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Polypharmacy, benzodiazepines, and antidepressants, but not antipsychotics, are associated with increased falls risk in UK care home residents: a prospective multi-centre study (2020)
Journal Article
Izza, M. A. D., Lunt, E., Gordon, A. L., Gladman, J. R. F., Armstrong, S., & Logan, P. A. (2020). Polypharmacy, benzodiazepines, and antidepressants, but not antipsychotics, are associated with increased falls risk in UK care home residents: a prospective multi-centre study. European Geriatric Medicine, 11, 1043-1050. https://doi.org/10.1007/s41999-020-00376-1

Purpose: Falls and polypharmacy are both common in care home residents. Deprescribing of medications in residents with increased falls risk is encouraged. Psychotropic medications are known to increase falls risk in older adults. These drugs are ofte... Read More about Polypharmacy, benzodiazepines, and antidepressants, but not antipsychotics, are associated with increased falls risk in UK care home residents: a prospective multi-centre study.

Prevalence of chronic kidney disease in adults in England: comparison of nationally representative cross-sectional surveys from 2003 to 2016 (2020)
Journal Article
Hounkpatin, H. O., Harris, S., Fraser, S. D., Day, J., Mindell, J. S., Taal, M. W., …Roderick, P. J. (2020). Prevalence of chronic kidney disease in adults in England: comparison of nationally representative cross-sectional surveys from 2003 to 2016. BMJ Open, 10(8), Article e038423. https://doi.org/10.1136/bmjopen-2020-038423

Objectives: To identify recent trends in chronic kidney disease (CKD) prevalence in England and explore their association with changes in sociodemographic, behavioural and clinical factors. Design: Pooled cross-sectional analysis. Setting: Health... Read More about Prevalence of chronic kidney disease in adults in England: comparison of nationally representative cross-sectional surveys from 2003 to 2016.

The clinical significance of oestrogen receptor expression in breast ductal carcinoma in situ (2020)
Journal Article
Miligy, I. M., Toss, M. S., Shiino, S., Oni, G., Syed, B. M., Khout, H., …Rakha, E. A. (2020). The clinical significance of oestrogen receptor expression in breast ductal carcinoma in situ. British Journal of Cancer, 123(10), 1513-1520. https://doi.org/10.1038/s41416-020-1023-3

Background: Oestrogen receptor (ER) in invasive breast cancer (BC) predicts response to endocrine therapy (ET) and provides prognostic value. In this study, we investigated the value of ER expression in ductal carcinoma in situ (DCIS) in terms of out... Read More about The clinical significance of oestrogen receptor expression in breast ductal carcinoma in situ.

Health-related quality of life, functional impairment and comorbidity in people with mild-to-moderate chronic kidney disease: a cross-sectional study (2020)
Journal Article
Fraser, S. D., Barker, J., Roderick, P. J., Yuen, H. M., Shardlow, A., Morris, J. E., …Taal, M. W. (2020). Health-related quality of life, functional impairment and comorbidity in people with mild-to-moderate chronic kidney disease: a cross-sectional study. BMJ Open, 10, Article e040286. https://doi.org/10.1136/bmjopen-2020-040286

Objectives: To determine the associations between comorbidities, health-related quality of life (HRQoL) and functional impairment in people with mild-to-moderate chronic kidney disease (CKD) in primary care. Design: Cross-sectional analysis at 5-y... Read More about Health-related quality of life, functional impairment and comorbidity in people with mild-to-moderate chronic kidney disease: a cross-sectional study.

Molecular Transducers of Human Skeletal Muscle Remodeling under Different Loading States (2020)
Journal Article
Stokes, T., Timmons, J. A., Crossland, H., Tripp, T. R., Murphy, K., McGlory, C., …Phillips, S. M. (2020). Molecular Transducers of Human Skeletal Muscle Remodeling under Different Loading States. Cell Reports, 32(5), Article 107980. https://doi.org/10.1016/j.celrep.2020.107980

Loading of skeletal muscle changes the tissue phenotype reflecting altered metabolic and functional demands. In humans, heterogeneous adaptation to loading complicates the identification of the underpinning molecular regulators. A within-person diffe... Read More about Molecular Transducers of Human Skeletal Muscle Remodeling under Different Loading States.

Glucagon-like peptide 1 infusions overcome anabolic resistance to feeding in older human muscle (2020)
Journal Article
Abdulla, H., Phillips, B. E., Wilkinson, D. J., Limb, M., Jandova, T., Bass, J. J., …Atherton, P. J. (2020). Glucagon-like peptide 1 infusions overcome anabolic resistance to feeding in older human muscle. Aging Cell, 19(9), Article e13202. https://doi.org/10.1111/acel.13202

© 2020 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd Background: Despite its known insulin-independent effects, glucagon-like peptide-1 (GLP-1) role in muscle protein turnover has not been explored under fed-stat... Read More about Glucagon-like peptide 1 infusions overcome anabolic resistance to feeding in older human muscle.

Effect of Sodium-Glucose Cotransporter-2 Inhibitors on Endothelial Function: A Systematic Review of Preclinical Studies (2020)
Journal Article
Alshnbari, A. S., Millar, S. A., O’Sullivan, S. E., & Idris, I. (2020). Effect of Sodium-Glucose Cotransporter-2 Inhibitors on Endothelial Function: A Systematic Review of Preclinical Studies. Diabetes Therapy, 11, 1947–1963. https://doi.org/10.1007/s13300-020-00885-z

Introduction While the beneficial effects of sodium-glucose cotransporter-2 (SGLT-2) inhibitors on cardiovascular and renal outcomes are recognized, their direct effects on endothelial function remain unclear. We, therefore, undertook a systematic... Read More about Effect of Sodium-Glucose Cotransporter-2 Inhibitors on Endothelial Function: A Systematic Review of Preclinical Studies.

Biology of oestrogen-receptor positive primary of core needle biopsy samples and correlation with clinical outcome (2020)
Journal Article
Parks, R. M., Albanghali, M., Syed, B. M., Green, A. R., Ellis, I. O., & Cheung, K. L. (2020). Biology of oestrogen-receptor positive primary of core needle biopsy samples and correlation with clinical outcome. Cancers, 12(8), Article 2067. https://doi.org/10.3390/cancers12082067

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. The majority of biological profiling studies use surgical excision (SE) samples, excluding patients receiving nonsurgical and neoadjuvant therapy. We propose using core needle biopsy (CNB) for... Read More about Biology of oestrogen-receptor positive primary of core needle biopsy samples and correlation with clinical outcome.

Education of family members to support weaning to solids and nutrition in later infancy in term-born infants (2020)
Journal Article
Ojha, S., Elfzzani, Z., Kwok, T. C., & Dorling, J. (2020). Education of family members to support weaning to solids and nutrition in later infancy in term-born infants. Cochrane Database of Systematic Reviews, 2020(7), Article CD012241. https://doi.org/10.1002/14651858.cd012241.pub2

Review question We reviewed the evidence for effects of nutrition education about appropriate feeding practices during weaning on growth and development in children born at term gestation. Background Around the world, over 150 million childr... Read More about Education of family members to support weaning to solids and nutrition in later infancy in term-born infants.

Absence of an ageing‐related increase in fibre type grouping in athletes and non‐athletes (2020)
Journal Article
Messa, G. A., Piasecki, M., Rittweger, J., McPhee, J. S., Koltai, E., Radak, Z., …Degens, H. (2020). Absence of an ageing‐related increase in fibre type grouping in athletes and non‐athletes. Scandinavian Journal of Medicine and Science in Sports, 30(11), 2057-2069. https://doi.org/10.1111/sms.13778

The ageing‐related loss of muscle mass is thought to be partly attributable to motor neuron loss and motor unit remodelling that result in fibre type grouping. We examined fibre type grouping in 19‐ to 85‐year‐old athletes and non‐athletes and evalua... Read More about Absence of an ageing‐related increase in fibre type grouping in athletes and non‐athletes.

Adapting care for older cancer patients during the COVID-19 pandemic: Recommendations from the International Society of Geriatric Oncology (SIOG) COVID-19 Working Group (2020)
Journal Article
Battisti, N. M. L., Mislang, A. R., Cooper, L., O'Donovan, A., Audisio, R. A., Cheung, K. L., …Wildiers, H. (2020). Adapting care for older cancer patients during the COVID-19 pandemic: Recommendations from the International Society of Geriatric Oncology (SIOG) COVID-19 Working Group. Journal of Geriatric Oncology, 11(8), 1190-1198. https://doi.org/10.1016/j.jgo.2020.07.008

© 2020 Elsevier Inc. The COVID-19 pandemic poses a barrier to equal and evidence-based management of cancer in older adults. The International Society of Geriatric Oncology (SIOG) formed a panel of experts to develop consensus recommendations on the... Read More about Adapting care for older cancer patients during the COVID-19 pandemic: Recommendations from the International Society of Geriatric Oncology (SIOG) COVID-19 Working Group.

The management of adult appendicitis during the COVID-19 pandemic: an interim analysis of a UK cohort study (2020)
Journal Article
Javanmard-Emamghissi, H., Boyd-Carson, H., Hollyman, M., Doleman, B., Adiamah, A., Lund, J. N., …The COVID: HAREM (Had Appendicitis, Resolved/Recurred Emergency Morbidity/Mortality) Collaborators Group. (2021). The management of adult appendicitis during the COVID-19 pandemic: an interim analysis of a UK cohort study. Techniques in Coloproctology, 25(4), 401–411. https://doi.org/10.1007/s10151-020-02297-4

Background Acute appendicitis (AA) is the most common general surgical emergency. Early laparoscopic appendicectomy is the gold-standard management. SARS-CoV-2 (COVID-19) brought concerns of increased perioperative mortality and spread of infection... Read More about The management of adult appendicitis during the COVID-19 pandemic: an interim analysis of a UK cohort study.

The association of skin autofluorescence with cardiovascular events and all-cause mortality in persons with chronic kidney disease stage 3: A prospective cohort study (2020)
Journal Article
Shardlow, A., McIntyre, N. J., Kolhe, N. V., Nellums, L. B., Fluck, R. J., McIntyre, C. W., & Taal, M. W. (2020). The association of skin autofluorescence with cardiovascular events and all-cause mortality in persons with chronic kidney disease stage 3: A prospective cohort study. PLoS Medicine, 17(7), e1003163. https://doi.org/10.1371/journal.pmed.1003163

A Systematic Review of Minor Phytocannabinoids with Promising Neuroprotective Potential (2020)
Journal Article
Stone, N. L., Murphy, A. J., England, T. J., & O’Sullivan, S. E. (2020). A Systematic Review of Minor Phytocannabinoids with Promising Neuroprotective Potential. British Journal of Pharmacology, https://doi.org/10.1111/bph.15185

Embase and Pubmed were systematically searched for articles addressing the neuroprotective properties of phytocannabinoids, aside from cannabidiol and Δ9‐tetrahydrocannabinol, including Δ9‐tetrahydrocannabinolic acid (Δ9‐THCA), Δ9‐tetrahydrocannabiva... Read More about A Systematic Review of Minor Phytocannabinoids with Promising Neuroprotective Potential.

Research with older people in a world with COVID-19: identification of current and future priorities, challenges and opportunities (2020)
Journal Article
Richardson, S. J., Carroll, C. B., Close, J., Gordon, A. L., O’Brien, J., Quinn, T. J., …Witham, M. D. (2020). Research with older people in a world with COVID-19: identification of current and future priorities, challenges and opportunities. Age and Ageing, 49(6), 901–906. https://doi.org/10.1093/ageing/afaa149

Older people are disproportionately affected by the COVID-19 pandemic, which has had a profound impact on research as well as clinical service delivery. This commentary identifies key challenges and opportunities in continuing to conduct research wit... Read More about Research with older people in a world with COVID-19: identification of current and future priorities, challenges and opportunities.

Targeted genotype analyses of GWAS-derived lean body mass and handgrip strength-associated single nucleotide polymorphisms in elite masters athletes (2020)
Journal Article
Crossland, H., Piasecki, J., McCormick, D., Phillips, B. E., Wilkinson, D. J., Smith, K., …Atherton, P. J. (2020). Targeted genotype analyses of GWAS-derived lean body mass and handgrip strength-associated single nucleotide polymorphisms in elite masters athletes. AJP - Regulatory, Integrative and Comparative Physiology, 319(2), R184-R194. https://doi.org/10.1152/ajpregu.00110.2020

Recent large genome-wide association studies (GWAS) have independently identified a set of genetic loci associated with lean body mass (LBM) and handgrip strength (HGS). Evaluation of these candidate single nucleotide polymorphisms (SNPs) may be usef... Read More about Targeted genotype analyses of GWAS-derived lean body mass and handgrip strength-associated single nucleotide polymorphisms in elite masters athletes.

COVID-19 highlights the need for universal adoption of standards of medical care for physicians in nursing homes in Europe (2020)
Journal Article
O’Neill, D., Briggs, R., Holmerová, I., Samuelsson, O., Gordon, A. L., Martin, F. C., & The Special Interest Group in Long Term Care of the European Geriatric Medicine Society. (2020). COVID-19 highlights the need for universal adoption of standards of medical care for physicians in nursing homes in Europe. European Geriatric Medicine, 11(4), 645–650. https://doi.org/10.1007/s41999-020-00347-6

The nursing home sector has seen a disproportionately high number of deaths as part of the COVID-19 pandemic. This reflects, in part, the frailty and vulnerability of older people living in care homes but has also, in part, been a consequence of the... Read More about COVID-19 highlights the need for universal adoption of standards of medical care for physicians in nursing homes in Europe.

Protocol for a realist review of General Practitioners’ Role in Advancing Practice in Care Homes (GRAPE study) (2020)
Journal Article
Gordon, A. L., Devi, R., Williams, C., Goodman, C., Sartain, K., & Chadborn, N. H. (2020). Protocol for a realist review of General Practitioners’ Role in Advancing Practice in Care Homes (GRAPE study). BMJ Open, 10(6), Article e036221. https://doi.org/10.1136/bmjopen-2019-036221

Introduction Older people who live in care homes have a high level of need with complex health conditions. In addition to providing medical care to residents, general practitioners (GPs) play a role as gatekeeper for access to services, as well as l... Read More about Protocol for a realist review of General Practitioners’ Role in Advancing Practice in Care Homes (GRAPE study).