall (1989) describe... Read More about Identity and public realm.

A flaw in Kripke's modal argument? (2012)
Journal Article

Advanced geometry modelling of 3D woven reinforcements in polymer composites: processing and performance analysis (2012)
Conference Proceeding

Numerical methods have become increasingly effective tools for analysis and design of composite materials. This study investigates how the inclusion of geometrical variations in modelling 3D woven fabrics affects the accuracy of numerical predictions... Read More about Advanced geometry modelling of 3D woven reinforcements in polymer composites: processing and performance analysis.

Efficient online subspace learning with an indefinite kernel for visual tracking and recognition (2012)
Journal Article

We propose an exact framework for online learning with a family of indefinite (not positive) kernels. As we study the case of nonpositive kernels, we first show how to extend kernel principal component analysis (KPCA) from a reproducing kernel Hilber... Read More about Efficient online subspace learning with an indefinite kernel for visual tracking and recognition.

Calpain system protein expression in basal-like and triple-negative invasive breast cancer (2012)
Journal Article

Background: Basal-like and triple-negative breast tumours encompass an important clinical subgroup and biomarkers that can prognostically stratify these patients are required. Materials and methods: We investigated two breast cancer tissue microarr... Read More about Calpain system protein expression in basal-like and triple-negative invasive breast cancer.

Increased Responses to the Actions of Fibroblast Growth Factor 21 on Energy Balance and Body Weight in a Seasonal Model of Adiposity (2012)
Journal Article

The present study aimed to investigate the actions of fibroblast growth factor 21 (FGF21) on energy balance in a natural model of relative fatness, the Siberian hamster. Hamsters were studied under long days (LD) to promote weight gain, or short days... Read More about Increased Responses to the Actions of Fibroblast Growth Factor 21 on Energy Balance and Body Weight in a Seasonal Model of Adiposity.

Sliding mode contouring control design using nonlinear sliding surface for three-dimensional machining (2012)
Journal Article

Machining accuracy as well as consumed energy saving are important issues in machining by multi-axis feed drive systems. The contour error, which is defined as the error component orthogonal to the desired contour curve, is a good indicator of machin... Read More about Sliding mode contouring control design using nonlinear sliding surface for three-dimensional machining.

Measures of body habitus are associated with lung function in adults with cystic fibrosis: a population-based study (2012)
Journal Article

Background Body habitus differences may explain some of the variation in lung function between individuals with cystic fibrosis (CF). We tested the hypothesis that measures of lean muscle mass and obesity are independently associated with lung funct... Read More about Measures of body habitus are associated with lung function in adults with cystic fibrosis: a population-based study.

The covariance of multi-field perturbations, pseudo-susy and fNL (2012)
Journal Article

We reconsider cosmological perturbation theory for multi-component scalars, enforcing covariance in field-space, and ensuring that phyical observations are independent of field re-definitions. We use the formalism to clarify some issues in the litera... Read More about The covariance of multi-field perturbations, pseudo-susy and fNL.

Engaging with economic evaluation methods: insights from small and medium enterprises in the UK medical devices industry after training workshops (2012)
Journal Article

Background With increased governmental interest in value assessment of technologies and where medical device manufacturers are finding it increasingly necessary to become more familiar with economic evaluation methods, the study sought to explore... Read More about Engaging with economic evaluation methods: insights from small and medium enterprises in the UK medical devices industry after training workshops.