Knockdown of microRNA-21 Inhibits Proliferation and Increases Cell Death by Targeting Programmed Cell Death 4 (PDCD4) in Pancreatic Ductal Adenocarcinoma
(2010)
Journal Article
Bhatti, I., Lee, A., James, V., Hall, R. I., Lund, J. N., Tufarelli, C., …Larvin, M. (2011). Knockdown of microRNA-21 Inhibits Proliferation and Increases Cell Death by Targeting Programmed Cell Death 4 (PDCD4) in Pancreatic Ductal Adenocarcinoma. Journal of Gastrointestinal Surgery, 15(1), 199-208. https://doi.org/10.1007/s11605-010-1381-x
All Outputs (48)
LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing (2010)
Journal Article
James, V., Zhang, Y., Foxler, D. E., de Moor, C. H., Kong, Y. W., Webb, T. M., …Sharp, T. V. (2010). LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing. Proceedings of the National Academy of Sciences, 107(28), 12499-12504. https://doi.org/10.1073/pnas.0914987107In recent years there have been major advances with respect to the identification of the protein components and mechanisms of microRNA (miRNA) mediated silencing. However, the complete and precise repertoire of components and mechanism(s) of action r... Read More about LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing.
Stoichiometric imbalance in the receptor complex contributes to dysfunctional BMPR-II mediated signalling in pulmonary arterial hypertension (2008)
Journal Article
Nasim, M. T., Ghouri, A., Patel, B., James, V., Rudarakanchana, N., Morrell, N. W., & Trembath, R. C. (2008). Stoichiometric imbalance in the receptor complex contributes to dysfunctional BMPR-II mediated signalling in pulmonary arterial hypertension. Human Molecular Genetics, 17(11), 1683-1694. https://doi.org/10.1093/hmg/ddn059
Characterization of theBMPR25′-Untranslated Region and a Novel Mutation in Pulmonary Hypertension (2007)
Journal Article
Aldred, M. A., Machado, R. D., James, V., Morrell, N. W., & Trembath, R. C. (2007). Characterization of theBMPR25′-Untranslated Region and a Novel Mutation in Pulmonary Hypertension. American Journal of Respiratory and Critical Care Medicine, 176(8), 819-824. doi:10.1164/rccm.200701-164oc
Serotonin Increases Susceptibility to Pulmonary Hypertension in BMPR2 -Deficient Mice (2006)
Journal Article
Long, L., MacLean, M. R., Jeffery, T. K., Morecroft, I., Yang, X., Rudarakanchana, N., …Morrell, N. W. (2006). Serotonin Increases Susceptibility to Pulmonary Hypertension in BMPR2 -Deficient Mice. Circulation Research, 98(6), 818-827. doi:10.1161/01.res.0000215809.47923.fd
Mutations of the TGF-β type II receptor BMPR2 in pulmonary arterial hypertension (2006)
Journal Article
Machado, R. D., Aldred, M. A., James, V., Harrison, R. E., Patel, B., Schwalbe, E. C., …Trembath, R. C. (2006). Mutations of the TGF-β type II receptor BMPR2 in pulmonary arterial hypertension. Human Mutation, 27(2), 121-132. https://doi.org/10.1002/humu.20285Pulmonary arterial hypertension (PAH) is clinically characterized by a sustained elevation in mean pulmonary artery pressure leading to significant morbidity and mortality. The disorder is typically sporadic, and in such cases the term idiopathic PAH... Read More about Mutations of the TGF-β type II receptor BMPR2 in pulmonary arterial hypertension.
BMPR2 gene rearrangements account for a significant proportion of mutations in familial and idiopathic pulmonary arterial hypertension (2006)
Journal Article
Aldred, M. A., Vijayakrishnan, J., James, V., Soubrier, F., Gomez-Sanchez, M. A., Martensson, G., …Trembath, R. C. (2006). BMPR2 gene rearrangements account for a significant proportion of mutations in familial and idiopathic pulmonary arterial hypertension. Human Mutation, 27(2), 212-213. https://doi.org/10.1002/humu.9398
Investigation of Second Genetic Hits at the BMPR2 Locus as a Modulator of Disease Progression in Familial Pulmonary Arterial Hypertension (2005)
Journal Article
Machado, R. D., James, V., Southwood, M., Harrison, R. E., Atkinson, C., Stewart, S., …Aldred, M. A. (2005). Investigation of Second Genetic Hits at the BMPR2 Locus as a Modulator of Disease Progression in Familial Pulmonary Arterial Hypertension. Circulation, 111(5), 607-613. doi:10.1161/01.cir.0000154543.07679.08