All Outputs (27)

Discontinuation and restarting in patients on statin therapy: a cohort study using a primary care database (2016)
Journal Article
Vinogradova, Y., Coupland, C., Brindle, P., & Hippisley-Cox, J. (in press). Discontinuation and restarting in patients on statin therapy: a cohort study using a primary care database. BMJ, 353, Article i3305. https://doi.org/10.1136/bmj.i3305

Objectives: To estimate rates of discontinuation and restarting of statins, and to identify patient characteristics associated with either discontinuation or restarting.

Design: Prospective open cohort study.

Setting: 664 general practices con... Read More about Discontinuation and restarting in patients on statin therapy: a cohort study using a primary care database.

Patients who discontinued statin treatment: a protocol for cohort study using primary care data (2015)
Journal Article
Vinogradova, Y., Coupland, C., Brindle, P., & Hippisley-Cox, J. (2015). Patients who discontinued statin treatment: a protocol for cohort study using primary care data. BMJ Open, 5(10), https://doi.org/10.1136/bmjopen-2015-008701

Introduction: Risk thresholds for using statins to prevent cardiovascular disease (CVD) have recently been lowered, so an increasing number of patients are now prescribed these drugs. Although the safety of long-term statin use has been generally est... Read More about Patients who discontinued statin treatment: a protocol for cohort study using primary care data.

Use of combined oral contraceptives and risk of venous thromboembolism: nested case-control studies using the QResearch and CPRD databases (2015)
Journal Article
Vinogradova, Y., Coupland, C., & Hippisley-Cox, J. (2015). Use of combined oral contraceptives and risk of venous thromboembolism: nested case-control studies using the QResearch and CPRD databases. BMJ, 350, Article h2135. https://doi.org/10.1136/bmj.h2135

Exposure to combined oral contraceptives and risk of venous thromboembolism: a protocol for nested case–control studies using the QResearch and the CPRD databases (2014)
Journal Article
Vinogradova, Y., Coupland, C., & Hippisley-Cox, J. (2014). Exposure to combined oral contraceptives and risk of venous thromboembolism: a protocol for nested case–control studies using the QResearch and the CPRD databases. BMJ Open, 4(4), Article e004499. https://doi.org/10.1136/bmjopen-2013-004499

Exposure to bisphosphonates and risk of common non-gastrointestinal cancers: series of nested case–control studies using two primary-care databases (2013)
Journal Article
Vinogradova, Y., Coupland, C., & Hippisley-Cox, J. (2013). Exposure to bisphosphonates and risk of common non-gastrointestinal cancers: series of nested case–control studies using two primary-care databases. British Journal of Cancer, 109, https://doi.org/10.1038/bjc.2013.383

Background: Bisphosphonates are the most commonly prescribed osteoporosis drugs but long-term effects are unclear, although antitumour properties are known from preclinical studies.
Methods: Nested case–control studies were conducted to investigate... Read More about Exposure to bisphosphonates and risk of common non-gastrointestinal cancers: series of nested case–control studies using two primary-care databases.

Exposure to bisphosphonates and risk of cancer: a protocol for nested caseecontrol studies using the QResearch primary care database (2012)
Journal Article
Vinogradova, Y., Coupland, C., & Hippisley-Cox, J. (2012). Exposure to bisphosphonates and risk of cancer: a protocol for nested caseecontrol studies using the QResearch primary care database. BMJ Open, 2(1), Article e000548. https://doi.org/10.1136/bmjopen-2011-000548

Introduction: Bisphosphonates are becoming
a common treatment for osteoporosis particularly after
discovery of the association between hormone
replacement therapy and increased risk of breast
cancer. As osteoporosis develops with age, treatment... Read More about Exposure to bisphosphonates and risk of cancer: a protocol for nested caseecontrol studies using the QResearch primary care database.

Protocol to assess risk of venous thromboembolism associated with use of hormone replacement therapy in real world settings: two nested case-control studies in primary care
Other
Vinogradova, Y., Coupland, C., Mustafa, M., & Hippisley-Cox, J. Protocol to assess risk of venous thromboembolism associated with use of hormone replacement therapy in real world settings: two nested case-control studies in primary care

Hormone replacement therapy (HRT) is used to help women suffering from menopausal symptoms. Although effective, the therapy may have a rare but serious side effect – an increased risk of venous thromboembolism (VTE). Previous studies have not been... Read More about Protocol to assess risk of venous thromboembolism associated with use of hormone replacement therapy in real world settings: two nested case-control studies in primary care.