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Outer membrane protein size and LPS O-antigen define protective antibody targeting to the Salmonella surface (2020)
Journal Article
Domínguez-Medina, C. C., Pérez-Toledo, M., Schager, A. E., Marshall, J. L., Cook, C. N., Bobat, S., …Cunningham, A. F. (2020). Outer membrane protein size and LPS O-antigen define protective antibody targeting to the Salmonella surface. Nature Communications, 11, Article 851. https://doi.org/10.1038/s41467-020-14655-9

Lipopolysaccharide (LPS) O-antigen (O-Ag) is known to limit antibody binding to surface antigens, although the relationship between antibody, O-Ag and other outer-membrane antigens is poorly understood. Here we report, immunization with the trimeric... Read More about Outer membrane protein size and LPS O-antigen define protective antibody targeting to the Salmonella surface.

Is it just about grazing? UK citizens have diverse preferences for how dairy cows should be managed (2020)
Journal Article
Jackson, A., Green, M., Millar, K., & Kaler, J. (2020). Is it just about grazing? UK citizens have diverse preferences for how dairy cows should be managed. Journal of Dairy Science, 103(4), 3250-3263. https://doi.org/10.3168/jds.2019-17111

© 2020 American Dairy Science Association Conflicting views between the dairy industry and the public about how dairy cows should be managed, together with an increase in the availability of alternatives to dairy foods, challenge future markets for m... Read More about Is it just about grazing? UK citizens have diverse preferences for how dairy cows should be managed.

The intravenous pharmacokinetics of butorphanol and detomidine dosed in combination compared with individual dose administrations to exercised horses (2020)
Journal Article
Paine, S. W., Bright, J., Scarth, J. P., Hincks, P. R., Pearce, C. M., Hannan, C., …Hillyer, L. (2020). The intravenous pharmacokinetics of butorphanol and detomidine dosed in combination compared with individual dose administrations to exercised horses. Journal of Veterinary Pharmacology and Therapeutics, 43(2), 162-170. https://doi.org/10.1111/jvp.12838

In equine and racing practice, detomidine and butorphanol are commonly used in combination for their sedative properties. The aim of the study was to produce detection times to better inform European veterinary surgeons, so that both drugs can be use... Read More about The intravenous pharmacokinetics of butorphanol and detomidine dosed in combination compared with individual dose administrations to exercised horses.

Giving calves 'the best start': Perceptions of colostrum management on dairy farms in England (2020)
Journal Article
Palczynski, L., Bleach, E., Brennan, M., & Robinson, P. (2020). Giving calves 'the best start': Perceptions of colostrum management on dairy farms in England. Animal Welfare Journal, 29(1), 45-58. https://doi.org/10.7120/09627286.29.1.045

Good colostrum management can confer protective immunity to newborn calves, making calves less susceptible to infectious disease, and fundamentally improving both their short- and long-term health, welfare and productivity. Industry recommendations c... Read More about Giving calves 'the best start': Perceptions of colostrum management on dairy farms in England.

Field survey to evaluate space allowances for dairy cows in Great Britain (2020)
Journal Article
Thompson, J. S., Huxley, J. N., Hudson, C. D., Kaler, J., Gibbons, J., & Green, M. J. (2020). Field survey to evaluate space allowances for dairy cows in Great Britain. Journal of Dairy Science, 103(4), 3745-3759. https://doi.org/10.3168/jds.2019-17004

© 2020 American Dairy Science Association Housing conditions can affect health of cows by increasing exposure to biological, chemical, and physical hazards, resulting in increased disease. A report in 2014 indicated that 99% of UK dairy cows are hous... Read More about Field survey to evaluate space allowances for dairy cows in Great Britain.

Differential expression of HERV-W in peripheral blood in multiple sclerosis and healthy patients in two different ethnic groups (2020)
Journal Article
Tarlinton, R., Wang, B., Morandi, E., Gran, B., Khaibullin, T., Martynova, E., …Khaiboullina, S. (2020). Differential expression of HERV-W in peripheral blood in multiple sclerosis and healthy patients in two different ethnic groups. Frontiers in Pharmacology, 10, Article 1645. https://doi.org/10.3389/fphar.2019.01645

Copyright © 2020 Tarlinton, Wang, Morandi, Gran, Khaiboullin, Martynova, Rizvanov and Khaiboullina. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction... Read More about Differential expression of HERV-W in peripheral blood in multiple sclerosis and healthy patients in two different ethnic groups.

Toxoplasma gondii tkl1 Deletion Mutant Is a Promising Vaccine against Acute, Chronic, and Congenital Toxoplasmosis in Mice (2020)
Journal Article
Wang, J., Liang, Q., Li, T., He, J., Bai, M., Cao, X., …Zhu, X. (2020). Toxoplasma gondii tkl1 Deletion Mutant Is a Promising Vaccine against Acute, Chronic, and Congenital Toxoplasmosis in Mice. Journal of Immunology, 204(6), 1562-1570. https://doi.org/10.4049/jimmunol.1900410

In this study, we generated a tkl1 deletion mutant in the Toxoplasma gondii type 1 RH (RHΔtkl1) strain and tested the protective efficacies of vaccination using RHΔtkl1 tachyzoites against acute, chronic, and congenital T. gondii infections in Kunmin... Read More about Toxoplasma gondii tkl1 Deletion Mutant Is a Promising Vaccine against Acute, Chronic, and Congenital Toxoplasmosis in Mice.

Detrimental effects of uterine disease and lipopolysaccharide on luteal angiogenesis (2020)
Journal Article
Mohammed, Z. A., Robinson, R. S., Harris, R., McLaughlin, Y., Turnbull, K. E., Mann, G. E., & Woad, K. J. (2020). Detrimental effects of uterine disease and lipopolysaccharide on luteal angiogenesis. Journal of Endocrinology, 245(1), 79-92. https://doi.org/10.1530/JOE-19-0443

© 2020 Society for Endocrinology Reproductive tract inflammatory disease (RTID) commonly occurs after the traumatic events of parturition and adversely affects follicular function. This study is the first to describe the cellular and steroidogenic ch... Read More about Detrimental effects of uterine disease and lipopolysaccharide on luteal angiogenesis.

An improved cleaning system to reduce microbial contamination of poultry transport crates in the United Kingdom (2020)
Journal Article
Atterbury, R., Gigante, A., Tinker, D., Howell, M., & Allen, V. (2020). An improved cleaning system to reduce microbial contamination of poultry transport crates in the United Kingdom. Journal of Applied Microbiology, 128(6), 1776-1784. https://doi.org/10.1111/jam.14576

© 2020 The Society for Applied Microbiology Aim: Following previous research on improving the cleaning of crates used to transport broiler chickens from the farm to the abattoir, a demonstration project was undertaken to investigate improvements in c... Read More about An improved cleaning system to reduce microbial contamination of poultry transport crates in the United Kingdom.

Novel insights into viral infection and oncogenesis from Koala Retrovirus (KoRV) infection of HEK293T cells (2020)
Journal Article
Sarker, N., Tarlinton, R., Owen, H., David Emes, R., Seddon, J., Simmons, G., & Meers, J. (2020). Novel insights into viral infection and oncogenesis from Koala Retrovirus (KoRV) infection of HEK293T cells. Gene, 733, Article 144366. https://doi.org/10.1016/j.gene.2020.144366

Koala retrovirus is thought to be an underlying cause of high levels of neoplasia and immunosuppression in koalas. While epidemiology studies suggest a strong link between KoRV and disease it has been difficult to prove causality because of the compl... Read More about Novel insights into viral infection and oncogenesis from Koala Retrovirus (KoRV) infection of HEK293T cells.

Quantitative analysis of calf mortality in Great Britain (2020)
Journal Article
Hyde, R. M., Green, M. J., Sherwin, V. E., Hudson, C., Gibbons, J., Forshaw, T., …Down, P. M. (2020). Quantitative analysis of calf mortality in Great Britain. Journal of Dairy Science, 103(3), 2615–2623. https://doi.org/10.3168/jds.2019-17383

National bodies in Great Britain (GB) have expressed concern over young stock health and welfare and identified calf survival as a priority; however, no national data have been available to quantify mortality rates. The aim of this study was to quant... Read More about Quantitative analysis of calf mortality in Great Britain.

Automated detection of lameness in sheep using machine learning approaches: novel insights into behavioural differences among lame and non-lame sheep (2020)
Journal Article
Kaler, J., Mitsch, J., Vázquez-Diosdado, J. A., Bollard, N., Dottorini, T., & Ellis, K. A. (2020). Automated detection of lameness in sheep using machine learning approaches: novel insights into behavioural differences among lame and non-lame sheep. Royal Society Open Science, 7(1), Article 190824. https://doi.org/10.1098/rsos.190824

Lameness in sheep is the biggest cause of concern regarding poor health and welfare among sheep producing countries. Best practice for lameness relies on rapid treatment, yet there are no objective measures of lameness detection. Use of accelerometer... Read More about Automated detection of lameness in sheep using machine learning approaches: novel insights into behavioural differences among lame and non-lame sheep.

Definition of hourly urine output influences reported incidence and staging of acute kidney injury (2020)
Journal Article
Allen, J. C., Gardner, D. S., Skinner, H., Harvey, D., Sharman, A., & Devonald, M. A. (2020). Definition of hourly urine output influences reported incidence and staging of acute kidney injury. BMC Nephrology, 21(1), Article 19. https://doi.org/10.1186/s12882-019-1678-2

© 2020 The Author(s). Background: Acute kidney injury (AKI) is commonly defined using the KDIGO system, which includes criteria based on reduced urine output (UO). There is no consensus on whether UO should be measured using consecutive hourly readin... Read More about Definition of hourly urine output influences reported incidence and staging of acute kidney injury.

Koala retrovirus viral load and disease burden in distinct northern and southern koala populations (2020)
Journal Article
Sarker, N., Fabijan, J., Owen, H., Seddon, J., Simmons, G., Speight, N., …Tarlinton, R. E. (2020). Koala retrovirus viral load and disease burden in distinct northern and southern koala populations. Scientific Reports, 10(1), 263. https://doi.org/10.1038/s41598-019-56546-0

Koala retrovirus (KoRV) displays features of both an endogenous and exogenous virus and is linked to neoplasia and immunosuppression in koalas. This study explores the apparent differences in the nature and impact of KoRV infection between geographic... Read More about Koala retrovirus viral load and disease burden in distinct northern and southern koala populations.

Blood Vessels Under the Microscope (2020)
Journal Article
Machado, M. J. C., Mitchell, C. A., Franklin, J., Thorpe, A., & Rutland, C. S. (2020). Blood Vessels Under the Microscope. Frontiers for Young Minds, 7, Article 151. https://doi.org/10.3389/frym.2019.00151

This paper looks at blood vessels. All humans and animals have blood vessels, including your pet rabbit or dog, a whale or a giraffe! We need blood vessels to stay alive. This paper answers many questions, including what blood vessels are used for an... Read More about Blood Vessels Under the Microscope.

All-trans retinoic acid (ATRA)-induced TFEB expression is required for myeloid differentiation in acute promyelocytic leukemia (APL) (2020)
Journal Article
Orfali, N., O'Donovan, T. R., Cahill, M. R., Benjamin, D., Nanus, D. M., McKenna, S. L., …Mongan, N. P. (2020). All-trans retinoic acid (ATRA)-induced TFEB expression is required for myeloid differentiation in acute promyelocytic leukemia (APL). European Journal of Haematology, 104(3), 236-250. https://doi.org/10.1111/ejh.13367

© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd Objective: In acute promyelocytic leukemia (APL), normal retinoid signaling is disrupted by an abnormal PML-RARα fusion oncoprotein, leading to a block in cell differentiation. Ther... Read More about All-trans retinoic acid (ATRA)-induced TFEB expression is required for myeloid differentiation in acute promyelocytic leukemia (APL).

Appropriate dairy calf feeding from birth to weaning: “it’s an investment for the future” (2020)
Journal Article
Palczynski, L. J., Bleach, E. C. L., Brennan, M. L., & Robinson, P. A. (2020). Appropriate dairy calf feeding from birth to weaning: “it’s an investment for the future”. Animals, 10(1), Article 116. https://doi.org/10.3390/ani10010116

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Dairy calves must be fed appropriately to meet their nutritional needs, supporting optimal growth and development to achieve the recommended target age at first calving (AFC) of 24 months. Tra... Read More about Appropriate dairy calf feeding from birth to weaning: “it’s an investment for the future”.