Mutations in hepatitis C virus p7 reduce both the egress and infectivity of assembled particles via impaired proton channel function
(2013)
Journal Article
Bentham, M. J., Foster, T. L., McCormick, C., & Griffin, S. (2013). Mutations in hepatitis C virus p7 reduce both the egress and infectivity of assembled particles via impaired proton channel function. Journal of General Virology, 94, 2236-2248. https://doi.org/10.1099/vir.0.054338-0
Hepatitis C virus (HCV) p7 protein is critical for the efficient production of infectious virions in culture. p7 undergoes genotype-specific protein–protein interactions as well as displaying channel-forming activity, making it unclear whether the ph... Read More about Mutations in hepatitis C virus p7 reduce both the egress and infectivity of assembled particles via impaired proton channel function.