All Outputs (361)

Synovitis and bone marrow lesions associate with symptoms and radiographic progression in hand osteoarthritis: a systematic review and meta-analysis of observational studies (2021)
Journal Article
Obotiba, A. D., Swain, S., Kaur, J., Yaseen, K., Doherty, M., Zhang, W., & Abhishek, A. (2021). Synovitis and bone marrow lesions associate with symptoms and radiographic progression in hand osteoarthritis: a systematic review and meta-analysis of observational studies. Osteoarthritis and Cartilage, 29(7), 946-955. https://doi.org/10.1016/j.joca.2021.03.018

Aims: To systematically review observational studies for the association between features detected on ultrasound (US) and magnetic resonance imaging (MRI) and, symptoms, signs and radiographic progression of hand osteoarthritis (OA). Methods: Medline... Read More about Synovitis and bone marrow lesions associate with symptoms and radiographic progression in hand osteoarthritis: a systematic review and meta-analysis of observational studies.

Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the UK primary care setting (2021)
Journal Article
Swain, S., Coupland, C., Mallen, C., Kuo, C. F., Sarmanova, A., Bierma-Zeinstra, S. M., …Zhang, W. (2021). Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the UK primary care setting. Rheumatology, 60(9), 4327-4339. https://doi.org/10.1093/rheumatology/keab067

OBJECTIVE: To determine the burden of comorbidities in OA and their temporal relationships in the UK. METHODS: The Clinical Practice Research Datalink (CPRD) GOLD was used to identify people with incident OA and age, gender and practice matched n... Read More about Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the UK primary care setting.

Magnetic resonance imaging of the gastrointestinal tract shows reduced small bowel motility and altered chyme in cystic fibrosis compared to controls (2021)
Preprint / Working Paper
Dellschaft, N. S., Ng, C., Hoad, C., Marciani, L., Spiller, R., Stewart, I., …Smyth, A. R. Magnetic resonance imaging of the gastrointestinal tract shows reduced small bowel motility and altered chyme in cystic fibrosis compared to controls

Systematic review and meta-analysis of anakinra, sarilumab, siltuximab and tocilizumab for COVID-19 (2021)
Journal Article
Khan, F. A., Stewart, I., Fabbri, L., Moss, S., Robinson, K., Smyth, A. R., & Jenkins, G. (2021). Systematic review and meta-analysis of anakinra, sarilumab, siltuximab and tocilizumab for COVID-19. Thorax, 76(9), 907-919. https://doi.org/10.1136/thoraxjnl-2020-215266

Background There is accumulating evidence for an overly activated immune response in severe COVID-19, with several studies exploring the therapeutic role of immunomodulation. Through systematic review and meta-analysis, we assess the effectiveness of... Read More about Systematic review and meta-analysis of anakinra, sarilumab, siltuximab and tocilizumab for COVID-19.

A systematic review and meta-analysis of Anakinra, Sarilumab, Siltuximab and Tocilizumab for Covid-19 (2021)
Preprint / Working Paper
Khan, F., Fabbri, L., Stewart, I., Robinson A., K., Smyth, A. R., & Jenkins, G. A systematic review and meta-analysis of Anakinra, Sarilumab, Siltuximab and Tocilizumab for Covid-19

Background There is accumulating evidence for an overly activated immune response in severe Covid-19, with several studies exploring the therapeutic role of immunomodulation. Through systematic review and meta-analysis, we assess the effectiveness of... Read More about A systematic review and meta-analysis of Anakinra, Sarilumab, Siltuximab and Tocilizumab for Covid-19.

Randomised controlled trial of tailored support to increase physical activity and reduce smoking in smokers not immediately ready to quit: protocol for the Trial of physical Activity-assisted Reduction of Smoking (TARS) Study (2020)
Journal Article
Taylor, A., Thompson, T. P., Ussher, M., Aveyard, P., Murray, R. L., Harris, T., …Preece, D. (2020). Randomised controlled trial of tailored support to increase physical activity and reduce smoking in smokers not immediately ready to quit: protocol for the Trial of physical Activity-assisted Reduction of Smoking (TARS) Study. BMJ Open, 10(12), Article e043331. https://doi.org/10.1136/bmjopen-2020-043331

Defining stable glaucoma: a Delphi consensus survey of UK optometrists with a specialist interest in Glaucoma (2020)
Journal Article
Lakhani, B. K., Giannouladis, K., Leighton, P., Spry, P. G. D., Harper, R. A., & King, A. J. (2021). Defining stable glaucoma: a Delphi consensus survey of UK optometrists with a specialist interest in Glaucoma. Eye, 35(9), 2524-2534. https://doi.org/10.1038/s41433-020-01251-w

Background Increasing demand on hospital services has led to the development of alternative community-based services, often run by optometrists for monitoring ‘stable’ and low-risk glaucoma patients. Methods An online Delphi exercise was underta... Read More about Defining stable glaucoma: a Delphi consensus survey of UK optometrists with a specialist interest in Glaucoma.

A randomised controlled trial to assess the effectiveness and cost-effectiveness of tailored web- and text-based smoking cessation support in primary care: iQuit in Practice II trial protocol (Preprint) (2020)
Preprint / Working Paper
Proctor, J., Naughton, F., Sloan, M., Hopewell, S., Brimicombe, J., Prevost, T., …Sutton, S. A randomised controlled trial to assess the effectiveness and cost-effectiveness of tailored web- and text-based smoking cessation support in primary care: iQuit in Practice II trial protocol (Preprint)

Background: The prevalence of smoking is in decline, however, it continues to be a major public health burden. In England, primary care is the health setting that provides smoking cessation support to the most smokers. However, this setting has one o... Read More about A randomised controlled trial to assess the effectiveness and cost-effectiveness of tailored web- and text-based smoking cessation support in primary care: iQuit in Practice II trial protocol (Preprint).

Editorial Comment: Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control (2020)
Journal Article
Coupland, C. A., Hill, T., Dening, T., Morriss, R., Moore, M., & Hippisley-Cox, J. (2020). Editorial Comment: Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control. International Braz J Urol, 46(2), 283-284. https://doi.org/10.1590/S1677-5538.IBJU.2020.02.10

Re: Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case Control Study (2019)
Journal Article
Wein, A. J., Coupland, C. A. C., Hill, T., Dening, T., Morriss, R., Moore, M., & Hippisley-Cox, J. (2019). Re: Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case Control Study. Journal of Urology, The, 202(6), 1103-1104. https://doi.org/10.1097/01.ju.0000585420.46543.d2

Interventions to promote oral nutritional behaviours in people living with neurodegenerative disorders of the motor system: A systematic review (2019)
Journal Article
Essat, M., Archer, R., Williams, I., Zarotti, N., Coates, E., Clowes, M., …McDermott, C. (2020). Interventions to promote oral nutritional behaviours in people living with neurodegenerative disorders of the motor system: A systematic review. Clinical Nutrition, 39(8), 2547-2556. https://doi.org/10.1016/j.clnu.2019.11.015

Background & aims Weight loss is common in people with neurodegenerative diseases of the motor system (NDMS), such as Parkinson's disease and Amyotrophic Lateral Sclerosis, and is associated with reduced quality of life, functional ability and survi... Read More about Interventions to promote oral nutritional behaviours in people living with neurodegenerative disorders of the motor system: A systematic review.

An evaluation of risk-based monitoring in pragmatic trials in UK Clinical Trials Units (2019)
Journal Article
Beever, D., & Swaby, L. (2019). An evaluation of risk-based monitoring in pragmatic trials in UK Clinical Trials Units. Trials, 20(1), Article 556. https://doi.org/10.1186/s13063-019-3619-6

Background Good Clinical Practice guidelines issued in 2016 encourage risk-based approaches to monitoring clinical trials. This study compared current risk assessment and monitoring approaches in UK Clinical Trials Units (CTUs) with the published gu... Read More about An evaluation of risk-based monitoring in pragmatic trials in UK Clinical Trials Units.

ASSERT (Acute Sacral inSufficiEncy fractuRe augmenTation) randomised controlled, feasibility in older people trial: a study protocol (2019)
Journal Article
van Berkel, D., Ong, T., Drummond, A., Hendrick, P., Leighton, P., Jones, M., …Sahota, O. (2019). ASSERT (Acute Sacral inSufficiEncy fractuRe augmenTation) randomised controlled, feasibility in older people trial: a study protocol. BMJ Open, 9(7), Article 032111. https://doi.org/10.1136/bmjopen-2019-032111

Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study (2019)
Journal Article
Coupland, C. A., Hill, T., Dening, T., Morriss, R., Moore, M., & Hippisley-Cox, J. (2019). Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study. JAMA Internal Medicine, 179(8), 1084-1093. https://doi.org/10.1001/jamainternmed.2019.0677

IMPORTANCE Anticholinergic medicines have short-term cognitive adverse effects, but it is uncertain whether long-term use of these drugs is associated with an increased risk of dementia. OBJECTIVE To assess associations between anticholinergic dr... Read More about Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study.

P018 RENAL adverse events and gastrointestinal bleeding with ibuprofen use in preterm neonates with patent ductus arteriosus (PDA) (2019)
Presentation / Conference Contribution
Al-Turkait, A., Abramson, J., Choonara, I., Szatkowski, L., & Ojha, S. (2019). P018 RENAL adverse events and gastrointestinal bleeding with ibuprofen use in preterm neonates with patent ductus arteriosus (PDA). Archives of Disease in Childhood, 104(7), Article e2. https://doi.org/10.1136/archdischild-2019-nppc.28

Origins of lifetime health around the time of conception: causes and consequences (2018)
Journal Article
Fleming, T., Watkins, A., Velazquez, M., Mathers, J., Prentice, A., Stephenson, J., …Keith, G. (2018). Origins of lifetime health around the time of conception: causes and consequences. Lancet, 391(10132), 1842-1852. https://doi.org/10.1016/S0140-6736%2818%2930312-X

Parental environmental factors, including diet, body composition, metabolism, and stress, affect the health and chronic disease risk of people throughout their lives, as captured in the Developmental Origins of Health and Disease concept. Research ac... Read More about Origins of lifetime health around the time of conception: causes and consequences.

368 CFHealthHub: development and evaluation of videos incorporating peer description of successful self-management with inhaled therapies in adults with CF used to build self-efficacy to support self-care within the CFHealthHub complex intervention (2017)
Journal Article
Kirkpatrick, S., Arden, M., Beever, D., Bradley, J., Cantrill, H., Daniels, T., …Wildman, M. (2017). 368 CFHealthHub: development and evaluation of videos incorporating peer description of successful self-management with inhaled therapies in adults with CF used to build self-efficacy to support self-care within the CFHealthHub complex intervention. Journal of Cystic Fibrosis, 16(Suppl 1), S155-S156. https://doi.org/10.1016/s1569-1993%2817%2930699-9

Interventions made by UK pharmacists to minimise risk from paediatric prescribing errors (2016)
Journal Article
Alenezi, S., Abramson, J., Smith, C., Sammons, H., & Conroy, S. (2016). Interventions made by UK pharmacists to minimise risk from paediatric prescribing errors. Archives of Disease in Childhood, 101(9), Article e2. https://doi.org/10.1136/archdischild-2016-311535.65

The PAndemic INfluenza Triage in the Emergency Department (PAINTED) pilot cohort study (2015)
Journal Article
Goodacre, S., Irving, A., Wilson, R., Beever, D., & Challen, K. (2015). The PAndemic INfluenza Triage in the Emergency Department (PAINTED) pilot cohort study. Health Technology Assessment, 19(3), 1-70. https://doi.org/10.3310/hta19030

Background Research needs to be undertaken rapidly in the event of an influenza pandemic to develop and evaluate triage methods for people presenting to the emergency department with suspected pandemic influenza. Objectives We aimed to pilot a r... Read More about The PAndemic INfluenza Triage in the Emergency Department (PAINTED) pilot cohort study.

Maternal Obesity and Infant Mortality: A Meta-Analysis (2014)
Journal Article

BACKGROUND AND OBJECTIVES: Despite numerous studies reporting an elevated risk of infant mortality among women who are obese, the magnitude of the association is unclear. A systematic review and meta-analysis was undertaken to assess the association... Read More about Maternal Obesity and Infant Mortality: A Meta-Analysis.