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All Outputs (386)

Experiences and impact of psychiatric inpatient admissions far away from home: a qualitative study with young people, parents/carers and healthcare professionals (2024)
Journal Article
Roe, J., Holland, J., Burn, A., Hopkin, E., Wild, L., Fisher, M., …Sayal, K. (2024). Experiences and impact of psychiatric inpatient admissions far away from home: a qualitative study with young people, parents/carers and healthcare professionals. BMJ Mental Health, 27(1), Article e300991. https://doi.org/10.1136/bmjment-2024-300991

Background: There are significant clinical, policy and societal concerns about the impact on young people (YP), from admission to psychiatric wards far from home. However, research evidence is scarce.
Aims: To investigate the impact of at-distance... Read More about Experiences and impact of psychiatric inpatient admissions far away from home: a qualitative study with young people, parents/carers and healthcare professionals.

Seeing the Invisible: A Photovoice Exploration of Living With and Managing the Invisible Symptoms of Multiple Sclerosis (2024)
Journal Article
Parker, L.-S., Topcu, G., De Boos, D., Bale, C., & das Nair, R. (2024). Seeing the Invisible: A Photovoice Exploration of Living With and Managing the Invisible Symptoms of Multiple Sclerosis. Clinical Psychological Science, https://doi.org/10.1177/21677026231220846

In this photovoice study, we explored how people with multiple sclerosis (MS) experience living with and managing invisible symptoms in daily life. Twelve people with MS produced digital images over a 2-week period to capture their experiences of inv... Read More about Seeing the Invisible: A Photovoice Exploration of Living With and Managing the Invisible Symptoms of Multiple Sclerosis.

The Impact of COVID-19 on the Employment of People With Multiple Sclerosis: A Multi-Methods Study (2024)
Journal Article
De Dios Perez, B., Pritchard, C., Powers, K., das Nair, R., Evangelou, N., Ford, H., …Radford, K. (2024). The Impact of COVID-19 on the Employment of People With Multiple Sclerosis: A Multi-Methods Study. International Journal of Ms Care, 26(Q3), 174-186. https://doi.org/10.7224/1537-2073.2023-049

Background: The COVID-19 pandemic led to approximately half of the working population in the United Kingdom being unable to work temporarily. This study aims to understand the employment needs and experiences of people with multiple sclerosis (MS) in... Read More about The Impact of COVID-19 on the Employment of People With Multiple Sclerosis: A Multi-Methods Study.

Semi-supervised information fusion for medical image analysis: Recent progress and future perspectives (2024)
Journal Article
Weng, Y., Zhang, Y., Wang, W., & Dening, T. (2024). Semi-supervised information fusion for medical image analysis: Recent progress and future perspectives. Information Fusion, 106, Article 102263. https://doi.org/10.1016/j.inffus.2024.102263

Supervised machine learning requires training on the dataset with annotation. However, fine-grained annotation is very expensive to acquire. In the medical image analysis domain, the sheer volume of data and lack of annotation limit the performance o... Read More about Semi-supervised information fusion for medical image analysis: Recent progress and future perspectives.

A critical review of established tinnitus patient-reported outcomes as measures of Tinnitus Severity and Tinnitus Distress and exemplar analysis of the Tinnitus Handicap Inventory as a formative or reflective measure (2024)
Journal Article
Clarke, N. A., Hoare, D. J., & Trigg, A. (2024). A critical review of established tinnitus patient-reported outcomes as measures of Tinnitus Severity and Tinnitus Distress and exemplar analysis of the Tinnitus Handicap Inventory as a formative or reflective measure. Frontiers in Audiology and Otology, 1, Article 1325137. https://doi.org/10.3389/fauot.2023.1325137

Tinnitus Severity and Tinnitus Distress are frequently referenced and conflated constructs in research, measured using established tinnitus patient-reported outcome measures (PROs). Confusion regarding these constructs and their relation to fundament... Read More about A critical review of established tinnitus patient-reported outcomes as measures of Tinnitus Severity and Tinnitus Distress and exemplar analysis of the Tinnitus Handicap Inventory as a formative or reflective measure.

Connectivity-guided intermittent theta burst versus repetitive transcranial magnetic stimulation for treatment-resistant depression: a randomized controlled trial (2024)
Journal Article
Morriss, R., Briley, P. M., Webster, L., Abdelghani, M., Barber, S., Bates, P., …Auer, D. P. (2024). Connectivity-guided intermittent theta burst versus repetitive transcranial magnetic stimulation for treatment-resistant depression: a randomized controlled trial. Nature Medicine, 30(2), 403–413. https://doi.org/10.1038/s41591-023-02764-z

Disruption in reciprocal connectivity between the right anterior insula and the left dorsolateral prefrontal cortex is associated with depression and may be a target for neuromodulation. In a five-center, parallel, double-blind, randomized controlled... Read More about Connectivity-guided intermittent theta burst versus repetitive transcranial magnetic stimulation for treatment-resistant depression: a randomized controlled trial.

Effectiveness and cost-effectiveness of online recorded recovery narratives in improving quality of life for people with non-psychotic mental health problems: a pragmatic randomized controlled trial (2024)
Journal Article
Slade, M., Rennick‐Egglestone, S., Elliott, R. A., Newby, C., Robinson, C., Gavan, S. P., Paterson, L., Ali, Y., Yeo, C., Glover, T., Pollock, K., Callard, F., Priebe, S., Thornicroft, G., Repper, J., Keppens, J., Smuk, M., Franklin, D., Walcott, R., Harrison, J., …Llewellyn-Beardsley, J. (2024). Effectiveness and cost-effectiveness of online recorded recovery narratives in improving quality of life for people with non-psychotic mental health problems: a pragmatic randomized controlled trial. World Psychiatry, 23(1), 101-112. https://doi.org/10.1002/wps.21176

Narratives describing first-hand experiences of recovery from mental health problems are widely available. Emerging evidence suggests that engaging with mental health recovery narratives can benefit people experiencing mental health problems, but no... Read More about Effectiveness and cost-effectiveness of online recorded recovery narratives in improving quality of life for people with non-psychotic mental health problems: a pragmatic randomized controlled trial.

Development of the impact of tinnitus in children questionnaire (iTICQ) (2024)
Journal Article
Smith, H., Fackrell, K., Kennedy, V., Barry, J. G., Benton, C., Partridge, L., & Hoare, D. J. (2024). Development of the impact of tinnitus in children questionnaire (iTICQ). Frontiers in Audiology and Otology, 1, Article 1323864. https://doi.org/10.3389/fauot.2023.1323864

Introduction: Tinnitus is a common disorder of the auditory system. Questionnaires are essential tools for clinical assessment and research. Whilst many questionnaires are available to measure different aspects of tinnitus complaint in adults, there... Read More about Development of the impact of tinnitus in children questionnaire (iTICQ).

Enhancing emotion regulation with an in situ socially assistive robot among LGBTQ+ youth with self-harm ideation: protocol for a randomised controlled trial (2024)
Journal Article
Williams, A. J., Cleare, S., Borschmann, R., Tench, C. R., Gross, J., Hollis, C., …Slovak, P. (2024). Enhancing emotion regulation with an in situ socially assistive robot among LGBTQ+ youth with self-harm ideation: protocol for a randomised controlled trial. BMJ Open, 14(1), Article e079801. https://doi.org/10.1136/bmjopen-2023-079801

Introduction: Purrble, a socially assistive robot, was codesigned with children to support in situ emotion regulation. Preliminary evidence has found that LGBTQ+ youth are receptive to Purrble and find it to be an acceptable intervention to assist wi... Read More about Enhancing emotion regulation with an in situ socially assistive robot among LGBTQ+ youth with self-harm ideation: protocol for a randomised controlled trial.

Supporting employers and their employees with mental hEalth conditions to remain eNgaged and producTive at wORk (MENTOR): A feasibility randomised controlled trial (2024)
Journal Article
Prudenzi, A., Gill, K., MacArthur, M., Hastings, O., Moukhtarian, T., Jadhakhan, F., …Marwaha, S. (2024). Supporting employers and their employees with mental hEalth conditions to remain eNgaged and producTive at wORk (MENTOR): A feasibility randomised controlled trial. Journal of Contextual Behavioral Science, 31, Article 100720. https://doi.org/10.1016/j.jcbs.2023.100720

Employees with mental health conditions often struggle to remain in employment. During the COVID-19 pandemic, these employees faced additional stressors, including worsening mental health and work productivity. In 2020, as part of a larger programme... Read More about Supporting employers and their employees with mental hEalth conditions to remain eNgaged and producTive at wORk (MENTOR): A feasibility randomised controlled trial.

The Role of Stem Cells as Therapeutics for Ischaemic Stroke (2024)
Journal Article
Ya, J., Pellumbaj, J., Hashmat, A., & Bayraktutan, U. (2024). The Role of Stem Cells as Therapeutics for Ischaemic Stroke. Cells, 13(2), Article 112. https://doi.org/10.3390/cells13020112

Stroke remains one of the leading causes of death and disability worldwide. Current reperfusion treatments for ischaemic stroke are limited due to their narrow therapeutic window in rescuing ischaemic penumbra. Stem cell therapy offers a promising al... Read More about The Role of Stem Cells as Therapeutics for Ischaemic Stroke.

Dual Antiplatelet Treatment up to 72 Hours after Ischemic Stroke (2023)
Journal Article
Gao, Y., Chen, W., Pan, Y., Jing, J., Wang, C., Johnston, S. C., …Wang, Y. (2023). Dual Antiplatelet Treatment up to 72 Hours after Ischemic Stroke. New England Journal of Medicine, 389(26), 2413-2424. https://doi.org/10.1056/nejmoa2309137

BACKGROUND: Dual antiplatelet treatment has been shown to lower the risk of recurrent stroke as compared with aspirin alone when treatment is initiated early (≤24 hours) after an acute mild stroke. The effect of clopidogrel plus aspirin as compared w... Read More about Dual Antiplatelet Treatment up to 72 Hours after Ischemic Stroke.

"Far Away from Home": Adolescent inpatient admissions far from home, out- of-area or to adult wards: A national surveillance study.) in collaboration with the CAPSS Scientific Committee (2023)
Journal Article
Holland, J., Dubicka, B., Ford, T., & Wagner, A. (2023). "Far Away from Home": Adolescent inpatient admissions far from home, out- of-area or to adult wards: A national surveillance study.) in collaboration with the CAPSS Scientific Committee. BMJ Mental Health, 26(1), Article e300843. https://doi.org/10.1136/bmjment-2023-300843

Background: The increasing prevalence and acuity of mental disorders among children and adolescents have placed pressure on services, including inpatient care, and resulted in young people being admitted at-distance or to adult wards. Little empirica... Read More about "Far Away from Home": Adolescent inpatient admissions far from home, out- of-area or to adult wards: A national surveillance study.) in collaboration with the CAPSS Scientific Committee.

Denoising Diffusion MRI: Considerations and implications for analysis (2023)
Journal Article
Manzano-Patron, J.-P., Moeller, S., Andersson, J. L. R., Ugurbil, K., Yacoub, E., & Sotiropoulos, S. N. (2024). Denoising Diffusion MRI: Considerations and implications for analysis. Imaging Neuroscience, 2, 1-29. https://doi.org/10.1101/2023.07.24.550348

Development of diffusion MRI (dMRI) denoising approaches has experienced considerable growth over the last years. As noise can inherently reduce accuracy and precision in measurements, its effects have been well characterised both in terms of uncerta... Read More about Denoising Diffusion MRI: Considerations and implications for analysis.

Analysis of Endothelial Progenitor Cell Subtypes as Clinical Biomarkers for Elderly Patients with Ischaemic Stroke (2023)
Journal Article
ABDULKADIR, R., RAKKAR, K., OTHMAN, O., SPRIGG, N., BATH, P., & BAYRAKTUTAN, U. (2023). Analysis of Endothelial Progenitor Cell Subtypes as Clinical Biomarkers for Elderly Patients with Ischaemic Stroke. Scientific Reports, 13, Article 21843. https://doi.org/10.1038/s41598-023-48907-7

Endothelial progenitor cells (EPCs), expressing markers for stemness (CD34), immaturity (CD133) and endothelial maturity (KDR), may determine the extent of post-stroke vascular repair. Given the prevalence of stroke in elderly, this study explored wh... Read More about Analysis of Endothelial Progenitor Cell Subtypes as Clinical Biomarkers for Elderly Patients with Ischaemic Stroke.

Analysis of endothelial progenitor cell subtypes as clinical biomarkers for elderly patients with ischaemic stroke (2023)
Journal Article
Kadir, R. R. A., Rakkar, K., Othman, O. A., Sprigg, N., Bath, P. M., & Bayraktutan, U. (2023). Analysis of endothelial progenitor cell subtypes as clinical biomarkers for elderly patients with ischaemic stroke. Scientific Reports, 13(1), Article 21843. https://doi.org/10.1038/s41598-023-48907-7

Endothelial progenitor cells (EPCs), expressing markers for stemness (CD34), immaturity (CD133) and endothelial maturity (KDR), may determine the extent of post-stroke vascular repair. Given the prevalence of stroke in elderly, this study explored wh... Read More about Analysis of endothelial progenitor cell subtypes as clinical biomarkers for elderly patients with ischaemic stroke.

Pet ownership and grief - Exploring how pet ownership effects owners' mental wellbeing during times of grief, a qualitative pilot study (2023)
Journal Article
French, B., Anctil, Z., Brown, B., & Hall, S. (2023). Pet ownership and grief - Exploring how pet ownership effects owners' mental wellbeing during times of grief, a qualitative pilot study. Pet Behaviour Science, 15, 1-19

Animal-assisted interventions (AAIs) have exhibited encouraging outcomes in enhancing human mental health. However, research has investigated the potential benefits of untrained pets for human mental wellbeing, as training animals for AAI can be cost... Read More about Pet ownership and grief - Exploring how pet ownership effects owners' mental wellbeing during times of grief, a qualitative pilot study.

Prevention of infections and fever to improve outcome in older patients with acute stroke (PRECIOUS): a randomised, open, phase III, multifactorial, clinical trial with blinded outcome assessment (2023)
Journal Article
de Jonge, J. C., Sluis, W. M., Reinink, H., Bath, P. M., Woodhouse, L. J., Zweedijk, B., …van der Worp, H. B. (2024). Prevention of infections and fever to improve outcome in older patients with acute stroke (PRECIOUS): a randomised, open, phase III, multifactorial, clinical trial with blinded outcome assessment. Lancet Regional Health – Europe, 36, Article 100782. https://doi.org/10.1016/j.lanepe.2023.100782

Background

Infections and fever after stroke are associated with poor functional outcome or death. We assessed whether prophylactic treatment with anti-emetic, antibiotic, or antipyretic medication would improve functional outcome in older patient... Read More about Prevention of infections and fever to improve outcome in older patients with acute stroke (PRECIOUS): a randomised, open, phase III, multifactorial, clinical trial with blinded outcome assessment.

Developing a list of core competencies for medical aspects of healthcare delivery in care homes: scoping review and Delphi process (2023)
Journal Article
McCarthy, L., Borley, K., Ancelin, T., Carroll, R., Chadborn, N., Blundell, A. G., & Gordon, A. L. (2023). Developing a list of core competencies for medical aspects of healthcare delivery in care homes: scoping review and Delphi process. Age and Ageing, 52(12), Article afad237. https://doi.org/10.1093/ageing/afad237

BACKGROUND: Care home residents live with frailty and multiple long-term conditions. Their medical management is complex and specialised. We set out to develop a list of core competencies for doctors providing medical care in long-term care homes. ME... Read More about Developing a list of core competencies for medical aspects of healthcare delivery in care homes: scoping review and Delphi process.