All Outputs (427)

Development and validation of a new algorithm for improved cardiovascular risk prediction (2024)
Journal Article
Hippisley-Cox, J., Coupland, C. A. C., Bafadhel, M., Russell, R. E. K., Sheikh, A., Brindle, P., & Channon, K. M. (2024). Development and validation of a new algorithm for improved cardiovascular risk prediction. Nature Medicine, 30, 1440-1447. https://doi.org/10.1038/s41591-024-02905-y

QRISK algorithms use data from millions of people to help clinicians identify individuals at high risk of cardiovascular disease (CVD). Here, we derive and externally validate a new algorithm, which we have named QR4, that incorporates novel risk fac... Read More about Development and validation of a new algorithm for improved cardiovascular risk prediction.

Uptake and 4-week quit rates from an opt-out co-located smoking cessation service delivered alongside community-based low-dose computed tomography screening within the Yorkshire Lung Screening Trial (2024)
Journal Article
Murray, R. L., Alexandris, P., Baldwin, D., Brain, K., Britton, J., Crosbie, P. A. J., Gabe, R., Lewis, S., Parrott, S., Quaife, S. L., Tam, H. Z., Wu, Q., Beeken, R., Copeland, H., Eckert, C., Hancock, N., Lindop, J., McCutchan, G., Marshall, C., Neal, R. D., …Callister, M. E. (2024). Uptake and 4-week quit rates from an opt-out co-located smoking cessation service delivered alongside community-based low-dose computed tomography screening within the Yorkshire Lung Screening Trial. European Respiratory Journal, 63(4), Article 2301768. https://doi.org/10.1183/13993003.01768-2023

BACKGROUND: Up to 50% of those attending for low-dose computed tomography screening for lung cancer continue to smoke and co-delivery of smoking cessation services alongside screening may maximise clinical benefit. Here we present data from an opt-ou... Read More about Uptake and 4-week quit rates from an opt-out co-located smoking cessation service delivered alongside community-based low-dose computed tomography screening within the Yorkshire Lung Screening Trial.

Effect of 3 months and 12 months of financial incentives on 12-month postpartum smoking cessation maintenance: a randomised controlled trial (2024)
Journal Article
Lewis, S., Mckell, J., Coleman, T., Cooper, S., Orton, S., Bauld, L., & Usher, J. (2024). Effect of 3 months and 12 months of financial incentives on 12-month postpartum smoking cessation maintenance: a randomised controlled trial. Addiction, 119(8), 1352-1363. https://doi.org/10.1111/add.16487

Background and aims
Offering financial incentives is effective for smoking cessation during pregnancy. We tested the effectiveness of financial incentives for maintaining postpartum cessation, comparing 12-month and 3-month incentives with each othe... Read More about Effect of 3 months and 12 months of financial incentives on 12-month postpartum smoking cessation maintenance: a randomised controlled trial.

Effect of 3 months and 12 months of financial incentives on 12‐month postpartum smoking cessation maintenance: A randomized controlled trial (2024)
Journal Article
Ussher, M., Best, C., Lewis, S., McKell, J., Coleman, T., Cooper, S., …Bauld, L. (2024). Effect of 3 months and 12 months of financial incentives on 12‐month postpartum smoking cessation maintenance: A randomized controlled trial. Addiction, 119(8), 1352-1363. https://doi.org/10.1111/add.16487

Background and aims

Offering financial incentives is effective for smoking cessation during pregnancy. We tested the effectiveness of financial incentives for maintaining postpartum cessation, comparing 12-month and 3-month incentives with each ot... Read More about Effect of 3 months and 12 months of financial incentives on 12‐month postpartum smoking cessation maintenance: A randomized controlled trial.

Patterns and trends of medicinal poisoning substances: a population-based cohort study of injuries in 0-11 year old children from 1998-2018 (2024)
Journal Article
Tyrrell, E. G., Orton, E., Tata, L. J., & Kendrick, D. (2024). Patterns and trends of medicinal poisoning substances: a population-based cohort study of injuries in 0-11 year old children from 1998-2018. Archives of Public Health, 82(1), Article 50. https://doi.org/10.1186/s13690-024-01268-7

Background
There have been sharp increases in antidepressant and opioid prescriptions over the last 10 years, as well as increased over-the-counter medicine availability. However, the impact on childhood medicinal poisonings rates, particularly by s... Read More about Patterns and trends of medicinal poisoning substances: a population-based cohort study of injuries in 0-11 year old children from 1998-2018.

Precision Medicine—Are We There Yet? A Narrative Review of Precision Medicine’s Applicability in Primary Care (2024)
Journal Article
Evans, W., Meslin, E. M., Kai, J., & Qureshi, N. (2024). Precision Medicine—Are We There Yet? A Narrative Review of Precision Medicine’s Applicability in Primary Care. Journal of Personalized Medicine, 14(4), Article 418. https://doi.org/10.3390/jpm14040418

Precision medicine (PM), also termed stratified, individualised, targeted, or personalised medicine, embraces a rapidly expanding area of research, knowledge, and practice. It brings together two emerging health technologies to deliver better individ... Read More about Precision Medicine—Are We There Yet? A Narrative Review of Precision Medicine’s Applicability in Primary Care.

Facilitators and barriers to asylum seeker and refugee oral health care access: a qualitative systematic review (2024)
Journal Article
Wainman, N. E., Phillips, O. . R., & Morling, J. R. (2024). Facilitators and barriers to asylum seeker and refugee oral health care access: a qualitative systematic review. British Dental Journal, https://doi.org/10.1038/s41415-024-7235-9

Objectives Asylum seekers and refugees (ASRs) encounter barriers when accessing oral health care (OHC). A qualitative systematic review was conducted to understand the perceptions, attitudes, behaviours and experiences of ASRs regarding their OHC. Th... Read More about Facilitators and barriers to asylum seeker and refugee oral health care access: a qualitative systematic review.

COVID-19 experience of people with severe mental health conditions and families in South Africa (2024)
Journal Article
Brooke-Sumner, C., Rapiya, B., Myers, B., Petersen, I., Hanlon, C., Repper, J., & Asher, L. (2024). COVID-19 experience of people with severe mental health conditions and families in South Africa. South African Journal of Psychiatry, 30, Article a2207. https://doi.org/10.4102/sajpsychiatry.v30i0.2207

Background: People with severe mental health conditions, such as schizophrenia, and their family caregivers are underserved in low- and middle-income countries where structured psychosocial support in the community is often lacking. This can present... Read More about COVID-19 experience of people with severe mental health conditions and families in South Africa.

The impact of conflict on infectious disease: a systematic literature review (2024)
Journal Article
Marou, V., Vardavas, C. I., Aslanoglou, K., Nikitara, K., Plyta, Z., Leonardi-Bee, J., …Suk, J. E. (2024). The impact of conflict on infectious disease: a systematic literature review. Conflict and Health, 18(1), Article 27. https://doi.org/10.1186/s13031-023-00568-z

Background: Conflict situations, armed or not, have been associated with emergence and transmission of infectious diseases. This review aims to identify the pathways through which infectious diseases emerge within conflict situations and to outline a... Read More about The impact of conflict on infectious disease: a systematic literature review.

Discontinuation of anti-tumour necrosis factor alpha treatment owing to blood test abnormalities, and cost-effectiveness of alternate blood monitoring strategies (2024)
Journal Article
Abhishek, A., Stevenson, M. D., Nakafero, G., Grainge, M. J., Evans, I., Alabas, O., Card, T., Taal, M. W., Aithal, G. P., Fox, C. P., Mallen, C. D., van der Windt, D. A., Riley, R. D., Warren, R. B., & Williams, H. C. (2024). Discontinuation of anti-tumour necrosis factor alpha treatment owing to blood test abnormalities, and cost-effectiveness of alternate blood monitoring strategies. British Journal of Dermatology, 190(4), 559-564. https://doi.org/10.1093/bjd/ljad430

Background: There is no evidence base to support the use of 6-monthly monitoring blood tests for the early detection of liver, blood and renal toxicity during established anti-tumour necrosis factor alpha (TNFα) treatment. Objectives: To evaluate the... Read More about Discontinuation of anti-tumour necrosis factor alpha treatment owing to blood test abnormalities, and cost-effectiveness of alternate blood monitoring strategies.

The majority of observational studies in leading peer-reviewed medicine journals are not registered and do not have a publicly accessible protocol: a scoping review (2024)
Journal Article
Leducq, S., Zaki, F., Hollestein, L. M., Apfelbacher, C., Ponna, N. P., Mazmudar, R., & Gran, S. (2024). The majority of observational studies in leading peer-reviewed medicine journals are not registered and do not have a publicly accessible protocol: a scoping review. Journal of Clinical Epidemiology, 170, Article 111341. https://doi.org/10.1016/j.jclinepi.2024.111341

Objectives
Observational studies are not subject to the same requirements as randomized controlled trials, such as registration or publishing a protocol. The aim of this scoping review was to estimate the registration rate of observational studies i... Read More about The majority of observational studies in leading peer-reviewed medicine journals are not registered and do not have a publicly accessible protocol: a scoping review.

The majority of observational studies in leading peer-reviewed medicine journals are not registered and do not have a publicly accessible protocol: a scoping review (2024)
Journal Article
Leducq, S., Zaki, F., Hollestein, L. M., Apfelbacher, C., Ponna, N. P., Mazmudar, R., & Gran, S. (2024). The majority of observational studies in leading peer-reviewed medicine journals are not registered and do not have a publicly accessible protocol: a scoping review. Journal of Clinical Epidemiology, 170, Article 111341. https://doi.org/10.1016/j.jclinepi.2024.111341

Objectives
Observational studies are not subject to the same requirements as randomized controlled trials, such as registration or publishing a protocol. The aim of this scoping review was to estimate the registration rate of observational studies i... Read More about The majority of observational studies in leading peer-reviewed medicine journals are not registered and do not have a publicly accessible protocol: a scoping review.

Experts’ views on translating NHS support to stop smoking in pregnancy into a comprehensive digital intervention (2024)
Journal Article
McDaid, L., Belderson, P., Emery, J., Coleman, T., Leonardi-Bee, J., & Naughton, F. (in press). Experts’ views on translating NHS support to stop smoking in pregnancy into a comprehensive digital intervention. PLOS Digital Health, 3(3), Article e0000472. https://doi.org/10.1371/journal.pdig.0000472

Many pregnant smokers need support to quit successfully. In the United Kingdom, trained smoking cessation advisors deliver structured behavioural counselling alongside access to free nicotine replacement therapy (NRT); known as the ‘Standard Treatmen... Read More about Experts’ views on translating NHS support to stop smoking in pregnancy into a comprehensive digital intervention.

Behaviour support in dentistry: A Delphi study to agree terminology in behaviour management (2024)
Journal Article
Mac Giolla Phadraig, C., Healy, O., Fisal, A. A., Yarascavitch, C., van Harten, M., Nunn, J., Newton, T., Sturmey, P., Asimakopoulou, K., Daly, B., Hosey, M. T., Kammer, P. V., Dougall, A., Geddis‐Regan, A., Pradhan, A., Setiawan, A. S., Kerr, B., Friedman, C. S., Cornelius, B. W., Stirling, C., …Krämer, S. (2024). Behaviour support in dentistry: A Delphi study to agree terminology in behaviour management. Community Dentistry and Oral Epidemiology, 52(4), 550-571. https://doi.org/10.1111/cdoe.12953

Objectives: Dental behaviour support (DBS) describes all specific techniques practiced to support patients in their experience of professional oral healthcare. DBS is roughly synonymous with behaviour management, which is an outdated concept. There i... Read More about Behaviour support in dentistry: A Delphi study to agree terminology in behaviour management.

Potential smoke-free dividend across local areas in England: A cross-sectional analysis (2024)
Journal Article
Morris, D., Gillespie, D., Dockrell, M., Cook, M., Horton, M., Brown, J., & Langley, T. (2024). Potential smoke-free dividend across local areas in England: A cross-sectional analysis. Tobacco Control, https://doi.org/10.1136/tc-2023-058264

Background
The value that might be added to local economies each year through the money that people who smoke tobacco would save if everyone quit smoking is called the “smoke-free dividend”. This study aimed to estimate the value of the smoke-free d... Read More about Potential smoke-free dividend across local areas in England: A cross-sectional analysis.

Substantial cost savings of ultrasound-based management over magnetic resonance imaging-based management in an inflammatory bowel disease service (2024)
Journal Article
Radford, S. J., Abdul-Aema, B., Tench, C., Leighton, P., Coad, J., & Moran, G. W. (2024). Substantial cost savings of ultrasound-based management over magnetic resonance imaging-based management in an inflammatory bowel disease service. Scandinavian Journal of Gastroenterology, 59(6), 683-689. https://doi.org/10.1080/00365521.2024.2330588

Background: Imaging is used to monitor disease activity in small bowel Crohn’s disease (CD). Magnetic Resonance Enterography is often employed as a first modality in the United Kingdom for assessment and monitoring; however, waiting times, cost, pati... Read More about Substantial cost savings of ultrasound-based management over magnetic resonance imaging-based management in an inflammatory bowel disease service.

Prevalence, regional patterns and socio-demographic factors associated with poly-tobacco use in India: A secondary data analysis (2024)
Journal Article
Bantwal, P., Kulkarni, M. M., Kamath, V. G., Naik, A. K., Fogarty, A. W., Dhar, M., & Ahankari, A. S. (2024). Prevalence, regional patterns and socio-demographic factors associated with poly-tobacco use in India: A secondary data analysis. PLOS Global Public Health, 4(3), Article e0002999. https://doi.org/10.1371/journal.pgph.0002999

Background: Tobacco use is associated with early, intermediate and long-term complications throughout the life course. With an influx of newer products containing nicotine, poly-tobacco use is slowly emerging as a public health concern, that is defin... Read More about Prevalence, regional patterns and socio-demographic factors associated with poly-tobacco use in India: A secondary data analysis.

Patient and health professional views on risk-stratified monitoring of immune-suppressing treatment in adults with inflammatory diseases (2024)
Journal Article
Fuller, A., Hancox, J., Williams, H. C., Card, T., Taal, M. W., Aithal, G. P., Fox, C. P., Mallen, C. D., Maxwell, J. R., Bingham, S., Vedhara, K., & Abhishek, A. (in press). Patient and health professional views on risk-stratified monitoring of immune-suppressing treatment in adults with inflammatory diseases. Rheumatology, Article keae175. https://doi.org/10.1093/rheumatology/keae175

Objective
To explore the acceptability of an individualised risk-stratified approach to monitoring for target-organ toxicity in adult patients with immune-mediated inflammatory diseases established on immune-suppressing treatment(s).

Methods
Adu... Read More about Patient and health professional views on risk-stratified monitoring of immune-suppressing treatment in adults with inflammatory diseases.

Uptake and safety of pneumococcal vaccination in adults with immune mediated inflammatory diseases: a UK wide observational study (2024)
Journal Article
Nakafero, G., Grainge, M. J., Card, T., Mallen, C. D., Nguyen Van-Tam, J. S., Abhishek, A., & . (2024). Uptake and safety of pneumococcal vaccination in adults with immune mediated inflammatory diseases: a UK wide observational study. Rheumatology, Article keae160. https://doi.org/10.1093/rheumatology/keae160

Objective The uptake and safety of pneumococcal vaccination in people with immune mediated inflammatory diseases (IMIDs) is poorly understood. We investigated the UK wide pneumococcal vaccine uptake in adults with IMIDs and explored the association b... Read More about Uptake and safety of pneumococcal vaccination in adults with immune mediated inflammatory diseases: a UK wide observational study.

Commentary: A comparative randomized clinical trial evaluating the efficacy and safety of tacrolimus versus hydrocortisone as a topical treatment of atopic dermatitis in children (2024)
Journal Article
Harvey, J., Stuart, B., & Williams, H. C. (2024). Commentary: A comparative randomized clinical trial evaluating the efficacy and safety of tacrolimus versus hydrocortisone as a topical treatment of atopic dermatitis in children. Frontiers in Pharmacology, 15, Article 1372259. https://doi.org/10.3389/fphar.2024.1372259