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The Impact of Delirium on Recovery in Geriatric Rehabilitation after Acute Infection (2024)
Journal Article
Minnema, J., Polinder-Bos, H., Cesari, M., Dockery, F., Everink, I., Francis, B., Gordon, A., Grund, S., Perez Bazan, L., Eruslanova, K., Topinková, E., Vassallo, M., Faes, M., van Tol, L., Caljouw, M., Achterberg, W., & Haaksma, M. (2024). The Impact of Delirium on Recovery in Geriatric Rehabilitation after Acute Infection. Journal of the American Medical Directors Association, 25(8), Article 105002. https://doi.org/10.1016/j.jamda.2024.03.113

Objectives
Delirium is common during acute infection in older patients and is associated with functional decline. Geriatric rehabilitation (GR) can help older patients to return to their premorbid functional level. It is unknown whether delirium aff... Read More about The Impact of Delirium on Recovery in Geriatric Rehabilitation after Acute Infection.

Serum levels of hydroxylated metabolites of arachidonic acid cross-sectionally and longitudinally predict knee pain progression: an observational cohort study (2024)
Journal Article
Turnbull, J., Jha, R. R., Gowler, P. R., Ferrands-Bentley, R., Kim, D.-H., Barrett, D. A., Sarmanova, A., Fernandes, G. S., Doherty, M., Zhang, W., Walsh, D. A., Valdes, A. M., & Chapman, V. (2024). Serum levels of hydroxylated metabolites of arachidonic acid cross-sectionally and longitudinally predict knee pain progression: an observational cohort study. Osteoarthritis and Cartilage, 32(8), 990-1000. https://doi.org/10.1016/j.joca.2024.04.006

Objective: To examine associations between serum oxylipins, which regulate tissue repair and pain signalling, and knee pain/radiographic osteoarthritis (OA) at baseline and knee pain at 3 year follow-up.

Method: Baseline, and 3 year follow-up, kne... Read More about Serum levels of hydroxylated metabolites of arachidonic acid cross-sectionally and longitudinally predict knee pain progression: an observational cohort study.

The rat Osteoarthritis Bone Score: a new histological system for scoring subchondral pathology in rat knees analogous to histological correlates of human OA bone marrow lesions (2024)
Presentation / Conference Contribution
McWilliams, D. F., Shahtaheri, M., Koushesh, S., Joseph, C., Gowler, P., Chapman, V., …Walsh, D. A. (2024). The rat Osteoarthritis Bone Score: a new histological system for scoring subchondral pathology in rat knees analogous to histological correlates of human OA bone marrow lesions. Osteoarthritis and Cartilage, 32(Supplement 1), S432. https://doi.org/10.1016/j.joca.2024.02.633

Purpose (the aim of the study): Bone marrow lesions (BMLs) are detected by MRI in the in human osteoarthritis (OA) subchondral bone and associated with pain. We previously described 7 histological features associated with BMLs from which we developed... Read More about The rat Osteoarthritis Bone Score: a new histological system for scoring subchondral pathology in rat knees analogous to histological correlates of human OA bone marrow lesions.

Sustained adenosine release: Revealing its impact on osteogenic signalling pathways of human mesenchymal stromal cells (2024)
Journal Article
Hajiali, H., McLaren, J., Gonzalez-García, C., Abdelrazig, S., Kim, D.-H., Dalby, M. J., Salmerón-Sánchez, M., & Rose, F. R. (2024). Sustained adenosine release: Revealing its impact on osteogenic signalling pathways of human mesenchymal stromal cells. Engineered Regeneration, 5(2), 255-268. https://doi.org/10.1016/j.engreg.2024.04.002

Non-healing fractures, a global health concern arising from trauma, osteoporosis, and tumours, can lead to severe disabilities. Adenosine, integral to cellular energy metabolism, gains prominence in bone regeneration via adenosine A2B receptor activa... Read More about Sustained adenosine release: Revealing its impact on osteogenic signalling pathways of human mesenchymal stromal cells.

Impact of the COVID-19 pandemic on hospital episodes for falls and fractures associated with new-onset disability and frailty in England: a national cohort study (2024)
Journal Article
Thomas, S., Littleboy, K., Foubert, J., Nafilyan, V., Bannister, N., Routen, A., Morriss, R., Khunti, K., Armstrong, N., Gray, L. J., & Gordon, A. L. (2024). Impact of the COVID-19 pandemic on hospital episodes for falls and fractures associated with new-onset disability and frailty in England: a national cohort study. Age and Ageing, 53(4), Article afae071. https://doi.org/10.1093/ageing/afae071

Background: Older people with frailty are at risk of harm from immobility or isolation, yet data about how COVID-19 lockdowns affected them are limited. Falls and fractures are easily measurable adverse outcomes correlated with frailty. We investigat... Read More about Impact of the COVID-19 pandemic on hospital episodes for falls and fractures associated with new-onset disability and frailty in England: a national cohort study.

Association Between Hyperuricemia and Ultrasound-Detected Hand Synovitis (2024)
Journal Article
Jiang, T., Weng, Q., Zhang, Y., Zhang, W., Doherty, M., Sarmanova, A., Yang, Z., Yang, T., Li, J., Liu, K., Wang, Y., Obotiba, A. D., Zeng, C., Lei, G., & Wei, J. (2024). Association Between Hyperuricemia and Ultrasound-Detected Hand Synovitis. Arthritis Care and Research, 76(8), 1187-1194. https://doi.org/10.1002/acr.25342

Objective
Although hand synovitis is prevalent in the older population, the etiology remains unclear. Hyperuricemia, a modifiable metabolic disorder, may serve as an underlying mechanism of hand synovitis, but little is known about their relationshi... Read More about Association Between Hyperuricemia and Ultrasound-Detected Hand Synovitis.

Discontinuation of anti-tumour necrosis factor alpha treatment owing to blood test abnormalities, and cost-effectiveness of alternate blood monitoring strategies (2024)
Journal Article
Abhishek, A., Stevenson, M. D., Nakafero, G., Grainge, M. J., Evans, I., Alabas, O., Card, T., Taal, M. W., Aithal, G. P., Fox, C. P., Mallen, C. D., van der Windt, D. A., Riley, R. D., Warren, R. B., & Williams, H. C. (2024). Discontinuation of anti-tumour necrosis factor alpha treatment owing to blood test abnormalities, and cost-effectiveness of alternate blood monitoring strategies. British Journal of Dermatology, 190(4), 559-564. https://doi.org/10.1093/bjd/ljad430

Background: There is no evidence base to support the use of 6-monthly monitoring blood tests for the early detection of liver, blood and renal toxicity during established anti-tumour necrosis factor alpha (TNFα) treatment. Objectives: To evaluate the... Read More about Discontinuation of anti-tumour necrosis factor alpha treatment owing to blood test abnormalities, and cost-effectiveness of alternate blood monitoring strategies.

Exploratory factor analysis and Rasch analysis to assess the structural validity of the Adult Social Care Outcomes Toolkit Proxy version (ASCOT-Proxy) completed by care home staff (2024)
Journal Article
Rand, S., Towers, A., Allan, S., Webster, L., Palmer, S., Carroll, R., …Goodman, C. (2024). Exploratory factor analysis and Rasch analysis to assess the structural validity of the Adult Social Care Outcomes Toolkit Proxy version (ASCOT-Proxy) completed by care home staff. Quality of Life Research, 33, 1555-1567. https://doi.org/10.1007/s11136-024-03631-1

Purpose.

Rasch analysis and exploratory factor analysis (EFA) were used to evaluate the structural validity of the ASCOT-Proxy measures completed by staff on behalf of older adults resident in care homes, by comparison to the ASCOT-SCT4, the meas... Read More about Exploratory factor analysis and Rasch analysis to assess the structural validity of the Adult Social Care Outcomes Toolkit Proxy version (ASCOT-Proxy) completed by care home staff.

Associations between zinc deficiency, taste changes and salivary flow rate following gastric bypass and sleeve gastrectomy surgeries (2024)
Journal Article
Mozaffar, B., Mozaffar, H., Alkharaiji, M., Elbahrawy, A., & Idris, I. (2024). Associations between zinc deficiency, taste changes and salivary flow rate following gastric bypass and sleeve gastrectomy surgeries. Journal of Nutrition and Metabolism, 2024, Article 1197571. https://doi.org/10.1155/2024/1197571

Background. The prevalence of taste change (hypogeusia) and its association with zinc deficiency is unclear due to differences in methods of assessment. We investigate the prevalence of hypogeusia using mixed methods and link it with changes in zinc... Read More about Associations between zinc deficiency, taste changes and salivary flow rate following gastric bypass and sleeve gastrectomy surgeries.

Patient and health professional views on risk-stratified monitoring of immune-suppressing treatment in adults with inflammatory diseases (2024)
Journal Article
Fuller, A., Hancox, J., Williams, H. C., Card, T., Taal, M. W., Aithal, G. P., Fox, C. P., Mallen, C. D., Maxwell, J. R., Bingham, S., Vedhara, K., & Abhishek, A. (in press). Patient and health professional views on risk-stratified monitoring of immune-suppressing treatment in adults with inflammatory diseases. Rheumatology, Article keae175. https://doi.org/10.1093/rheumatology/keae175

Objective
To explore the acceptability of an individualised risk-stratified approach to monitoring for target-organ toxicity in adult patients with immune-mediated inflammatory diseases established on immune-suppressing treatment(s).

Methods
Adu... Read More about Patient and health professional views on risk-stratified monitoring of immune-suppressing treatment in adults with inflammatory diseases.

Uptake and safety of pneumococcal vaccination in adults with immune mediated inflammatory diseases: a UK wide observational study (2024)
Journal Article
Nakafero, G., Grainge, M. J., Card, T., Mallen, C. D., Nguyen Van-Tam, J. S., Abhishek, A., & . (2024). Uptake and safety of pneumococcal vaccination in adults with immune mediated inflammatory diseases: a UK wide observational study. Rheumatology, Article keae160. https://doi.org/10.1093/rheumatology/keae160

Objective The uptake and safety of pneumococcal vaccination in people with immune mediated inflammatory diseases (IMIDs) is poorly understood. We investigated the UK wide pneumococcal vaccine uptake in adults with IMIDs and explored the association b... Read More about Uptake and safety of pneumococcal vaccination in adults with immune mediated inflammatory diseases: a UK wide observational study.

Getting the message across; a realist study of the role of communication and information exchange processes in delivering stroke Early Supported Discharge services in England (2024)
Journal Article
Chouliara, N., Cameron, T., Byrne, A., & Fisher, R. (2024). Getting the message across; a realist study of the role of communication and information exchange processes in delivering stroke Early Supported Discharge services in England. PLoS ONE, 19(3), Article e0298140. https://doi.org/10.1371/journal.pone.0298140

Background: Stroke early supported discharge (ESD) involves the co-ordinated transfer of care from hospital to home. The quality of communication processes between professionals delivering ESD and external stakeholders may have a role to play in stre... Read More about Getting the message across; a realist study of the role of communication and information exchange processes in delivering stroke Early Supported Discharge services in England.

Getting the message across: a realist study of the role of communication and information exchange processes in delivering Stroke Early Supported Discharge services in England (2024)
Journal Article
Chouliara, N., Cameron, T., Byrne, A., & Fisher, R. (2024). Getting the message across: a realist study of the role of communication and information exchange processes in delivering Stroke Early Supported Discharge services in England. PLoS ONE, 19(3), Article e0298140. https://doi.org/10.1371/journal.pone.0298140

Background
Stroke early supported discharge (ESD) involves the co-ordinated transfer of care from hospital to home. The quality of communication processes between professionals delivering ESD and external stakeholders may have a role to play in stre... Read More about Getting the message across: a realist study of the role of communication and information exchange processes in delivering Stroke Early Supported Discharge services in England.

Development of a Job Retention Vocational Rehabilitation Intervention for People with Multiple Sclerosis Following the Person-Based Approach (2024)
Journal Article
De Dios Pérez, B., das Nair, R., & Radford, K. (2024). Development of a Job Retention Vocational Rehabilitation Intervention for People with Multiple Sclerosis Following the Person-Based Approach. Clinical Rehabilitation, 38(7), 965-978. https://doi.org/10.1177/02692155241235956

Objective
To describe the process of developing a job retention vocational rehabilitation intervention for people with multiple sclerosis.

Design
We used the person-based approach, to develop interventions through an iterative process incorporat... Read More about Development of a Job Retention Vocational Rehabilitation Intervention for People with Multiple Sclerosis Following the Person-Based Approach.

The association of painful and non-painful morbidities with frailty: a cross sectional analysis of a cohort of community dwelling older people in England (2024)
Journal Article
Chaplin, W. J., Lewis, H. R., Shahtaheri, S. M., Millar, B. S., McWilliams, D. F., Gladman, J. R. F., & Walsh, D. A. (2024). The association of painful and non-painful morbidities with frailty: a cross sectional analysis of a cohort of community dwelling older people in England. BMC Geriatrics, 24, Article 158. https://doi.org/10.1186/s12877-023-04602-w

Introduction
The association between chronic pain and frailty might indicate that pain is an independent driver of frailty but might alternatively be explained by inclusion within frailty identification tools of morbidities that commonly lead to chr... Read More about The association of painful and non-painful morbidities with frailty: a cross sectional analysis of a cohort of community dwelling older people in England.

Melatonin is a potential novel analgesic agent for osteoarthritis: Evidence from cohort studies in humans and preclinical research in rats (2024)
Journal Article
Li, H., Zhou, B., Wu, J., Zhang, Y., Zhang, W., Doherty, M., Deng, X., Wang, N., Xie, D., Wang, Y., Xie, H., Li, C., Wei, J., Lei, G., & Zeng, C. (2024). Melatonin is a potential novel analgesic agent for osteoarthritis: Evidence from cohort studies in humans and preclinical research in rats. Journal of Pineal Research, 76(2), Article e12945. https://doi.org/10.1111/jpi.12945

Melatonin exhibits potential for pain relief and long-term safety profile. We examined the analgesic effects of oral melatonin on osteoarthritis (OA) and investigated the underlying mechanism. Using data from a UK primary care database, we conducted... Read More about Melatonin is a potential novel analgesic agent for osteoarthritis: Evidence from cohort studies in humans and preclinical research in rats.

Peer mentoring for people with acquired brain injury – a systematic review (2024)
Journal Article
De Dios Perez, B., Morris, R. P., Craven, K., & Radford, K. A. (2024). Peer mentoring for people with acquired brain injury – a systematic review. Brain Injury, 38(4), 316-329. https://doi.org/10.1080/02699052.2024.2310779

Introduction: Over 100 million people worldwide live with disabilities resulting from an acquired brain injury (ABI). ABI survivors experience cognitive and physical problems and require support to resume an active life. They can benefit from support... Read More about Peer mentoring for people with acquired brain injury – a systematic review.

2023 EULAR recommendations on imaging in diagnosis and management of crystal-induced arthropathies in clinical practice (2024)
Journal Article
Mandl, P., D'Agostino, M. A., Navarro-Compán, V., Geßl, I., Sakellariou, G., Abhishek, A., …Filippou, G. (2024). 2023 EULAR recommendations on imaging in diagnosis and management of crystal-induced arthropathies in clinical practice. Annals of the Rheumatic Diseases, 83, 752-759. https://doi.org/10.1136/ard-2023-224771

Objective: To formulate evidence-based recommendations and overarching principles on the use of imaging in the clinical management of crystal-induced arthropathies (CiAs). Methods: An international task force of 25 rheumatologists, radiologists, meth... Read More about 2023 EULAR recommendations on imaging in diagnosis and management of crystal-induced arthropathies in clinical practice.

Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation (2024)
Journal Article
Abhishek, A., Grainge, M., Card, T., Williams, H. C., Taal, M. W., Aithal, G. P., …Riley, R. (2024). Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation. RMD Open, 10(1), Article e003980. https://doi.org/10.1136/rmdopen-2023-003980

Background Sulfasalazine-induced cytopenia, nephrotoxicity and hepatotoxicity is uncommon during long-term treatment. Some guidelines recommend 3 monthly monitoring blood tests indefinitely during long-term treatment while others recommend stopping m... Read More about Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation.