Structure-activity relationships of the sustained effects of adenosine A2A receptor agonists driven by slow dissociation kinetics
(2017)
Journal Article
Hothersall, J. D., Guo, D., Sarda, S., Sheppard, R. J., Chen, H., Keur, W., …Rawlins, P. B. (2017). Structure-activity relationships of the sustained effects of adenosine A2A receptor agonists driven by slow dissociation kinetics. Molecular Pharmacology, 91(1), https://doi.org/10.1124/mol.116.105551
The duration of action of adenosine A2A receptor (A2A) agonists is critical for their clinical efficacy, and we sought to better understand how this can be optimized. The in vitro temporal response profiles of a panel of A2A agonists were studied usi... Read More about Structure-activity relationships of the sustained effects of adenosine A2A receptor agonists driven by slow dissociation kinetics.