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All Outputs (414)

A randomised controlled trial to assess the effectiveness and cost-effectiveness of tailored web- and text-based smoking cessation support in primary care: iQuit in Practice II trial protocol (Preprint) (2020)
Preprint / Working Paper
Proctor, J., Naughton, F., Sloan, M., Hopewell, S., Brimicombe, J., Prevost, T., …Sutton, S. A randomised controlled trial to assess the effectiveness and cost-effectiveness of tailored web- and text-based smoking cessation support in primary care: iQuit in Practice II trial protocol (Preprint)

Background: The prevalence of smoking is in decline, however, it continues to be a major public health burden. In England, primary care is the health setting that provides smoking cessation support to the most smokers. However, this setting has one o... Read More about A randomised controlled trial to assess the effectiveness and cost-effectiveness of tailored web- and text-based smoking cessation support in primary care: iQuit in Practice II trial protocol (Preprint).

Interventions to promote oral nutritional behaviours in people living with neurodegenerative disorders of the motor system: A systematic review (2019)
Journal Article
Essat, M., Archer, R., Williams, I., Zarotti, N., Coates, E., Clowes, M., …McDermott, C. (2020). Interventions to promote oral nutritional behaviours in people living with neurodegenerative disorders of the motor system: A systematic review. Clinical Nutrition, 39(8), 2547-2556. https://doi.org/10.1016/j.clnu.2019.11.015

Background & aims
Weight loss is common in people with neurodegenerative diseases of the motor system (NDMS), such as Parkinson's disease and Amyotrophic Lateral Sclerosis, and is associated with reduced quality of life, functional ability and survi... Read More about Interventions to promote oral nutritional behaviours in people living with neurodegenerative disorders of the motor system: A systematic review.

An evaluation of risk-based monitoring in pragmatic trials in UK Clinical Trials Units (2019)
Journal Article
Beever, D., & Swaby, L. (2019). An evaluation of risk-based monitoring in pragmatic trials in UK Clinical Trials Units. Trials, 20(1), Article 556. https://doi.org/10.1186/s13063-019-3619-6

Background
Good Clinical Practice guidelines issued in 2016 encourage risk-based approaches to monitoring clinical trials. This study compared current risk assessment and monitoring approaches in UK Clinical Trials Units (CTUs) with the published gu... Read More about An evaluation of risk-based monitoring in pragmatic trials in UK Clinical Trials Units.

Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study (2019)
Journal Article
Coupland, C. A., Hill, T., Dening, T., Morriss, R., Moore, M., & Hippisley-Cox, J. (2019). Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study. JAMA Internal Medicine, 179(8), 1084-1093. https://doi.org/10.1001/jamainternmed.2019.0677

IMPORTANCE Anticholinergic medicines have short-term cognitive adverse effects, but it
is uncertain whether long-term use of these drugs is associated with an increased risk of dementia.

OBJECTIVE To assess associations between anticholinergic dr... Read More about Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study.

Origins of lifetime health around the time of conception: causes and consequences (2018)
Journal Article
Fleming, T., Watkins, A., Velazquez, M., Mathers, J., Prentice, A., Stephenson, J., …Keith, G. (2018). Origins of lifetime health around the time of conception: causes and consequences. Lancet, 391(10132), 1842-1852. https://doi.org/10.1016/S0140-6736%2818%2930312-X

Parental environmental factors, including diet, body composition, metabolism, and stress, affect the health and chronic disease risk of people throughout their lives, as captured in the Developmental Origins of Health and Disease concept. Research ac... Read More about Origins of lifetime health around the time of conception: causes and consequences.

368 CFHealthHub: development and evaluation of videos incorporating peer description of successful self-management with inhaled therapies in adults with CF used to build self-efficacy to support self-care within the CFHealthHub complex intervention (2017)
Journal Article
Kirkpatrick, S., Arden, M., Beever, D., Bradley, J., Cantrill, H., Daniels, T., …Wildman, M. (2017). 368 CFHealthHub: development and evaluation of videos incorporating peer description of successful self-management with inhaled therapies in adults with CF used to build self-efficacy to support self-care within the CFHealthHub complex intervention. Journal of Cystic Fibrosis, 16(Suppl 1), S155-S156. https://doi.org/10.1016/s1569-1993%2817%2930699-9

The PAndemic INfluenza Triage in the Emergency Department (PAINTED) pilot cohort study (2015)
Journal Article
Goodacre, S., Irving, A., Wilson, R., Beever, D., & Challen, K. (2015). The PAndemic INfluenza Triage in the Emergency Department (PAINTED) pilot cohort study. Health Technology Assessment, 19(3), 1-70. https://doi.org/10.3310/hta19030

Background
Research needs to be undertaken rapidly in the event of an influenza pandemic to develop and evaluate triage methods for people presenting to the emergency department with suspected pandemic influenza.

Objectives
We aimed to pilot a r... Read More about The PAndemic INfluenza Triage in the Emergency Department (PAINTED) pilot cohort study.

How to read a cohort study (2014)
Book Chapter
Tata, L. J. (2014). How to read a cohort study. In N. J. Talley, G. Richard Locke III, P. Moayyedi, J. West, & Y. A. Saito (Eds.), GI Epidemiology: Diseases and Clinical Methodology (15-29). (Second). John Wiley & Sons, Ltd. https://doi.org/10.1002/9781118727072.ch2

The cohort is the basis of all epidemiologic study designs as it is the closest way to study the natural progression of people's life course over which the temporal relationship between exposures and outcomes can be assessed. Although a cohort is def... Read More about How to read a cohort study.

Supporting public involvement in research design and grant development: a case study of a public involvement award scheme managed by a National Institute for Health Research (NIHR) Research Design Service (RDS) (2013)
Journal Article
Boote, J. D., Twiddy, M., Baird, W., Birks, Y., Clarke, C., & Beever, D. (2015). Supporting public involvement in research design and grant development: a case study of a public involvement award scheme managed by a National Institute for Health Research (NIHR) Research Design Service (RDS). Health Expectations, 18(5), 1481-1493. https://doi.org/10.1111/hex.12130

Background
It is good practice for the public to be involved in developing health research. Resources should be available for researchers to fund the involvement of the public in the development of their grants.

Objective
To describe a funding a... Read More about Supporting public involvement in research design and grant development: a case study of a public involvement award scheme managed by a National Institute for Health Research (NIHR) Research Design Service (RDS).

Act now against new NHS competition regulations (2013)
Journal Article
Davis, J., Banks, I., Wrigley, D., Peedell, C., Pollock, A., McPherson, K., …Chandy, R. (2013). Act now against new NHS competition regulations. BMJ, 346, https://doi.org/10.1136/bmj.f1819

An open letter to the BMA and the Academy of Medical Royal Colleges calls on them to make a joint public statement of opposition to the amended section 75 regulations