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All Outputs (427)

Origins of lifetime health around the time of conception: causes and consequences (2018)
Journal Article
Fleming, T., Watkins, A., Velazquez, M., Mathers, J., Prentice, A., Stephenson, J., Barker, M., Saffery, R., Yajnik, C., Eckert, J., Hanson, M., Terrence, F., Peter, G., & Keith, G. (2018). Origins of lifetime health around the time of conception: causes and consequences. Lancet, 391(10132), 1842-1852. https://doi.org/10.1016/S0140-6736%2818%2930312-X

Parental environmental factors, including diet, body composition, metabolism, and stress, affect the health and chronic disease risk of people throughout their lives, as captured in the Developmental Origins of Health and Disease concept. Research ac... Read More about Origins of lifetime health around the time of conception: causes and consequences.

368 CFHealthHub: development and evaluation of videos incorporating peer description of successful self-management with inhaled therapies in adults with CF used to build self-efficacy to support self-care within the CFHealthHub complex intervention (2017)
Journal Article
Kirkpatrick, S., Arden, M., Beever, D., Bradley, J., Cantrill, H., Daniels, T., …Wildman, M. (2017). 368 CFHealthHub: development and evaluation of videos incorporating peer description of successful self-management with inhaled therapies in adults with CF used to build self-efficacy to support self-care within the CFHealthHub complex intervention. Journal of Cystic Fibrosis, 16(Suppl 1), S155-S156. https://doi.org/10.1016/s1569-1993%2817%2930699-9

The PAndemic INfluenza Triage in the Emergency Department (PAINTED) pilot cohort study (2015)
Journal Article
Goodacre, S., Irving, A., Wilson, R., Beever, D., & Challen, K. (2015). The PAndemic INfluenza Triage in the Emergency Department (PAINTED) pilot cohort study. Health Technology Assessment, 19(3), 1-70. https://doi.org/10.3310/hta19030

Background
Research needs to be undertaken rapidly in the event of an influenza pandemic to develop and evaluate triage methods for people presenting to the emergency department with suspected pandemic influenza.

Objectives
We aimed to pilot a r... Read More about The PAndemic INfluenza Triage in the Emergency Department (PAINTED) pilot cohort study.

How to read a cohort study (2014)
Book Chapter
Tata, L. J. (2014). How to read a cohort study. In N. J. Talley, G. Richard Locke III, P. Moayyedi, J. West, & Y. A. Saito (Eds.), GI Epidemiology: Diseases and Clinical Methodology (15-29). (Second). John Wiley & Sons, Ltd. https://doi.org/10.1002/9781118727072.ch2

The cohort is the basis of all epidemiologic study designs as it is the closest way to study the natural progression of people's life course over which the temporal relationship between exposures and outcomes can be assessed. Although a cohort is def... Read More about How to read a cohort study.

Supporting public involvement in research design and grant development: a case study of a public involvement award scheme managed by a National Institute for Health Research (NIHR) Research Design Service (RDS) (2013)
Journal Article
Boote, J. D., Twiddy, M., Baird, W., Birks, Y., Clarke, C., & Beever, D. (2015). Supporting public involvement in research design and grant development: a case study of a public involvement award scheme managed by a National Institute for Health Research (NIHR) Research Design Service (RDS). Health Expectations, 18(5), 1481-1493. https://doi.org/10.1111/hex.12130

Background
It is good practice for the public to be involved in developing health research. Resources should be available for researchers to fund the involvement of the public in the development of their grants.

Objective
To describe a funding a... Read More about Supporting public involvement in research design and grant development: a case study of a public involvement award scheme managed by a National Institute for Health Research (NIHR) Research Design Service (RDS).

Act now against new NHS competition regulations (2013)
Journal Article
Davis, J., Banks, I., Wrigley, D., Peedell, C., Pollock, A., McPherson, K., …Chandy, R. (2013). Act now against new NHS competition regulations. BMJ, 346, https://doi.org/10.1136/bmj.f1819

An open letter to the BMA and the Academy of Medical Royal Colleges calls on them to make a joint public statement of opposition to the amended section 75 regulations

Evaluating the effectiveness of a schools-based programme to promote exercise self-efficacy in children and young people with risk factors for obesity: Steps to active kids (STAK) (2011)
Journal Article
Glazebrook, C., Batty, M. J., Mullan, N., MacDonald, I., Nathan, D., Sayal, K., …Hollis, C. (2011). Evaluating the effectiveness of a schools-based programme to promote exercise self-efficacy in children and young people with risk factors for obesity: Steps to active kids (STAK). BMC Public Health, 11, Article 830. https://doi.org/10.1186/1471-2458-11-830

Background
Low levels of physical activity in children have been linked to an increased risk of obesity, but many children lack confidence in relation to exercise (exercise self-efficacy). Factors which can impact on confidence include a chronic hea... Read More about Evaluating the effectiveness of a schools-based programme to promote exercise self-efficacy in children and young people with risk factors for obesity: Steps to active kids (STAK).

Acute medical unit comprehensive geriatric assessment intervention study (AMIGOS): Study protocol for a randomised controlled trial (2011)
Journal Article
Edmans, J., Conroy, S., Harwood, R., Lewis, S., Elliott, R. A., Logan, P., …Gladman, J. (2011). Acute medical unit comprehensive geriatric assessment intervention study (AMIGOS): Study protocol for a randomised controlled trial. Trials, 12, Article 200. https://doi.org/10.1186/1745-6215-12-200

Background
Many older people presenting to Acute Medical Units (AMU) are discharged after only a short stay (< 72 hours), yet many re-present to hospital or die within 1 year. Comprehensive Geriatric Assessment may improve patient outcomes for this... Read More about Acute medical unit comprehensive geriatric assessment intervention study (AMIGOS): Study protocol for a randomised controlled trial.

Garlic as an inhibitor of pseudomonas aeruginosa quorum sensing in cystic fibrosis - A pilot randomized controlled trial (2010)
Journal Article
Smyth, A. R., Cifelli, P. M., Ortori, C. A., Righetti, K., Lewis, S., Erskine, P., …Knox, A. (2010). Garlic as an inhibitor of pseudomonas aeruginosa quorum sensing in cystic fibrosis - A pilot randomized controlled trial. Pediatric Pulmonology, 45(4), 356-362. https://doi.org/10.1002/ppul.21193

Pseudomonas aeruginosa forms biofilms in the cystic fibrosis lung. Quorum sensing (QS) controls biofilm maturation, immune evasion, antibiotic tolerance and virulence factor production. Garlic shows QS inhibitory activity in vitro and in animal model... Read More about Garlic as an inhibitor of pseudomonas aeruginosa quorum sensing in cystic fibrosis - A pilot randomized controlled trial.

Clinical trials: the viewpoint of children with a chronic illness compared with healthy children (2009)
Journal Article
Cherrill, J., Hudson, H., Cocking, C., Unsworth, V., Franck, L., Fakis, A., McIntyre, J., & Choonara, I. (2009). Clinical trials: the viewpoint of children with a chronic illness compared with healthy children. Archives of Disease in Childhood, 95(3), 229-232. https://doi.org/10.1136/adc.2009.159145

The views of over 200 children (11–16 years old, who were either healthy or attending paediatric medical clinics with a chronic illness) on issues relating to paediatric clinical trials were determined by a questionnaire. Children with a chronic illn... Read More about Clinical trials: the viewpoint of children with a chronic illness compared with healthy children.

Safety in paediatric clinical trials - a 7-year review (2008)
Journal Article
Sammons, H., Gray, C., Hudson, H., Cherrill, J., & Choonara, I. (2008). Safety in paediatric clinical trials - a 7-year review. Acta Paediatrica, 97(4), 474-477. https://doi.org/10.1111/j.1651-2227.2008.00676.x

Aim: The safety of clinical trials in children has not been previously studied. We aimed to identify how safety is monitored and the extent of adverse drug reactions (ADRs).

Methods: A literature review of the Medline Database for therapeutic clin... Read More about Safety in paediatric clinical trials - a 7-year review.

Influence of ursodeoxycholic acid on the mortality and malignancy associated with primary biliary cirrhosis: A population-based cohort study (2007)
Journal Article
Jackson, H., Solaymani-Dodaran, M., Card, T. R., Aithal, G. P., Logan, R., & West, J. (2007). Influence of ursodeoxycholic acid on the mortality and malignancy associated with primary biliary cirrhosis: A population-based cohort study. Hepatology, 46(4), 1131-1137. https://doi.org/10.1002/hep.21795

There is debate over the mortality and malignancy risk in people with primary biliary cirrhosis (PBC) and whether this risk is reduced by use of ursodeoxycholic acid. To investigate this issue, we identified 930 people with PBC and 9,202 control subj... Read More about Influence of ursodeoxycholic acid on the mortality and malignancy associated with primary biliary cirrhosis: A population-based cohort study.