All Outputs (89)

Efficacy and safety of intensive versus conventional glucose targets in people with type 2 diabetes: a systematic review and meta-analysis (2023)
Journal Article
Aldafas, R., Crabtree, T., Vinogradova, Y., Gordon, J. P., & Idris, I. (2023). Efficacy and safety of intensive versus conventional glucose targets in people with type 2 diabetes: a systematic review and meta-analysis. Expert Review of Endocrinology and Metabolism, 18(1), 95-110. https://doi.org/10.1080/17446651.2023.2166489

Objective: The aim of study is to re-evaluate the risk-benefits of intensive glycemic control in the context of multi-factorial intervention in adults with T2D. Methods: We searched Ovid MEDLINE, Embase, Cochrane, and CINHAL for randomized contro... Read More about Efficacy and safety of intensive versus conventional glucose targets in people with type 2 diabetes: a systematic review and meta-analysis.

Loss of muscle mass in the immediate post-operative period is associated with inadequate dietary protein and energy intake (2023)
Journal Article
Hardy, E. J., Deane, C. S., Lund, J. N., & Phillips, B. E. (2023). Loss of muscle mass in the immediate post-operative period is associated with inadequate dietary protein and energy intake. European Journal of Clinical Nutrition, 77, 503-505. https://doi.org/10.1038/s41430-023-01264-0

Despite the implementation of ‘Enhanced Recovery After Surgery’ (ERAS) protocols, major abdominal surgery is still associated with significant and detrimental losses of muscle mass and function in the post-operative period. Although ERAS protocols ad... Read More about Loss of muscle mass in the immediate post-operative period is associated with inadequate dietary protein and energy intake.

Clinical academics' experiences during the COVID-19 pandemic: a qualitative study of challenges and opportunities when working at the clinical frontline (2023)
Journal Article
Trusson, D., Rowley, E., & Bramley, L. (2023). Clinical academics' experiences during the COVID-19 pandemic: a qualitative study of challenges and opportunities when working at the clinical frontline. BMJ Leader, 7(4), 266-272. https://doi.org/10.1136/leader-2020-000414

Objectives: This study explored the experiences of clinical academics during the COVID-19 pandemic. The aim was to identify challenges and benefits associated with returning to, or increasing hours at, the clinical frontline. Design: Qualitative data... Read More about Clinical academics' experiences during the COVID-19 pandemic: a qualitative study of challenges and opportunities when working at the clinical frontline.

Classification of patients with osteoarthritis through clusters of comorbidities using 633 330 individuals from Spain (2023)
Journal Article
Pineda-Moncusí, M., Dernie, F., Dell’Isola, A., Kamps, A., Runhaar, J., Swain, S., …Khalid, S. (2023). Classification of patients with osteoarthritis through clusters of comorbidities using 633 330 individuals from Spain. Rheumatology, 62(11), 3592-3600. https://doi.org/10.1093/rheumatology/kead038

To explore clustering of comorbidities among patients with a new diagnosis of osteoarthritis (OA) and estimate the 10-year mortality risk for each identified cluster. This is a population-based cohort study of individuals with first incident diagnosi... Read More about Classification of patients with osteoarthritis through clusters of comorbidities using 633 330 individuals from Spain.

Risk of liver fibrosis associated with long-term methotrexate therapy may be overestimated (2023)
Journal Article
Atallah, E., Grove, J. I., Crooks, C., Burden-Teh, E., Abhishek, A., Moreea, S., …Aithal, G. P. (2023). Risk of liver fibrosis associated with long-term methotrexate therapy may be overestimated. Journal of Hepatology, 78(5), 989-997. https://doi.org/10.1016/j.jhep.2022.12.034

Background & Aims: The risk of significant liver fibrosis from prolonged methotrexate (MTX) exposure has been estimated at around 5%, prompting intensive monitoring strategies. However, the evidence is derived from retrospective studies that under-re... Read More about Risk of liver fibrosis associated with long-term methotrexate therapy may be overestimated.

Reply on: International, multidisciplinary Delphi consensus recommendations on non-pharmacological interventions for fibromyalgia (2023)
Journal Article
Kundakci, B., Hall, M., Atzeni, F., Branco, J., Buskila, D., Clauw, D., …Abhishek, A. (2023). Reply on: International, multidisciplinary Delphi consensus recommendations on non-pharmacological interventions for fibromyalgia. Seminars in Arthritis and Rheumatism, 59, Article 152162. https://doi.org/10.1016/j.semarthrit.2023.152162

Chronic pain in people living with dementia: challenges to recognising and managing pain, and personalising intervention by phenotype (2023)
Journal Article
Collins, J. T., Harwood, R. H., Cowley, A., Di Lorito, C., Ferguson, E., Minicucci, M. F., …Gladman, J. R. (2023). Chronic pain in people living with dementia: challenges to recognising and managing pain, and personalising intervention by phenotype. Age and Ageing, 52(1), Article afac306. https://doi.org/10.1093/ageing/afac306

Pain is common in people with dementia, and pain can exacerbate the behavioural and psychological symptoms of dementia. Effective pain management is challenging, not least in people with dementia. Impairments of cognition, communication and abstract... Read More about Chronic pain in people living with dementia: challenges to recognising and managing pain, and personalising intervention by phenotype.

Comparative efficacy of exercise therapy and oral non-steroidal anti-inflammatory drugs and paracetamol for knee or hip osteoarthritis: a network meta-analysis of randomised controlled trials (2023)
Journal Article
Weng, Q., Goh, S.-L., Wu, J., Persson, M. S., Wei, J., Sarmanova, A., …Zhang, W. (2023). Comparative efficacy of exercise therapy and oral non-steroidal anti-inflammatory drugs and paracetamol for knee or hip osteoarthritis: a network meta-analysis of randomised controlled trials. British Journal of Sports Medicine, 57(15), 990-996. https://doi.org/10.1136/bjsports-2022-105898

OBJECTIVE: Clinical guidelines recommend exercise as a core treatment for knee or hip osteoarthritis (OA). However, how its analgesic effect compares to analgesics, for example, oral non-steroidal anti-inflammatory drugs (NSAIDs) and paracetamol-the... Read More about Comparative efficacy of exercise therapy and oral non-steroidal anti-inflammatory drugs and paracetamol for knee or hip osteoarthritis: a network meta-analysis of randomised controlled trials.

Reproducible microbiome composition signatures of anxiety and depressive symptoms (2023)
Journal Article
Kouraki, A., Kelly, A., Vijay, A., Gohir, S., Astbury, S., Georgopoulos, V., …Valdes, A. M. (2023). Reproducible microbiome composition signatures of anxiety and depressive symptoms. Computational and Structural Biotechnology Journal, 21, 5326-5336. https://doi.org/10.1016/j.csbj.2023.10.035

The gut microbiome is a significant contributor to mental health, with growing evidence linking its composition to anxiety and depressive disorders. Gut microbiome composition is associated with signs of anxiety and depression both in clinically diag... Read More about Reproducible microbiome composition signatures of anxiety and depressive symptoms.