All Outputs (1369)

Bacillus subtilis engineered for aerospace medicine: a platform for on-demand production of pharmaceutical peptides (2023)
Journal Article
Vallota-Eastman, A., Bui, C., Williams, P. M., Valentine, D. L., Loftus, D., & Rothschild, L. (2023). Bacillus subtilis engineered for aerospace medicine: a platform for on-demand production of pharmaceutical peptides. Frontiers in Space Technologies, 4, Article 1181843. https://doi.org/10.3389/frspt.2023.1181843

Biologics, such as pharmaceutical peptides, have notoriously short shelf lives, insufficient for long-duration space flight missions to the Moon or Mars. To enable the sustainable presence of humans on the Moon or Mars, we must develop methods for on... Read More about Bacillus subtilis engineered for aerospace medicine: a platform for on-demand production of pharmaceutical peptides.

Optimisation of diffuse Raman spectroscopy for in-vivo quantification of foreign body response in small animal model (2023)
Journal Article
Dooley, M., Luckett, J., Alexander, M. R., Matousek, P., Dehghani, H., Ghaemmaghami, A. M., & Notingher, I. (2023). Optimisation of diffuse Raman spectroscopy for in-vivo quantification of foreign body response in small animal model. Biomedical Optics Express, 14(12), 6592-6606. https://doi.org/10.1364/BOE.512118

Diffuse Raman spectroscopy (DRS) allows subsurface molecular analysis of optically turbid samples. Numerical modelling of light propagation was used as a method for improving the design of an DRS instrument to maximize the signal to noise ratio (SNR)... Read More about Optimisation of diffuse Raman spectroscopy for in-vivo quantification of foreign body response in small animal model.

Optimization of diffuse Raman spectroscopy for in-vivo quantification of foreign body response in a small animal model (2023)
Journal Article
Dooley, M., Luckett, J., Alexander, M. R., Matousek, P., Dehghani, H., Ghaemmaghami, A. M., & Notingher, I. (2023). Optimization of diffuse Raman spectroscopy for in-vivo quantification of foreign body response in a small animal model. Biomedical Optics Express, 14(12), 6592-6606. https://doi.org/10.1364/boe.512118

Diffuse Raman spectroscopy (DRS) allows subsurface molecular analysis of optically turbid samples. Numerical modeling of light propagation was used as a method for improving the design of an DRS instrument to maximize the signal to noise ratio (SNR)... Read More about Optimization of diffuse Raman spectroscopy for in-vivo quantification of foreign body response in a small animal model.

Sustained Release of Dexamethasone from 3D-Printed Scaffolds Modulates Macrophage Activation and Enhances Osteogenic Differentiation (2023)
Journal Article
Majrashi, M., Yang, J., Ghaemmaghami, A., Kotowska, A., Hicks, J. M., & Scurr, D. (2023). Sustained Release of Dexamethasone from 3D-Printed Scaffolds Modulates Macrophage Activation and Enhances Osteogenic Differentiation. ACS Applied Materials and Interfaces, 15(49), 56623–56638. https://doi.org/10.1021/acsami.3c09774

Enhancing osteogenesis via modulating immune cells is emerging as a new approach to address current challenges in repairing bone defects and fractures. However, much remains unknown about the crosstalk between immune cells and osteolineage cells duri... Read More about Sustained Release of Dexamethasone from 3D-Printed Scaffolds Modulates Macrophage Activation and Enhances Osteogenic Differentiation.

Co-assembling living material as an in vitro lung epithelial infection model (2023)
Journal Article
Wu, Y., Romero, M., Robertson, S. N., Fenn, S., Fisher, L., Willingham, I., …Mata, A. (2024). Co-assembling living material as an in vitro lung epithelial infection model. Matter, 7(1), 216-236. https://doi.org/10.1016/j.matt.2023.10.029

Biofilms are robust living 3D materials that play key roles in nature but also cause major problems, such as tolerance to antibiotic treatment. Recreation of these living structures in vitro is critical to understand their biology and develop solutio... Read More about Co-assembling living material as an in vitro lung epithelial infection model.

Evaluation of the Rational Drug Use (RDU) literacy among undergraduate students (2023)
Journal Article
Supapaan, T. S., Low, B. Y., Anderson, C., Boonlue, T., Puripunyavanich, N., Khumsikiew, J., …Poonphol, P. (2023). Evaluation of the Rational Drug Use (RDU) literacy among undergraduate students. Pharmacy Practice, 21(4), Article 2867. https://doi.org/10.18549/PharmPract.2023.4.2867

Background: Irrational drug usage is a global concern. WHO recommended a strategy for integrating education and awareness on the rational use of medicine into general education programs.

Objective: To evaluate the rational drug use (RDU) literacy... Read More about Evaluation of the Rational Drug Use (RDU) literacy among undergraduate students.

Modelled-Microgravity Reduces Virulence Factor Production in Staphylococcus aureus through Downregulation of agr-Dependent Quorum Sensing (2023)
Journal Article
Green, M. J., Murray, E. J., Williams, P., Ghaemmaghami, A. M., Aylott, J. W., & Williams, P. M. (2023). Modelled-Microgravity Reduces Virulence Factor Production in Staphylococcus aureus through Downregulation of agr-Dependent Quorum Sensing. International Journal of Molecular Sciences, 24(21), Article 15997. https://doi.org/10.3390/ijms242115997

Bacterial contamination during space missions is problematic for human health and damages filters and other vital support systems. Staphylococcus aureus is both a human commensal and an opportunistic pathogen that colonizes human tissues and causes a... Read More about Modelled-Microgravity Reduces Virulence Factor Production in Staphylococcus aureus through Downregulation of agr-Dependent Quorum Sensing.

A CROSS-SECTIONAL STUDY TO EXPLORE THE PRESCRIBING OF DRUGS WITH POTENTIAL DRUG GENE INTERACTIONS IN IRISH PRIMARY CARE (2023)
Presentation / Conference Contribution
Johnson, L., Youssef, E., O'Shea, J., Ledwidge, M., Thornley, T., Gallagher, J., & Ryan, C. (2023, October). A CROSS-SECTIONAL STUDY TO EXPLORE THE PRESCRIBING OF DRUGS WITH POTENTIAL DRUG GENE INTERACTIONS IN IRISH PRIMARY CARE. Poster presented at ESCP Aberdeen Symposium 2023: Innovations in Clinical Pharmacy Practice, Education and Research, Aberdeen, UK

Background and Objective: Pharmacogenetics (PGx) is being increasingly recognised as a strategy for medicines optimisation and prevention of adverse drug reactions. According to guidelines produced by the Clinical Pharmacogenetics Implementation Cons... Read More about A CROSS-SECTIONAL STUDY TO EXPLORE THE PRESCRIBING OF DRUGS WITH POTENTIAL DRUG GENE INTERACTIONS IN IRISH PRIMARY CARE.

Design, synthesis and biological evaluation of novel indanones derivatives as potent acetylcholinesterase/monoamine oxidase B inhibitors (2023)
Journal Article
Hu, Z., Zhou, S., Li, J., Li, X., Zhou, Y., Zhu, Z., …Liu, J. (2023). Design, synthesis and biological evaluation of novel indanones derivatives as potent acetylcholinesterase/monoamine oxidase B inhibitors. Future Medicinal Chemistry, 15(20), 1823-1841. https://doi.org/10.4155/fmc-2023-0206

Aim: Based on a multitarget design strategy, a series of novel indanone-1-benzyl-1,2,3,6-tetrahydropyridin hybrids were identified for the potential treatment of Alzheimer's disease (AD). Results: These compounds exhibited significant inhibitory acti... Read More about Design, synthesis and biological evaluation of novel indanones derivatives as potent acetylcholinesterase/monoamine oxidase B inhibitors.

Characterisation of Aberrant Metabolic Pathways in Hepatoblastoma Using Liquid Chromatography and Tandem Mass Spectrometry (LC-MS/MS) (2023)
Journal Article
Whitby, A., Pabla, P., Shastri, B., Amugi, L., Del Río-Álvarez, Á., Kim, D., …Dandapani, M. (2023). Characterisation of Aberrant Metabolic Pathways in Hepatoblastoma Using Liquid Chromatography and Tandem Mass Spectrometry (LC-MS/MS). Cancers, 15(21), Article 5182. https://doi.org/10.3390/cancers15215182

Hepatoblastoma (HB) is a rare childhood tumour with an evolving molecular landscape. We present the first comprehensive metabolomic analysis using untargeted and targeted liquid chromatography coupled to high-resolution tandem mass spectrometry (LC-M... Read More about Characterisation of Aberrant Metabolic Pathways in Hepatoblastoma Using Liquid Chromatography and Tandem Mass Spectrometry (LC-MS/MS).

A time-resolved Förster resonance energy transfer assay to investigate inhibitor binding to ABCG2 (2023)
Preprint / Working Paper
Mitchell-White, J. I., Briggs, D. A., Mistry, S. J., Mbiwan, H. A., Kellam, B., Holliday, N. D., …Kerr, I. D. A time-resolved Förster resonance energy transfer assay to investigate inhibitor binding to ABCG2

The human ATP-binding cassette (ABC) transporter, ABCG2 is responsible for multidrug resistance in some tumours. Detailed knowledge of its activity is crucial for understanding drug transport and resistance in cancer, and has implications for wider p... Read More about A time-resolved Förster resonance energy transfer assay to investigate inhibitor binding to ABCG2.

Bioactive and chemically defined hydrogels with tunable stiffness guide cerebral organoid formation and modulate multi-omics plasticity in cerebral organoids (2023)
Journal Article
Isik, M., Okesola, B. O., Eylem, C. C., Kocak, E., Nemutlu, E., D'Este, M., …Derkus, B. (2023). Bioactive and chemically defined hydrogels with tunable stiffness guide cerebral organoid formation and modulate multi-omics plasticity in cerebral organoids. Acta Biomaterialia, 171, 223-238. https://doi.org/10.1016/j.actbio.2023.09.040

Organoids are an emerging technology with great potential in human disease modelling, drug development, diagnosis, tissue engineering, and regenerative medicine. Organoids as 3D-tissue culture systems have gained special attention in the past decades... Read More about Bioactive and chemically defined hydrogels with tunable stiffness guide cerebral organoid formation and modulate multi-omics plasticity in cerebral organoids.

Spaceflight Induces Strength Decline in Caenorhabditis elegans (2023)
Journal Article
Soni, P., Edwards, H., Anupom, T., Rahman, M., Lesanpezeshki, L., Blawzdziewicz, J., …Vanapalli, S. A. (2023). Spaceflight Induces Strength Decline in Caenorhabditis elegans. Cells, 12(20), Article 2470. https://doi.org/10.3390/cells12202470

Background: Understanding and countering the well-established negative health consequences of spaceflight remains a primary challenge preventing safe deep space exploration. Targeted/personalized therapeutics are at the forefront of space medicine st... Read More about Spaceflight Induces Strength Decline in Caenorhabditis elegans.

CCR4‐NOT differentially controls host versus virus poly(a)‐tail length and regulates HCMV infection (2023)
Journal Article
Burgess, H. M., Grande, R., Riccio, S., Dinesh, I., Winkler, G. S., Depledge, D. P., & Mohr, I. (2023). CCR4‐NOT differentially controls host versus virus poly(a)‐tail length and regulates HCMV infection. EMBO Reports, 24(12), Article e56327. https://doi.org/10.15252/embr.202256327

Unlike most RNA and DNA viruses that broadly stimulate mRNA decay and interfere with host gene expression, human cytomegalovirus (HCMV) extensively remodels the host translatome without producing an mRNA decay enzyme. By performing a targeted loss-of... Read More about CCR4‐NOT differentially controls host versus virus poly(a)‐tail length and regulates HCMV infection.

Radiofrequency cold plasma – A novel tool for flavour modification in fresh and freeze-dried strawberries (2023)
Journal Article
Warne, G. R., Lim, M., Wilkinson, K., Hessel, V., Williams, P. M., & Fisk, I. D. (2023). Radiofrequency cold plasma – A novel tool for flavour modification in fresh and freeze-dried strawberries. Innovative Food Science and Emerging Technologies, 90, Article 103497. https://doi.org/10.1016/j.ifset.2023.103497

Cold plasma treatment is an emerging non-thermal food processing tool. This study aimed to identify how cold plasma can improve the aroma of a model space food system (freeze-dried strawberries) by mitigating freeze-drying aroma losses. Cold plasma s... Read More about Radiofrequency cold plasma – A novel tool for flavour modification in fresh and freeze-dried strawberries.

Discovery of novel β-elemene hybrids with hydrogen sulfide-releasing moiety possessing cardiovascular protective activity for the treatment of atherosclerosis (2023)
Journal Article
Zhu, W., Wu, H., He, C., Zhu, H., Yao, H., Cao, Y., …Xu, J. (2023). Discovery of novel β-elemene hybrids with hydrogen sulfide-releasing moiety possessing cardiovascular protective activity for the treatment of atherosclerosis. RSC Medicinal Chemistry, https://doi.org/10.1039/d3md00447c

Herein, a series of novel β-elemene hybrids with different types of hydrogen sulfide (H2S) donors was designed and synthesized for the first time. In addition, all compounds were tested for H2S release in phosphate buffer solution assay, among which... Read More about Discovery of novel β-elemene hybrids with hydrogen sulfide-releasing moiety possessing cardiovascular protective activity for the treatment of atherosclerosis.

Microflow synthesis of a formulation of phosphorus fertiliser to enhance the P content in soil and P uptake in wheat (2023)
Journal Article
Nguyen Quang Le, T., Robertson, K., Escribà-Gelonch, M., Marschner, P., Nghiep Tran, N., Williams, P. M., …Hessel, V. (2023). Microflow synthesis of a formulation of phosphorus fertiliser to enhance the P content in soil and P uptake in wheat. Green Chemistry, 25(22), 9422-9437. https://doi.org/10.1039/d3gc02859c

Highly soluble commercial phosphorus (P) fertilisers have been the most common form of P applied in agriculture for decades, but their releasing efficiency can be low because phosphate ions can easily bind with cations in the soil to form precipitate... Read More about Microflow synthesis of a formulation of phosphorus fertiliser to enhance the P content in soil and P uptake in wheat.

Bioinspired 3D-printed scaffold embedding DDAB-nano ZnO/nanofibrous microspheres for regenerative diabetic wound healing (2023)
Journal Article
Metwally, W. M., El-Habashy, S. E., El-Hosseiny, L. S., Essawy, M. M., Eltaher, H. M., El-Khordagui, L., & El-Khordagui, L. K. (2023). Bioinspired 3D-printed scaffold embedding DDAB-nano ZnO/nanofibrous microspheres for regenerative diabetic wound healing. Biofabrication, 16(1), Article 015001. https://doi.org/10.1088/1758-5090/acfd60

There is a constant demand for novel materials/biomedical devices to accelerate the healing of hard-to-heal wounds. Herein, an innovative 3D-printed bioinspired construct was developed as an antibacterial/regenerative scaffold for diabetic wound heal... Read More about Bioinspired 3D-printed scaffold embedding DDAB-nano ZnO/nanofibrous microspheres for regenerative diabetic wound healing.

Structure and function of molecular machines involved in deadenylation-dependent 5′-3′ mRNA degradation (2023)
Journal Article
Zhao, Q., Pavanello, L., Bartlam, M., & Winkler, G. S. (2023). Structure and function of molecular machines involved in deadenylation-dependent 5′-3′ mRNA degradation. Frontiers in Genetics, 14, Article 1233842. https://doi.org/10.3389/fgene.2023.1233842

In eukaryotic cells, the synthesis, processing, and degradation of mRNA are important processes required for the accurate execution of gene expression programmes. Fully processed cytoplasmic mRNA is characterised by the presence of a 5′cap structure... Read More about Structure and function of molecular machines involved in deadenylation-dependent 5′-3′ mRNA degradation.

High molecular weight kininogen interactions with the homologs prekallikrein and factor XI: importance to surface-induced coagulation (2023)
Journal Article
Mohammed, B. M., Sun, M., Cheng, Q., Litvak, M., McCrae, K. R., Emsley, J., …Gailani, D. (2024). High molecular weight kininogen interactions with the homologs prekallikrein and factor XI: importance to surface-induced coagulation. Journal of Thrombosis and Haemostasis, 22(1), 225-237. https://doi.org/10.1016/j.jtha.2023.09.027

Background: In plasma, high molecular weight kininogen (HK) is either free or bound to prekallikrein (PK) or factor (F) XI (FXI). During contact activation, HK is thought to anchor PK and FXI to surfaces, facilitating their conversion to the protease... Read More about High molecular weight kininogen interactions with the homologs prekallikrein and factor XI: importance to surface-induced coagulation.