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All Outputs (434)

Lessons from the PROTECT-CH COVID-19 platform trial in care homes (2024)
Journal Article
Bath, P. M., Ball, J., Boyd, M., Gage, H., Glover, M., Godfrey, M., Guthrie, B., Hewitt, J., Howard, R., Jaki, T., Juszczak, E., Lasserson, D., Leighton, P., Leyland, V., Shen Lim, W., Logan, P., Meakin, G., Montgomery, A., Ogollah, R., Passmore, P., …Gordon, A. L. (in press). Lessons from the PROTECT-CH COVID-19 platform trial in care homes. Health Technology Assessment,

Ethnic disparities in lung cancer incidence and differences in diagnostic characteristics: a population-based cohort study in England (2024)
Journal Article
Tzu-Hsuan Chen, D., Hirst, J., Coupland, C. A., Liao, W., Baldwin, D. R., & Hippisley-Cox, J. (2025). Ethnic disparities in lung cancer incidence and differences in diagnostic characteristics: a population-based cohort study in England. The Lancet Regional Health Europe, 48, Article 101124. https://doi.org/10.1016/j.lanepe.2024.101124

Background
Lung cancer is a leading cause of mortality, yet disparities in lung cancer across different sociodemographic groups in the UK remain unclear. This study investigates ethnicity and sociodemographic disparities and differences in lung canc... Read More about Ethnic disparities in lung cancer incidence and differences in diagnostic characteristics: a population-based cohort study in England.

How and why do community stakeholders participate in the national stroke audit in England? Findings from a mixed-method online survey (2024)
Journal Article
Russell, L., Chouliara, N., Lewis, S., James, M., & Fisher, R. (2024). How and why do community stakeholders participate in the national stroke audit in England? Findings from a mixed-method online survey. BMC Health Services Research, 24, Article 1358. https://doi.org/10.1186/s12913-024-11653-1

Background

National audit programmes are a recognised means of assessing quality of healthcare by collecting and reporting data in relation to evidence-based standards. The Sentinel Stroke National Audit Programme is a prospective audit of process... Read More about How and why do community stakeholders participate in the national stroke audit in England? Findings from a mixed-method online survey.

Formative work for the LEGEND (Low EnerGy DiEt iN adolescents with type 2 diabetes and obesity) study: a worked example of patient and public involvement in research (2024)
Journal Article
Blake, H., Law, J., Procter, E., Barrett, T., & Sachdev, P. (2024). Formative work for the LEGEND (Low EnerGy DiEt iN adolescents with type 2 diabetes and obesity) study: a worked example of patient and public involvement in research. Practical Diabetes, 41(4), 27-31. https://doi.org/10.1002/pdi.2520

This study uses evidence-based guidance to report on patient and public involvement and engagement activity that informed the design of a feasibility trial to explore the use of low energy diet for children and young people with type 2 diabetes. Over... Read More about Formative work for the LEGEND (Low EnerGy DiEt iN adolescents with type 2 diabetes and obesity) study: a worked example of patient and public involvement in research.

The association between drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a case-control study (2024)
Journal Article
Swiderski, M., Vinogradova, Y., Knaggs, R. D., Harman, K., Harwood, R. H., Prasad, V., Persson, M. S. M., Figueredo, G., Layfield, C., & Gran, S. (2024). The association between drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a case-control study. British Journal of Dermatology, Article ljae416. https://doi.org/10.1093/bjd/ljae416

Background
Bullous pemphigoid (BP) is an autoimmune skin disease that affects mainly older people. Numerous drugs have been previously associated with BP based on case series and small hospital-based studies. More reliable and precise estimates of a... Read More about The association between drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a case-control study.

Combined magnetic resonance imaging, high resolution manometry and a randomised trial of bisacodyl versus hyoscine shows the significance of an enlarged colon in constipation: the RECLAIM study (2024)
Journal Article
Wilkinson-Smith, V., Scott, M., Menys, A., Wiklendt, L., MARCIANI, L., Atkinson, D., Sansone, S., Zdanavciene, A., Coupland, C., Knowles, C., Dinning, P., Taylor, S., Gowland, P., Hoad, C., Corsetti, M., & Spiller, R. (2024). Combined magnetic resonance imaging, high resolution manometry and a randomised trial of bisacodyl versus hyoscine shows the significance of an enlarged colon in constipation: the RECLAIM study. Gut, https://doi.org/10.1136/gutjnl-2024-332755

Background
Colonic motility in constipation can be assessed non-invasively using MRI.

Objective
To compare MRI with high resolution colonic manometry (HRCM) for predicting treatment response.

Design
Part 1: 44 healthy volunteers (HV), 43... Read More about Combined magnetic resonance imaging, high resolution manometry and a randomised trial of bisacodyl versus hyoscine shows the significance of an enlarged colon in constipation: the RECLAIM study.

Combined MRI, high-resolution manometry and a randomised trial of bisacodyl versus hyoscine show the significance of an enlarged colon in constipation: the RECLAIM study (2024)
Journal Article
Wilkinson-Smith, V., Scott, M., Menys, A., Wiklendt, L., Marciani, L., Atkinson, D., Sansone, S., Zdanaviciene, A., Coupland, C., Knowles, C. H., Dinning, P., Taylor, S. A., Gowland, P., Hoad, C. L., Corsetti, M., & Spiller, R. C. (2024). Combined MRI, high-resolution manometry and a randomised trial of bisacodyl versus hyoscine show the significance of an enlarged colon in constipation: the RECLAIM study. Gut, https://doi.org/10.1136/gutjnl-2024-332755

Background: Colonic motility in constipation can be assessed non-invasively using MRI.

Objective: To compare MRI with high-resolution colonic manometry (HRCM) for predicting treatment response.

Design: Part 1: 44 healthy volunteers (HVs), 43 pa... Read More about Combined MRI, high-resolution manometry and a randomised trial of bisacodyl versus hyoscine show the significance of an enlarged colon in constipation: the RECLAIM study.

Monitoring university student response to social distancing policy during the SARS-CoV-2 pandemic using Bluetooth: the RADAR study (2024)
Journal Article
Bolton, K. J., Mendez-Villalon, A., Nanji, H., Jia, R., Ayling, K., Figueredo, G., & Vedhara, K. (in press). Monitoring university student response to social distancing policy during the SARS-CoV-2 pandemic using Bluetooth: the RADAR study. Mathematics in Medical and Life Sciences,

Aim: We use the Remote Assessment of Disease and Relapses platform (RADAR) to collect Bluetooth contact and location data from university students. We test the ability of this technology to objectively capture social interaction, explore the propensi... Read More about Monitoring university student response to social distancing policy during the SARS-CoV-2 pandemic using Bluetooth: the RADAR study.

Implementing vocational rehabilitation for people with multiple sclerosis in the UK National Health Service: a mixed-methods feasibility study (2024)
Journal Article
De Dios Perez, B., Holmes, J., Elder, T., Lindley, R., Evangelou, N., das Nair, R., Senior, C., Booth, V., Hassard, J., Ford, H. L., Newsome, I., & Radford, K. (2024). Implementing vocational rehabilitation for people with multiple sclerosis in the UK National Health Service: a mixed-methods feasibility study. Disability and Rehabilitation, https://doi.org/10.1080/09638288.2024.2417031

Purpose: To implement a job retention vocational rehabilitation (VR) intervention (MSVR) for people with multiple sclerosis (MS) and their employers in the UK National Health Service (NHS). Methods: Multicentre, single-arm feasibility study with post... Read More about Implementing vocational rehabilitation for people with multiple sclerosis in the UK National Health Service: a mixed-methods feasibility study.

The CO-produced Psychosocial INtervention delivered by GPs to young people after self-harm (COPING): protocol for a feasibility study (2024)
Journal Article
Mughal, F., Chew-Graham, C. A., Saunders, B., Lawton, S. A., Lewis, S., Smith, J., Lancaster, G., Townsend, E., Armitage, C. J., Bower, P., Kapur, N., Kessler, D., Realpe, A. X., Wiles, N., Ougrin, D., & Lewis, M. (2024). The CO-produced Psychosocial INtervention delivered by GPs to young people after self-harm (COPING): protocol for a feasibility study. NIHR Open Research, 4, Article 27. https://doi.org/10.3310/nihropenres.13576.2

Background: Self-harm in young people is a growing concern and reducing rates a global priority. Rates of self-harm documented in general practice have been increasing for young people in the UK in the last two decades, especially in 13–16-year-olds.... Read More about The CO-produced Psychosocial INtervention delivered by GPs to young people after self-harm (COPING): protocol for a feasibility study.

A Scoping Review of Electronic Health Records Based Screening Algorithms for Familial Hypercholesterolemia (2024)
Journal Article
Osei, J., Razavi, A. C., Otchere, B., Bonful, G., Akoto, N., Akyea, R. K., Qureshi, N., Coronado, F., Moonesinghe, R., Kolor, K., Mensah, G. A., Sperling, L., & Khoury, M. J. (2024). A Scoping Review of Electronic Health Records Based Screening Algorithms for Familial Hypercholesterolemia. JACC: Advances, https://doi.org/10.1016/j.jacadv.2024.101297

Background
Familial hypercholesterolemia (FH) is a common genetic disorder that is strongly associated with premature cardiovascular disease. Effective diagnosis and appropriate treatment of FH can reduce cardiovascular disease risk; however, FH is... Read More about A Scoping Review of Electronic Health Records Based Screening Algorithms for Familial Hypercholesterolemia.

Enhanced Infant Movement Analysis Using Transformer-Based Fusion of Diverse Video Features for Neurodevelopmental Monitoring (2024)
Journal Article
Turner, A., & Sharkey, D. (2024). Enhanced Infant Movement Analysis Using Transformer-Based Fusion of Diverse Video Features for Neurodevelopmental Monitoring. Sensors, 24(20), Article 6619. https://doi.org/10.3390/s24206619

Neurodevelopment is a highly intricate process, and early detection of abnormalities is critical for optimizing outcomes through timely intervention. Accurate and cost-effective diagnostic methods for neurological disorders, particularly in infants,... Read More about Enhanced Infant Movement Analysis Using Transformer-Based Fusion of Diverse Video Features for Neurodevelopmental Monitoring.

Peer-led recovery groups for people with psychosis in South Africa (PRIZE): results of a randomized controlled feasibility trial (2024)
Journal Article
Asher, L., Brooke-Sumner, C., Rapiya, B., Repper, J., Reddy, T., Myers-Franchi, B., Faris, G., Petersen, I., & Hanlon, C. (2024). Peer-led recovery groups for people with psychosis in South Africa (PRIZE): results of a randomized controlled feasibility trial. Epidemiology and Psychiatric Sciences, 33, Article e47. https://doi.org/10.1017/S2045796024000556

Aims
The aims of this feasibility trial were to assess the acceptability and feasibility of peer-led recovery groups for people with psychosis in a low-resource South African setting, to assess the feasibility of trial methods, and to determine key... Read More about Peer-led recovery groups for people with psychosis in South Africa (PRIZE): results of a randomized controlled feasibility trial.

Peer-led recovery groups for people with psychosis in South Africa (PRIZE): results of a randomized controlled feasibility trial (2024)
Journal Article
Asher, L., Rapiya, B., Repper, J., Reddy, T., Myers-Franchi, B., Faris, G., Petersen, I., Hanlon, C., & Brooke-Sumner, C. (2024). Peer-led recovery groups for people with psychosis in South Africa (PRIZE): results of a randomized controlled feasibility trial. Epidemiology and Psychiatric Sciences, 33, Article e47. https://doi.org/10.1017/S2045796024000556

Aims
The aims of this feasibility trial were to assess the acceptability and feasibility of peer-led recovery groups for people with psychosis in a low-resource South African setting, to assess the feasibility of trial methods, and to determine key... Read More about Peer-led recovery groups for people with psychosis in South Africa (PRIZE): results of a randomized controlled feasibility trial.

Pneumococcal pneumonia trends in adults hospitalised with community-acquired pneumonia over 10 years (2013-2023), and the role of serotype 3 (2024)
Journal Article
Lansbury, L., McKeever, T. M., Lawrence, H., Pick, H., Baskaran, V., Edwards-Pritchard, R. C., Matthews, L., Bailey, H., Ashton, D., Bendall, L., Rodrigo, C., Daniel, P., Litt, D., Eletu, S., Parmar, H., Sheppard, C. L., Ladhani, S., Trotter, C., & Lim, W. S. (in press). Pneumococcal pneumonia trends in adults hospitalised with community-acquired pneumonia over 10 years (2013-2023), and the role of serotype 3. Thorax,

Collagenase Injection versus Limited Fasciectomy for Dupuytren’s Contracture (2024)
Journal Article
Dias, J., Tharmanathan, P., Arundel, C., Welch, C., Math, M., Wu, Q., Leighton, P., Armaou, M., Johnson, N., James, S., Cooke, J., Bainbridge, L., Craigen, M., Warwick, D., Brady, S., Flett, L. G., Jones, J., Knowlson, C. N., Watson, M., Keding, A., …Torgerson, D. (2024). Collagenase Injection versus Limited Fasciectomy for Dupuytren’s Contracture. New England Journal of Medicine, 391(16), https://doi.org/10.1056/NEJMoa2312631

Background
Treatments for Dupuytren’s contracture include limited fasciectomy and collagenase injection. Comparisons of the effectiveness of these treatments have been limited.

Methods
We performed an unblinded, multicenter, pragmatic, two-group... Read More about Collagenase Injection versus Limited Fasciectomy for Dupuytren’s Contracture.

Practicality, Validity, and Responsiveness of Using the Proxy Version of the Child Health Utility–9 Dimensions With Children Aged 2 to 5 Years (2024)
Journal Article
Sach, T. H., Williams, H. C., Allen, H., Boyle, R., Kelleher, M., Brown, S., Cork, M., Flohr, C., Jay, N., Lartey, S., Davies, C., Lawton, S., Perkin, M., Ridd, M., Brooks, J., Tarr, S., Wyatt, L., & Thomas, K. (2024). Practicality, Validity, and Responsiveness of Using the Proxy Version of the Child Health Utility–9 Dimensions With Children Aged 2 to 5 Years. Value in Health, https://doi.org/10.1016/j.jval.2024.08.010


Objectives
To assess the practicality, validity and responsiveness of proxy CHU-9D in children aged 2-5 years.

Methods
We used data from BEEP, a UK randomised co... Read More about Practicality, Validity, and Responsiveness of Using the Proxy Version of the Child Health Utility–9 Dimensions With Children Aged 2 to 5 Years.

Development of a Vocational Rehabilitation Intervention to support Return to Work and Wellbeing following Major Trauma: A Person-Based Approach (2024)
Journal Article
Radford, K., Kettlewell, J., das Nair, R., Morriss, R., Holmes, J., Kellezi, B., Timmons, S., Jones, T., Tressider, H., Andrews, I., Bridger, K., Patel, P., Lindley, R., De Dios Perez, B., Statham, A., Jones, T., Hoffman, K., James, M., Kendrick, D., & ROWTATE study team. (2024). Development of a Vocational Rehabilitation Intervention to support Return to Work and Wellbeing following Major Trauma: A Person-Based Approach. BMJ Open, 14(10), Article e085724. https://doi.org/10.1136/bmjopen-2024-085724+

Objectives: Major trauma centres save lives but rehabilitation to support return-to-work (RTW) is lacking. This paper describes development of a vocational rehabilitation intervention (the ROWTATE intervention) to support RTW following traumatic inju... Read More about Development of a Vocational Rehabilitation Intervention to support Return to Work and Wellbeing following Major Trauma: A Person-Based Approach.

Recent advances in the influenza virus vaccine landscape: a comprehensive overview of technologies and trials (2024)
Journal Article
Clark, T. W., Tregoning, J. S., Lister, H., Poletti, T., Amin, F., & Nguyen-Van-Tam, J. S. (in press). Recent advances in the influenza virus vaccine landscape: a comprehensive overview of technologies and trials. Clinical Microbiology Reviews, https://doi.org/10.1128/cmr.00025-24

In the United Kingdom (UK) in 2022/23, influenza virus infections returned to the levels recorded before the COVID-19 pandemic, exerting a substantial burden on an already stretched National Health Service (NHS) through increased primary and emergenc... Read More about Recent advances in the influenza virus vaccine landscape: a comprehensive overview of technologies and trials.