All Outputs (1423)

Modelling the influence of climate and vector control interventions on arbovirus transmission (2024)
Journal Article
Fairbanks, E. L., Daly, J. M., & Tildesley, M. J. (in press). Modelling the influence of climate and vector control interventions on arbovirus transmission. Viruses,

Most mathematical models that assess the vectorial capacity of disease-transmitting insects typically focus on the influence of climatic factors to predict variations across different times and locations, or examine the impact of vector control inter... Read More about Modelling the influence of climate and vector control interventions on arbovirus transmission.

Development of resident and migratory three-spined stickleback, Gasterosteus aculeatus (2024)
Journal Article
Barnes, M., Chakrabarti, L., & MacColl, A. D. C. (2024). Development of resident and migratory three-spined stickleback, Gasterosteus aculeatus. PLoS ONE, 19(7), Article e0295485. https://doi.org/10.1371/journal.pone.0295485

The three-spined stickleback (Gasterosteus aculeatus) is a teleost fish and a model organism in evolutionary ecology, useful for both laboratory and natural experiments. It is especially valued for the substantial intraspecific variation in morpholog... Read More about Development of resident and migratory three-spined stickleback, Gasterosteus aculeatus.

Functional Characterization of Six Eukaryotic Translation Initiation Factors of Toxoplasma gondii Using the CRISPR-Cas9 System (2024)
Journal Article
Kou, Y.-J., Gao, J., Li, R., Ma, Z.-Y., Elsheikha, H. M., Wu, X.-J., Zheng, X.-N., Wang, M., & Zhu, X.-Q. (2024). Functional Characterization of Six Eukaryotic Translation Initiation Factors of Toxoplasma gondii Using the CRISPR-Cas9 System. International Journal of Molecular Sciences, 25(14), Article 7834. https://doi.org/10.3390/ijms25147834

Eukaryotic translation initiation factors (eIFs) are crucial for initiating protein translation and ensuring the correct assembly of mRNA-ribosomal subunit complexes. In this study, we investigated the effects of deleting six eIFs in the apicomplexan... Read More about Functional Characterization of Six Eukaryotic Translation Initiation Factors of Toxoplasma gondii Using the CRISPR-Cas9 System.

Footbathing and Foot Trimming, and No Quarantine: Risks for High Prevalence of Lameness in a Random Sample of 269 Sheep Flocks in England, 2022 (2024)
Journal Article
Lewis, K. E., Green, M., Clifton, R., Monaghan, E., Prosser, N., Nabb, E., & Green, L. (2024). Footbathing and Foot Trimming, and No Quarantine: Risks for High Prevalence of Lameness in a Random Sample of 269 Sheep Flocks in England, 2022. Animals, 14(14), Article 2066. https://doi.org/10.3390/ani14142066

Since 2004, the prevalence of lameness in sheep flocks in England has reduced as farmers have adopted evidence-based management practices to control lameness. In 2011, the Farm Animal Welfare Council proposed a target prevalence of

A scoping review on intraoperative and postoperative surgical castration complications in domesticated equids (2024)
Journal Article
Rodden, E. B., Suthers, J. M., Busschers, E., Burford, J. H., & Freeman, S. L. (2024). A scoping review on intraoperative and postoperative surgical castration complications in domesticated equids. Equine Veterinary Journal, https://doi.org/10.1111/evj.14122

Background: Castration is the most common surgical procedure in domesticated equids; surgical techniques used and perioperative management vary considerably. Objectives: To identify and chart the current evidence on perioperative complications associ... Read More about A scoping review on intraoperative and postoperative surgical castration complications in domesticated equids.

Identification of Predictive Biomarkers of Lameness in Transition Dairy Cows (2024)
Journal Article
Cardoso, A. S., Whitby, A., Green, M. J., Kim, D.-H., & Randall, L. V. (2024). Identification of Predictive Biomarkers of Lameness in Transition Dairy Cows. Animals, 14(14), Article 2030. https://doi.org/10.3390/ani14142030

The aim of this study was to identify with a high level of confidence metabolites previously identified as predictors of lameness and understand their biological relevance by carrying out pathway analyses. For the dairy cattle sector, lameness is a m... Read More about Identification of Predictive Biomarkers of Lameness in Transition Dairy Cows.

Multiple novel caliciviruses identified from stoats (Mustela erminea) in the United Kingdom (2024)
Journal Article
Hinds, J., Apaa, T., Parry, R. H., Withers, A. J., MacKenzie, L., Staley, C., Morrison, J., Bennett, M., Bremner-Harrison, S., Chadwick, E. A., Hailer, F., Harrison, S. W., Lambin, X., Loose, M., Mathews, F., Tarlinton, R., & Blanchard, A. (2024). Multiple novel caliciviruses identified from stoats (Mustela erminea) in the United Kingdom. Access Microbiology, 6(7), Article 000813.v4. https://doi.org/10.1099/acmi.0.000813.v4

The Caliciviridae family, comprising positive-sense RNA viruses, is characterised by its non-enveloped, small virions, broad host range, and notable tendency for host switching. These viruses are primarily associated with gastroenteric disease, thoug... Read More about Multiple novel caliciviruses identified from stoats (Mustela erminea) in the United Kingdom.

Trace metal accumulation through the environment and wildlife at two derelict lead mines in Wales (2024)
Journal Article
Sartorius, A., Johnson, M. F., Young, S., Bennett, M., Baiker, K., Edwards, P., & Yon, L. (2024). Trace metal accumulation through the environment and wildlife at two derelict lead mines in Wales. Heliyon, 10(14), Article e34265. https://doi.org/10.1016/j.heliyon.2024.e34265

Trace metal pollution is globally widespread, largely resulting from human activities. Due to the persistence and high toxicity of trace metals, these pollutants can have serious effects across ecosystems. However, few studies have directly assessed... Read More about Trace metal accumulation through the environment and wildlife at two derelict lead mines in Wales.

Exposure to blue light reduces antimicrobial resistant Pseudomonas aeruginosa isolated from dog ear infections (2024)
Journal Article
Gigante, A. M., Hadis, M. A., Secker, B., Shaw, S., Cooper, P. R., Palin, W. M., …Atterbury, R. J. (2024). Exposure to blue light reduces antimicrobial resistant Pseudomonas aeruginosa isolated from dog ear infections. Frontiers in Microbiology, 15, 1-11. https://doi.org/10.3389/fmicb.2024.1414412

Introduction: Pseudomonas aeruginosa is a leading cause of canine otitis externa. Enrofloxacin is often applied topically to treat this condition, although recalcitrant and recurring infections are common. There is evidence that exposure to blue ligh... Read More about Exposure to blue light reduces antimicrobial resistant Pseudomonas aeruginosa isolated from dog ear infections.

Role of pseudotyped viruses in understanding epidemiology, pathogenesis and immunity of viral diseases affecting both horses and humans (2024)
Journal Article
Sedgwick, R. L., Elbohy, O., & Daly, J. M. (2024). Role of pseudotyped viruses in understanding epidemiology, pathogenesis and immunity of viral diseases affecting both horses and humans. Virology, 597, Article 110164. https://doi.org/10.1016/j.virol.2024.110164

In this review, we explore how pseudotyped viruses (PVs) are being applied to the study of viruses affecting both humans and horses. For the purposes of this review, we define PVs as non-replicative viruses with the core of one virus and the surface... Read More about Role of pseudotyped viruses in understanding epidemiology, pathogenesis and immunity of viral diseases affecting both horses and humans.

UK horse owners and veterinary practitioners' experiences of decision‐making for critical cases of colic (2024)
Journal Article
Burrell, K. L., Burford, J. H., England, G. C., & Freeman, S. L. (2024). UK horse owners and veterinary practitioners' experiences of decision‐making for critical cases of colic. Equine Veterinary Journal, https://doi.org/10.1111/evj.14124

Background: The survival of horses diagnosed with critical colic (requiring referral or euthanasia) relies on rapid and effective decision-making by the owner and veterinary practitioner. Objectives: To explore UK horse owners' and veterinary practit... Read More about UK horse owners and veterinary practitioners' experiences of decision‐making for critical cases of colic.

Altered landscape of total RNA, tRNA and sncRNA modifications in the liver and spleen of mice infected by Toxoplasma gondii (2024)
Journal Article
Zhang, X.-X., Sun, Y.-Z., Wang, W., Gao, Y., Wei, X.-Y., Sun, H.-C., Wang, C.-R., Ni, H.-B., Yang, X., Elsheikha, H. M., & Guo, H.-P. (2024). Altered landscape of total RNA, tRNA and sncRNA modifications in the liver and spleen of mice infected by Toxoplasma gondii. PLoS Neglected Tropical Diseases, 18(6), Article e0012281. https://doi.org/10.1371/journal.pntd.0012281

Background Pathogens can impact host RNA modification machinery to establish a favorable cellular environment for their replication. In the present study, we investigated the effect of Toxoplasma gondii infection on host RNA modification profiles... Read More about Altered landscape of total RNA, tRNA and sncRNA modifications in the liver and spleen of mice infected by Toxoplasma gondii.

Comparative cytotoxicity of Acanthamoeba castellanii-derived conditioned medium on human corneal epithelial and stromal cells (2024)
Journal Article
Alhazmi, A., Sidney, L. E., Hopkinson, A., & Elsheikha, H. M. (2024). Comparative cytotoxicity of Acanthamoeba castellanii-derived conditioned medium on human corneal epithelial and stromal cells. Acta Tropica, 257, Article 107288. https://doi.org/10.1016/j.actatropica.2024.107288

Soluble factors in the secretome of Acanthamoeba castellanii play crucial roles in the pathogenesis of Acanthamoeba keratitis (AK). Investigating the pathological effects of A. castellanii-derived conditioned medium (ACCM) on ocular cells can provide... Read More about Comparative cytotoxicity of Acanthamoeba castellanii-derived conditioned medium on human corneal epithelial and stromal cells.

MicroRNA biogenesis is broadly disrupted by inhibition of the splicing factor SF3B1 (2024)
Journal Article
Downie Ruiz Velasco, A., Parsons, A. L., Heatley, M. C., Martin, A. R. G., Smart, A. D., Shah, N., & Jopling, C. L. (2024). MicroRNA biogenesis is broadly disrupted by inhibition of the splicing factor SF3B1. Nucleic Acids Research, Article gkae505. https://doi.org/10.1093/nar/gkae505

In animals, microRNA (miRNA) biogenesis begins with cotranscriptional cleavage of the primary (pri-)miRNA by the Microprocessor complex. Cotranscriptional splicing has been shown to influence Microprocessor cleavage when miRNAs are hosted in introns... Read More about MicroRNA biogenesis is broadly disrupted by inhibition of the splicing factor SF3B1.

The importance of 3D fibre architecture in cancer and implications for biomaterial model design (2024)
Journal Article
Ashworth, J. C., & Cox, T. R. (2024). The importance of 3D fibre architecture in cancer and implications for biomaterial model design. Nature Reviews Cancer, 24(7), 461-479. https://doi.org/10.1038/s41568-024-00704-8

The need for improved prediction of clinical response is driving the development of cancer models with enhanced physiological relevance. A new concept of ‘precision biomaterials’ is emerging, encompassing patient-mimetic biomaterial models that seek... Read More about The importance of 3D fibre architecture in cancer and implications for biomaterial model design.

A case of renal amyloidosis associated with udder cleft dermatitis in an adult dairy cow (2024)
Journal Article
Capuzzello, G., Nicola, I., & Gray, A. (2024). A case of renal amyloidosis associated with udder cleft dermatitis in an adult dairy cow. Large Animal Review, 30(3), 145-149

Amyloidosis is a group of disorders characterised by the injurious deposition of abnormal proteins in tissues. Most common in cattle and other animals is secondary or reactive systemic amyloidosis associated with chronic inflammation, resulting in de... Read More about A case of renal amyloidosis associated with udder cleft dermatitis in an adult dairy cow.

Sub-optimal paternal diet at the time of mating disrupts maternal adaptations to pregnancy in the late gestation mouse (2024)
Journal Article
Khoshkerdar, A., Eid, N., Batra, V., Baker, N., Holmes, N., Henson, S., Sang, F., Wright, V., McLaren, J., Shakesheff, K., Woad, K. J., Morgan, H. L., & Watkins, A. J. (2024). Sub-optimal paternal diet at the time of mating disrupts maternal adaptations to pregnancy in the late gestation mouse. Nutrients, 16(12), Article 1879. https://doi.org/10.3390/nu16121879

Pregnancy represents a stage during which maternal physiology and homeostatic regulation undergo dramatic change and adaptation. The fundamental purpose of these adaptations is to ensure the survival of her offspring through adequate nutrient provisi... Read More about Sub-optimal paternal diet at the time of mating disrupts maternal adaptations to pregnancy in the late gestation mouse.

Root-soil-microbiome management is key to the success of Regenerative Agriculture (2024)
Journal Article
Mooney, S., Castrillo, G., Cooper, H., & Bennett, M. (2024). Root-soil-microbiome management is key to the success of Regenerative Agriculture. Nature Food, 5, 451–453. https://doi.org/10.1038/s43016-024-01001-1

Building soil health and manipulating the soil microbiome, alongside targeted plant breeding that prioritizes preferential root architectural development, hold the key to the future success of regenerative agriculture. Greater integration is needed b... Read More about Root-soil-microbiome management is key to the success of Regenerative Agriculture.

Comparative transcriptome reprogramming in oak galls containing asexual or sexual generations of gall wasps (2024)
Journal Article
Bellows, E., Heatley, M., Shah, N., Archer, N., Giles, T., & Fray, R. (2024). Comparative transcriptome reprogramming in oak galls containing asexual or sexual generations of gall wasps. Plant Biology, 26(5), 798-810. https://doi.org/10.1111/plb.13670

Oak gall wasps have evolved strategies to manipulate the developmental pathways of their host to induce gall formation. This provides shelter and nutrients for the developing larva. Galls are entirely host tissue; however, the initiation, development... Read More about Comparative transcriptome reprogramming in oak galls containing asexual or sexual generations of gall wasps.

Using Object-Oriented Simulation to Assess the Impact of the Frequency and Accuracy of Mobility Scoring on the Estimation of Epidemiological Parameters for Lameness in Dairy Herds (2024)
Journal Article
Clifton, R., Hyde, R., Can, E., Barden, M., Manning, A., Bradley, A., …O’Grady, L. (2024). Using Object-Oriented Simulation to Assess the Impact of the Frequency and Accuracy of Mobility Scoring on the Estimation of Epidemiological Parameters for Lameness in Dairy Herds. Animals, 14(12), 1760. https://doi.org/10.3390/ani14121760

Mobility scoring data can be used to estimate the prevalence, incidence, and duration of lameness in dairy herds. Mobility scoring is often performed infrequently with variable sensitivity, but how this impacts the estimation of lameness parameters i... Read More about Using Object-Oriented Simulation to Assess the Impact of the Frequency and Accuracy of Mobility Scoring on the Estimation of Epidemiological Parameters for Lameness in Dairy Herds.