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Differences in MAT gene distribution and expression between Rhynchosporium species on grasses (2014)
Journal Article
King, K., West, J., Fitt, B., & Dyer, P. S. (2015). Differences in MAT gene distribution and expression between Rhynchosporium species on grasses. Plant Pathology, 64(2), https://doi.org/10.1111/ppa.12265

Leaf blotch is a globally important disease of barley crops and other grasses that is caused by at least five host-specialized species in the fungal genus Rhynchosporium. The pathogen R. commune (specialized to barley, brome-grass and Italian ryegras... Read More about Differences in MAT gene distribution and expression between Rhynchosporium species on grasses.

Genome-wide Functional Analysis of Plasmodium Protein Phosphatases Reveals Key Regulators of Parasite Development and Differentiation (2014)
Journal Article
Guttery, D. S., TEWARI, R., Poulin, B., Ramaprasad, A., Wall, R. J., Ferguson, D. J., …Pain, A. (2014). Genome-wide Functional Analysis of Plasmodium Protein Phosphatases Reveals Key Regulators of Parasite Development and Differentiation. Cell Host and Microbe, 16(1), 128-140. https://doi.org/10.1016/j.chom.2014.05.020

Reversible protein phosphorylation regulated by kinases and phosphatases controls many cellular processes. Although essential functions for the malaria parasite kinome have been reported, the roles of most protein phosphatases (PPs) during Plasmodium... Read More about Genome-wide Functional Analysis of Plasmodium Protein Phosphatases Reveals Key Regulators of Parasite Development and Differentiation.

An Immunological Marker of Tolerance to Infection in Wild Rodents (2014)
Journal Article
Jackson, J. A., Hall, A. J., Friberg, I. M., Ralli, C., Lowe, A., Zawadzka, M., …Begon, M. (2014). An Immunological Marker of Tolerance to Infection in Wild Rodents. PLoS Biology, 12(7), Article e1001901. https://doi.org/10.1371/journal.pbio.1001901

Hosts are likely to respond to parasitic infections by a combination of resistance (expulsion of pathogens) and tolerance (active mitigation of pathology). Of these strategies, the basis of tolerance in animal hosts is relatively poorly understood, w... Read More about An Immunological Marker of Tolerance to Infection in Wild Rodents.

The Effects of Conformational Constraints in the Polyamine Moiety of Philanthotoxins on AMPAR Inhibition (2014)
Journal Article
Franzyk, H., Grzeskowiak, J. W., Tikhonov, D. B., Jaroszewski, J. W., & Mellor, I. R. (2014). The Effects of Conformational Constraints in the Polyamine Moiety of Philanthotoxins on AMPAR Inhibition. ChemMedChem, 9(8), 1725-1731. https://doi.org/10.1002/cmdc.201402109

Philanthotoxin‐433 (PhTX‐433) is a known potent inhibitor of ionotropic glutamate receptors, and analogues have been synthesised to identify more potent and selective antagonists. Herein we report the synthesis of four PhTXs with a cyclopropane moiet... Read More about The Effects of Conformational Constraints in the Polyamine Moiety of Philanthotoxins on AMPAR Inhibition.

Molecular Mechanisms of Bitopic Ligand Engagement with the M1 Muscarinic Acetylcholine Receptor (2014)
Journal Article
Keov, P., Lopez, L., Devine, S. M., Valant, C., Lane, J. R., Scammells, P. J., …Christopoulos, A. (2014). Molecular Mechanisms of Bitopic Ligand Engagement with the M1 Muscarinic Acetylcholine Receptor. Journal of Biological Chemistry, 289(34), 23817-23837. https://doi.org/10.1074/jbc.M114.582874

TBPB and 77-LH-28-1 are selective agonists of the M1 muscarinic acetylcholine receptor (mAChR) that may gain their selectivity through a bitopic mechanism, interacting concomitantly with the orthosteric site and part of an allosteric site. The curren... Read More about Molecular Mechanisms of Bitopic Ligand Engagement with the M1 Muscarinic Acetylcholine Receptor.

Expression of Arginase I in Myeloid Cells Limits Control of Residual Disease after Radiation Therapy of Tumors in Mice (2014)
Journal Article
Crittenden, M. R., Savage, T., Cottam, B., Baird, J., Rodriguez, P. C., Newell, P., …Gough, M. J. (2014). Expression of Arginase I in Myeloid Cells Limits Control of Residual Disease after Radiation Therapy of Tumors in Mice. Radiation Research, 182(2), 182-190. https://doi.org/10.1667/rr13493.1

An accumulating body of evidence demonstrates that radiation therapy can generate adaptive immune responses that contribute to tumor control. However, in the absence of additional immune therapy, the adaptive immune response is insufficient to preven... Read More about Expression of Arginase I in Myeloid Cells Limits Control of Residual Disease after Radiation Therapy of Tumors in Mice.

Erratum: Genes involved in the induction of liver growth by peroxisome proliferators (Toxicol. Res. (2014) DOI: 10.1039/c3tx50110h) (2014)
Journal Article
Amer, A. H., Wall, R. J., Malla, S., Aboobaker, A., Sang, F., Avery, S. V., …Bell, D. R. (2014). Erratum: Genes involved in the induction of liver growth by peroxisome proliferators (Toxicol. Res. (2014) DOI: 10.1039/c3tx50110h). Toxicology Research, 3(5), 401. https://doi.org/10.1039/C4TX90012J

The authors would like to add an additional acknowledgement as follows: We wish to acknowledge Fikry Abushofa for technical assistance.

Effect of fructose and sucralose on flow-mediated vasodilatation in healthy, white European males (2014)
Journal Article
Memon, M. Q., Simpson, E. J., & Macdonald, I. A. (2014). Effect of fructose and sucralose on flow-mediated vasodilatation in healthy, white European males. Journal- Pakistan Medical Association, 64(7), 743-747

Objective: To assess how acute consumption of fructose affects flow-mediated dilatation in brachial artery. Methods: The randomised cross-over study was conducted at the University of Nottingham's Medical School, Nottingham, United Kingdom in July 20... Read More about Effect of fructose and sucralose on flow-mediated vasodilatation in healthy, white European males.

Identification of Angiostrongylus cantonensis and other nematodes using the SSU rDNA in Achatina fulica populations of Metro Manila (2014)
Journal Article
Constantino-Santos, D. M., Basiao, Z. U., Wade, C. M., Santos, B. S., & Fontanilla, I. K. (2014). Identification of Angiostrongylus cantonensis and other nematodes using the SSU rDNA in Achatina fulica populations of Metro Manila. Tropical Biomedicine, 31(2), 327-335

Angiostrongylus cantonensis is a parasitic nematode that causes eosinophilic meningitis in humans. Accidental infection occurs by consumption of contaminated intermediates, such as the giant African land snail, Achatina fulica. This study surveyed th... Read More about Identification of Angiostrongylus cantonensis and other nematodes using the SSU rDNA in Achatina fulica populations of Metro Manila.

Kinetic analysis of antagonist-occupied adenosine-A3 receptors within membrane microdomains of individual cells provides evidence of receptor dimerization and allosterism (2014)
Journal Article
Corriden, R., Kilpatrick, L. E., Kellam, B., Briddon, S. J., & Hill, S. J. (2014). Kinetic analysis of antagonist-occupied adenosine-A3 receptors within membrane microdomains of individual cells provides evidence of receptor dimerization and allosterism. FASEB Journal, 28(10), 4211-4222. https://doi.org/10.1096/fj.13-247270

© The Author(s). In our previous work, using a fluorescent adenosine-A3 receptor (A3AR) agonist and fluorescence correlation spectroscopy (FCS), we demonstrated highaffinity labeling of the active receptor (R∗) conformation. In the current study, we... Read More about Kinetic analysis of antagonist-occupied adenosine-A3 receptors within membrane microdomains of individual cells provides evidence of receptor dimerization and allosterism.

Detergent-free purification of ABC (ATP-binding-cassette) transporters (2014)
Journal Article
Gulati, S., Jamshad, M., Knowles, T. J., Morrison, K. A., Downing, R., Cant, N., …Rothnie, A. J. (2014). Detergent-free purification of ABC (ATP-binding-cassette) transporters. Biochemical Journal, 461(2), 269-278. https://doi.org/10.1042/BJ20131477

ABC (ATP-binding-cassette) transporters carry out many vital functions and are involved in numerous diseases, but study of the structure and function of these proteins is often hampered by their large size and membrane location. Membrane protein puri... Read More about Detergent-free purification of ABC (ATP-binding-cassette) transporters.

Theta-Burst Stimulation of Hippocampal Slices Induces Network-Level Calcium Oscillations and Activates Analogous Gene Transcription to Spatial Learning (2014)
Journal Article
Murphy, K. J., Sheridan, G. K., O'Connor, J. J., Moeendarbary, E., & Pickering, M. (2014). Theta-Burst Stimulation of Hippocampal Slices Induces Network-Level Calcium Oscillations and Activates Analogous Gene Transcription to Spatial Learning. PLoS ONE, 9(6), Article e100546. https://doi.org/10.1371/journal.pone.0100546

Over four decades ago, it was discovered that high-frequency stimulation of the dentate gyrus induces long-term potentiation (LTP) of synaptic transmission. LTP is believed to underlie how we process and code external stimuli before converting it to... Read More about Theta-Burst Stimulation of Hippocampal Slices Induces Network-Level Calcium Oscillations and Activates Analogous Gene Transcription to Spatial Learning.

Transcriptional regulation of Drosophila gonad formation (2014)
Journal Article
Tripathy, R., Kunwar, P. S., Sano, H., & Renault, A. D. (2014). Transcriptional regulation of Drosophila gonad formation. Developmental Biology, 392(2), https://doi.org/10.1016/j.ydbio.2014.05.026

The formation of the Drosophila embryonic gonad, involving the fusion of clusters of somatic gonadal precursor cells (SGPs) and their ensheathment of germ cells, provides a simple and genetically tractable model for the interplay between cells during... Read More about Transcriptional regulation of Drosophila gonad formation.

Stochastic specification of primordial germ cells from mesoderm precursors in axolotl embryos (2014)
Journal Article
Chatfield, J., O'Reilly, M.-A., Bachvarova, R. F., Ferjentsik, Z., Redwood, C., Walmsley, M., …JOhnson, A. D. (2014). Stochastic specification of primordial germ cells from mesoderm precursors in axolotl embryos. Development, 141(12), 2429-2440. https://doi.org/10.1242/dev.105346

A common feature of development in most vertebrate models is the early segregation of the germ line from the soma. For example, in Xenopus and zebrafish embryos primordial germ cells (PGCs) are specified by germ plasm that is inherited from the egg;... Read More about Stochastic specification of primordial germ cells from mesoderm precursors in axolotl embryos.

A pro-inflammatory signalome is constitutively activated by C33Y mutant TNF receptor 1 in TNF receptor-associated periodic syndrome (TRAPS) (2014)
Journal Article
Negm, O. H., Mannsperger, H. A., McDermott, E. M., Drewe, E., Powell, R. J., Todd, I., …Tighe, P. J. (2014). A pro-inflammatory signalome is constitutively activated by C33Y mutant TNF receptor 1 in TNF receptor-associated periodic syndrome (TRAPS). European Journal of Immunology, 44(7), 2096-2110. https://doi.org/10.1002/eji.201344328

Mutations in TNFRSF1A encoding TNF receptor 1 (TNFR1) cause the autosomal dominant TNF receptor-associated periodic syndrome (TRAPS): a systemic autoinflammatory disorder. Misfolding, intracellular aggregation, and ligand-independent signaling by mut... Read More about A pro-inflammatory signalome is constitutively activated by C33Y mutant TNF receptor 1 in TNF receptor-associated periodic syndrome (TRAPS).

Photoperiodic regulation of FGF21 production in the Siberian hamster (2014)
Journal Article
Samms, R. J., Fowler, M. J., Cooper, S., Emmerson, P., Coskun, T., Adams, A. C., …Ebling, F. J. (2014). Photoperiodic regulation of FGF21 production in the Siberian hamster. Hormones and Behavior, 66(1), 180-185. https://doi.org/10.1016/j.yhbeh.2014.03.013

FGF21 is an endocrine member of the fibroblast growth factor superfamily that has been shown to play an important role in the physiological response to nutrient deprivation. Food restriction enhances hepatic FGF21 production, which serves to engage a... Read More about Photoperiodic regulation of FGF21 production in the Siberian hamster.

Sex differences in endothelial function in porcine coronary arteries: a role for H2O2and gap junctions? (2014)
Journal Article
Wong, P., Roberts, R., & Randall, M. (2014). Sex differences in endothelial function in porcine coronary arteries: a role for H2O2and gap junctions?. British Journal of Pharmacology, 171(11), https://doi.org/10.1111/bph.12595

BACKGROUND AND PURPOSE: Cardiovascular risk is higher in men and postmenopausal women compared with premenopausal women. This may be due to sex differences in endothelial function. Here, sex differences in endothelial function of porcine coronary art... Read More about Sex differences in endothelial function in porcine coronary arteries: a role for H2O2and gap junctions?.

Spatiotemporal variation in the endangered Thymus decussatus in a hyper-arid environment (2014)
Journal Article
Thompson, K., & Gilbert, F. (2015). Spatiotemporal variation in the endangered Thymus decussatus in a hyper-arid environment. Journal of Plant Ecology, 8(1), https://doi.org/10.1093/jpe/rtu004

Aims: Arid environments are resource limited, with scarcity of water the key limiting factor, but hyper-arid environments are rarely studied. We test for spatial and temporal variation in ecologically important characteristics to deduce plant adaptat... Read More about Spatiotemporal variation in the endangered Thymus decussatus in a hyper-arid environment.

The causal role of breakfast in energy balance and health: a randomized controlled trial in lean adults (2014)
Journal Article
Betts, J. A., Richardson, J. D., Chowdhury, E. A., Holman, G. D., Tsintzas, K., & Thompson, D. (2014). The causal role of breakfast in energy balance and health: a randomized controlled trial in lean adults. American Journal of Clinical Nutrition, 100(2), https://doi.org/10.3945/ajcn.114.083402

Background: Popular beliefs that breakfast is the most important meal of the day are grounded in cross-sectional observations that link breakfast to health, the causal nature of which remains to be explored under real-life conditions. Objective: The... Read More about The causal role of breakfast in energy balance and health: a randomized controlled trial in lean adults.