All Outputs (336)

Remote ischemic conditioning for stroke: A critical systematic review (2023)
Journal Article
Keevil, H., Phillips, B. E., & England, T. J. (in press). Remote ischemic conditioning for stroke: A critical systematic review. International Journal of Stroke, 19(3), 271-279. https://doi.org/10.1177/17474930231191082

Remote ischemic conditioning (RIC) is the application of brief periods of ischemia to an organ or tissue with the aim of inducing protection from ischemia in a distant organ. It was first developed as a cardioprotective strategy but has been increasi... Read More about Remote ischemic conditioning for stroke: A critical systematic review.

The clinical utility of QbTest in supporting the assessment and monitoring of Attention-Deficit/Hyperactivity Disorder (ADHD): What do paediatricians need to know? (2023)
Journal Article
Hall, C. L., Bellato, A., Kirk, J. D., & Hollis, C. (2023). The clinical utility of QbTest in supporting the assessment and monitoring of Attention-Deficit/Hyperactivity Disorder (ADHD): What do paediatricians need to know?. Paediatrics and Child Health, 33(9), 259-264. https://doi.org/10.1016/j.paed.2023.06.006

The assessment of Attention-Deficit/Hyperactivity Disorder (ADHD) typically relies on subjective observer reports from parents, teachers, or the young person, combined with clinical observation and history. Children and young people often experience... Read More about The clinical utility of QbTest in supporting the assessment and monitoring of Attention-Deficit/Hyperactivity Disorder (ADHD): What do paediatricians need to know?.

Using mobile health technology to assess childhood autism in low-resource community settings in India: An innovation to address the detection gap (2023)
Journal Article
Dubey, I., Bishain, R., Dasgupta, J., Bhavnani, S., Belmonte, M. K., Gliga, T., …Chakrabarti, B. (2024). Using mobile health technology to assess childhood autism in low-resource community settings in India: An innovation to address the detection gap. Autism, 28(3), 755–769. https://doi.org/10.1177/13623613231182801

A diagnosis of autism typically depends on clinical assessments by highly trained professionals. This high resource demand poses a challenge in low-resource settings. Digital assessment of neurodevelopmental symptoms by non-specialists provides a pot... Read More about Using mobile health technology to assess childhood autism in low-resource community settings in India: An innovation to address the detection gap.

Relationship between autonomic arousal and attention orienting in children and adolescents with ADHD, autism and co-occurring ADHD and autism (2023)
Journal Article
Bellato, A., Arora, I., Kochhar, P., Ropar, D., Hollis, C., & Groom, M. J. (2023). Relationship between autonomic arousal and attention orienting in children and adolescents with ADHD, autism and co-occurring ADHD and autism. Cortex, 166, 306-321. https://doi.org/10.1016/j.cortex.2023.06.002

Introduction Attention-Deficit/Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) may be characterized by different profiles of visual attention orienting. However, there are also many inconsistent findings emerging from the literature... Read More about Relationship between autonomic arousal and attention orienting in children and adolescents with ADHD, autism and co-occurring ADHD and autism.

Listening efficiency in adult cochlear-implant users compared with normally-hearing controls at ecologically relevant signal-to-noise ratios (2023)
Journal Article
Perea Pérez, F., Hartley, D. E. H., Kitterick, P. T., Zekveld, A. A., Naylor, G., & Wiggins, I. M. (2023). Listening efficiency in adult cochlear-implant users compared with normally-hearing controls at ecologically relevant signal-to-noise ratios. Frontiers in Human Neuroscience, 17, Article 1214485. https://doi.org/10.3389/fnhum.2023.1214485

Introduction: Due to having to work with an impoverished auditory signal, cochlear-implant (CI) users may experience reduced speech intelligibility and/or increased listening effort in real-world listening situations, compared to their normally-heari... Read More about Listening efficiency in adult cochlear-implant users compared with normally-hearing controls at ecologically relevant signal-to-noise ratios.

TNF-α evokes blood-brain barrier dysfunction through activation of Rho-kinase and neurokinin 1 receptor (2023)
Journal Article
Gao, X., & Bayraktutan, U. (2023). TNF-α evokes blood-brain barrier dysfunction through activation of Rho-kinase and neurokinin 1 receptor. Immunobiology, 228(5), Article 152706. https://doi.org/10.1016/j.imbio.2023.152706

Ischaemic stroke, accompanied by neuroinflammation, impairs blood–brain barrier (BBB) integrity through a complex mechanism involving activation of both RhoA/Rho kinase/myosin light chain-2 and neurokinin 1 receptor (NK1R). Using an in vitro model of... Read More about TNF-α evokes blood-brain barrier dysfunction through activation of Rho-kinase and neurokinin 1 receptor.

Risk of COVID-19 in people with multiple sclerosis who are seronegative following vaccination (2023)
Journal Article
Zaloum, S. A., Wood, C. H., Tank, P., Upcott, M., Vickaryous, N., Anderson, V., …Tallantyre, E. C. (2023). Risk of COVID-19 in people with multiple sclerosis who are seronegative following vaccination. Multiple Sclerosis Journal, 29(8), 979-989. https://doi.org/10.1177/13524585231185247

Background: People with multiple sclerosis (pwMS) treated with certain disease-modifying therapies (DMTs) have attenuated IgG response following COVID-19 vaccination; however, the clinical consequences remain unclear. Objective: To report CO... Read More about Risk of COVID-19 in people with multiple sclerosis who are seronegative following vaccination.

“It’s not just for the Past but it’s for the Here and Now”: Gift-Giver Perspectives on the Memory Machine to Gift Digital Memories (2023)
Presentation / Conference Contribution
Gibson, R., Babbage, C. M., Wagner, H. G., Price, D. J., Martindale, S., Chadborn, N. H., …Perez Vallejos, E. (2023). “It’s not just for the Past but it’s for the Here and Now”: Gift-Giver Perspectives on the Memory Machine to Gift Digital Memories. In DIS '23: Proceedings of the 2023 ACM Designing Interactive Systems Conference (987-1001). https://doi.org/10.1145/3563657.3595962

We present the design of the Memory Machine (MeMa), a technology probe that can store, contextualise, and document media to represent memories. We accumulate vast physical and digital possessions throughout our lives, making it difficult to distingui... Read More about “It’s not just for the Past but it’s for the Here and Now”: Gift-Giver Perspectives on the Memory Machine to Gift Digital Memories.

A systematic review of ambulance service-based randomised controlled trials in stroke (2023)
Journal Article
Dixon, M., Appleton, J. P., Siriwardena, A. N., Williams, J., & Bath, P. M. (2023). A systematic review of ambulance service-based randomised controlled trials in stroke. Neurological Sciences, 44(12), 4363-4378. https://doi.org/10.1007/s10072-023-06910-w

Background: Treatment for stroke is time-dependent, and ambulance services play a vital role in the early recognition, assessment and transportation of stroke patients. Innovations which begin in ambulance services to expedite delivery of treatments... Read More about A systematic review of ambulance service-based randomised controlled trials in stroke.

Optimising the analysis of vascular prevention trials: Re-Assessment of the TARDIS trial, the first prevention trial to adopt an ordinal primary outcome measure (2023)
Journal Article
Woodhouse, L. J., Montgomery, A. A., Pocock, S., James, M., Ranta, A., Bath, P. M., & TARDIS Investigators, T. I. (2023). Optimising the analysis of vascular prevention trials: Re-Assessment of the TARDIS trial, the first prevention trial to adopt an ordinal primary outcome measure. Contemporary Clinical Trials Communications, 35, Article 101186. https://doi.org/10.1016/j.conctc.2023.101186

Background: Ordinalised vascular outcomes incorporating event severity are more informative than binary outcomes that just include event numbers. The TARDIS trial was the first vascular prevention study to use an ordinalised vascular outcome as its p... Read More about Optimising the analysis of vascular prevention trials: Re-Assessment of the TARDIS trial, the first prevention trial to adopt an ordinal primary outcome measure.

Examining the Use of Autonomous Systems for Home Health Support using a Smart Mirror (2023)
Preprint / Working Paper
Dowthwaite, L., Reyez Cruz, G., Pena, A. R., Pepper, C., Jäger, N., Barnard, P., …Benford, S. Examining the Use of Autonomous Systems for Home Health Support using a Smart Mirror

The home is becoming a key location for healthcare delivery, including the use of technology driven by autonomous systems (AS) to monitor and support healthcare plans. Using the example of a smart mirror, this paper describes the outcomes of focus gr... Read More about Examining the Use of Autonomous Systems for Home Health Support using a Smart Mirror.

TrustScapes: A visualisation tool to capture stakeholders' concerns and recommendations about data protection, algorithmic bias, and online safety (2023)
Journal Article
Ito-Jaeger, S., Lane, G., Dowthwaite, L., Webb, H., Patel, M., Rawsthorne, M., …Perez Vallejos, E. (2023). TrustScapes: A visualisation tool to capture stakeholders' concerns and recommendations about data protection, algorithmic bias, and online safety. International Journal of Qualitative Methods, 22, 1-10. https://doi.org/10.1177/1609406923118696

This paper presents a new methodological approach, TrustScapes, an open access tool designed to identify and visualise stakeholders’ concerns and policy recommendations on data protection, algorithmic bias, and online safety for a fairer and more tru... Read More about TrustScapes: A visualisation tool to capture stakeholders' concerns and recommendations about data protection, algorithmic bias, and online safety.

TrustScapes: A Visualisation Tool to Capture Stakeholders’ Concerns and Recommendations About Data Protection, Algorithmic Bias, and Online Safety (2023)
Journal Article
Ito-Jaeger, S., Lane, G., Dowthwaite, L., Webb, H., Patel, M., Rawsthorne, M., …Perez Vallejos, E. (2023). TrustScapes: A Visualisation Tool to Capture Stakeholders’ Concerns and Recommendations About Data Protection, Algorithmic Bias, and Online Safety. International Journal of Qualitative Methods, 22, https://doi.org/10.1177/16094069231186965

This paper presents a new methodological approach, TrustScapes, an open access tool designed to identify and visualise stakeholders’ concerns and policy recommendations on data protection, algorithmic bias, and online safety for a fairer and more tru... Read More about TrustScapes: A Visualisation Tool to Capture Stakeholders’ Concerns and Recommendations About Data Protection, Algorithmic Bias, and Online Safety.

A predictive model of carer resilience in dementia family caregiving: A structural equation modelling approach (2023)
Journal Article
Leung, P., Orrell, M., Yates, L., & Orgeta, V. (2023). A predictive model of carer resilience in dementia family caregiving: A structural equation modelling approach. International Journal of Geriatric Psychiatry, 38(7), Article e5945. https://doi.org/10.1002/gps.5945

Objectives: This study aimed to investigate the mediating effects of quality of the caregiving relationship and other carer and person with dementia variables in predicting carer resilience over time. Method: Carers of people with mild and moderate d... Read More about A predictive model of carer resilience in dementia family caregiving: A structural equation modelling approach.

Surgery for Malignant Acute Ischemic Stroke: A Narrative Review of the Knowns and Unknowns (2023)
Journal Article
Krishnan, K., Hollingworth, M., Nguyen, T. N., Kumaria, A., Kirkman, M. A., Basu, S., …Sprigg, N. (2023). Surgery for Malignant Acute Ischemic Stroke: A Narrative Review of the Knowns and Unknowns. Seminars in Neurology, 43(3), 370-387. https://doi.org/10.1055/s-0043-1771208

Malignant acute ischemic stroke (AIS) is characterized by acute neurological deterioration caused by progressive space-occupying brain edema, often occurring in the first hours to days after symptom onset. Without any treatment, the result is often f... Read More about Surgery for Malignant Acute Ischemic Stroke: A Narrative Review of the Knowns and Unknowns.

Does knowledge of liver fibrosis affect high-risk drinking behaviour (KLIFAD): an open-label pragmatic feasibility randomised controlled trial (2023)
Journal Article
Subhani, M., Enki, D. G., Knight, H., Jones, K. A., Sprange, K., Rennick-Egglestone, S., …Ryder, S. D. (2023). Does knowledge of liver fibrosis affect high-risk drinking behaviour (KLIFAD): an open-label pragmatic feasibility randomised controlled trial. eClinicalMedicine, 61, Article 102069. https://doi.org/10.1016/j.eclinm.2023.102069

Background: Early identification followed by effective behaviour interventions is pivotal to changing the natural history of alcohol-related liver disease. We examined the feasibility of using transient elastography based advice and alcohol recovery... Read More about Does knowledge of liver fibrosis affect high-risk drinking behaviour (KLIFAD): an open-label pragmatic feasibility randomised controlled trial.

Community Occupational Therapy in Dementia intervention for people with mild to moderate dementia and their family carers in the UK: the VALID research programme including RCT (2023)
Journal Article
Wenborn, J., Mountain, G., Moniz-Cook, E., Poland, F., King, M., Omar, R., …Orrell, M. (2023). Community Occupational Therapy in Dementia intervention for people with mild to moderate dementia and their family carers in the UK: the VALID research programme including RCT. Programme Grants for Applied Research, 11(5), 1-76. https://doi.org/10.3310/rgtj7429

Background People with dementia find it increasingly difficult to carry out daily activities (activities of daily living), and may require increasing support from family carers. Researchers in the Netherlands developed the Community Occupational T... Read More about Community Occupational Therapy in Dementia intervention for people with mild to moderate dementia and their family carers in the UK: the VALID research programme including RCT.

Brain perfusion imaging by multi‐delay arterial spin labeling: Impact of modeling dispersion and interaction with denoising strategies and pathology (2023)
Journal Article
Pires Monteiro, S., Pinto, J., Chappell, M. A., Fouto, A., Baptista, M. V., Vilela, P., & Figueiredo, P. (2023). Brain perfusion imaging by multi‐delay arterial spin labeling: Impact of modeling dispersion and interaction with denoising strategies and pathology. Magnetic Resonance in Medicine, 90(5), 1889-1904. https://doi.org/10.1002/mrm.29783

Purpose: Arterial spin labeling (ASL) acquisitions at multiple post-labeling delays may provide more accurate quantification of cerebral blood flow (CBF), by fitting appropriate kinetic models and simultaneously estimating relevant parameters such as... Read More about Brain perfusion imaging by multi‐delay arterial spin labeling: Impact of modeling dispersion and interaction with denoising strategies and pathology.

Substance P reversibly compromises the integrity and function of blood-brain barrier (2023)
Journal Article
Gao, X., & Bayraktutan, U. (2023). Substance P reversibly compromises the integrity and function of blood-brain barrier. Peptides, 167, Article 171048. https://doi.org/10.1016/j.peptides.2023.171048

Background Substance P (SP) plays a role in vasodilatation and tissue integrity through its receptor, neurokinin 1 (NK1R). However, its specific effect on blood-brain barrier (BBB) remains unknown. Methods The impact of SP on the integrity/funct... Read More about Substance P reversibly compromises the integrity and function of blood-brain barrier.

Differences Between Online Trial Participants Who Have Used Statutory Mental Health Services and Those Who Have Not: Analysis of Baseline Data From 2 Pragmatic Trials of a Digital Health Intervention. (2023)
Journal Article
Rennick-Egglestone, S., Newby, C., Robinson, C., Yeo, C., Ng, F., Elliott, R., …Slade, M. (2023). Differences Between Online Trial Participants Who Have Used Statutory Mental Health Services and Those Who Have Not: Analysis of Baseline Data From 2 Pragmatic Trials of a Digital Health Intervention. Journal of Medical Internet Research, 25, Article e44687. https://doi.org/10.2196/44687

Background: Digital health interventions (DHIs) are an established element of mental health service provision internationally. Regulators have positioned the best practice standard of evidence as an interventional study with a comparator reflective o... Read More about Differences Between Online Trial Participants Who Have Used Statutory Mental Health Services and Those Who Have Not: Analysis of Baseline Data From 2 Pragmatic Trials of a Digital Health Intervention..