All Outputs (2211)

The development of a 3D immunocompetent model of human skin (2013)
Journal Article
Chau, D. Y., Johnson, C., MacNeil, S., Haycock, J. W., & Ghaemmaghami, A. M. (2013). The development of a 3D immunocompetent model of human skin. Biofabrication, 5(3), Article 035011. https://doi.org/10.1088/1758-5082/5/3/035011

As the first line of defence, skin is regularly exposed to a variety of biological, physical and chemical insults. Therefore, determining the skin sensitization potential of new chemicals is of paramount importance from the safety assessment and regu... Read More about The development of a 3D immunocompetent model of human skin.

Augmented pain behavioural responses to intra-articular injection of nerve growth factor in two animal models of osteoarthritis (2013)
Journal Article
Ashraf, S., Mapp, P. I., Chapman, V., Burston, J., Bennett, A., & Walsh, D. A. (2014). Augmented pain behavioural responses to intra-articular injection of nerve growth factor in two animal models of osteoarthritis. Annals of the Rheumatic Diseases, 73(9), 1710-1718. https://doi.org/10.1136/annrheumdis-2013-203416

VEGF-A165b Is an Endogenous Neuroprotective Splice Isoform of Vascular Endothelial Growth Factor A inVivo and inVitro (2013)
Journal Article
Beazley-Long, N., Hua, J., Jehle, T., Hulse, R. P., Dersch, R., Lehrling, C., …Donaldson, L. F. (2013). VEGF-A165b Is an Endogenous Neuroprotective Splice Isoform of Vascular Endothelial Growth Factor A inVivo and inVitro. American Journal of Pathology, 183(3), 918-929. https://doi.org/10.1016/j.ajpath.2013.05.031

Vascular endothelial growth factor (VEGF) A is generated as two isoform families by alternative RNA splicing, represented by VEGF-A165a and VEGF-A165b. These isoforms have opposing actions on vascular permeability, angiogenesis, and vasodilatation. T... Read More about VEGF-A165b Is an Endogenous Neuroprotective Splice Isoform of Vascular Endothelial Growth Factor A inVivo and inVitro.

Heterogeneous models place the root of the placental mammal phylogeny (2013)
Journal Article
Morgan, C. C., Foster, P. G., Webb, A. E., Pisani, D., McInerney, J. O., & O'Connell, M. J. (2013). Heterogeneous models place the root of the placental mammal phylogeny. Molecular Biology and Evolution, 30(9), 2145-2156. https://doi.org/10.1093/molbev/mst117

Heterogeneity among life traits in mammals has resulted in considerable phylogenetic conflict, particularly concerning the position of the placental root. Layered upon this are gene-and lineage-specific variation in amino acid substitution rates and... Read More about Heterogeneous models place the root of the placental mammal phylogeny.

Suboptimal evolutionary novel environments promote singular altered gravity responses of transcriptome during Drosophila metamorphosis (2013)
Journal Article
Herranz, R., Larkin, O. J., Hill, R. J., Lopez-Vidriero, I., van Loon, J. J., & Medina, F. J. (2013). Suboptimal evolutionary novel environments promote singular altered gravity responses of transcriptome during Drosophila metamorphosis. BMC Evolutionary Biology, 13(June), Article 10. https://doi.org/10.1186/1471-2148-13-133

Background Previous experiments have shown that the reduced gravity aboard the International Space Station (ISS) causes important alterations in Drosophila gene expression. These changes were shown to be intimately linked to environmental space-fl... Read More about Suboptimal evolutionary novel environments promote singular altered gravity responses of transcriptome during Drosophila metamorphosis.

Host-parasite genotypic interactions in the honey bee: The dynamics of diversity (2013)
Journal Article
Evison, S. E., Fazio, G., Chappell, P., Foley, K., Jensen, A. B., & Hughes, W. O. (2013). Host-parasite genotypic interactions in the honey bee: The dynamics of diversity. Ecology and Evolution, 3(7), 2214-2222. https://doi.org/10.1002/ece3.599

Parasites are thought to be a major driving force shaping genetic variation in their host, and are suggested to be a significant reason for the maintenance of sexual reproduction. A leading hypothesis for the occurrence of multiple mating (polyandry)... Read More about Host-parasite genotypic interactions in the honey bee: The dynamics of diversity.

Caspase-1 is a novel target of p63 in tumor suppression (2013)
Journal Article
Celardo, I., Grespi, F., Antonov, A., Bernassola, F., Garabadgiu, A. V., Melino, G., & Amelio, I. (2013). Caspase-1 is a novel target of p63 in tumor suppression. Cell Death and Disease, 4(5), Article e645. https://doi.org/10.1038/cddis.2013.175

p63 is a p53 family transcription factor, which besides unique roles in epithelial development, shares tumor suppressive activity with its homolog p53. The p63 gene has different transcriptional start sites, which generate two N-terminal isoforms (tr... Read More about Caspase-1 is a novel target of p63 in tumor suppression.

Can long-range PCR be used to amplify genetically divergent mitochondrial genomes for comparative phylogenetics?: a case study within spiders (Arthropoda: Araneae) (2013)
Journal Article
Briscoe, A. G., Goodacre, S., Masta, S. E., Taylor, M. I., Arnedo, M. A., Penney, D., …Creer, S. (2013). Can long-range PCR be used to amplify genetically divergent mitochondrial genomes for comparative phylogenetics?: a case study within spiders (Arthropoda: Araneae). PLoS ONE, 8(5), Article 8. https://doi.org/10.1371/journal.pone.0062404

The development of second generation sequencing technology has resulted in the rapid production of large volumes of sequence data for relatively little cost, thereby substantially increasing the quantity of data available for phylogenetic studies. De... Read More about Can long-range PCR be used to amplify genetically divergent mitochondrial genomes for comparative phylogenetics?: a case study within spiders (Arthropoda: Araneae).

Pathway specific modulation of S1P1 receptor signalling in rat and human astrocytes (2013)
Journal Article
Healy, L. M., Sheridan, G. K., Pritchard, A. J., Rutkowska, A., Mullershausen, F., & Dev, K. K. (2013). Pathway specific modulation of S1P1 receptor signalling in rat and human astrocytes. British Journal of Pharmacology, 169(5), 1114-1129. https://doi.org/10.1111/bph.12207

Background and Purpose The sphingosine 1-phosphate receptor subtype 1 (S1P1R) is modulated by phosphorylated FTY720 (pFTY720), which causes S1P1R internalization preventing lymphocyte migration thus limiting autoimmune response. Studies indicate that... Read More about Pathway specific modulation of S1P1 receptor signalling in rat and human astrocytes.

The putative influence of the agr operon upon survival mechanisms used by Clostridium acetobutylicum (2013)
Journal Article
Jabbari, S., Steiner, E., Heap, J. T., Winzer, K., Minton, N. P., & King, J. R. (2013). The putative influence of the agr operon upon survival mechanisms used by Clostridium acetobutylicum. Mathematical Biosciences, 243(2), https://doi.org/10.1016/j.mbs.2013.03.005

The bacterium Clostridium acetobutylicum produces acids as an energy-yielding process during exponential growth. An acidic environment, however, is toxic to the cells and two survival mechanisms are in place to prevent them from dying. Firstly, durin... Read More about The putative influence of the agr operon upon survival mechanisms used by Clostridium acetobutylicum.

The role of lectins in allergic sensitization and allergic disease (2013)
Journal Article
Salazar, F., Sewell, H. F., Shakib, F., & Ghaemmaghami, A. M. (2013). The role of lectins in allergic sensitization and allergic disease. Journal of Allergy and Clinical Immunology, 132(1), 27-36. https://doi.org/10.1016/j.jaci.2013.02.001

Allergic diseases are a global public health issue affecting millions of persons around the world. However, full understanding of the molecular basis of this group of chronic inflammatory disorders remains rather elusive. Recently, the role of carboh... Read More about The role of lectins in allergic sensitization and allergic disease.

Act now against new NHS competition regulations (2013)
Journal Article
Davis, J., Banks, I., Wrigley, D., Peedell, C., Pollock, A., McPherson, K., …Chandy, R. (2013). Act now against new NHS competition regulations. BMJ, 346, https://doi.org/10.1136/bmj.f1819

An open letter to the BMA and the Academy of Medical Royal Colleges calls on them to make a joint public statement of opposition to the amended section 75 regulations

The history of African village chickens: an archaeological and molecular perspective (2013)
Journal Article
Mwacharo, J., Bjornstad, G., Han, J., & Hanotte, O. (2013). The history of African village chickens: an archaeological and molecular perspective. African Archaeological Review, 30(1), https://doi.org/10.1007/s10437-013-9128-1

The history of the introduction and dispersal of village chickens across the African continent is a subject of intense debate and speculation among scholars. Here, we synthesize and summarise the current scientific genetic and nongenetic knowledge in... Read More about The history of African village chickens: an archaeological and molecular perspective.

Allosteric approaches to GPCR drug discovery (2013)
Journal Article
Lane, J. R., & Ijzerman, A. P. (2013). Allosteric approaches to GPCR drug discovery. Drug Discovery Today: Technologies, 10(2), e219-e221. https://doi.org/10.1016/j.ddtec.2013.01.006

Expanding the repertoire of gene tools for precise manipulation of the Clostridium difficile genome: allelic exchange using pyrE alleles (2013)
Journal Article
Ng, Y. K., Ehsaan, M., Philip, S., Collery, M. M., Janoir, C., Collignon, A., …Minton, N. P. (2013). Expanding the repertoire of gene tools for precise manipulation of the Clostridium difficile genome: allelic exchange using pyrE alleles. PLoS ONE, 8(2), Article 13. https://doi.org/10.1371/journal.pone.0056051

Sophisticated genetic tools to modify essential biological processes at the molecular level are pivotal in elucidating the molecular pathogenesis of Clostridium difficile, a major cause of healthcare associated disease. Here we have developed an effi... Read More about Expanding the repertoire of gene tools for precise manipulation of the Clostridium difficile genome: allelic exchange using pyrE alleles.

Multiple factors modulate biofilm formation by the anaerobic pathogen Clostridium difficile (2013)
Journal Article
Dapa, T., Leuzzi, R., Ng, Y. K., Baban, S. T., Adamo, R., Kuehne, S. A., …Unnikrishnan, M. (2013). Multiple factors modulate biofilm formation by the anaerobic pathogen Clostridium difficile. Journal of Bacteriology, 195(3), https://doi.org/10.1128/JB.01980-12

Bacteria within biofilms are protected from multiple stresses, including immune responses and antimicrobial agents. The biofilm-forming ability of bacterial pathogens has been associated with increased antibiotic resistance and chronic recurrent infe... Read More about Multiple factors modulate biofilm formation by the anaerobic pathogen Clostridium difficile.

Specificity and Function of Archaeal DNA Replication Initiator Proteins (2013)
Journal Article
Samson, R. Y., Xu, Y., Gadelha, C., Stone, T. A., Faqiri, J. N., Li, D., …Bell, S. D. (2013). Specificity and Function of Archaeal DNA Replication Initiator Proteins. Cell Reports, 3(2), 485-496. https://doi.org/10.1016/j.celrep.2013.01.002

Chromosomes with multiple DNA replication origins are a hallmark of Eukaryotes and some Archaea. All eukaryal nuclear replication origins are defined by the origin recognition complex (ORC) that recruits the replicative helicase MCM(2-7) via Cdc6 and... Read More about Specificity and Function of Archaeal DNA Replication Initiator Proteins.

Proteomic Analysis of Clathrin Interactions in Trypanosomes Reveals Dynamic Evolution of Endocytosis (2013)
Journal Article
Adung'a, V. O., Gadelha, C., & Field, M. C. (2013). Proteomic Analysis of Clathrin Interactions in Trypanosomes Reveals Dynamic Evolution of Endocytosis. Traffic, 14(4), 440-457. https://doi.org/10.1111/tra.12040

Endocytosis is a vital cellular process maintaining the cell surface, modulating signal transduction and facilitating nutrient acquisition. In metazoa, multiple endocytic modes are recognized, but for many unicellular organisms the process is likely... Read More about Proteomic Analysis of Clathrin Interactions in Trypanosomes Reveals Dynamic Evolution of Endocytosis.

ERK phosphorylation of MED14 in promoter complexes during mitogen-induced gene activation by Elk-1 (2013)
Journal Article
Galbraith, M. D., Saxton, J., Li, L., Shelton, S. J., Zhang, H., Espinosa, J. M., & Shaw, P. E. (2013). ERK phosphorylation of MED14 in promoter complexes during mitogen-induced gene activation by Elk-1. Nucleic Acids Research, 41(22), https://doi.org/10.1093/nar/gkt837

The ETS domain transcription factor Elk-1 stimulates expression of immediate early genes (IEGs) in response to mitogens. These events require phosphorylation of Elk-1 by extracellular signal-regulated kinase (ERK) and phosphorylation-dependent intera... Read More about ERK phosphorylation of MED14 in promoter complexes during mitogen-induced gene activation by Elk-1.

Synthesis, functional and binding profile of (R)-apomorphine based homobivalent ligands targeting the dopamine D2 receptor (2013)
Journal Article
Shonberg, J., Lane, J. R., Scammells, P. J., & Capuano, B. (2013). Synthesis, functional and binding profile of (R)-apomorphine based homobivalent ligands targeting the dopamine D2 receptor. MedChemComm, 4(9), 1290-1296. https://doi.org/10.1039/c3md00154g

Bivalent ligands represent useful tools to investigate the phenomenon of GPCR dimerization. We synthesized bivalent ligands based on (R)-apomorphine with variations in spacer length, and assessed these compounds in functional and binding assays at th... Read More about Synthesis, functional and binding profile of (R)-apomorphine based homobivalent ligands targeting the dopamine D2 receptor.