All Outputs (189)

Risk of alcohol-related liver disease in the offspring of parents with alcohol-related liver disease: A nationwide cohort study (2023)
Journal Article
Jepsen, P., West, J., Kann, A. E., Kraglund, F., Morling, J., Crooks, C., & Askgaard, G. (2024). Risk of alcohol-related liver disease in the offspring of parents with alcohol-related liver disease: A nationwide cohort study. Hepatology, 80(2), 418-427. https://doi.org/10.1097/hep.0000000000000747

Background and aims: Offspring of patients with alcohol-related liver disease (ALD) may have higher risk of ALD. We examined their risk of ALD and survival with ALD.

Approach & Results: We used Danish nationwide registries to identify offspring of... Read More about Risk of alcohol-related liver disease in the offspring of parents with alcohol-related liver disease: A nationwide cohort study.

How to use the Harmonising Outcome Measures for Eczema Core Outcome Set for atopic dermatitis trials: a users’ guide (2023)
Journal Article
Thomas, K. S., Howells, L., Leshem, Y. A., Simpson, E. L., Apfelbacher, C., Spuls, P. I., …Stuart, B. L. (2024). How to use the Harmonising Outcome Measures for Eczema Core Outcome Set for atopic dermatitis trials: a users’ guide. British Journal of Dermatology, 190(4), 527-535. https://doi.org/10.1093/bjd/ljad497

Background
The Harmonising Outcome Measures for Eczema (HOME) initiative has agreed upon the Core Outcome Set (COS) for use in atopic dermatitis (AD) clinical trials, but additional guidance is needed to maximize its uptake.

Objectives
To provid... Read More about How to use the Harmonising Outcome Measures for Eczema Core Outcome Set for atopic dermatitis trials: a users’ guide.

Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation (2023)
Preprint / Working Paper
Abhishek, A., Grainge, M. J., Card, T., Williams, H. C., Taal, M. W., Aithal, G. P., Fox, C. P., Mallen, C. D., Stevenson, M. D., Nakafero, G., & Riley, R. D. Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation

Background Sulfasalazine induced cytopenia, nephrotoxicity, and hepatotoxicity is uncommon during long-term treatment. Some guidelines recommend three monthly monitoring blood-tests indefinitely while others recommend stopping monitoring after one ye... Read More about Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation.

Association Between Physical Activity and Arterial Stiffness in Patients with Type 2 Diabetes in Ningbo, China: A Cross-Sectional Study (2023)
Journal Article
Li, X., Chattopadhyay, K., Chen, X., Li, J., Xu, M., Chen, X., & Li, L. (2023). Association Between Physical Activity and Arterial Stiffness in Patients with Type 2 Diabetes in Ningbo, China: A Cross-Sectional Study. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 16, 4133-4141. https://doi.org/10.2147/dmso.s438344

Aim: The study aimed to investigate the association between physical activity and arterial stiffness in patients with type 2 diabetes mellitus (T2DM) in Ningbo, China. Methods: A cross-sectional study was conducted using the Metabolic Management Cent... Read More about Association Between Physical Activity and Arterial Stiffness in Patients with Type 2 Diabetes in Ningbo, China: A Cross-Sectional Study.

Development of a Motivation Communication Training to Aid Diabetes-Specialist Podiatrists With Adherence Discussions (2023)
Journal Article
Hancox, J., Chaplin, W., Hilton, C., Gray, K., Game, F., & Vedhara, K. (2023). Development of a Motivation Communication Training to Aid Diabetes-Specialist Podiatrists With Adherence Discussions. Health Education and Behavior, 51(2), 240 -250. https://doi.org/10.1177/10901981231216744

Diabetic foot ulcers (DFUs) impact a substantial proportion of patients with diabetes, with high recurrence rates, severe complications, and significant financial burden to health care systems. Adherence to treatment advice (e.g., limiting weight-bea... Read More about Development of a Motivation Communication Training to Aid Diabetes-Specialist Podiatrists With Adherence Discussions.

Ex vivo assessment of basal cell carcinoma surgical margins in Mohs surgery by autofluorescence-Raman spectroscopy: A pilot study (2023)
Journal Article
Boitor, R., Varma, S., Sharma, A., Elsheikh, S., Kulkarni, K., Eldib, K., …Notingher, I. (2024). Ex vivo assessment of basal cell carcinoma surgical margins in Mohs surgery by autofluorescence-Raman spectroscopy: A pilot study. JEADV Clinical Practice, 3(2), 498-507. https://doi.org/10.1002/jvc2.336

Background: Autofluorescence (AF)‐Raman spectroscopy is a technology that can detect tumour tissue in surgically excised skin specimens. The technique does not require tissue fixation, staining, labelling or sectioning, and provides quantitative diag... Read More about Ex vivo assessment of basal cell carcinoma surgical margins in Mohs surgery by autofluorescence-Raman spectroscopy: A pilot study.

Factors associated with nonattendance at annual diabetes check-up in Ningbo, China: a case-control study (2023)
Journal Article
Li, L., Chattopadhyay, K., Li, X., Yu, J., Xu, M., Chen, X., …Li, J. (2023). Factors associated with nonattendance at annual diabetes check-up in Ningbo, China: a case-control study. Frontiers in Public Health, 11, Article 1247406. https://doi.org/10.3389/fpubh.2023.1247406

Background: Type 2 diabetes mellitus (T2DM) is a grave issue in China. The annual check-up is recommended in clinical guidelines on T2DM. It plays an important role in monitoring and managing the condition and detecting and managing any comorbidities... Read More about Factors associated with nonattendance at annual diabetes check-up in Ningbo, China: a case-control study.

Age and sex differences in LDL cholesterol distribution in adults in Malaysia: A cross-sectional study (2010 -2021) (2023)
Journal Article
Chalitsios, C. V., Akyea, R. K., Abdul-Hamid, H., Leonardi-Bee, J., Kanchau, J. D., Kamal, A., …Qureshi, N. (2023). Age and sex differences in LDL cholesterol distribution in adults in Malaysia: A cross-sectional study (2010 -2021). International Journal of General Medicine, 2023(16), 5885—5888. https://doi.org/10.2147/IJGM.S423091

Cardiovascular disease (CVD) is the leading cause of death worldwide. Hypercholesterolaemia, especially higher low-density lipoprotein cholesterol (LDL-c), has been recognised as one of the major key risk factors for CVD. Lipid lowering treatments, s... Read More about Age and sex differences in LDL cholesterol distribution in adults in Malaysia: A cross-sectional study (2010 -2021).

Dynamic updating of clinical survival prediction models in a changing environment (2023)
Journal Article
Tanner, K. T., Keogh, R. H., Coupland, C. A. C., Hippisley-Cox, J., & Diaz-Ordaz, K. (2023). Dynamic updating of clinical survival prediction models in a changing environment. Diagnostic and Prognostic Research, 7, Article 24. https://doi.org/10.1186/s41512-023-00163-z

Background
Over time, the performance of clinical prediction models may deteriorate due to changes in clinical management, data quality, disease risk and/or patient mix. Such prediction models must be updated in order to remain useful. In this study... Read More about Dynamic updating of clinical survival prediction models in a changing environment.

Two-week break in methotrexate treatment and COVID-19 vaccine response: a prospective, open label, two-arm parallel-group, multicentre, superiority, randomised controlled trial (2023)
Journal Article
Abhishek, A., Peckham, N., Pade, C., Gibbons, J. M., Cureton, L., Francis, A., …Study investigators, V. (2024). Two-week break in methotrexate treatment and COVID-19 vaccine response: a prospective, open label, two-arm parallel-group, multicentre, superiority, randomised controlled trial. The Lancet Rheumatology, 6(2), E92-E104. https://doi.org/10.1016/S2665-9913%2823%2900298-9

Background
Methotrexate is the first-line treatment for immune-mediated inflammatory diseases and reduces vaccine-induced immunity. We evaluated if a 2-week interruption of methotrexate treatment immediately after COVID-19 booster vaccination improv... Read More about Two-week break in methotrexate treatment and COVID-19 vaccine response: a prospective, open label, two-arm parallel-group, multicentre, superiority, randomised controlled trial.

Effect of a 2-week interruption in methotrexate treatment on COVID-19 vaccine response in people with immune-mediated inflammatory diseases (VROOM study): a randomised, open label, superiority trial (2023)
Journal Article
Abhishek, A., Peckham, N., Pade, C., Gibbons, J. M., Cureton, L., Francis, A., …Cook, J. A. (2023). Effect of a 2-week interruption in methotrexate treatment on COVID-19 vaccine response in people with immune-mediated inflammatory diseases (VROOM study): a randomised, open label, superiority trial. The Lancet Rheumatology, 6(2), e92-e104. https://doi.org/10.1016/s2665-9913%2823%2900298-9

Background: Methotrexate is the first-line treatment for immune-mediated inflammatory diseases and reduces vaccine-induced immunity. We evaluated if a 2-week interruption of methotrexate treatment immediately after COVID-19 booster vaccination improv... Read More about Effect of a 2-week interruption in methotrexate treatment on COVID-19 vaccine response in people with immune-mediated inflammatory diseases (VROOM study): a randomised, open label, superiority trial.

Pneumococcal serotypes and risk factors in adult community-acquired pneumonia 2018–20; a multicentre UK cohort study (2023)
Journal Article
Lansbury, L., Lawrence, H., McKeever, T. M., French, N., Aston, S., Hill, A. T., …Lim, W. S. (2024). Pneumococcal serotypes and risk factors in adult community-acquired pneumonia 2018–20; a multicentre UK cohort study. Lancet Regional Health – Europe, 37, Article 100812. https://doi.org/10.1016/j.lanepe.2023.100812

Background: Higher-valency pneumococcal vaccines are anticipated. We aimed to describe serotype distribution and risk factors for vaccine-serotype community-acquired pneumonia (CAP) in the two years pre-SARS-CoV-2 pandemic. Methods: We conducted a pr... Read More about Pneumococcal serotypes and risk factors in adult community-acquired pneumonia 2018–20; a multicentre UK cohort study.

Cost-effectiveness of Spironolactone for Adult Female Acne (SAFA): economic evaluation alongside a randomised controlled trial (2023)
Journal Article
Pyne, S., Sach, T. H., Lawrence, M., Renz, S., Eminton, Z., Stuart, B., …Santer, M. (2023). Cost-effectiveness of Spironolactone for Adult Female Acne (SAFA): economic evaluation alongside a randomised controlled trial. BMJ Open, 13(12), Article e073245. https://doi.org/10.1136/bmjopen-2023-073245

Objective This study aims to estimate the cost-effectiveness of oral spironolactone plus routine topical treatment compared with routine topical treatment alone for persistent acne in adult women from a British NHS perspective over 24 weeks. Design E... Read More about Cost-effectiveness of Spironolactone for Adult Female Acne (SAFA): economic evaluation alongside a randomised controlled trial.

How Should a Vape Shop-Based Smoking Cessation Intervention Be Delivered? A Qualitative Study (2023)
Journal Article
Langley, T., Young, E., Hunter, A., & Bains, M. (2024). How Should a Vape Shop-Based Smoking Cessation Intervention Be Delivered? A Qualitative Study. Nicotine and Tobacco Research, 26(10), 1355-1361. https://doi.org/10.1093/ntr/ntad236

Introduction

Encouraging smokers to quit smoking tobacco using e-cigarettes could substantially reduce smoking-related diseases. Vape shops (VS) therefore have the potential to play an important role in supporting smoking cessation. The aim of thi... Read More about How Should a Vape Shop-Based Smoking Cessation Intervention Be Delivered? A Qualitative Study.

International melanoma and non melanoma skin cancer mortality trends: is it time to refocus our attention? (2023)
Journal Article
Venables, Z. C., Gran, S., Levell, N. J., Yiu, Z. Z. N., & Proby, C. M. (2024). International melanoma and non melanoma skin cancer mortality trends: is it time to refocus our attention?. Clinical and Experimental Dermatology, 49(5), 514–516. https://doi.org/10.1093/ced/llad438

Treatment of Hidradenitis Suppurativa Evaluation Study: the THESEUS prospective cohort study (2023)
Journal Article
Ingram, J. R., Bates, J., Cannings-John, R., Collier, F., Gibbons, A., Harris, C., …Thomas-Jones, E. (2023). Treatment of Hidradenitis Suppurativa Evaluation Study: the THESEUS prospective cohort study. Health Technology Assessment, 27(30), https://doi.org/10.3310/HWNM2189

Background

Hidradenitis suppurativa is a chronic inflammatory skin disease characterised by recurrent inflammatory lesions and skin tunnels in flexural sites such as the axilla. Deroofing of skin tunnels and laser treatment are standard hidradenit... Read More about Treatment of Hidradenitis Suppurativa Evaluation Study: the THESEUS prospective cohort study.

Evidence-based appraisal of the role of SJTs in selection (2023)
Journal Article
Sahota, G., McLachlan, J., Patterson, F., & Tiffin, P. (2023). Evidence-based appraisal of the role of SJTs in selection. Clinical Medicine, 23(6), 641-642. https://doi.org/10.7861/clinmed.2023-0295

A recent opinion article in Clinical Medicine promoted a new preference-based algorithm to allocate training places for the UK Foundation Programme Office (UKFPO). This replaced the previous process, which ranked candidates based on medical school ac... Read More about Evidence-based appraisal of the role of SJTs in selection.

Embedding genomics across the NHS: a primary care perspective (2023)
Journal Article
Hayward, J., Evans, W., Miller, E., & Rafi, I. (2023). Embedding genomics across the NHS: a primary care perspective. Future Healthcare Journal, 10(3), 263-269. https://doi.org/10.7861/fhj.2023-0116

Primary care remains the point of access to the NHS as well as having key roles in care coordination and prescribing. Therefore, embedding of genomic medicine in the NHS relies on successful implementation into the primary care landscape. Primary car... Read More about Embedding genomics across the NHS: a primary care perspective.

Antibody response to four doses of SARS-CoV-2 vaccine in rare autoimmune rheumatic diseases: an observational study (2023)
Journal Article
Gumber, L., Jackson, H., Gomez, N., Hopkins, G., Tucis, D., Chakravorty, M., …Fairclough, L. (2023). Antibody response to four doses of SARS-CoV-2 vaccine in rare autoimmune rheumatic diseases: an observational study. Rheumatology Advances in Practice, 7(3), Article rkad097. https://doi.org/10.1093/rap/rkad097

Objective: Antibody responses to coronavirus disease 2019 (COVID-19) vaccines are reduced among immunocompromised patients but are not well quantified among people with rare disease. We conducted an observational study to evaluate the antibody respon... Read More about Antibody response to four doses of SARS-CoV-2 vaccine in rare autoimmune rheumatic diseases: an observational study.

Assessment of ethnic inequalities in diagnostic coding of familial hypercholesterolaemia (FH): A cross-sectional database study in Lambeth, South London (2023)
Journal Article
Molokhia, M., Wierzbicki, A., Williams, H., Kirubakaran, A., Devani, R., Durbaba, S., …Qureshi, N. (2023). Assessment of ethnic inequalities in diagnostic coding of familial hypercholesterolaemia (FH): A cross-sectional database study in Lambeth, South London. Atherosclerosis, 388, Article 117353. https://doi.org/10.1016/j.atherosclerosis.2023.117353

Background and aims: Differences in the perceived prevalence of familial hypercholesterolemia (FH) by ethnicity are unclear. In this study, we aimed to assess the prevalence, determinants and management of diagnostically-coded FH in an ethnically div... Read More about Assessment of ethnic inequalities in diagnostic coding of familial hypercholesterolaemia (FH): A cross-sectional database study in Lambeth, South London.