PU.1 is a major transcriptional activator of the tumour suppressor gene LIMD1

Foxler, Daniel E.; James, Victoria; Shelton, Samuel J.; de A. Vallim, Thomas Q.; Shaw, Peter E.; Sharp, Tyson V.

doi:10.1016/j.febslet.2011.03.013

All Outputs (2)

MicroRNA-mediated gene silencing: are we close to a unifying model? (2011)
Journal Article
James, V., Wong, S. C., & Sharp, T. V. (2012). MicroRNA-mediated gene silencing: are we close to a unifying model?. BioMolecular Concepts, 3(1), 29-40. https://doi.org/10.1515/bmc.2011.047

PU.1 is a major transcriptional activator of the tumour suppressor gene LIMD1 (2011)
Journal Article
Foxler, D. E., James, V., Shelton, S. J., de A. Vallim, T. Q., Shaw, P. E., & Sharp, T. V. (2011). PU.1 is a major transcriptional activator of the tumour suppressor gene LIMD1. FEBS Letters, 585(7), 1089-1096. https://doi.org/10.1016/j.febslet.2011.03.013

LIMD1 is a tumour suppressor gene (TSG) down regulated in ∼80% of lung cancers with loss also demonstrated in breast and head and neck squamous cell carcinomas. LIMD1 is also a candidate TSG in childhood acute lymphoblastic leukaemia. Mechanistically... Read More about PU.1 is a major transcriptional activator of the tumour suppressor gene LIMD1.