Outer membrane protein size and LPS O-antigen define protective antibody targeting to the Salmonella surface
(2020)
Journal Article
Domínguez-Medina, C. C., Pérez-Toledo, M., Schager, A. E., Marshall, J. L., Cook, C. N., Bobat, S., …Cunningham, A. F. (2020). Outer membrane protein size and LPS O-antigen define protective antibody targeting to the Salmonella surface. Nature Communications, 11, Article 851. https://doi.org/10.1038/s41467-020-14655-9
Lipopolysaccharide (LPS) O-antigen (O-Ag) is known to limit antibody binding to surface antigens, although the relationship between antibody, O-Ag and other outer-membrane antigens is poorly understood. Here we report, immunization with the trimeric... Read More about Outer membrane protein size and LPS O-antigen define protective antibody targeting to the Salmonella surface.