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All Outputs (14)

Morbidity and complications of diabetes mellitus in children and adolescents in Ghana: study design and rationale (2020)
Preprint / Working Paper
Essuman, V. A., Tagoe, N. N., Akpalu, J., Essuman, A., Sackey, A., Hayfron-Benjamin, C., …Amoaku, W. Morbidity and complications of diabetes mellitus in children and adolescents in Ghana: study design and rationale

Background: Diabetes is associated with premature morbidity and mortality from its many complications. There is limited data on the chronic complications of diabetes in children and adolescents in sub-Saharan Africa. Objective: The study aims t... Read More about Morbidity and complications of diabetes mellitus in children and adolescents in Ghana: study design and rationale.

Comparison of the Morphology of the Foveal Pit Between African and Caucasian Populations (2020)
Journal Article
Zouache, M. A., Silvestri, G., Amoaku, W. M., Silvestri, V., Hubbard, W. C., Pappas, C., …Hageman, G. S. (2020). Comparison of the Morphology of the Foveal Pit Between African and Caucasian Populations. Translational Vision Science & Technology, 9(5), Article 24. https://doi.org/10.1167/tvst.9.5.24

Purpose: The purpose of this study was to characterize foveal pit morphology in an African (Ghanaian) population, to compare it to that of a Caucasian group and to determine if it varied with age in the two populations. Methods: The depth, diamet... Read More about Comparison of the Morphology of the Foveal Pit Between African and Caucasian Populations.

Hypercapnia augments resistive exercise‐induced elevations in intraocular pressure in older individuals (2020)
Journal Article
Mekjavic, I. B., Amoaku, W., Mlinar, T., & Mekjavic, P. J. (2020). Hypercapnia augments resistive exercise‐induced elevations in intraocular pressure in older individuals. Experimental Physiology, 105(4), 641-651. https://doi.org/10.1113/ep088236

The present study assessed the effect of 6° head down (establishing the cephalad displacement noted in astronauts in microgravity) prone (simulating the effect on the eye) tilt during rest and exercise (simulating exercise performed by astronauts to... Read More about Hypercapnia augments resistive exercise‐induced elevations in intraocular pressure in older individuals.

Patient-reported reasons for delay in diagnosis of age-related macular degeneration: a national survey (2019)
Journal Article
Parfitt, A., Boxell, E., Amoaku, W. M., & Bradley, C. (2019). Patient-reported reasons for delay in diagnosis of age-related macular degeneration: a national survey. BMJ Open Ophthalmology, 4(1), Article e000276. https://doi.org/10.1136/bmjophth-2019-000276

© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. Objectives To investigate whether people with age-related macular degeneration (AMD) are able to self-detect... Read More about Patient-reported reasons for delay in diagnosis of age-related macular degeneration: a national survey.

Biofeedback fixation training method for improving eccentric vision in patients with loss of foveal function secondary to different maculopathies (2019)
Journal Article
Morales, M. U., Saker, S., Wilde, C., Rubinstein, M., Limoli, P., & Amoaku, W. M. (2020). Biofeedback fixation training method for improving eccentric vision in patients with loss of foveal function secondary to different maculopathies. International Ophthalmology, 40, 305–312. https://doi.org/10.1007/s10792-019-01180-y

© 2019, The Author(s). Purpose: Fixation stability (FS) of the preferred retinal locus (PRL) may be improved by biofeedback fixation training (BFT) with microperimetry. Such training can be done on the patient’s PRL or in different retinal loci with... Read More about Biofeedback fixation training method for improving eccentric vision in patients with loss of foveal function secondary to different maculopathies.

Prevalence of optic disc haemorrhages in an elderly UK Caucasian population and possible association with reticular pseudodrusen—the Bridlington Eye Assessment Project (BEAP): a cross-sectional study (2002–2006) (2018)
Journal Article
Wilde, C., Poostchi, A., Narendran, R., MacNab, H. K., Hillman, J. G., Alexander, P., …Vernon, S. A. (2019). Prevalence of optic disc haemorrhages in an elderly UK Caucasian population and possible association with reticular pseudodrusen—the Bridlington Eye Assessment Project (BEAP): a cross-sectional study (2002–2006). Eye, 33(4), 580-586. https://doi.org/10.1038/s41433-018-0263-4

Aims: To determine disc haemorrhages (DH) prevalence in an elderly UK population-the Bridlington Eye Assessment Project (BEAP). Methods: Thirty-degree (30°) fundus photographs (3549 participants ≥65 years) were graded for DH/macula changes. Glaucoma... Read More about Prevalence of optic disc haemorrhages in an elderly UK Caucasian population and possible association with reticular pseudodrusen—the Bridlington Eye Assessment Project (BEAP): a cross-sectional study (2002–2006).

Epiretinal Membrane Surgery Outcomes in Eyes with Subretinal Drusenoid Deposits: A Case Control Study (2018)
Journal Article
Wilde, C., Awad, M., Dua, H., Gandhewar, R., Chen, H., & Amoaku, W. M. (2018). Epiretinal Membrane Surgery Outcomes in Eyes with Subretinal Drusenoid Deposits: A Case Control Study. Ophthalmology Retina, 2(12), 1218-1226. https://doi.org/10.1016/j.oret.2018.06.009

© 2018 Purpose: To evaluate outcomes of epiretinal membrane (ERM) surgery in eyes with subretinal drusenoid deposits (SRDDs) and to compare them with those with isolated ERM. Design: Retrospective case-control study of consecutive patients who underw... Read More about Epiretinal Membrane Surgery Outcomes in Eyes with Subretinal Drusenoid Deposits: A Case Control Study.

Heterodimers of photoreceptor-specific nuclear receptor (PNR/NR2E3) and peroxisome proliferator-activated receptor (PPARγ) are disrupted by retinal disease-associated mutations (2017)
Journal Article
Fulton, J., Mazumder, B., Whitchurch, J., Monteiro, C. J., Collins, H. M., Chan, C. M., …Heery, D. M. (2017). Heterodimers of photoreceptor-specific nuclear receptor (PNR/NR2E3) and peroxisome proliferator-activated receptor (PPARγ) are disrupted by retinal disease-associated mutations. Cell Death and Disease, 8, Article e2677. https://doi.org/10.1038/cddis.2017.98

Photoreceptor-specific nuclear receptor (PNR/NR2E3) and Tailless homolog (TLX/NR2E1) are human orthologs of the NR2E group, a subgroup of phylogenetically related members of the Nuclear Receptor (NR) superfamily of transcription factors. We assessed... Read More about Heterodimers of photoreceptor-specific nuclear receptor (PNR/NR2E3) and peroxisome proliferator-activated receptor (PPARγ) are disrupted by retinal disease-associated mutations.

The effect of hyperglycaemia on permeability and the expression of junctional complex molecules in human retinal and choroidal endothelial cells. (2014)
Journal Article

Diabetic retinopathy is the leading cause of preventable blindness in the working population and its prevalence continues to increase as the worldwide prevalence of diabetes grows. Diabetic choroidopathy is less well studied and occurs in the late st... Read More about The effect of hyperglycaemia on permeability and the expression of junctional complex molecules in human retinal and choroidal endothelial cells..