All Outputs (5)

Origin and evolution of the bread wheat D genome (2024)
Journal Article
Cavalet-Giorsa, E., González-Muñoz, A., Athiyannan, N., Holden, S., Salhi, A., Gardener, C., Quiroz-Chávez, J., Rustamova, S. M., Elkot, A. F., Patpour, M., Rasheed, A., Mao, L., Lagudah, E. S., Periyannan, S. K., Sharon, A., Himmelbach, A., Reif, J. C., Knauft, M., Mascher, M., Stein, N., …Krattinger, S. G. (2024). Origin and evolution of the bread wheat D genome. Nature, 633, 848-855. https://doi.org/10.1038/s41586-024-07808-z

Bread wheat (Triticum aestivum) is a globally dominant crop and major source of calories and proteins for the human diet. Compared with its wild ancestors, modern bread wheat shows lower genetic diversity, caused by polyploidisation, domestication an... Read More about Origin and evolution of the bread wheat D genome.

TNF-α evokes blood-brain barrier dysfunction through activation of Rho-kinase and neurokinin 1 receptor (2023)
Journal Article
Gao, X., & Bayraktutan, U. (2023). TNF-α evokes blood-brain barrier dysfunction through activation of Rho-kinase and neurokinin 1 receptor. Immunobiology, 228(5), Article 152706. https://doi.org/10.1016/j.imbio.2023.152706

Ischaemic stroke, accompanied by neuroinflammation, impairs blood–brain barrier (BBB) integrity through a complex mechanism involving activation of both RhoA/Rho kinase/myosin light chain-2 and neurokinin 1 receptor (NK1R). Using an in vitro model of... Read More about TNF-α evokes blood-brain barrier dysfunction through activation of Rho-kinase and neurokinin 1 receptor.

Substance P reversibly compromises the integrity and function of blood-brain barrier (2023)
Journal Article
Gao, X., & Bayraktutan, U. (2023). Substance P reversibly compromises the integrity and function of blood-brain barrier. Peptides, 167, Article 171048. https://doi.org/10.1016/j.peptides.2023.171048

Background
Substance P (SP) plays a role in vasodilatation and tissue integrity through its receptor, neurokinin 1 (NK1R). However, its specific effect on blood-brain barrier (BBB) remains unknown.

Methods
The impact of SP on the integrity/funct... Read More about Substance P reversibly compromises the integrity and function of blood-brain barrier.

Effects of substance P on human cerebral microvascular endothelial cell line hCMEC/D3 are mediated exclusively through a truncated NK-1 receptor and depend on cell confluence (2022)
Journal Article
Gao, X., Frakich, N., Filippini, P., Edwards, L. J., Vinkemeier, U., Gran, B., Tanasescu, R., Bayraktutan, U., Colombo, S., & Constantinescu, C. S. (2022). Effects of substance P on human cerebral microvascular endothelial cell line hCMEC/D3 are mediated exclusively through a truncated NK-1 receptor and depend on cell confluence. Neuropeptides, 95, Article 102265. https://doi.org/10.1016/j.npep.2022.102265

The neuropeptide substance P (SP) mediates pain transmission, immune modulation, vasodilation and neurogenic inflammation. Its role in the peripheral nervous system has been well characterised. However, its actions on the blood-brain barrier (BBB) ar... Read More about Effects of substance P on human cerebral microvascular endothelial cell line hCMEC/D3 are mediated exclusively through a truncated NK-1 receptor and depend on cell confluence.

Education (2021)
Book Chapter
Gao, X., & Thondhlana, J. (2021). Education. In S. Pihlaja (Ed.), Analysing Religious Discourse (179-196). Cambridge University Press