Design, synthesis and biological evaluation of pyridine-chalcone derivatives as novel microtubule-destabilizing agents
(2019)
Journal Article
Xu, F., Li, W., Shuai, W., Yang, L., Bi, Y., Ma, C., …Xu, J. (2019). Design, synthesis and biological evaluation of pyridine-chalcone derivatives as novel microtubule-destabilizing agents. European Journal of Medicinal Chemistry, 173, 1-14. https://doi.org/10.1016/j.ejmech.2019.04.008
Further optimization of the trimethoxyphenyl scaffold of parent chalcone compound (2a) by introducing a pyridine ring afforded a series of novel pyridine-chalcone derivatives as potential anti-tubulin agents. All the target compounds were evaluated f... Read More about Design, synthesis and biological evaluation of pyridine-chalcone derivatives as novel microtubule-destabilizing agents.