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All Outputs (418)

Pneumococcal pneumonia trends in adults hospitalised with community-acquired pneumonia over 10 years (2013-2023), and the role of serotype 3 (2024)
Journal Article
Lansbury, L., McKeever, T. M., Lawrence, H., Pick, H., Baskaran, V., Edwards-Pritchard, R. C., Matthews, L., Bailey, H., Ashton, D., Bendall, L., Rodrigo, C., Daniel, P., Litt, D., Eletu, S., Parmar, H., Sheppard, C. L., Ladhani, S., Trotter, C., & Lim, W. S. (in press). Pneumococcal pneumonia trends in adults hospitalised with community-acquired pneumonia over 10 years (2013-2023), and the role of serotype 3. Thorax,

Development of a Vocational Rehabilitation Intervention to support Return to Work and Wellbeing following Major Trauma: A Person-Based Approach (2024)
Journal Article
Radford, K., Kettlewell, J., das Nair, R., Morriss, R., Holmes, J., Kellezi, B., Timmons, S., Jones, T., Tressider, H., Andrews, I., Bridger, K., Patel, P., Lindley, R., De Dios Perez, B., Statham, A., Jones, T., Hoffman, K., James, M., Kendrick, D., & ROWTATE study team. (2024). Development of a Vocational Rehabilitation Intervention to support Return to Work and Wellbeing following Major Trauma: A Person-Based Approach. BMJ Open, 14(10), Article e085724. https://doi.org/10.1136/bmjopen-2024-085724+

Objectives: Major trauma centres save lives but rehabilitation to support return-to-work (RTW) is lacking. This paper describes development of a vocational rehabilitation intervention (the ROWTATE intervention) to support RTW following traumatic inju... Read More about Development of a Vocational Rehabilitation Intervention to support Return to Work and Wellbeing following Major Trauma: A Person-Based Approach.

Examining support marshalling within an asynchronous online peer support forum for individuals affected by dementia (2024)
Journal Article
Coulson, N. S., & Talbot, C. V. (in press). Examining support marshalling within an asynchronous online peer support forum for individuals affected by dementia. Journal of Health Psychology, 1-14. https://doi.org/10.1177/13591053241287029

Online support communities may provide individuals affected by dementia opportunities for reciprocal peer support, however, the support marshalling strategies employed and their success remain unclear. Analysis of100 randomly selected conversation th... Read More about Examining support marshalling within an asynchronous online peer support forum for individuals affected by dementia.

Clinical and cost-effectiveness of spironolactone in treating persistent facial acne in women: SAFA double-blinded RCT (2024)
Journal Article
Santer, M., Lawrence, M., Pyne, S., Renz, S., L Stuart, B., Sach, T., Ridd, M., S Thomas, K., Nuttall, J., Permyakova, N., Eminton, Z., Francis, N., Little, P., Muller, I., Soulsby, I., Thomas, K., Griffiths, G., & M Layton, A. (2024). Clinical and cost-effectiveness of spironolactone in treating persistent facial acne in women: SAFA double-blinded RCT. Health Technology Assessment, 28(56), https://doi.org/10.3310/MYJT6804

Background
Acne is common, can cause significant impact on quality of life and is a frequent reason for long-term antibiotic use. Spironolactone has been prescribed for acne in women for many years, but robust evidence is lacking.

Objective
To e... Read More about Clinical and cost-effectiveness of spironolactone in treating persistent facial acne in women: SAFA double-blinded RCT.

Efficacy and safety of statins, ezetimibe and statins-ezetimibe therapies for children and adolescents with heterozygous familial hypercholesterolaemia: Systematic review, pairwise and network meta-analyses of randomised controlled trials (2024)
Journal Article
Llewellyn, A., Simmonds, M., Marshall, D., Harden, M., Woods, B., Humphries, S. E., Ramaswami, U., Priestley-Barnham, L., Fisher, M., Tata, L. J., & Qureshi, N. (2024). Efficacy and safety of statins, ezetimibe and statins-ezetimibe therapies for children and adolescents with heterozygous familial hypercholesterolaemia: Systematic review, pairwise and network meta-analyses of randomised controlled trials. Atherosclerosis, Article 118598. https://doi.org/10.1016/j.atherosclerosis.2024.118598

Background and aims
Statins, ezetimibe and statins-ezetimibe combination therapy are recommended lipid-lowering therapies (LLTs) in children with heterozygous familial hypercholesterolaemia (HeFH). However, their relative effectiveness is not well u... Read More about Efficacy and safety of statins, ezetimibe and statins-ezetimibe therapies for children and adolescents with heterozygous familial hypercholesterolaemia: Systematic review, pairwise and network meta-analyses of randomised controlled trials.

Global rapid review of interventions to tackle the harms of illicit tobacco (2024)
Journal Article
Davies, N., Bogdanovica, I., Bains, M., Jayes, L., & Langley, T. E. (2024). Global rapid review of interventions to tackle the harms of illicit tobacco. Tobacco Control, https://doi.org/10.1136/tc-2024-058728

Objective This review aimed to assess interventions designed to reduce harm from illicit tobacco (IT). We evaluated health outcomes, cost-effectiveness, the advantages and disadvantages of interventions, and contextual factors affecting implementatio... Read More about Global rapid review of interventions to tackle the harms of illicit tobacco.

Paradigmatic perspectives of research on the self-regulated learning of non-western learners in health professions education: a scoping review protocol (2024)
Journal Article
Yoosoof, F., Ihsan, F. R., Agius, S., Coulson, N., Freeman, K., & Cooper, N. (2024). Paradigmatic perspectives of research on the self-regulated learning of non-western learners in health professions education: a scoping review protocol. JBI Evidence Synthesis, https://doi.org/10.11124/jbies-24-00144

Objective:
The objective of this review will be to explore the paradigmatic perspectives of research on self-regulated learning in non-western learners in health professions education.

Introduction:
Studies show that there are significant cult... Read More about Paradigmatic perspectives of research on the self-regulated learning of non-western learners in health professions education: a scoping review protocol.

Exploring parents’ experiences, attitudes and understanding of gastro-oesophageal reflux in infants (2024)
Journal Article
McVicar, K., Szatkowski, L., Ojha, S., Tunster, S., & Bains, M. (2024). Exploring parents’ experiences, attitudes and understanding of gastro-oesophageal reflux in infants. PLoS ONE, https://doi.org/10.1371/journal.pone.0309081

Background:
Gastro-oesophageal reflux (GOR) affects nearly half of infants. Parents play a crucial role in management but more understanding of their attitudes and experiences is needed to inform future education, support and research. This study a... Read More about Exploring parents’ experiences, attitudes and understanding of gastro-oesophageal reflux in infants.

Sexual and reproductive health needs of women with severe mental illness in low- and middle-income countries: A scoping review (2024)
Journal Article
Sisodia, S., Hammond, Z., Leonardi-Bee, J., Hanlon, C., & Asher, L. (in press). Sexual and reproductive health needs of women with severe mental illness in low- and middle-income countries: A scoping review. PLoS ONE,

Background

This scoping review aimed to understand the extent and type of evidence in relation to sexual and reproductive health needs of women with severe mental illness (SMI) in low- and middle-income countries (LMIC) and to summarise those nee... Read More about Sexual and reproductive health needs of women with severe mental illness in low- and middle-income countries: A scoping review.

Rapid Eczema Trials: Addressing patient priorities from the eczema priority setting partnership (2024)
Journal Article
Campbell, E. L., Fong, W. C. G., Roberts, A., & Thomas, K. S. (2024). Rapid Eczema Trials: Addressing patient priorities from the eczema priority setting partnership. British Journal of Dermatology, Article ljae362. https://doi.org/10.1093/bjd/ljae362

In this letter, we describe the Rapid Eczema Trials co-production project, which aims to plug some of the research gaps that remain following the 2011 James Lind Alliance Eczema Priority Setting Partnership (PSP) exercise. We highlight similarities b... Read More about Rapid Eczema Trials: Addressing patient priorities from the eczema priority setting partnership.

Carriage of Streptococcus pneumoniae in adults hospitalised with community-acquired pneumonia (2024)
Journal Article
Lansbury, L., McKeever, T. M., Lawrence, H., Pick, H., Baskaran, V., Edwards-Pritchard, R. C., Ashton, D., Rodrigo, C., Daniel, P., Litt, D., Eletu, S., Parmar, H., Sheppard, C. L., Ladhani, S., Trotter, C., & Lim, W. S. (2024). Carriage of Streptococcus pneumoniae in adults hospitalised with community-acquired pneumonia. Journal of Infection, 89(5), Article 106277. https://doi.org/10.1016/j.jinf.2024.106277

Objectives

We aimed to determine the prevalence of and risk factors for nasopharyngeal and oral pneumococcal carriage in adults with community-acquired pneumonia (CAP), and the relationship between carried and disease-causing serotypes.

Methods... Read More about Carriage of Streptococcus pneumoniae in adults hospitalised with community-acquired pneumonia.

Barriers to diagnosing and treating vulval lichen sclerosus: a survey study (2024)
Journal Article
Crew, A., Leatherland, R., Clarke, L., Owen, C., & Simpson, R. (in press). Barriers to diagnosing and treating vulval lichen sclerosus: a survey study. British Journal of General Practice,

Background
Vulval lichen sclerosus (VLS) is a chronic inflammatory condition that is frequently misdiagnosed and under-recognised. To date, qualitative research focuses on lived experience of VLS, with women attributing diagnostic delay to poor int... Read More about Barriers to diagnosing and treating vulval lichen sclerosus: a survey study.

Paternal under and over nutrition modify semen composition and preimplantation embryo developmental kinetics in mice (2024)
Journal Article
Morgan, H. L., Eid, N., Holmes, N., Henson, S., Wright, V., Coveney, C., Winder, C., O’Neil, D. M., Dunn, W. B., Boocock, D. J., & Watkins, A. J. (2024). Paternal under and over nutrition modify semen composition and preimplantation embryo developmental kinetics in mice. BMC Biology, 22, Article 207. https://doi.org/10.1186/s12915-024-01992-0

Background: The importance of parental diet in relation to eventual offspring health is increasing in prominence due to the increased frequency of parents of reproductive age consuming poor diets. Whilst maternal health and offspring outcome have bee... Read More about Paternal under and over nutrition modify semen composition and preimplantation embryo developmental kinetics in mice.

Short-term risk of cardiovascular events in people newly diagnosed with gout (2024)
Journal Article
Cipolletta, E., Nakafero, G., Richette, P., Avery, A. J., Mamas, M. A., Tata, L. J., & Abhishek, A. (2024). Short-term risk of cardiovascular events in people newly diagnosed with gout. Arthritis and Rheumatology, https://doi.org/10.1002/art.42986

Objectives
To investigate the temporal association between first diagnosis of gout and cardiovascular events in the short-term.

Methods
We performed a self-controlled case series analysis and a cohort study using data from linked primary care, h... Read More about Short-term risk of cardiovascular events in people newly diagnosed with gout.

Primary liver cancer risk and mortality in patients with alcohol-related cirrhosis in England and Denmark: observational cohort studies (2024)
Journal Article
Jensen, M. D., West, J., Crooks, C., Morling, J. R., Kraglund, F., Card, T., Askgaard, G., & Jepsen, P. (2024). Primary liver cancer risk and mortality in patients with alcohol-related cirrhosis in England and Denmark: observational cohort studies. American Journal of Gastroenterology, https://doi.org/10.14309/ajg.0000000000003077

Background & Aims:

Patients with alcohol-related cirrhosis (ALD cirrhosis) have an increased risk of primary liver cancer (hepatocellular carcinoma [HCC] or intrahepatic cholangiocarcinoma [iCCA]). England recommends surveillance for HCC in these... Read More about Primary liver cancer risk and mortality in patients with alcohol-related cirrhosis in England and Denmark: observational cohort studies.

What is the relationship between raising the minimum legal sales age of tobacco above 20 and cigarette smoking? A systematic review (2024)
Journal Article
Davies, N., Bogdanovica, I., McGill, S., & Murray, R. L. (2024). What is the relationship between raising the minimum legal sales age of tobacco above 20 and cigarette smoking? A systematic review. Nicotine and Tobacco Research, https://doi.org/10.1093/ntr/ntae206

Introduction
There is considerable interest in raising the age of sale of tobacco above the conventional age of 18. We systematically reviewed whether raising the minimum legal sales age of tobacco (MLSA) to 20 or above is associated with reduced pr... Read More about What is the relationship between raising the minimum legal sales age of tobacco above 20 and cigarette smoking? A systematic review.