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All Outputs (429)

Formative work for the LEGEND (Low EnerGy DiEt iN adolescents with type 2 diabetes and obesity) study: a worked example of patient and public involvement in research (2024)
Journal Article
Blake, H., Law, J., Procter, E., Barrett, T., & Sachdev, P. (2024). Formative work for the LEGEND (Low EnerGy DiEt iN adolescents with type 2 diabetes and obesity) study: a worked example of patient and public involvement in research. Practical Diabetes, 41(4), 27-31. https://doi.org/10.1002/pdi.2520

This study uses evidence-based guidance to report on patient and public involvement and engagement activity that informed the design of a feasibility trial to explore the use of low energy diet for children and young people with type 2 diabetes. Over... Read More about Formative work for the LEGEND (Low EnerGy DiEt iN adolescents with type 2 diabetes and obesity) study: a worked example of patient and public involvement in research.

Implementing vocational rehabilitation for people with multiple sclerosis in the UK National Health Service: a mixed-methods feasibility study (2024)
Journal Article
De Dios Perez, B., Holmes, J., Elder, T., Lindley, R., Evangelou, N., das Nair, R., Senior, C., Booth, V., Hassard, J., Ford, H. L., Newsome, I., & Radford, K. (2024). Implementing vocational rehabilitation for people with multiple sclerosis in the UK National Health Service: a mixed-methods feasibility study. Disability and Rehabilitation, https://doi.org/10.1080/09638288.2024.2417031

Purpose: To implement a job retention vocational rehabilitation (VR) intervention (MSVR) for people with multiple sclerosis (MS) and their employers in the UK National Health Service (NHS). Methods: Multicentre, single-arm feasibility study with post... Read More about Implementing vocational rehabilitation for people with multiple sclerosis in the UK National Health Service: a mixed-methods feasibility study.

Combined MRI, high-resolution manometry and a randomised trial of bisacodyl versus hyoscine show the significance of an enlarged colon in constipation: the RECLAIM study (2024)
Journal Article
Wilkinson-Smith, V., Scott, M., Menys, A., Wiklendt, L., Marciani, L., Atkinson, D., Sansone, S., Zdanaviciene, A., Coupland, C., Knowles, C. H., Dinning, P., Taylor, S. A., Gowland, P., Hoad, C. L., Corsetti, M., & Spiller, R. C. (2024). Combined MRI, high-resolution manometry and a randomised trial of bisacodyl versus hyoscine show the significance of an enlarged colon in constipation: the RECLAIM study. Gut, https://doi.org/10.1136/gutjnl-2024-332755

Background: Colonic motility in constipation can be assessed non-invasively using MRI.

Objective: To compare MRI with high-resolution colonic manometry (HRCM) for predicting treatment response.

Design: Part 1: 44 healthy volunteers (HVs), 43 pa... Read More about Combined MRI, high-resolution manometry and a randomised trial of bisacodyl versus hyoscine show the significance of an enlarged colon in constipation: the RECLAIM study.

Monitoring university student response to social distancing policy during the SARS-CoV-2 pandemic using Bluetooth: the RADAR study (2024)
Journal Article
Bolton, K. J., Mendez-Villalon, A., Nanji, H., Jia, R., Ayling, K., Figueredo, G., & Vedhara, K. (in press). Monitoring university student response to social distancing policy during the SARS-CoV-2 pandemic using Bluetooth: the RADAR study. Mathematics in Medical and Life Sciences,

Aim: We use the Remote Assessment of Disease and Relapses platform (RADAR) to collect Bluetooth contact and location data from university students. We test the ability of this technology to objectively capture social interaction, explore the propensi... Read More about Monitoring university student response to social distancing policy during the SARS-CoV-2 pandemic using Bluetooth: the RADAR study.

The CO-produced Psychosocial INtervention delivered by GPs to young people after self-harm (COPING): protocol for a feasibility study (2024)
Journal Article
Mughal, F., Chew-Graham, C. A., Saunders, B., Lawton, S. A., Lewis, S., Smith, J., Lancaster, G., Townsend, E., Armitage, C. J., Bower, P., Kapur, N., Kessler, D., Realpe, A. X., Wiles, N., Ougrin, D., & Lewis, M. (in press). The CO-produced Psychosocial INtervention delivered by GPs to young people after self-harm (COPING): protocol for a feasibility study. NIHR Open Research, 4, Article 27. https://doi.org/10.3310/nihropenres.13576.2

Background
Self-harm in young people is a growing concern and reducing rates a global priority. Rates of self-harm documented in general practice have been increasing for young people in the UK in the last two decades, especially in 13–16-year-olds.... Read More about The CO-produced Psychosocial INtervention delivered by GPs to young people after self-harm (COPING): protocol for a feasibility study.

A Scoping Review of Electronic Health Records Based Screening Algorithms for Familial Hypercholesterolemia (2024)
Journal Article
Osei, J., Razavi, A. C., Otchere, B., Bonful, G., Akoto, N., Akyea, R. K., Qureshi, N., Coronado, F., Moonesinghe, R., Kolor, K., Mensah, G. A., Sperling, L., & Khoury, M. J. (2024). A Scoping Review of Electronic Health Records Based Screening Algorithms for Familial Hypercholesterolemia. JACC: Advances, https://doi.org/10.1016/j.jacadv.2024.101297

Background
Familial hypercholesterolemia (FH) is a common genetic disorder that is strongly associated with premature cardiovascular disease. Effective diagnosis and appropriate treatment of FH can reduce cardiovascular disease risk; however, FH is... Read More about A Scoping Review of Electronic Health Records Based Screening Algorithms for Familial Hypercholesterolemia.

Enhanced Infant Movement Analysis Using Transformer-Based Fusion of Diverse Video Features for Neurodevelopmental Monitoring (2024)
Journal Article
Turner, A., & Sharkey, D. (2024). Enhanced Infant Movement Analysis Using Transformer-Based Fusion of Diverse Video Features for Neurodevelopmental Monitoring. Sensors, 24(20), Article 6619. https://doi.org/10.3390/s24206619

Neurodevelopment is a highly intricate process, and early detection of abnormalities is critical for optimizing outcomes through timely intervention. Accurate and cost-effective diagnostic methods for neurological disorders, particularly in infants,... Read More about Enhanced Infant Movement Analysis Using Transformer-Based Fusion of Diverse Video Features for Neurodevelopmental Monitoring.

Peer-led recovery groups for people with psychosis in South Africa (PRIZE): results of a randomized controlled feasibility trial (2024)
Journal Article
Asher, L., Brooke-Sumner, C., Rapiya, B., Repper, J., Reddy, T., Myers-Franchi, B., Faris, G., Petersen, I., & Hanlon, C. (2024). Peer-led recovery groups for people with psychosis in South Africa (PRIZE): results of a randomized controlled feasibility trial. Epidemiology and Psychiatric Sciences, 33, Article e47. https://doi.org/10.1017/S2045796024000556

Aims
The aims of this feasibility trial were to assess the acceptability and feasibility of peer-led recovery groups for people with psychosis in a low-resource South African setting, to assess the feasibility of trial methods, and to determine key... Read More about Peer-led recovery groups for people with psychosis in South Africa (PRIZE): results of a randomized controlled feasibility trial.

Peer-led recovery groups for people with psychosis in South Africa (PRIZE): results of a randomized controlled feasibility trial (2024)
Journal Article
Asher, L., Rapiya, B., Repper, J., Reddy, T., Myers-Franchi, B., Faris, G., Petersen, I., Hanlon, C., & Brooke-Sumner, C. (2024). Peer-led recovery groups for people with psychosis in South Africa (PRIZE): results of a randomized controlled feasibility trial. Epidemiology and Psychiatric Sciences, 33, Article e47. https://doi.org/10.1017/S2045796024000556

Aims
The aims of this feasibility trial were to assess the acceptability and feasibility of peer-led recovery groups for people with psychosis in a low-resource South African setting, to assess the feasibility of trial methods, and to determine key... Read More about Peer-led recovery groups for people with psychosis in South Africa (PRIZE): results of a randomized controlled feasibility trial.

Pneumococcal pneumonia trends in adults hospitalised with community-acquired pneumonia over 10 years (2013-2023), and the role of serotype 3 (2024)
Journal Article
Lansbury, L., McKeever, T. M., Lawrence, H., Pick, H., Baskaran, V., Edwards-Pritchard, R. C., Matthews, L., Bailey, H., Ashton, D., Bendall, L., Rodrigo, C., Daniel, P., Litt, D., Eletu, S., Parmar, H., Sheppard, C. L., Ladhani, S., Trotter, C., & Lim, W. S. (in press). Pneumococcal pneumonia trends in adults hospitalised with community-acquired pneumonia over 10 years (2013-2023), and the role of serotype 3. Thorax,

Development of a Vocational Rehabilitation Intervention to support Return to Work and Wellbeing following Major Trauma: A Person-Based Approach (2024)
Journal Article
Radford, K., Kettlewell, J., das Nair, R., Morriss, R., Holmes, J., Kellezi, B., Timmons, S., Jones, T., Tressider, H., Andrews, I., Bridger, K., Patel, P., Lindley, R., De Dios Perez, B., Statham, A., Jones, T., Hoffman, K., James, M., Kendrick, D., & ROWTATE study team. (2024). Development of a Vocational Rehabilitation Intervention to support Return to Work and Wellbeing following Major Trauma: A Person-Based Approach. BMJ Open, 14(10), Article e085724. https://doi.org/10.1136/bmjopen-2024-085724+

Objectives: Major trauma centres save lives but rehabilitation to support return-to-work (RTW) is lacking. This paper describes development of a vocational rehabilitation intervention (the ROWTATE intervention) to support RTW following traumatic inju... Read More about Development of a Vocational Rehabilitation Intervention to support Return to Work and Wellbeing following Major Trauma: A Person-Based Approach.

Recent advances in the influenza virus vaccine landscape: a comprehensive overview of technologies and trials (2024)
Journal Article
Clark, T. W., Tregoning, J. S., Lister, H., Poletti, T., Amin, F., & Nguyen-Van-Tam, J. S. (in press). Recent advances in the influenza virus vaccine landscape: a comprehensive overview of technologies and trials. Clinical Microbiology Reviews, https://doi.org/10.1128/cmr.00025-24

In the United Kingdom (UK) in 2022/23, influenza virus infections returned to the levels recorded before the COVID-19 pandemic, exerting a substantial burden on an already stretched National Health Service (NHS) through increased primary and emergenc... Read More about Recent advances in the influenza virus vaccine landscape: a comprehensive overview of technologies and trials.

Examining support marshalling within an asynchronous online peer support forum for individuals affected by dementia (2024)
Journal Article
Coulson, N. S., & Talbot, C. V. (in press). Examining support marshalling within an asynchronous online peer support forum for individuals affected by dementia. Journal of Health Psychology, 1-14. https://doi.org/10.1177/13591053241287029

Online support communities may provide individuals affected by dementia opportunities for reciprocal peer support, however, the support marshalling strategies employed and their success remain unclear. Analysis of100 randomly selected conversation th... Read More about Examining support marshalling within an asynchronous online peer support forum for individuals affected by dementia.

Efficacy and safety of statins, ezetimibe and statins-ezetimibe therapies for children and adolescents with heterozygous familial hypercholesterolaemia: Systematic review, pairwise and network meta-analyses of randomised controlled trials (2024)
Journal Article
Llewellyn, A., Simmonds, M., Marshall, D., Harden, M., Woods, B., Humphries, S. E., Ramaswami, U., Priestley-Barnham, L., Fisher, M., Tata, L. J., & Qureshi, N. (2024). Efficacy and safety of statins, ezetimibe and statins-ezetimibe therapies for children and adolescents with heterozygous familial hypercholesterolaemia: Systematic review, pairwise and network meta-analyses of randomised controlled trials. Atherosclerosis, Article 118598. https://doi.org/10.1016/j.atherosclerosis.2024.118598

Background and aims
Statins, ezetimibe and statins-ezetimibe combination therapy are recommended lipid-lowering therapies (LLTs) in children with heterozygous familial hypercholesterolaemia (HeFH). However, their relative effectiveness is not well u... Read More about Efficacy and safety of statins, ezetimibe and statins-ezetimibe therapies for children and adolescents with heterozygous familial hypercholesterolaemia: Systematic review, pairwise and network meta-analyses of randomised controlled trials.

Development of the face-to-face component and recruitment strategy of a primary care digital social intervention for patients with asthma: Qualitative focus groups and interviews with stakeholders (2024)
Journal Article
Karampatakis, G. D., Kimber, S., Wood, H. E., Griffiths, C. J., Taylor, S. J. C., Li, X., Day, B., Mant, J., Relton, C., Watson, J. S., Marsh, V., Coulson, N. S., & De Simoni, A. (2024). Development of the face-to-face component and recruitment strategy of a primary care digital social intervention for patients with asthma: Qualitative focus groups and interviews with stakeholders. European Journal of General Practice, 30(1), Article 2407594. https://doi.org/10.1080/13814788.2024.2407594

BACKGROUND: 5.4 million people in the UK have asthma, with one third experiencing suboptimal control, leading to co-morbidities and increased healthcare use. A quarter of people with long-term conditions informally access peer support through online... Read More about Development of the face-to-face component and recruitment strategy of a primary care digital social intervention for patients with asthma: Qualitative focus groups and interviews with stakeholders.

Global rapid review of interventions to tackle the harms of illicit tobacco (2024)
Journal Article
Davies, N., Bogdanovica, I., Bains, M., Jayes, L., & Langley, T. E. (2024). Global rapid review of interventions to tackle the harms of illicit tobacco. Tobacco Control, https://doi.org/10.1136/tc-2024-058728

Objective This review aimed to assess interventions designed to reduce harm from illicit tobacco (IT). We evaluated health outcomes, cost-effectiveness, the advantages and disadvantages of interventions, and contextual factors affecting implementatio... Read More about Global rapid review of interventions to tackle the harms of illicit tobacco.