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All Outputs (40)

Pilot and quantitative evaluation of the TARGET acne toolkit by UK pharmacy professionals working in general practice (2024)
Journal Article
Sonnex, K., Thornley, T., Fleming, N., Lakha, A., Lecky, D. M., Pillay, I., …Boyd, M. (2024). Pilot and quantitative evaluation of the TARGET acne toolkit by UK pharmacy professionals working in general practice. BMJ Open, 14(7), Article e081641. https://doi.org/10.1136/bmjopen-2023-081641

Background: Acne vulgaris (acne) is a common skin condition sometimes needing topical or oral antibiotic treatment. Pharmacists and pharmacy technicians (together known as pharmacy professionals) working in general practice are well placed to ensure... Read More about Pilot and quantitative evaluation of the TARGET acne toolkit by UK pharmacy professionals working in general practice.

A large-scale and PCR-referenced vocal audio dataset for COVID-19 (2024)
Journal Article
Budd, J., Baker, K., Karoune, E., Coppock, H., Patel, S., Payne, R., …Holmes, C. (2024). A large-scale and PCR-referenced vocal audio dataset for COVID-19. Scientific Data, 11, Article 700. https://doi.org/10.1038/s41597-024-03492-w

The UK COVID-19 Vocal Audio Dataset is designed for the training and evaluation of machine learning models that classify SARS-CoV-2 infection status or associated respiratory symptoms using vocal audio. The UK Health Security Agency recruited volunta... Read More about A large-scale and PCR-referenced vocal audio dataset for COVID-19.

Estimating the prevalence of potential and actionable drug‐gene interactions in Irish primary care: A cross‐sectional study (2024)
Journal Article
Johnson, L., Youssef, E., O'Shea, J., Thornley, T., Gallagher, J., Ledwidge, M., & Ryan, C. (2024). Estimating the prevalence of potential and actionable drug‐gene interactions in Irish primary care: A cross‐sectional study. British Journal of Clinical Pharmacology, https://doi.org/10.1111/bcp.16122

Aims: Pharmacogenetics (PGx) is increasingly recognized as a strategy for medicines optimisation and prevention of adverse drug reactions. According to guidelines produced by the Clinical Pharmacogenetics Implementation Consortium (CPIC) and the Dutc... Read More about Estimating the prevalence of potential and actionable drug‐gene interactions in Irish primary care: A cross‐sectional study.

Evaluating the role of primary care pharmacy technicians in antimicrobial stewardship (AMS) and acne management using TARGET resources (2024)
Journal Article
Lakha, A., Fleming, N., Sonnex, K., Thornley, T., Anderson, C., Hand, . K., & Ashiru-Oredope, D. (2024). Evaluating the role of primary care pharmacy technicians in antimicrobial stewardship (AMS) and acne management using TARGET resources. JAC-Antimicrobial Resistance, 6(1), Article dlae011. https://doi.org/10.1093/jacamr/dlae011

Background: Inappropriate antibiotic prescribing is accelerating antimicrobial resistance (AMR) (Antibiotic resistant infections and associated deaths increase https://www.gov.uk/government/news/antibiotic-resistant-infections-And-Associated-deaths-i... Read More about Evaluating the role of primary care pharmacy technicians in antimicrobial stewardship (AMS) and acne management using TARGET resources.

Audio-based AI classifiers show no evidence of improved COVID-19 screening over simple symptoms checkers (2024)
Journal Article
Coppock, H., Nicholson, G., Kiskin, I., Koutra, V., Baker, K., Budd, J., …Holmes, C. (2024). Audio-based AI classifiers show no evidence of improved COVID-19 screening over simple symptoms checkers. Nature Machine Intelligence, 6, 229-242. https://doi.org/10.1038/s42256-023-00773-8

Recent work has reported that respiratory audio-trained AI classifiers can accurately predict SARS-CoV-2 infection status. However, it has not yet been determined whether such model performance is driven by latent audio biomarkers with true causal li... Read More about Audio-based AI classifiers show no evidence of improved COVID-19 screening over simple symptoms checkers.

Perceived current and future roles of UK-based community pharmacy professionals in the long-term management of acne (2023)
Journal Article
Sonnex, K., Thornley, T., Fleming, N., Lakha, A., Lecky, D. M., Pillay, I., …Ashiru-Oredope, D. (2023). Perceived current and future roles of UK-based community pharmacy professionals in the long-term management of acne. Exploratory Research in Clinical and Social Pharmacy, 11, Article 100310. https://doi.org/10.1016/j.rcsop.2023.100310

Introduction: Acne is a common skin condition treated in community pharmacy but moderate to severe cases may need referral to general practice for treatment that may include topical or oral antimicrobial treatments. Pharmacy teams working in the comm... Read More about Perceived current and future roles of UK-based community pharmacy professionals in the long-term management of acne.

What affected UK adults’ adherence to medicines during the COVID-19 pandemic? Cross-sectional survey in a representative sample of people with long-term conditions (2023)
Journal Article
Penner, L. S., Armitage, C. J., Thornley, T., Whelan, P., Chuter, A., Allen, T., & Elliott, R. A. (2024). What affected UK adults’ adherence to medicines during the COVID-19 pandemic? Cross-sectional survey in a representative sample of people with long-term conditions. Journal of Public Health, 32(2), 325-338. https://doi.org/10.1007/s10389-022-01813-0

Aim Medicines non-adherence is associated with poorer outcomes and higher costs. COVID-19 affected access to healthcare, with increased reliance on remote methods, including medicines supply. This study aimed to identify what affected people’s adher... Read More about What affected UK adults’ adherence to medicines during the COVID-19 pandemic? Cross-sectional survey in a representative sample of people with long-term conditions.

Mixed-Method Evaluation of a Community Pharmacy Antimicrobial Stewardship Intervention (PAMSI) (2022)
Journal Article
Hayes, C. V., Lecky, D. M., Pursey, F., Thomas, A., Ashiru-Oredope, D., Saei, A., …McNulty, C. A. M. (2022). Mixed-Method Evaluation of a Community Pharmacy Antimicrobial Stewardship Intervention (PAMSI). Healthcare, 10(7), Article 1288. https://doi.org/10.3390/healthcare10071288

The community pharmacy antimicrobial stewardship intervention (PAMSI) is multi-faceted and underpinned by behavioural science, consisting of the TARGET Antibiotic Checklist, staff e-Learning, and patient-facing materials. This mixed-method study eval... Read More about Mixed-Method Evaluation of a Community Pharmacy Antimicrobial Stewardship Intervention (PAMSI).

Pharmacogenetics: optimising prescribing in primary care (2022)
Journal Article
Youssef, E., Thornley, T., Guchelaar, H., & Wright, D. J. (2022). Pharmacogenetics: optimising prescribing in primary care. Prescriber, 33(5), 10-13. https://doi.org/10.1002/psb.1982

Pharmacogenetic (PGx) testing to personalise prescribing of certain medicines can improve patient outcomes and reduce adverse drug reactions. This article summarises the key findings of the PGx Impact study, designed to estimate the impact of pre-emp... Read More about Pharmacogenetics: optimising prescribing in primary care.

Implementation of a Pharmacogenomic Testing Service through Community Pharmacy in the Netherlands: Results from an Early Service Evaluation (2021)
Journal Article
Thornley, T., Esquivel, B., Wright, D. J., van den Dop, H., Kirkdale, C. L., & Youssef, E. (2021). Implementation of a Pharmacogenomic Testing Service through Community Pharmacy in the Netherlands: Results from an Early Service Evaluation. Pharmacy, 9(1), Article 38. https://doi.org/10.3390/pharmacy9010038

Community pharmacy services have evolved to include medical and pharmaceutical interventions alongside dispensing. While established pharmacogenomic (PGx) testing is available throughout the Netherlands, this is primarily based in hospital environmen... Read More about Implementation of a Pharmacogenomic Testing Service through Community Pharmacy in the Netherlands: Results from an Early Service Evaluation.

Estimating the potential impact of implementing pre-emptive pharmacogenetic testing in primary care across the UK (2021)
Journal Article
Youssef, E., Kirkdale, C. L., Wright, D. J., Guchelaar, H. J., & Thornley, T. (2021). Estimating the potential impact of implementing pre-emptive pharmacogenetic testing in primary care across the UK. British Journal of Clinical Pharmacology, 87(7), 2907-2925. https://doi.org/10.1111/bcp.14704

Aims: Pharmacogenetics (PGx) in the UK is currently implemented in secondary care for a small group of high-risk medicines. However, most prescribing takes place in primary care, with a large group of medicines influenced by commonly occurring geneti... Read More about Estimating the potential impact of implementing pre-emptive pharmacogenetic testing in primary care across the UK.

Accessing Mole-Scanning through Community Pharmacy: A Pilot Service in Collaboration with Dermatology Specialists (2020)
Journal Article
Kirkdale, C. L., Archer, Z., Thornley, T., Wright, D., Valeur, M., Gourlay, N., & Ayerst, K. (2020). Accessing Mole-Scanning through Community Pharmacy: A Pilot Service in Collaboration with Dermatology Specialists. Pharmacy, 8(4), Article 231. https://doi.org/10.3390/pharmacy8040231

Early identification and treatment of malignant melanoma is crucial to prevent mortality. The aim of this work was to describe the uptake, profile of users and service outcomes of a mole scanning service in the community pharmacy setting in the UK. I... Read More about Accessing Mole-Scanning through Community Pharmacy: A Pilot Service in Collaboration with Dermatology Specialists.

Feasibility of a community pharmacy antimicrobial stewardship intervention (PAMSI): An innovative approach to improve patients' understanding of their antibiotics (2020)
Journal Article
Allison, R., Chapman, S., Howard, P., Thornley, T., Ashiru-Oredope, D., Walker, S., …McNulty, C. A. (2020). Feasibility of a community pharmacy antimicrobial stewardship intervention (PAMSI): An innovative approach to improve patients' understanding of their antibiotics. JAC-Antimicrobial Resistance, 2(4), Article dlaa089. https://doi.org/10.1093/jacamr/dlaa089

Background: Community pharmacy staff have an opportunity to play a pivotal role in antimicrobial stewardship (AMS) due to their expertise in medicines and accessibility to patients. Objectives: To develop and test the feasibility of a pharmacy AMS in... Read More about Feasibility of a community pharmacy antimicrobial stewardship intervention (PAMSI): An innovative approach to improve patients' understanding of their antibiotics.

Over-The-Counter Codeine: Can Community Pharmacy Staff Nudge Customers into Its Safe and Appropriate Use? (2020)
Journal Article
Mody, S., Kirkdale, C. L., Thornley, T., Dickinson, A., Avery, A. J., Knaggs, R., …Bastable, R. (2020). Over-The-Counter Codeine: Can Community Pharmacy Staff Nudge Customers into Its Safe and Appropriate Use?. Pharmacy, 8(4), Article 185. https://doi.org/10.3390/pharmacy8040185

The misuse of opioids, including codeine which is sold over-the-counter (OTC) in United Kingdom (UK) community pharmacies, is a growing public health concern. An educational Patient Safety Card was developed and piloted to see if it nudged customers... Read More about Over-The-Counter Codeine: Can Community Pharmacy Staff Nudge Customers into Its Safe and Appropriate Use?.

Exploring barriers to the sustainability of an electronic administration system in long-term care facilities: A case study approach (2020)
Journal Article
Karsan, Y., Anderson, C., Boyd, M. J., & Thornley, T. (2020). Exploring barriers to the sustainability of an electronic administration system in long-term care facilities: A case study approach. Research in Social and Administrative Pharmacy, 17(6), 1066-1071. https://doi.org/10.1016/j.sapharm.2020.08.003

Background: The safe provision of medicines administration is a fundamental challenge faced in long-term care facilities (LTCFs). Many residents of LTCFs are frail older persons with multiple morbidities, and in addition to polypharmacy, are particul... Read More about Exploring barriers to the sustainability of an electronic administration system in long-term care facilities: A case study approach.

Improving Management of Respiratory Tract Infections in Community Pharmacies and Promoting Antimicrobial Stewardship: A Cluster Randomised Control Trial with a Self-Report Behavioural Questionnaire and Process Evaluation (2020)
Journal Article
Ashiru-Oredope, D., Doble, A., Thornley, T., Saei, A., Gold, N., Sallis, A., …Klinger, C. (2020). Improving Management of Respiratory Tract Infections in Community Pharmacies and Promoting Antimicrobial Stewardship: A Cluster Randomised Control Trial with a Self-Report Behavioural Questionnaire and Process Evaluation. Pharmacy, 8(1), Article 44. https://doi.org/10.3390/pharmacy8010044

In England, 81% of all antibiotic prescriptions originate in primary care/community settings, of which up to 20% are thought to be inappropriate. Community pharmacies are often the first point of community contact for patients with suspected infectio... Read More about Improving Management of Respiratory Tract Infections in Community Pharmacies and Promoting Antimicrobial Stewardship: A Cluster Randomised Control Trial with a Self-Report Behavioural Questionnaire and Process Evaluation.

Evaluation of a community pharmacy-led test-and-treat service for women with uncomplicated lower urinary tract infection in England (2020)
Journal Article
Thornley, T., Kirkdale, C. L., Beech, E., Howard, P., & Wilson, P. (2020). Evaluation of a community pharmacy-led test-and-treat service for women with uncomplicated lower urinary tract infection in England. JAC-Antimicrobial Resistance, 2(1), Article dlaa010. https://doi.org/10.1093/jacamr/dlaa010

Background: Uncomplicated lower urinary tract infections (UTIs) are common in women consulting primary healthcare, taking up GP resources. Delayed consultation can increase the risk of serious infections such as pyelonephritis or bacteraemia. Objecti... Read More about Evaluation of a community pharmacy-led test-and-treat service for women with uncomplicated lower urinary tract infection in England.

Antimicrobial use in UK long-term care facilities: Results of a point prevalence survey (2019)
Journal Article
Thornley, T., Ashiru-Oredope, D., Beech, E., Howard, P., Kirkdale, C. L., Elliott, H., …Roberts, A. (2019). Antimicrobial use in UK long-term care facilities: Results of a point prevalence survey. Journal of Antimicrobial Chemotherapy, 74(7), 2083-2090. https://doi.org/10.1093/jac/dkz135

Background: The majority of people in long-term care facilities (LTCFs) are aged 65 years and older, and most of their care needs are provided by the LTCF staff. Provision of healthcare services for residents in LTCFs is variable and can result in di... Read More about Antimicrobial use in UK long-term care facilities: Results of a point prevalence survey.

Diabetes Screening Through Community Pharmacies in England: A Cost-Effectiveness Study (2019)
Journal Article
Wright, D., Little, R., Turner, D., & Thornley, T. (2019). Diabetes Screening Through Community Pharmacies in England: A Cost-Effectiveness Study. Pharmacy, 7(1), Article 30. https://doi.org/10.3390/pharmacy7010030

Community pharmacies are commonly used to screen for patients with diabetes. The aim of this paper is to estimate the cost per test and cost per appropriately referred patient from a pharmacy perspective using a one-year decision tree model. One-way... Read More about Diabetes Screening Through Community Pharmacies in England: A Cost-Effectiveness Study.