All Outputs (4)

Antigenicity of chimeric and cyclic synthetic peptides based on nonstructural proteins of GBV-C/HGV (2005)
Journal Article
Pérez, T., Ercilla, G., Chan, W. C., & Haro, I. (2006). Antigenicity of chimeric and cyclic synthetic peptides based on nonstructural proteins of GBV-C/HGV. Journal of Peptide Science, 12(4), 267-278. https://doi.org/10.1002/psc.719

In this work, new putative epitopes located in nonstructural proteins of GBV-C/HGV were synthesized using solid-phase chemistry for their use in immunoassays. The antigens were obtained in linear, chimeric and cyclic forms with the main aim of improv... Read More about Antigenicity of chimeric and cyclic synthetic peptides based on nonstructural proteins of GBV-C/HGV.

Discovery of antagonist peptides against bacterial helicase-primase interaction in B. stearothermophilus by reverse yeast three-hybrid (2005)
Journal Article
Gardiner, L., Coyle, B. J., Chan, W. C., & Soultanas, P. (2005). Discovery of antagonist peptides against bacterial helicase-primase interaction in B. stearothermophilus by reverse yeast three-hybrid. Cell Chemistry Biology, 12(5), 595-604. https://doi.org/10.1016/j.chembiol.2005.04.007

Developing small-molecule antagonists against protein-protein interactions will provide powerful tools for mechanistic/functional studies and the discovery of new antibacterials. We have developed a reverse yeast three-hybrid approach that allows hig... Read More about Discovery of antagonist peptides against bacterial helicase-primase interaction in B. stearothermophilus by reverse yeast three-hybrid.

Modulation of pRb/E2F functions in the regulation of cell cycle and in cancer (2005)
Journal Article
Seville, L. L., Shah, N., Westwell, A. D., & Chan, W. C. (2005). Modulation of pRb/E2F functions in the regulation of cell cycle and in cancer. Current Cancer Drug Targets, 5(3), 159-170. https://doi.org/10.2174/1568009053765816

Cell proliferation is regulated by the cell cycle, and in order to divide the cell must enter a mitotic state. Prior to mitosis the cell is required to pass through a number of checkpoints, including the critical G1/S restriction point governed by th... Read More about Modulation of pRb/E2F functions in the regulation of cell cycle and in cancer.

Atomic force microscopy study of human amylin (20-29) fibrils (2005)
Journal Article
Sedman, V. L., Allen, S., Chan, W. C., Davies, M. C., Roberts, C. J., Tendler, S. J., & Williams, P. M. (2005). Atomic force microscopy study of human amylin (20-29) fibrils. Protein and Peptide Letters, 12(1), 79-83. https://doi.org/10.2174/0929866053406129

Here we present atomic force microscopy images of the fibrils formed by human amylin(20-29). This peptide is a fragment of the polypeptide amylin, the major proteinaceous component of amyloid deposits found in cases of type-II diabetes mellitus. Our... Read More about Atomic force microscopy study of human amylin (20-29) fibrils.