All Outputs (2)

Resistance mutations define specific antiviral effects for inhibitors of the hepatitis C virus p7 ion channel (2011)
Journal Article
Foster, T. L., Verow, M., Wozniak, A. L., Bentham, M. J., Thompson, J., Atkins, E., …Griffin, S. (2011). Resistance mutations define specific antiviral effects for inhibitors of the hepatitis C virus p7 ion channel. Hepatology, 54(1), 79-90. https://doi.org/10.1002/hep.24371

The hepatitis C virus (HCV) p7 ion channel plays a critical role during infectious virus production and represents an important new therapeutic target. Its activity is blocked by structurally distinct classes of small molecules, with sensitivity vary... Read More about Resistance mutations define specific antiviral effects for inhibitors of the hepatitis C virus p7 ion channel.

Cyclophilin A interacts with domain II of hepatitis C virus NS5A and stimulates RNA binding in an isomerase-dependent manner (2011)
Journal Article
Foster, T. L., Gallay, P., Stonehouse, N. J., & Harris, M. (2011). Cyclophilin A interacts with domain II of hepatitis C virus NS5A and stimulates RNA binding in an isomerase-dependent manner. Journal of Virology, 85(14), 7460-7464. https://doi.org/10.1128/jvi.00393-11

NS5A plays a critical, yet poorly defined, role in hepatitis C virus genome replication. The protein consists of three domains, each of which is able to bind independently to the 3′ untranslated region (UTR) of the viral positive strand genomic RNA.... Read More about Cyclophilin A interacts with domain II of hepatitis C virus NS5A and stimulates RNA binding in an isomerase-dependent manner.