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Hearing instruments for unilateral severe-to-profound sensorineural hearing loss in adults (2016)
Journal Article
Kitterick, P. T., Smith, S. N., & Lucas, L. (2016). Hearing instruments for unilateral severe-to-profound sensorineural hearing loss in adults. Ear and Hearing, 37(5), https://doi.org/10.1097/AUD.0000000000000313

Objectives: A systematic review of the literature and meta-analysis was conducted to assess the nature and quality of the evidence for the use of hearing instruments in adults with a unilateral severe-to-profound sensorineural hearing loss.
Design:... Read More about Hearing instruments for unilateral severe-to-profound sensorineural hearing loss in adults.

The Human Connectome Project's neuroimaging approach (2016)
Journal Article
Glasser, M. F., Smith, S. M., Marcus, D. S., Andersson, J. L., Auerbach, E. J., Behrens, T. E., …Van Essen, D. C. (2016). The Human Connectome Project's neuroimaging approach. Nature Neuroscience, 19(9), https://doi.org/10.1038/nn.4361

Noninvasive human neuroimaging has yielded many discoveries about the brain. Numerous methodological advances have also occurred, though inertia has slowed their adoption. This paper presents an integrated approach to data acquisition, analysis and s... Read More about The Human Connectome Project's neuroimaging approach.

Expression and regulation of immune-modulatory enzyme Indoleamine 2,3-dioxygenase (IDO) by human airway epithelial cells and its effect on T cell activation (2016)
Journal Article
Aldajani, W. A., Salazar, F., Sewell, H. F., Knox, A., & Ghaemmaghami, A. M. (2016). Expression and regulation of immune-modulatory enzyme Indoleamine 2,3-dioxygenase (IDO) by human airway epithelial cells and its effect on T cell activation. Oncotarget, 7(36), https://doi.org/10.18632/oncotarget.11586

Indoleamine 2,3-dioxygenase (IDO) catalyzes the degradation of tryptophan, which plays a critical role in immune suppression through regulating the production of a series of metabolites that are generally referred to as kynurenines. It has become inc... Read More about Expression and regulation of immune-modulatory enzyme Indoleamine 2,3-dioxygenase (IDO) by human airway epithelial cells and its effect on T cell activation.

Effect of contralateral medial olivocochlear feedback on perceptual estimates of cochlear gain and compression (2016)
Journal Article
Fletcher, M. D., Krumbholz, K., & de Boer, J. (2016). Effect of contralateral medial olivocochlear feedback on perceptual estimates of cochlear gain and compression. Journal of the Association for Research in Otolaryngology, 17(6), 559-575. https://doi.org/10.1007/s10162-016-0574-8

The active cochlear mechanism amplifies responses to low-intensity sounds, compresses the range of input sound intensities to a smaller output range, and increases cochlear frequency selectivity. The gain of the active mechanism can be modulated by t... Read More about Effect of contralateral medial olivocochlear feedback on perceptual estimates of cochlear gain and compression.

What is the evidence-base for atopic eczema treatments? A summary of published randomised controlled trials (2016)
Journal Article
Nankervis, H., Thomas, K., Delamere, F. M., Barbarot, S., Smith, S., Rogers, N. K., & Williams, H. C. (in press). What is the evidence-base for atopic eczema treatments? A summary of published randomised controlled trials. British Journal of Dermatology, 176(4), https://doi.org/10.1111/bjd.14999

Atopic eczema (AE) is a common chronic inflammatory skin condition. Whilst many AE treatment options are available, the evidence to support their efficacy varies in depth and quality. In 2000, an NIHR HTA systematic review identified and evaluated ex... Read More about What is the evidence-base for atopic eczema treatments? A summary of published randomised controlled trials.

Running and knee osteoarthritis: a systematic review and meta-analysis (2016)
Journal Article
Timmins, K. A., Batt, M. E., & Edwards, K. L. (2017). Running and knee osteoarthritis: a systematic review and meta-analysis. American Journal of Sports Medicine, 45(6), https://doi.org/10.1177/0363546516657531

Background:
Osteoarthritis (OA) is a chronic condition characterized by pain, impaired function, and reduced quality of life. A number of risk factors for knee OA have been identified, such as obesity, occupation, and injury. The association between... Read More about Running and knee osteoarthritis: a systematic review and meta-analysis.

Gene pathway development in human epicardial adipose tissue during early life (2016)
Journal Article
Ojha, S., Fainberg, H. P., Wilson, V., Pelella, G., Castellanos, M., May, S., …Budge, H. (in press). Gene pathway development in human epicardial adipose tissue during early life. JCI insight, 1(13), Article e87460. https://doi.org/10.1172/jci.insight.87460

Studies in rodents and newborn humans demonstrate the influence of brown adipose tissue (BAT) in temperature control and energy balance and a critical role in the regulation of body weight. Here, we obtained samples of epicardial adipose tissue (EAT)... Read More about Gene pathway development in human epicardial adipose tissue during early life.

Detection of modified forms of cytosine using sensitive immunohistochemistry (2016)
Journal Article
Abakir, A., Wheldon, L. M., Johnson, A. D., Laurent, P., & Ruzov, A. (in press). Detection of modified forms of cytosine using sensitive immunohistochemistry. Journal of Visualized Experiments, 114(e54416), https://doi.org/10.3791/54416

Methylation of cytosine bases (5-methylcytosine, 5mC) occurring in vertebrate genomes is usually associated with transcriptional silencing. 5-hydroxylmethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) are the recently discov... Read More about Detection of modified forms of cytosine using sensitive immunohistochemistry.

Occupational Therapy in HomEcare Re-ablement Services (OTHERS): results of a feasibility randomised controlled trial (2016)
Journal Article
Whitehead, P. J., Walker, M. F., Parry, R. H., Latif, Z., McGeorge, I. D., & Drummond, A. E. (2016). Occupational Therapy in HomEcare Re-ablement Services (OTHERS): results of a feasibility randomised controlled trial. BMJ Open, 6(8), Article e011868. https://doi.org/10.1136/bmjopen-2016-011868

Objectives: The objective of this study was to test the feasibility of conducting a randomised controlled trial (RCT) of an intervention targeted at activities of daily living (ADL), delivered by an occupational therapist, in homecare reablement.... Read More about Occupational Therapy in HomEcare Re-ablement Services (OTHERS): results of a feasibility randomised controlled trial.

Peer support and reminiscence therapy for people with dementia and their family carers: a factorial pragmatic randomised trial (2016)
Journal Article
Charlesworth, G., Burnell, K., Crellin, N., Hoare, Z., Hoe, J., Knapp, M., …Orrell, M. (in press). Peer support and reminiscence therapy for people with dementia and their family carers: a factorial pragmatic randomised trial. Journal of Neurology, Neurosurgery and Psychiatry, 87, https://doi.org/10.1136/jnnp-2016-313736

Objective: The objective of this study was to evaluate peer support and reminiscence therapy, separately and together, in comparison with usual care for people with dementia and their family carers.
Design: Factorial pragmatic randomised trial, anal... Read More about Peer support and reminiscence therapy for people with dementia and their family carers: a factorial pragmatic randomised trial.

Athletic population with spondylolysis: review of outcomes following surgical repair or conservative management (2016)
Journal Article
Panteliadis, P., Nagra, N. S., Edwards, K. L., Behrbalk, E., & Boszczyk, B. (2016). Athletic population with spondylolysis: review of outcomes following surgical repair or conservative management. Global Spine Journal, 6(6), https://doi.org/10.1055/s-0036-1586743

Objective

The study aims to critically review the outcomes associated with the surgical repair or conservative management of spondylolysis in athletes.

Methods

The English literature listed in MEDLINE/PubMed was reviewed to identify related... Read More about Athletic population with spondylolysis: review of outcomes following surgical repair or conservative management.

Robust anti-nociceptive effects of MAG lipase inhibition in a model of osteoarthritis pain (2016)
Journal Article
Burston, J. J., Mapp, P. I., Sarmad, S., Barrett, D. A., Niphakis, M. J., Cravatt, B. F., Walsh, D. A., & Chapman, V. (2016). Robust anti-nociceptive effects of MAG lipase inhibition in a model of osteoarthritis pain. British Journal of Pharmacology, 173(21), 3134-3144. https://doi.org/10.1111/bph.13574

BACKGROUND AND PURPOSE: Chronic pain is often a symptom of knee osteoarthritis (OA) for which current analgesics are either inadequate, or are associated with serious side effects. The endocannabinoid system may offer alternative targets for pain-rel... Read More about Robust anti-nociceptive effects of MAG lipase inhibition in a model of osteoarthritis pain.

Clinical outcomes and response of patients applying topical therapy for pyoderma gangrenosum: A prospective cohort study (2016)
Journal Article
Thomas, K. S., Ormerod, A. D., Craig, F. E., Greenlaw, N., Norrie, J., Mitchell, E., …Williams, H. C. (2016). Clinical outcomes and response of patients applying topical therapy for pyoderma gangrenosum: A prospective cohort study. Journal of The American Academy of Dermatology, 75(5), 940-949. https://doi.org/10.1016/j.jaad.2016.06.016

Background: pyoderma gangrenosum (PG) is an uncommon dermatosis with a limited evidence base for treatment.

Objective: to estimate the effectiveness of topical therapies in the treatment of PG.

Methods: prospective cohort study of UK secondary... Read More about Clinical outcomes and response of patients applying topical therapy for pyoderma gangrenosum: A prospective cohort study.

In vitro models of medulloblastoma: choosing the right tool for the job (2016)
Journal Article
Ivanov, D. P., Coyle, B., Walker, D. A., & Grabowska, A. M. (2016). In vitro models of medulloblastoma: choosing the right tool for the job. Journal of Biotechnology, 236, 10-25. https://doi.org/10.1016/j.jbiotec.2016.07.028

The recently-defined four molecular subgroups of medulloblastoma have required updating of our understanding of in vitro models to include molecular classification and risk stratification features from clinical practice. This review seeks to build a... Read More about In vitro models of medulloblastoma: choosing the right tool for the job.

A taxonomy of fatigue concepts and their relation to hearing loss (2016)
Journal Article
Hornsby, B. W., Naylor, G., & Bess, F. H. (2016). A taxonomy of fatigue concepts and their relation to hearing loss. Ear and Hearing, 37(Supp 1), Article 136S-144S. https://doi.org/10.1097/AUD.0000000000000289

Fatigue is common in individuals with a variety of chronic health conditions and can have significant negative effects on quality of life. Although limited in scope, recent work suggests persons with hearing loss may be at increased risk for fatigue,... Read More about A taxonomy of fatigue concepts and their relation to hearing loss.

Clinical and biological significance of RAD51 expression in breast cancer: a key DNA damage response protein (2016)
Journal Article
Alshareeda, A., Negm, O. H., Aleskandarany, M. A., Green, A. R., Nolan, C., Tighe, P. J., Madhusudan, S., Ellis, I. O., & Rakha, E. (2016). Clinical and biological significance of RAD51 expression in breast cancer: a key DNA damage response protein. Breast Cancer Research and Treatment, 159(1), 41-53. https://doi.org/10.1007/s10549-016-3915-8

Impaired DNA damage response (DDR) may play a fundamental role in the pathogenesis of breast cancer (BC). RAD51 is a key player in DNA double-strand break repair. In this study, we aimed to assess the biological and clinical significance of RAD51 exp... Read More about Clinical and biological significance of RAD51 expression in breast cancer: a key DNA damage response protein.

Non-invasive assessment of portal hypertension using quantitative magnetic resonance imaging (2016)
Journal Article
Palaniyappan, N., Cox, E., Bradley, C., Scott, R., Austin, A., O’Neill, R., Ramjas, G., Travis, S., White, H., Singh, R., Thurley, P., Guha, I. N., Francis, S., & Aithal, G. P. (2016). Non-invasive assessment of portal hypertension using quantitative magnetic resonance imaging. Journal of Hepatology, 65(6), 1131-1139. https://doi.org/10.1016/j.jhep.2016.07.021

Background & Aims

Hepatic venous pressure gradient (HVPG) measurement is currently the only validated technique to accurately evaluate changes in portal pressure. In this study, we evaluate the use of non-contrast quantitative magnetic resonance i... Read More about Non-invasive assessment of portal hypertension using quantitative magnetic resonance imaging.

Plasticity in bilateral superior temporal cortex: Effects of deafness and cochlear implantation on auditory and visual speech processing (2016)
Journal Article
Anderson, C. A., Lazard, D. S., & Hartley, D. E. (2017). Plasticity in bilateral superior temporal cortex: Effects of deafness and cochlear implantation on auditory and visual speech processing. Hearing Research, 343, 138-149. https://doi.org/10.1016/j.heares.2016.07.013

While many individuals can benefit substantially from cochlear implantation, the ability to perceive and understand auditory speech with a cochlear implant (CI) remains highly variable amongst adult recipients. Importantly, auditory performance with... Read More about Plasticity in bilateral superior temporal cortex: Effects of deafness and cochlear implantation on auditory and visual speech processing.