All Outputs (3704)

Structure-activity relationships of the sustained effects of adenosine A2A receptor agonists driven by slow dissociation kinetics (2017)
Journal Article
Hothersall, J. D., Guo, D., Sarda, S., Sheppard, R. J., Chen, H., Keur, W., …Rawlins, P. B. (2017). Structure-activity relationships of the sustained effects of adenosine A2A receptor agonists driven by slow dissociation kinetics. Molecular Pharmacology, 91(1), https://doi.org/10.1124/mol.116.105551

The duration of action of adenosine A2A receptor (A2A) agonists is critical for their clinical efficacy, and we sought to better understand how this can be optimized. The in vitro temporal response profiles of a panel of A2A agonists were studied usi... Read More about Structure-activity relationships of the sustained effects of adenosine A2A receptor agonists driven by slow dissociation kinetics.

Increased incidence of adult pneumococcal pneumonia during school holiday periods (2017)
Journal Article
Daniel, P., Rodrigo, C., Bewick, T., Sheppard, C., Greenwood, S., McKeever, T. M., …Lim, W. S. (2017). Increased incidence of adult pneumococcal pneumonia during school holiday periods. ERJ Open Research, 3(1), https://doi.org/10.1183/23120541.00100-2016

Child contact is a recognised risk factor for adult pneumococcal disease. Peaks in invasive pneumococcal disease incidence observed during winter holidays may be related to changes in social dynamics. This analysis was conducted to examine adult pneu... Read More about Increased incidence of adult pneumococcal pneumonia during school holiday periods.

A cohort study investigating the effects of first stage of the English tobacco point-of-sale display ban on awareness, susceptibility and smoking uptake among adolescents (2017)
Journal Article
Bogdanovica, I., McNeill, A., & Britton, J. (2017). A cohort study investigating the effects of first stage of the English tobacco point-of-sale display ban on awareness, susceptibility and smoking uptake among adolescents. BMJ Open, 7(1), Article e01245. https://doi.org/10.1136/bmjopen-2016-012451

Objective: A prospective evaluation of the effect of 2012 point-of-sale (PoS) display ban in supermarkets in England on perceived exposure to PoS displays, and on changes in susceptibility and smoking uptake among young people. Design: Cohort study... Read More about A cohort study investigating the effects of first stage of the English tobacco point-of-sale display ban on awareness, susceptibility and smoking uptake among adolescents.

Pharmacology of modulators of alternative splicing (2017)
Journal Article
Bates, D. O., Morris, J. C., Oltean, S., & Donaldson, L. F. (2017). Pharmacology of modulators of alternative splicing. Pharmacological Reviews, 69(1), https://doi.org/10.1124/pr.115.011239

More than 95% of genes in the human genome are alternatively spliced to form multiple transcripts, often encoding proteins with differing or opposing function. The control of alternative splicing is now being elucidated, and with this comes the oppor... Read More about Pharmacology of modulators of alternative splicing.