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Garlic as an inhibitor of pseudomonas aeruginosa quorum sensing in cystic fibrosis - A pilot randomized controlled trial (2010)
Journal Article
Smyth, A. R., Cifelli, P. M., Ortori, C. A., Righetti, K., Lewis, S., Erskine, P., …Knox, A. (2010). Garlic as an inhibitor of pseudomonas aeruginosa quorum sensing in cystic fibrosis - A pilot randomized controlled trial. Pediatric Pulmonology, 45(4), 356-362. https://doi.org/10.1002/ppul.21193

Pseudomonas aeruginosa forms biofilms in the cystic fibrosis lung. Quorum sensing (QS) controls biofilm maturation, immune evasion, antibiotic tolerance and virulence factor production. Garlic shows QS inhibitory activity in vitro and in animal model... Read More about Garlic as an inhibitor of pseudomonas aeruginosa quorum sensing in cystic fibrosis - A pilot randomized controlled trial.

Clinical trials: the viewpoint of children with a chronic illness compared with healthy children (2009)
Journal Article
Cherrill, J., Hudson, H., Cocking, C., Unsworth, V., Franck, L., Fakis, A., McIntyre, J., & Choonara, I. (2009). Clinical trials: the viewpoint of children with a chronic illness compared with healthy children. Archives of Disease in Childhood, 95(3), 229-232. https://doi.org/10.1136/adc.2009.159145

The views of over 200 children (11–16 years old, who were either healthy or attending paediatric medical clinics with a chronic illness) on issues relating to paediatric clinical trials were determined by a questionnaire. Children with a chronic illn... Read More about Clinical trials: the viewpoint of children with a chronic illness compared with healthy children.

Safety in paediatric clinical trials - a 7-year review (2008)
Journal Article
Sammons, H., Gray, C., Hudson, H., Cherrill, J., & Choonara, I. (2008). Safety in paediatric clinical trials - a 7-year review. Acta Paediatrica, 97(4), 474-477. https://doi.org/10.1111/j.1651-2227.2008.00676.x

Aim: The safety of clinical trials in children has not been previously studied. We aimed to identify how safety is monitored and the extent of adverse drug reactions (ADRs).

Methods: A literature review of the Medline Database for therapeutic clin... Read More about Safety in paediatric clinical trials - a 7-year review.

Influence of ursodeoxycholic acid on the mortality and malignancy associated with primary biliary cirrhosis: A population-based cohort study (2007)
Journal Article
Jackson, H., Solaymani-Dodaran, M., Card, T. R., Aithal, G. P., Logan, R., & West, J. (2007). Influence of ursodeoxycholic acid on the mortality and malignancy associated with primary biliary cirrhosis: A population-based cohort study. Hepatology, 46(4), 1131-1137. https://doi.org/10.1002/hep.21795

There is debate over the mortality and malignancy risk in people with primary biliary cirrhosis (PBC) and whether this risk is reduced by use of ursodeoxycholic acid. To investigate this issue, we identified 930 people with PBC and 9,202 control subj... Read More about Influence of ursodeoxycholic acid on the mortality and malignancy associated with primary biliary cirrhosis: A population-based cohort study.

Randomized controlled trial of the intraligamental use of a local anaesthetic (lignocaine 2%) versus controls in paediatric tooth extraction (2007)
Journal Article
Sammons, H. M., Unsworth, . V., Gray, C., Choonara, I., Cherrill, . J., & Quirke, W. (2007). Randomized controlled trial of the intraligamental use of a local anaesthetic (lignocaine 2%) versus controls in paediatric tooth extraction. International Journal of Paediatric Dentistry, 17(4), 297-303. https://doi.org/10.1111/j.1365-263x.2007.00832.x

Background. Children still experience pain upon waking following dental extraction under general anaesthesia. Local anaesthetic has been shown to reduce this pain, but needs to be administered via a method that causes minimum injury or distress to th... Read More about Randomized controlled trial of the intraligamental use of a local anaesthetic (lignocaine 2%) versus controls in paediatric tooth extraction.

Factors affecting participation in Sure Start programmes: a qualitative investigation of parents' views. (2007)
Journal Article
Avis, M., Bulman, D., & Leighton, P. (2007). Factors affecting participation in Sure Start programmes: a qualitative investigation of parents' views. Health and Social Care in the Community, 15(3), 203-211. https://doi.org/10.1111/j.1365-2524.2006.00673.x

The objectives of the present study were to examine the factors that parents identify as promoting or hindering participation in Sure Start programmes, and to identify methods for enhancing parents’ engagement with Sure Start. A qualitative, in-depth... Read More about Factors affecting participation in Sure Start programmes: a qualitative investigation of parents' views..

Clinical trials: the viewpoint of children (2007)
Journal Article
Cherrill, J., Hudson, H., Cocking, C., Unsworth, V., Franck, L., McIntyre, J., & Choonara, I. (2007). Clinical trials: the viewpoint of children. Archives of Disease in Childhood, 92(8), 712-713. https://doi.org/10.1136/adc.2006.114207

The views of 30 children (8–16 years old) attending paediatric medical clinics on paediatric clinical trials were determined by semi-structured interviews. Nineteen children recognised that there were risks involved with taking part in clinical trial... Read More about Clinical trials: the viewpoint of children.

Asthma as a barrier to children's physical activity: Implications for body mass index and mental health (2006)
Journal Article
Glazebrook, C., McPherson, A. C., Macdonald, I. A., Swift, J. A., Ramsay, C., Newbould, R., & Smyth, A. (2006). Asthma as a barrier to children's physical activity: Implications for body mass index and mental health. Pediatrics, 118(6), 2443-2449. https://doi.org/10.1542/peds.2006-1846

OBJECTIVES. The purpose of this work was to identify barriers to physical activity in children with asthma and to compare their customary activity levels, BMI and emotional well-being with that of children with other medical conditions. It was hypoth... Read More about Asthma as a barrier to children's physical activity: Implications for body mass index and mental health.

Fracture Risk in People With Primary Biliary Cirrhosis: A Population-Based Cohort Study (2006)
Journal Article
Solaymani–Dodaran, M., Card, T. R., Aithal, G. P., & West, J. (2006). Fracture Risk in People With Primary Biliary Cirrhosis: A Population-Based Cohort Study. Gastroenterology, 131(6), 1752-1757. https://doi.org/10.1053/j.gastro.2006.09.012


Background & Aims: Controversy exists as to whether people with primary biliary cirrhosis (PBC) have an increased risk of developing osteoporosis and the extent to which this may translate into an increased risk of fracture. We have performed a coh... Read More about Fracture Risk in People With Primary Biliary Cirrhosis: A Population-Based Cohort Study.