All Outputs (2211)

A novel role for the immunophilin FKBP52 in motor coordination (2016)
Journal Article
Young, M. J., Geiszler, P. C., & Pardon, M.-C. (in press). A novel role for the immunophilin FKBP52 in motor coordination. Behavioural Brain Research, 313, https://doi.org/10.1016/j.bbr.2016.07.015

FKBP52 is a ubiquitously distributed immunophilin that has been associated with wideranging functions in cell signalling as well as hormonal and stress responses. Amongst other pathways, it acts via complex-formation with corticosteroid receptors and... Read More about A novel role for the immunophilin FKBP52 in motor coordination.

Effects of prolonged hypoxia and bed rest on appetite and appetite-related hormones (2016)
Journal Article
Debevec, T., Simpson, E. J., Mekjavic, I. B., Eiken, O., & Macdonald, I. A. (2016). Effects of prolonged hypoxia and bed rest on appetite and appetite-related hormones. Appetite, 107, 28-37. https://doi.org/10.1016/j.appet.2016.07.005

Environmental hypoxia and inactivity have both been shown to modulate appetite. To elucidate the independent and combined effects of hypoxia and bed rest-induced inactivity on appetite-related hormones and subjective appetite, eleven healthy, non-obe... Read More about Effects of prolonged hypoxia and bed rest on appetite and appetite-related hormones.

The ecology of an adaptive radiation of three-spined stickleback from North Uist, Scotland (2016)
Journal Article
Magalhaes, I. S., D’Agostino, D., Hohenlohe, P. A., & MacColl, A. D. (2016). The ecology of an adaptive radiation of three-spined stickleback from North Uist, Scotland. Molecular Ecology, 25(17), 4319-4336. https://doi.org/10.1111/mec.13746

There has been a large focus on the genetics of traits involved in adaptation, but knowledge of the environmental variables leading to adaptive changes is surprisingly poor. Combined use of environmental data with morphological and genomic data shoul... Read More about The ecology of an adaptive radiation of three-spined stickleback from North Uist, Scotland.

Metabolic activity in dormant conidia ofAspergillus nigerand developmental changes during conidial outgrowth (2016)
Journal Article
Novodvorska, M., Stratford, M., Blythe, M. J., Wilson, R., Beniston, R. G., & Archer, D. B. (in press). Metabolic activity in dormant conidia ofAspergillus nigerand developmental changes during conidial outgrowth. Fungal Genetics and Biology, https://doi.org/10.1016/j.fgb.2016.07.002

The early stages of development of Aspergillus niger conidia during outgrowth were explored by combining genome-wide gene expression analysis (RNAseq), proteomics, Warburg manometry and uptake studies. Resting conidia suspended in water were demonstr... Read More about Metabolic activity in dormant conidia ofAspergillus nigerand developmental changes during conidial outgrowth.

Multivalent approaches and beyond: novel tools for the investigation of dopamine D2 receptor pharmacology (2016)
Journal Article
Kopinathan, A., Scammells, P. J., Lane, J. R., & Capuano, B. (2016). Multivalent approaches and beyond: novel tools for the investigation of dopamine D2 receptor pharmacology. Future Medicinal Chemistry, 8(11), 1349-1372. https://doi.org/10.4155/fmc-2016-0010

The dopamine D2 receptor (D2R) has been implicated in the symptomology of disorders such as schizophrenia and Parkinson's disease. Multivalent ligands provide useful tools to investigate emerging concepts of G protein-coupled receptor drug action suc... Read More about Multivalent approaches and beyond: novel tools for the investigation of dopamine D2 receptor pharmacology.

Low α-defensin gene copy number increases the risk for IgA nephropathy and renal dysfunction (2016)
Journal Article
Ai, Z., Li, M., Liu, W., Foo, J.-N., Mansouri, O., Yin, P., …Yu, X. (2016). Low α-defensin gene copy number increases the risk for IgA nephropathy and renal dysfunction. Science Translational Medicine, 8(345), Article 345ra88. https://doi.org/10.1126/scitranslmed.aaf2106

Although a major source of genetic variation, copy number variations (CNVs) and their involvement in disease development have not been well studied. Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. We perfo... Read More about Low α-defensin gene copy number increases the risk for IgA nephropathy and renal dysfunction.

Optically pure, structural and fluorescent analogues of a dimeric Y4 receptor agonist derived by an olefin metathesis approach (2016)
Journal Article
Liu, M., Mountford, S. J., Richardson, R. R., Groenen, M., Holliday, N. D., & Thompson, P. E. (2016). Optically pure, structural and fluorescent analogues of a dimeric Y4 receptor agonist derived by an olefin metathesis approach. Journal of Medicinal Chemistry, 59(13), 6059-6069. https://doi.org/10.1021/acs.jmedchem.6b00310

The dimeric peptide 1 (BVD-74D, as a diastereomeric mixture) is a potent and selective Neuropeptide Y Y4 receptor agonist. It represents a valuable candidate in developing traceable ligands for pharmacological studies of Y4 receptors, and as a lead c... Read More about Optically pure, structural and fluorescent analogues of a dimeric Y4 receptor agonist derived by an olefin metathesis approach.

Relationship between structural pathology and pain behaviour in a model of osteoarthritis (OA) (2016)
Journal Article
Nwosu, L. N., Mapp, P. I., Chapman, V., & Walsh, D. A. (2016). Relationship between structural pathology and pain behaviour in a model of osteoarthritis (OA). Osteoarthritis and Cartilage, 24(11), 1910-1917. https://doi.org/10.1016/j.joca.2016.06.012

Objectives To address the hypothesis that different types of established OA pain behaviours have associations with different aspects of articular pathology, we investigated the relationship between structural knee joint pathology and pain behaviour... Read More about Relationship between structural pathology and pain behaviour in a model of osteoarthritis (OA).

SAS6-like protein in Plasmodium indicates that conoid-associated apical complex proteins persist in invasive stages within the mosquito vector (2016)
Journal Article
Wall, R. J., Roques, M., Katris, N. J., Koreny, L., Stanway, R. R., Brady, D., …Tewari, R. (2016). SAS6-like protein in Plasmodium indicates that conoid-associated apical complex proteins persist in invasive stages within the mosquito vector. Scientific Reports, 6(1), https://doi.org/10.1038/srep28604

The SAS6-like (SAS6L) protein, a truncated paralogue of the ubiquitous basal body/centriole protein SAS6, has been characterised recently as a flagellum protein in trypanosomatids, but associated with the conoid in apicomplexan Toxoplasma. The conoid... Read More about SAS6-like protein in Plasmodium indicates that conoid-associated apical complex proteins persist in invasive stages within the mosquito vector.

Multiple Circulating Cytokines Are Coelevated in Chronic Obstructive Pulmonary Disease (2016)
Journal Article
Selvarajah, S., Todd, I., Tighe, P. J., John, M., Bolton, C. E., Harrison, T. W., & Fairclough, L. C. (2016). Multiple Circulating Cytokines Are Coelevated in Chronic Obstructive Pulmonary Disease. Mediators of Inflammation, 2016, 1-9. https://doi.org/10.1155/2016/3604842

Inflammatory biomarkers, including cytokines, are associated with COPD, but the association of particular circulating cytokines with systemic pathology remains equivocal. To investigate this, we developed a protein microarray system to detect multipl... Read More about Multiple Circulating Cytokines Are Coelevated in Chronic Obstructive Pulmonary Disease.

Effect of simvastatin on vascular tone in porcine coronary artery: potential role of the mitochondria (2016)
Journal Article
Almukhtar, H., Garle, M., Smith, P., & Roberts, R. E. (2016). Effect of simvastatin on vascular tone in porcine coronary artery: potential role of the mitochondria. Toxicology and Applied Pharmacology, 305, https://doi.org/10.1016/j.taap.2016.06.024

Statins induce acute vasorelaxation which may contribute to the overall benefits of statins in the treatment of cardiovascular disease. The mechanism underlying this relaxation is unknown. As statins have been shown to alter mitochondrial function, i... Read More about Effect of simvastatin on vascular tone in porcine coronary artery: potential role of the mitochondria.

Flexible and rapid construction of viral chimeras applied to hepatitis C virus (2016)
Journal Article
McClure, P. C., Urbanowicz, R. A., King, B. J., Cano-Crespo, S., Tarr, A. W., & Ball, J. K. (2016). Flexible and rapid construction of viral chimeras applied to hepatitis C virus. Journal of General Virology, 97(9), 2187-2193. https://doi.org/10.1099/jgv.0.000530

A novel and broadly applicable strategy combining site directed mutagenesis and DNA assembly for constructing seamless viral chimeras is described using Hepatitis C Virus as an exemplar. Full-length HCV genomic cloning cassettes, which contained flex... Read More about Flexible and rapid construction of viral chimeras applied to hepatitis C virus.

Alternative RNA splicing: contribution to pain and potential therapeutic strategy (2016)
Journal Article
Donaldson, L. F., & Beazley-Long, N. (in press). Alternative RNA splicing: contribution to pain and potential therapeutic strategy. Drug Discovery Today, https://doi.org/10.1016/j.drudis.2016.06.017

Since the sequencing of metazoan genomes began, it has become clear that the number of expressed proteins far exceeds the number of genes. It is now estimated that greater up to 98% of human genes give rise to multiple proteins through alternative pr... Read More about Alternative RNA splicing: contribution to pain and potential therapeutic strategy.

An international network (PlaNet) to evaluate a human placental testing platform for chemicals safety testing in pregnancy (2016)
Journal Article
Brownbill, P., Chernyavsky, I., Bottalico, B., Desoye, G., Hansson, S., Kenna, G., …Leach, L. (in press). An international network (PlaNet) to evaluate a human placental testing platform for chemicals safety testing in pregnancy. Reproductive Toxicology, https://doi.org/10.1016/j.reprotox.2016.06.006

tThe human placenta is a critical life-support system that nourishes and protects a rapidly growing fetus; aunique organ, species specific in structure and function. We consider the pressing challenge of providingadditional advice on the safety of pr... Read More about An international network (PlaNet) to evaluate a human placental testing platform for chemicals safety testing in pregnancy.

Recognition of membrane sterols by polyene antifungals amphotericin B and natamycin, a 13C MAS NMR Study (2016)
Journal Article
Ciesielski, F., Griffin, D. C., Loraine, J., Rittig, M., Delves-Broughton, J., & Bonev, B. B. (in press). Recognition of membrane sterols by polyene antifungals amphotericin B and natamycin, a 13C MAS NMR Study. Frontiers in Cell and Developmental Biology, 4, https://doi.org/10.3389/fcell.2016.00057

The molecular action of polyene macrolides with antifungal activity, amphotericin B and natamycin, involves recognition of sterols in membranes. Physicochemical and functional studies have contributed details to understanding the interactions between... Read More about Recognition of membrane sterols by polyene antifungals amphotericin B and natamycin, a 13C MAS NMR Study.

β2-Adrenoceptors on tumor cells play a critical role in stress-enhanced metastasis in a mouse model of breast cancer (2016)
Journal Article
Chang, A., Le, C. P., Walker, A. K., Creed, S. J., Pon, C. K., Albold, S., …Sloan, E. K. (2016). β2-Adrenoceptors on tumor cells play a critical role in stress-enhanced metastasis in a mouse model of breast cancer. Brain, Behavior, and Immunity, 57, 106-115. https://doi.org/10.1016/j.bbi.2016.06.011

© 2016 The Authors Chronic stress accelerates metastasis – the main cause of death in cancer patients – through the activation of β-adrenoceptors (βARs). We have previously shown that β2AR signaling in MDA-MB-231HM breast cancer cells, facilitates in... Read More about β2-Adrenoceptors on tumor cells play a critical role in stress-enhanced metastasis in a mouse model of breast cancer.

Irregular meal-pattern effects on energy expenditure, metabolism, and appetite regulation: a randomized controlled trial in healthy normal-weight women (2016)
Journal Article
Alhussain, M. H., Macdonald, I. A., & Taylor, M. A. (2016). Irregular meal-pattern effects on energy expenditure, metabolism, and appetite regulation: a randomized controlled trial in healthy normal-weight women. American Journal of Clinical Nutrition, 104(1), 21-32. https://doi.org/10.3945/ajcn.115.125401

Background: Obesity is increasing in parallel with greater all-day food availability. The latter may promote meal irregularity, dysregulation of the energy balance, and poor metabolic health. Objective: We investigated the effect of meal irregularit... Read More about Irregular meal-pattern effects on energy expenditure, metabolism, and appetite regulation: a randomized controlled trial in healthy normal-weight women.

Bright spots among the world's coral reefs (2016)
Journal Article
Cinner, J. E., Huchery, C., Macneill, M. A., Graham, N. A., McClanahan, T. R., Maina, J., …Mouillot, D. (2016). Bright spots among the world's coral reefs. Nature, 535(7612), 416-419. https://doi.org/10.1038/nature18607

© 2016 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Ongoing declines in the structure and function of the world's coral reefs require novel approaches to sustain these ecosystems and the millions of people who depend on... Read More about Bright spots among the world's coral reefs.

Ancient and modern DNA reveal dynamics of domestication and cross-continental dispersal of the dromedary (2016)
Journal Article
Almathen, F., Charruau, P., Mohandesan, E., Mwacharo, J. M., Orozco-terWengel, P., Pitt, D., …Burger, P. A. (2016). Ancient and modern DNA reveal dynamics of domestication and cross-continental dispersal of the dromedary. Proceedings of the National Academy of Sciences, 113(24), https://doi.org/10.1073/pnas.1519508113

Dromedaries have been fundamental to the development of human societies in arid landscapes and for long-distance trade across hostile hot terrains for 3,000 y. Today they continue to be an important livestock resource in marginal agro-ecological zone... Read More about Ancient and modern DNA reveal dynamics of domestication and cross-continental dispersal of the dromedary.

The impact of surface chemistry modification on macrophage polarisation (2016)
Journal Article
Rostam, H., Singh, S., Salazar, F., Magennis, P., Hook, A. L., Singh, T., …Ghaemmaghami, A. M. (2016). The impact of surface chemistry modification on macrophage polarisation. Immunobiology, 221(11), 1237-1246. https://doi.org/10.1016/j.imbio.2016.06.010

Macrophages are innate immune cells that have a central role in combating infection and maintaining tissue homeostasis. They exhibit remarkable plasticity in response to environmental cues. At either end of a broad activation spectrum are pro-inflamm... Read More about The impact of surface chemistry modification on macrophage polarisation.