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All Outputs (1131)

Real-time estimation of horizontal gaze angle by saccade integration using in-ear electrooculography (2018)
Journal Article
Hládek, Ľ., Porr, B., & Brimijoin, W. O. (2018). Real-time estimation of horizontal gaze angle by saccade integration using in-ear electrooculography. PLoS ONE, 13(1), Article e0190420. https://doi.org/10.1371/journal.pone.0190420

The manuscript proposes and evaluates a real-time algorithm for estimating eye gaze angle based solely on single-channel electrooculography (EOG), which can be obtained directly from the ear canal using conductive ear moulds. In contrast to conventio... Read More about Real-time estimation of horizontal gaze angle by saccade integration using in-ear electrooculography.

An observational feasibility study of a new anaesthesia drug storage tray (2018)
Journal Article
Almghairbi, D. S., Sharp, L., Griffiths, R., Evley, R., Gupta, S., & Moppett, I. K. (2018). An observational feasibility study of a new anaesthesia drug storage tray. Anaesthesia, 73(3), 356-364. https://doi.org/10.1111/anae.14187

Drug errors in the anaesthetic domain remains a serious cause of iatrogenic harm. To help reduce this issue, we aimed to explore the potential impact of a simple colour-coded tray to drug preparation and storage on safe drug administration during ana... Read More about An observational feasibility study of a new anaesthesia drug storage tray.

Data-Driven Approach for Auditory Profiling and Characterization of Individual Hearing Loss (2018)
Journal Article
Sanchez Lopez, R., Bianchi, F., Fereczkowski, M., Santurette, S., & Dau, T. (2018). Data-Driven Approach for Auditory Profiling and Characterization of Individual Hearing Loss. Trends in Hearing, 22, https://doi.org/10.1177/2331216518807400

Pure-tone audiometry still represents the main measure to characterize individual hearing loss and the basis for hearing-aid fitting. However, the perceptual consequences of hearing loss are typically associated not only with a loss of sensitivity bu... Read More about Data-Driven Approach for Auditory Profiling and Characterization of Individual Hearing Loss.

Diagnostic Criteria for Somatosensory Tinnitus: A Delphi Process and Face-to-Face Meeting to Establish Consensus (2018)
Journal Article
Michiels, S., Sanchez, T. G., Oron, Y., Gilles, A., Haider, H. F., Erlandsson, S., …Hall, D. A. (2018). Diagnostic Criteria for Somatosensory Tinnitus: A Delphi Process and Face-to-Face Meeting to Establish Consensus. Trends in Hearing, 22, 1-10. https://doi.org/10.1177/2331216518796403

Since somatic or somatosensory tinnitus (ST) was first described as a subtype of subjective tinnitus, where altered somatosensory afference from the cervical spine or temporomandibular area causes or changes a patient’s tinnitus perception, several s... Read More about Diagnostic Criteria for Somatosensory Tinnitus: A Delphi Process and Face-to-Face Meeting to Establish Consensus.

Incremental comprehension of pitch relationships in written music: Evidence from eye movements (2018)
Journal Article
Hadley, L. V., Sturt, P., Eerola, T., & Pickering, M. J. (2018). Incremental comprehension of pitch relationships in written music: Evidence from eye movements. Quarterly Journal of Experimental Psychology, 71(1), 211-219. https://doi.org/10.1080/17470218.2017.1307861

To investigate how proficient pianists comprehend pitch relationships in written music when they first encounter it, we conducted two experiments in which proficient pianists’ eyes were tracked while they read and played single-line melodies. In Expe... Read More about Incremental comprehension of pitch relationships in written music: Evidence from eye movements.

Statistical analysis plan for the ‘Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage’ (TICH-2) trial (2017)
Journal Article
Flaherty, K., Bath, P. M., Dineen, R., Law, Z., Scutt, P., Pocock, S., & Sprigg, N. (in press). Statistical analysis plan for the ‘Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage’ (TICH-2) trial. Trials, 18(1), Article 607. https://doi.org/10.1186/s13063-017-2341-5

Rationale

Aside from blood pressure lowering, treatment options for intracerebral haemorrhage remain limited and a proportion of patients will undergo early haematoma expansion with resultant significant morbidity and mortality. Tranexamic acid (T... Read More about Statistical analysis plan for the ‘Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage’ (TICH-2) trial.

Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial (2017)
Journal Article
Bath, P. M., Christensen, L. M., Woodhouse, L. J., Bentsen, L., Appleton, J. P., Krarup Hansen, C., Beridze, M., Thomsen, T. T., Christensen, H., Kruuse, C., Dineen, R. A., Jensen, H. H., Duley, L., Hansen, S. S., England, T. J., Petrovic, V., Flaherty, K., Beridze, N., Havard, D., Kakabadze, N., …Farren, P. (2018). Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial. Lancet, 391(10123), 850-859. https://doi.org/10.1016/S0140-6736%2817%2932849-0

Background: Intensive antiplatelet therapy with three agents might be more effective than guideline treatment for preventing recurrent events in patients with acute cerebral ischaemia. We aimed to compare the safety and efficacy of intensive antiplat... Read More about Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial.

Predictors of entering a hearing aid evaluation period: a prospective study in older hearing-help seekers (2017)
Journal Article
Pronk, M., Deeg, D. J., Versfeld, N. J., Heymans, M., Naylor, G., & Kramer, S. E. (in press). Predictors of entering a hearing aid evaluation period: a prospective study in older hearing-help seekers. Trends in Hearing, 21, https://doi.org/10.1177/2331216517744915

This study aimed to determine the predictors of entering a hearing aid evaluation period (HAEP) using a prospective design drawing on the health belief model and the transtheoretical model. In total, 377 older persons who presented with hearing probl... Read More about Predictors of entering a hearing aid evaluation period: a prospective study in older hearing-help seekers.

Quality of questionnaires for the assessment of otitis media with effusion in children (2017)
Journal Article
Wei Chern Gan, R., Daniel, M., Ridley, M., & Barry, J. G. (in press). Quality of questionnaires for the assessment of otitis media with effusion in children. Clinical Otolaryngology, 43(2), https://doi.org/10.1111/coa.13026

Objectives
Audiometric tests provide information about hearing in otitis media with effusion (OME). Questionnaires can supplement this information by supporting clinical history‐taking as well as potentially providing a standardized and comprehensiv... Read More about Quality of questionnaires for the assessment of otitis media with effusion in children.

A DCE-MRI Driven 3-D Reaction-Diffusion Model of Solid Tumor Growth (2017)
Journal Article
Roque, T., Risser, L., Kersemans, V., Smart, S., Allen, D., Kinchesh, P., …Chappell, M. A. (2018). A DCE-MRI Driven 3-D Reaction-Diffusion Model of Solid Tumor Growth. IEEE Transactions on Medical Imaging, 37(3), 724-732. https://doi.org/10.1109/tmi.2017.2779811

Predicting tumor growth and its response to therapy remains a major challenge in cancer research and strongly relies on tumor growth models. In this paper, we introduce, calibrate, and verify a novel image-driven reaction-diffusion model of avascular... Read More about A DCE-MRI Driven 3-D Reaction-Diffusion Model of Solid Tumor Growth.

TICH-2 Trial – Tranexamic Acid for Intracerebral Haemorrhage 2 (2017)
Presentation / Conference Contribution
Sprigg, N., Bath, P. M., Appleton, J., Law, Z., Flaherty, K., Scutt, P., …Ali, A. (2017). TICH-2 Trial – Tranexamic Acid for Intracerebral Haemorrhage 2.

Rationale: To assess in a pragmatic phase III prospective double blind randomised placebo-controlled trial whether tranexamic acid is safe and reduces death or dependency after spontaneous intracerebral haemorrhage (SICH). The results will determine... Read More about TICH-2 Trial – Tranexamic Acid for Intracerebral Haemorrhage 2.

Statistical analysis plan for the EuroHYP-1 trial: European multicentre, randomised, phase III clinical trial of the therapeutic hypothermia plus best medical treatment versus best medical treatment alone for acute ischaemic stroke (2017)
Journal Article
Winkel, P., Bath, P. M., Gluud, C., Lindschou, J., van der Worp, H. B., Macleod, M. R., …Schwab, S. (in press). Statistical analysis plan for the EuroHYP-1 trial: European multicentre, randomised, phase III clinical trial of the therapeutic hypothermia plus best medical treatment versus best medical treatment alone for acute ischaemic stroke. Trials, 18(1), https://doi.org/10.1186/s13063-017-2302-z

Background: Cooling may reduce infarct size and improve neurological outcomes in patients with ischaemic stroke. In phase II trials, cooling awake patients with ischaemic stroke has been shown to be feasible and safe, but the effects in functional ou... Read More about Statistical analysis plan for the EuroHYP-1 trial: European multicentre, randomised, phase III clinical trial of the therapeutic hypothermia plus best medical treatment versus best medical treatment alone for acute ischaemic stroke.

Gap-induced reductions of evoked potentials in the auditory cortex: a possible objective marker for the presence of tinnitus in animals (2017)
Journal Article
Berger, J. I., Owen, W., Wilson, C. A., Hockley, A., Coomber, B., Palmer, A. R., & Wallace, M. N. (2018). Gap-induced reductions of evoked potentials in the auditory cortex: a possible objective marker for the presence of tinnitus in animals. Brain Research, 1679, https://doi.org/10.1016/j.brainres.2017.11.026

Animal models of tinnitus are essential for determining the underlying mechanisms and testing pharmacotherapies. However, there is doubt over the validity of current behavioural methods for detecting tinnitus. Here, we applied a stimulus paradigm wid... Read More about Gap-induced reductions of evoked potentials in the auditory cortex: a possible objective marker for the presence of tinnitus in animals.

The minimum monitoring signal-to-noise ratio for off-axis signals and its implications for directional hearing aids (2017)
Journal Article
Archer-Boyd, A. W., Holman, J. A., & Brimijoin, W. O. (2018). The minimum monitoring signal-to-noise ratio for off-axis signals and its implications for directional hearing aids. Hearing Research, 357, 64-72. https://doi.org/10.1016/j.heares.2017.11.011

The signal-to-noise ratio (SNR) benefit of hearing aid directional microphones is dependent on the angle of the listener relative to the target, something that can change drastically and dynamically in a typical group conversation. When a new target... Read More about The minimum monitoring signal-to-noise ratio for off-axis signals and its implications for directional hearing aids.

Relationship between race and outcome in Asian, Black and Caucasian patients with spontaneous intracerebral haemorrhage: data from the Virtual International Stroke Trials Archive (VISTA) and Efficacy of Nitric Oxide in Stroke trial (ENOS) (2017)
Journal Article
Krishnan, K., Beishon, L., Berge, E., Christensen, H., Dineen, R. A., Ozturk, S., Sprigg, N., Wardlow, J. M., & Bath, P. M. (2018). Relationship between race and outcome in Asian, Black and Caucasian patients with spontaneous intracerebral haemorrhage: data from the Virtual International Stroke Trials Archive (VISTA) and Efficacy of Nitric Oxide in Stroke trial (ENOS). International Journal of Stroke, 13(4), https://doi.org/10.1177/1747493017744463

Background and purpose: Although poor prognosis after intracerebral haemorrhage relates to risk factors and haematoma characteristics, there is limited evidence for the effect of race-ethnicity.
Methods: Data from 1011 patients with intracerebral ha... Read More about Relationship between race and outcome in Asian, Black and Caucasian patients with spontaneous intracerebral haemorrhage: data from the Virtual International Stroke Trials Archive (VISTA) and Efficacy of Nitric Oxide in Stroke trial (ENOS).

Combined amplification and sound generation for tinnitus: a scoping review (2017)
Journal Article
Tutaj, L., Hoare, D. J., & Sereda, M. (2018). Combined amplification and sound generation for tinnitus: a scoping review. Ear and Hearing, 39(3), 412-422. https://doi.org/10.1097/AUD.0000000000000516

Objectives: In most cases, tinnitus is accompanied by some degree of hearing loss. Current tinnitus management guidelines recognize the importance of addressing hearing difficulties, with hearing aids being a common option. Sound therapy is the prefe... Read More about Combined amplification and sound generation for tinnitus: a scoping review.

Problems and life effects experienced by tinnitus research study volunteers: an exploratory study using the ICF classification (2017)
Journal Article
Manchaiah, V., Beukes, E. W., Granberg, S., Durisala, N., Baguley, D. M., Allen, P. M., & Andersson, G. (2017). Problems and life effects experienced by tinnitus research study volunteers: an exploratory study using the ICF classification. Journal of the American Academy of Audiology, https://doi.org/10.3766/jaaa.17094

Background: Tinnitus is one of the most distressing hearing-related symptoms. It is often associated with a range of physiological and psychological complications, such as depression, anxiety, and insomnia. Hence, approaching tinnitus from a biopsych... Read More about Problems and life effects experienced by tinnitus research study volunteers: an exploratory study using the ICF classification.