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All Outputs (1130)

Patients’ and Clinicians’ Views of the Psychological Components of Tinnitus Treatment That Could Inform Audiologists’ Usual Care: A Delphi Survey (2017)
Journal Article
Thompson, D. M., Taylor, J. A., Hall, D. A., Walker, D.-M., McMurran, M., Casey, A., …Hoare, D. J. (2018). Patients’ and Clinicians’ Views of the Psychological Components of Tinnitus Treatment That Could Inform Audiologists’ Usual Care: A Delphi Survey. Ear and Hearing, 39(2), 367-377. https://doi.org/10.1097/aud.0000000000000492

Background
Tinnitus is a phantom auditory sensation typified by subjective reports of a ringing or buzzing noise, and is associated with reduced quality of life and functional health status. Psychological therapies delivered by psychologists have be... Read More about Patients’ and Clinicians’ Views of the Psychological Components of Tinnitus Treatment That Could Inform Audiologists’ Usual Care: A Delphi Survey.

How to choose between measures of tinnitus loudness for clinical research?: a report on the reliability and validity of an investigator-administered test and a patient-reported measure using baseline data collected in a phase IIa drug trial (2017)
Journal Article
Hall, D. A., Mehta, R., & Fackrell, K. L. (2017). How to choose between measures of tinnitus loudness for clinical research?: a report on the reliability and validity of an investigator-administered test and a patient-reported measure using baseline data collected in a phase IIa drug trial. American Journal of Audiology, 26, https://doi.org/10.1044/2017_AJA-16-0129

Purpose: Loudness is a major auditory dimension of tinnitus, and is used to diagnose severity, counsel patients or as a measure of clinical efficacy in audiological research. There is no standard test for tinnitus loudness, but matching and rating me... Read More about How to choose between measures of tinnitus loudness for clinical research?: a report on the reliability and validity of an investigator-administered test and a patient-reported measure using baseline data collected in a phase IIa drug trial.

Assessment of consent models as an ethical consideration in the conduct of prehospital ambulance randomised controlled clinical trials: a systematic review (2017)
Journal Article
Armstrong, S., Langlois, A., Laparidou, D., Dixon, M., Appleton, J. P., Bath, P. M., …Siriwardena, A. N. (2017). Assessment of consent models as an ethical consideration in the conduct of prehospital ambulance randomised controlled clinical trials: a systematic review. BMC Medical Research Methodology, 17(1), Article 142. https://doi.org/10.1186/s12874-017-0423-4

Background

We sought to understand the main ethical considerations when conducting clinical trials in the prehospital ambulance based setting.

Methods

A systematic review of the literature on randomised controlled trials in ambulance setting... Read More about Assessment of consent models as an ethical consideration in the conduct of prehospital ambulance randomised controlled clinical trials: a systematic review.

Preventing cognitive decline and dementia from cerebral small vessel disease: The LACI-1 Trial. Protocol and statistical analysis plan of a phase IIa dose escalation trial testing tolerability, safety and effect on intermediary endpoints of isosorbide mononitrate and cilostazol, separately and in combination (2017)
Journal Article
Blair, G. W., Appleton, J. P., Law, Z. K., Doubal, F., Flaherty, K., Dooley, R., …Wardlaw, J. M. (2018). Preventing cognitive decline and dementia from cerebral small vessel disease: The LACI-1 Trial. Protocol and statistical analysis plan of a phase IIa dose escalation trial testing tolerability, safety and effect on intermediary endpoints of isosorbide mononitrate and cilostazol, separately and in combination. International Journal of Stroke, 13(5), 530-538. https://doi.org/10.1177/1747493017731947

Rationale

The pathophysiology of most lacunar stroke, a form of small vessel disease, is thought to differ from large artery atherothrombo- or cardio-embolic stroke. Licensed drugs, isosorbide mononitrate and cilostazol, have promising mechanisms... Read More about Preventing cognitive decline and dementia from cerebral small vessel disease: The LACI-1 Trial. Protocol and statistical analysis plan of a phase IIa dose escalation trial testing tolerability, safety and effect on intermediary endpoints of isosorbide mononitrate and cilostazol, separately and in combination.

Investigating the effect of cardiac oscillations and deadspace gas mixing during apnea using computer simulation (2017)
Presentation / Conference Contribution
Laviola, M., Das, A., Bates, D. G., & Hardman, J. G. (2017). Investigating the effect of cardiac oscillations and deadspace gas mixing during apnea using computer simulation. In 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) (337-340). https://doi.org/10.1109/EMBC.2017.8036831

Gaseous mixing in the anatomical deadspace with stimulation of respiratory ventilation through cardiogenic oscillations is an important physiological mechanism at the onset of apnea, which has been credited with various beneficial effects, e.g. reduc... Read More about Investigating the effect of cardiac oscillations and deadspace gas mixing during apnea using computer simulation.

Expanding the Scope of Biomolecule Monitoring with Ratiometric Signaling from Rare-Earth Upconverting Phosphors (2017)
Journal Article
Oakland, C., Andrews, M. B., Burgess, L., Jones, A., Hay, S., Harvey, P., & Natrajan, L. S. (2017). Expanding the Scope of Biomolecule Monitoring with Ratiometric Signaling from Rare-Earth Upconverting Phosphors. European Journal of Inorganic Chemistry, 2017(44), 5176-5185. https://doi.org/10.1002/ejic.201700717

Upconversion (UC) is a powerful mulitphoton mechanism that converts low‐energy photons into higher energy emission. One of the most investigated UC systems is upconverting phosphors (UCPs). Here, a new, one‐pot synthetic procedure was used to prepare... Read More about Expanding the Scope of Biomolecule Monitoring with Ratiometric Signaling from Rare-Earth Upconverting Phosphors.

Prevalence of a history of prior varicella/herpes zoster infection in multiple sclerosis (2017)
Journal Article
Manouchehrinia, A., Tanasescu, R., Kareem, H., Jerca, O. P., Jabeen, F., Shafei, R., …Constantinescu, C. S. (in press). Prevalence of a history of prior varicella/herpes zoster infection in multiple sclerosis. Journal of NeuroVirology, https://doi.org/10.1007/s13365-017-0569-1

Varicella zoster virus (VZV) infection has been implicated in multiple sclerosis (MS), but direct causal involvement has been disputed. Nevertheless, knowledge of VZV exposure is important, given the risk of serious complications of first exposure wh... Read More about Prevalence of a history of prior varicella/herpes zoster infection in multiple sclerosis.

The effect of different combinations of vascular, dependency and cognitive endpoints on the sample size required to detect a treatment effect in trials of treatments to improve outcome after lacunar and non-lacunar ischaemic stroke (2017)
Journal Article
Makin, S. D., Doubal, F., Quinn, T. J., Bath, P. M., Dennis, M. S., & Wardlaw, J. M. (in press). The effect of different combinations of vascular, dependency and cognitive endpoints on the sample size required to detect a treatment effect in trials of treatments to improve outcome after lacunar and non-lacunar ischaemic stroke. European Stroke Journal, 3(1), https://doi.org/10.1177/2396987317728854

Background

Endpoints that are commonly used in trials of moderate/severe stroke may be less frequent in patients with minor, non-disabling stroke thus inflating sample sizes. We tested whether trial efficiency might be improved with composite endp... Read More about The effect of different combinations of vascular, dependency and cognitive endpoints on the sample size required to detect a treatment effect in trials of treatments to improve outcome after lacunar and non-lacunar ischaemic stroke.

A systematic study of the sensitivity of partial volume correction methods for the quantification of perfusion from pseudo-continuous arterial spin labeling MRI (2017)
Journal Article
Zhao, M. Y., Mezue, M., Segerdahl, A. R., Okell, T. W., Tracey, I., Xiao, Y., & Chappell, M. A. (2017). A systematic study of the sensitivity of partial volume correction methods for the quantification of perfusion from pseudo-continuous arterial spin labeling MRI. NeuroImage, 162, 384-397. https://doi.org/10.1016/j.neuroimage.2017.08.072

Arterial spin labeling (ASL) MRI is a non-invasive technique for the quantification of cerebral perfusion, and pseudo-continuous arterial spin labeling (PCASL) has been recommended as the standard implementation by a recent consensus of the community... Read More about A systematic study of the sensitivity of partial volume correction methods for the quantification of perfusion from pseudo-continuous arterial spin labeling MRI.

Development of a method for determining binaural sensitivity to temporal fine structure (2017)
Journal Article
Füllgrabe, C., Harland, A. J., Sęk, A. P., & Moore, B. C. (2017). Development of a method for determining binaural sensitivity to temporal fine structure. International Journal of Audiology, https://doi.org/10.1080/14992027.2017.1366078

Objective: To develop and evaluate a test of the ability to process binaural temporal-fine-structure (TFS) information. The test was intended to provide a graded measure of TFS sensitivity for all listeners. Design: Sensitivity to TFS was assessed at... Read More about Development of a method for determining binaural sensitivity to temporal fine structure.

Core Outcome Domains for early phase clinical trials of sound-, psychology-, and pharmacology-based interventions to manage chronic subjective tinnitus in adults: The COMIT'ID study protocol for using a Delphi process and face-to-face meetings to establish consensus (2017)
Journal Article
Fackrell, K., Smith, H., Colley, V., Thacker, B., Horobin, A. J., Haider, H., …Hall, D. A. (2017). Core Outcome Domains for early phase clinical trials of sound-, psychology-, and pharmacology-based interventions to manage chronic subjective tinnitus in adults: The COMIT'ID study protocol for using a Delphi process and face-to-face meetings to establish consensus. Trials, 18(1), https://doi.org/10.1186/s13063-017-2123-0

© 2017 The Author(s). Background: The reporting of outcomes in clinical trials of subjective tinnitus indicates that many different tinnitus-related complaints are of interest to investigators, from perceptual attributes of the sound (e.g. loudness)... Read More about Core Outcome Domains for early phase clinical trials of sound-, psychology-, and pharmacology-based interventions to manage chronic subjective tinnitus in adults: The COMIT'ID study protocol for using a Delphi process and face-to-face meetings to establish consensus.

An economic evaluation of the healthcare cost of tinnitus management in the UK (2017)
Journal Article
Stockdale, D., McFerran, D., Brazier, P., Pritchard, C., Kay, T., Dowrick, C., & Hoare, D. J. (2017). An economic evaluation of the healthcare cost of tinnitus management in the UK. BMC Health Services Research, 17(577), https://doi.org/10.1186/s12913-017-2527-2

Background: There is no standard treatment pathway for tinnitus patients in the UK. Possible therapies include education and reassurance, cognitive behavioural therapies, modified tinnitus retraining therapy (education and sound enrichment), or ampli... Read More about An economic evaluation of the healthcare cost of tinnitus management in the UK.

Differential Phase Arrangement of Cellular Clocks along the Tonotopic Axis of the Mouse Cochlea Ex Vivo (2017)
Journal Article
Park, J., Cederroth, C. R., Basinou, V., Sweetapple, L., Buijink, R., Lundkvist, G. B., …Canlon, B. (2017). Differential Phase Arrangement of Cellular Clocks along the Tonotopic Axis of the Mouse Cochlea Ex Vivo. Current Biology, 27(17), 2623-2629. https://doi.org/10.1016/j.cub.2017.07.019

Topological distributions of individual cellular clocks have not been demonstrated in peripheral organs. The cochlea displays circadian patterns of core clock gene expression [1, 2]. PER2 protein is expressed in the hair cells and spiral ganglion neu... Read More about Differential Phase Arrangement of Cellular Clocks along the Tonotopic Axis of the Mouse Cochlea Ex Vivo.

Adaptive benefit of cross-modal plasticity following cochlear implantation in deaf adults (2017)
Journal Article
Anderson, C. A., Wiggins, I. M., Kitterick, P. T., & Hartley, D. E. H. (2017). Adaptive benefit of cross-modal plasticity following cochlear implantation in deaf adults. Proceedings of the National Academy of Sciences, 114(38), 10256-10261. https://doi.org/10.1073/pnas.1704785114

© 2017, National Academy of Sciences. All rights reserved. It has been suggested that visual language is maladaptive for hearing restoration with a cochlear implant (CI) due to cross-modal recruitment of auditory brain regions. Rehabilitative guideli... Read More about Adaptive benefit of cross-modal plasticity following cochlear implantation in deaf adults.

Automatic speech recognition predicts speech intelligibility and comprehension for listeners with simulated age-related hearing loss (2017)
Journal Article
Fontan, L., Ferrané, I., Farinas, J., Pinquier, J., Tardieu, J., Magnen, C., …Füllgrabe, C. (in press). Automatic speech recognition predicts speech intelligibility and comprehension for listeners with simulated age-related hearing loss. Journal of Speech, Language, and Hearing Research, https://doi.org/10.1044/2017_JSLHR-S-16-0269

Purpose: To assess speech processing for listeners with simulated age-related hearing loss (ARHL) and to investigate whether the observed performance can be replicated using an Automatic Speech Recognition (ASR) system. The long-term goal of this re... Read More about Automatic speech recognition predicts speech intelligibility and comprehension for listeners with simulated age-related hearing loss.

Situationally influenced tinnitus coping strategies: a mixed methods approach (2017)
Journal Article
Beukes, E. W., Manchaiah, V., Andersson, G., Allen, P. M., Terlizzi, P. M., & Baguley, D. M. (in press). Situationally influenced tinnitus coping strategies: a mixed methods approach. Disability and Rehabilitation, https://doi.org/10.1080/09638288.2017.1362708

Purpose: The primary aim of this study was to identify coping strategies used to manage problematic tinnitus situations. A secondary aim was to determine whether different approaches were related to the level of tinnitus distress, anxiety, depression... Read More about Situationally influenced tinnitus coping strategies: a mixed methods approach.

Validating and comparing stroke prognosis scales (2017)
Journal Article
Quinn, T. J., Singh, S., Lees, K. R., Bath, P. M., & Myint, P. K. (2017). Validating and comparing stroke prognosis scales. Neurology, 89(10), https://doi.org/10.1212/WNL.0000000000004332

Objective: To compare the prognostic accuracy of various acute stroke prognostic scales using a large, independent, clinical trials dataset.

Methods: We directly compared 8 stroke prognostic scales, chosen based on focused literature review (Acute... Read More about Validating and comparing stroke prognosis scales.

Homozygous resistance to thyroid hormone β: can combined antithyroid drug and triiodothyroacetic acid treatment prevent cardiac failure? (2017)
Journal Article
Moran, C., Habeb, A. M., Kahaly, G. J., Kampmann, C., Hughes, M., Marek, J., …Chatterjee, K. (2017). Homozygous resistance to thyroid hormone β: can combined antithyroid drug and triiodothyroacetic acid treatment prevent cardiac failure?. Journal of the Endocrine Society, 1(9), 1203-1212. https://doi.org/10.1210/js.2017-00204

Resistance to thyroid hormone β (RTHβ) due to homozygous THRB defects is exceptionally rare, with only five kindreds reported worldwide. Cardiac dysfunction, which can be life-threatening, is recognized in the disorder. Here we describe the clinical,... Read More about Homozygous resistance to thyroid hormone β: can combined antithyroid drug and triiodothyroacetic acid treatment prevent cardiac failure?.

Relationship between haemodynamic impairment and collateral blood flow in carotid artery disease (2017)
Journal Article
Hartkamp, N. S., Petersen, E. T., Chappell, M. A., Okell, T. W., Uyttenboogaart, M., Zeebregts, C. J., & Bokkers, R. P. (2018). Relationship between haemodynamic impairment and collateral blood flow in carotid artery disease. Journal of Cerebral Blood Flow and Metabolism, 38(11), 2021-2032. https://doi.org/10.1177/0271678x17724027

Collateral blood flow plays a pivotal role in steno-occlusive internal carotid artery (ICA) disease to prevent irreversible ischaemic damage. Our aim was to investigate the effect of carotid artery disease upon cerebral perfusion and cerebrovascular... Read More about Relationship between haemodynamic impairment and collateral blood flow in carotid artery disease.