All Outputs (11)

The Study of Cerebrospinal Fluid microRNAs in Spinal Cord Injury and Neurodegenerative Diseases: Methodological Problems and Possible Solutions (2021)
Journal Article
Baichurina, I., Valiullin, V., James, V., Rizvanov, A., & Mukhamedshina, Y. (2021). The Study of Cerebrospinal Fluid microRNAs in Spinal Cord Injury and Neurodegenerative Diseases: Methodological Problems and Possible Solutions. International Journal of Molecular Sciences, 23(1), Article 114. https://doi.org/10.3390/ijms23010114

Despite extensive research on neurological disorders, unanswered questions remain regarding the molecular mechanisms underpinning the course of these diseases, and the search continues for effective biomarkers for early diagnosis, prognosis, or thera... Read More about The Study of Cerebrospinal Fluid microRNAs in Spinal Cord Injury and Neurodegenerative Diseases: Methodological Problems and Possible Solutions.

Distinct small non-coding RNA landscape in the axons and released extracellular vesicles of developing primary cortical neurons and the axoplasm of adult nerves (2021)
Journal Article
Mesquita-Ribeiro, R., Fort, R. S., Rathbone, A., Farias, J., Lucci, C., James, V., …Dajas-Bailador, F. (2021). Distinct small non-coding RNA landscape in the axons and released extracellular vesicles of developing primary cortical neurons and the axoplasm of adult nerves. RNA Biology, 18(sup2), 832-855. https://doi.org/10.1080/15476286.2021.2000792

Neurons have highlighted the needs for decentralized gene expression and specific RNA function in somato-dendritic and axonal compartments, as well as in intercellular communication via extracellular vesicles (EVs). Despite advances in miRNA biology,... Read More about Distinct small non-coding RNA landscape in the axons and released extracellular vesicles of developing primary cortical neurons and the axoplasm of adult nerves.

Transcriptomic Analysis of Cardiomyocyte Extracellular Vesicles in Hypertrophic Cardiomyopathy Reveals Differential snoRNA Cargo (2021)
Journal Article
James, V., Nizamudeen, Z. A., Lea, D., Dottorini, T., Holmes, T. L., Johnson, B. B., …Smith, J. G. (2021). Transcriptomic Analysis of Cardiomyocyte Extracellular Vesicles in Hypertrophic Cardiomyopathy Reveals Differential snoRNA Cargo. Stem Cells and Development, 30(24), 1215-1227. https://doi.org/10.1089/scd.2021.0202

Hypertrophic cardiomyopathy (HCM) is characterised by increased left ventricular wall thickness that can lead to devastating conditions such as heart failure and sudden cardiac death. Despite extensive study, the mechanisms mediating many of the asso... Read More about Transcriptomic Analysis of Cardiomyocyte Extracellular Vesicles in Hypertrophic Cardiomyopathy Reveals Differential snoRNA Cargo.

Comparative pathology of dog and human prostate cancer (2021)
Journal Article
Ryman-Tubb, T., Lothion-Roy, J. H., Metzler, V. M., Harris, A. E., Robinson, B. D., Rizvanov, A. A., …de Brot, S. (2022). Comparative pathology of dog and human prostate cancer. Veterinary Medicine and Science, 8(1), 110-120. https://doi.org/10.1002/vms3.642

Though relatively rare in dogs, prostate cancer (PCa) is the most common non-cutaneous cancer in men. Human and canine prostate glands share many functional, anatomical and physiological features. Due to these similarities, canine PCa has been propos... Read More about Comparative pathology of dog and human prostate cancer.

Extracellular vesicles, tumor growth, and the metastatic process (2021)
Book Chapter
Wesson, F., Brown, T. J., & James, V. (2022). Extracellular vesicles, tumor growth, and the metastatic process. In D. Heymann (Ed.), Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside (275-284). (3rd). Elsevier. https://doi.org/10.1016/B978-0-12-821666-8.00058-X

Extracellular vesicles (EVs) form an important part of cell-to-cell communication, with roles in both health and disease. Within the cancer setting, this heterogenous population of extracellular messengers can have both pro- and antitumorigenic prope... Read More about Extracellular vesicles, tumor growth, and the metastatic process.

Extracellular Vesicles and Chronic Obstructive Pulmonary Disease (COPD): A Systematic Review (2021)
Preprint / Working Paper
Gomez, N., James, V., Onion, D., & Fairclough, L. Extracellular Vesicles and Chronic Obstructive Pulmonary Disease (COPD): A Systematic Review

Background: Chronic Obstructive Pulmonary Disease (COPD) is a common inflammatory disease of the airways characterized by irreversible airflow limitation, ranking the third highest cause of death worldwide. Extracellular vesicles (EVs) are important... Read More about Extracellular Vesicles and Chronic Obstructive Pulmonary Disease (COPD): A Systematic Review.

The Role of Extracellular Vesicles in the Development of a Cancer Stem Cell Microenvironment Niche and Potential Therapeutic Targets: a systematic review (2021)
Journal Article
Brown, T. J., & James, V. (2021). The Role of Extracellular Vesicles in the Development of a Cancer Stem Cell Microenvironment Niche and Potential Therapeutic Targets: a systematic review. Cancers, 13(10), Article 2435. https://doi.org/10.3390/cancers13102435

Cancer stem cells (CSCs) have increasingly been shown to be a crucial element of heterogenous tumors. Although a relatively small component of the population, they increase the resistance to treatment and the likelihood of recurrence. In recent years... Read More about The Role of Extracellular Vesicles in the Development of a Cancer Stem Cell Microenvironment Niche and Potential Therapeutic Targets: a systematic review.

Storage stability and delivery potential of cytochalasin B induced membrane vesicles (2021)
Journal Article
Kletukhina, S. K., Neustroeva, O. A., Kurbangaleeva, S. V., Salafutdinov, I. I., Rogov, A. M., James, V., …Gomzikova, M. O. (2021). Storage stability and delivery potential of cytochalasin B induced membrane vesicles. Biotechnology Reports, 30, Article e00616. https://doi.org/10.1016/j.btre.2021.e00616

Cell-free therapies based on extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) are considered as a promising tool for stimulating regeneration and immunomodulation. The need to develop a practical approach for large-scale produc... Read More about Storage stability and delivery potential of cytochalasin B induced membrane vesicles.

Mitochondria donation by mesenchymal stem cells: current understanding and mitochondria transplantation strategies (2021)
Journal Article
Gomzikova, M., James, V., & Rizvanov, A. (2021). Mitochondria donation by mesenchymal stem cells: current understanding and mitochondria transplantation strategies. Frontiers in Cell and Developmental Biology, 9, Article 653322. https://doi.org/10.3389/fcell.2021.653322

The phenomenon of mitochondria donation is found in various tissues of humans and animals and is attracting increasing attention. To date, numerous studies have described the transfer of mitochondria from stem cells to injured cells, leading to incre... Read More about Mitochondria donation by mesenchymal stem cells: current understanding and mitochondria transplantation strategies.

Blood Serum Cytokines in Patients with Subacute Spinal Cord Injury: A Pilot Study to Search for Biomarkers of Injury Severity (2021)
Journal Article
Ogurcov, S., Shulman, I., Garanina, E., Sabirov, D., Baichurina, I., Kuznetcov, M., …Mukhamedshina, Y. (2021). Blood Serum Cytokines in Patients with Subacute Spinal Cord Injury: A Pilot Study to Search for Biomarkers of Injury Severity. Brain Sciences, 11(3), Article 322. https://doi.org/10.3390/brainsci11030322

Background: Despite considerable interest in the search for a spinal cord injury (SCI) therapy, there is a critical need to develop a panel of diagnostic biomarkers to determine injury severity. In this regard, there is a requirement for continuing r... Read More about Blood Serum Cytokines in Patients with Subacute Spinal Cord Injury: A Pilot Study to Search for Biomarkers of Injury Severity.

Cytochalasin B-Induced Membrane Vesicles from Human Mesenchymal Stem Cells Overexpressing IL2 Are Able to Stimulate CD8+ T-Killers to Kill Human Triple Negative Breast Cancer Cells (2021)
Journal Article
Chulpanova, D. S., Gilazieva, Z. E., Kletukhina, S. K., Aimaletdinov, A. M., Garanina, E. E., James, V., …Solovyeva, V. V. (2021). Cytochalasin B-Induced Membrane Vesicles from Human Mesenchymal Stem Cells Overexpressing IL2 Are Able to Stimulate CD8+ T-Killers to Kill Human Triple Negative Breast Cancer Cells. Biology, 10(2), Article 141. https://doi.org/10.3390/biology10020141

Interleukin 2 (IL2) was one of the first cytokines used for cancer treatment due to its ability to stimulate anti-cancer immunity. However, recombinant IL2-based therapy is associated with high systemic toxicity and activation of regulatory T-cells,... Read More about Cytochalasin B-Induced Membrane Vesicles from Human Mesenchymal Stem Cells Overexpressing IL2 Are Able to Stimulate CD8+ T-Killers to Kill Human Triple Negative Breast Cancer Cells.