All Outputs (71)

Risk of Suicide After Dementia Diagnosis (2022)
Journal Article
Alothman, D., Card, T., Lewis, S., Tyrrell, E., Fogarty, A. W., & Marshall, C. R. (2022). Risk of Suicide After Dementia Diagnosis. JAMA Neurology, 79(11), 1148-1154. https://doi.org/10.1001/jamaneurol.2022.3094

Importance: Patients with dementia may be at an increased suicide risk. Identifying groups at greatest risk of suicide would support targeted risk reduction efforts by clinical dementia services. Objectives: To examine the association between a d... Read More about Risk of Suicide After Dementia Diagnosis.

Incidence, prevalence and survival in patients with Langerhans cell histiocytosis: A national registry study from England, 2013–2019 (2022)
Journal Article
Liu, H., Stiller, C. A., Crooks, C. J., Rous, B., Bythell, M., Broggio, J., …West, J. (2022). Incidence, prevalence and survival in patients with Langerhans cell histiocytosis: A national registry study from England, 2013–2019. British Journal of Haematology, 199(5), 728-738. https://doi.org/10.1111/bjh.18459

This analysis is the largest population-based study to date to provide contemporary and comprehensive epidemiological estimates of all third edition of the International Classification of Diseases for Oncology (ICD-O-3) coded Langerhans cell histiocy... Read More about Incidence, prevalence and survival in patients with Langerhans cell histiocytosis: A national registry study from England, 2013–2019.

Is vaccination against COVID-19 associated with autoimmune rheumatic disease flare? A self-controlled case series analysis (2022)
Journal Article
Nakafero, G., Grainge, M. J., Card, T., Mallen, C. D., Nguyen Van-Tam, J. S., Williams, H. C., & Abhishek, A. (2023). Is vaccination against COVID-19 associated with autoimmune rheumatic disease flare? A self-controlled case series analysis. Rheumatology, 62(4), 1445-1450. https://doi.org/10.1093/rheumatology/keac484

OBJECTIVES: To investigate the association between vaccination against coronavirus disease 2019 (COVID-19) and autoimmune rheumatic disease (AIRD) flare. MATERIAL AND METHODS: Patients with AIRDs vaccinated against COVID-19 who consulted for dise... Read More about Is vaccination against COVID-19 associated with autoimmune rheumatic disease flare? A self-controlled case series analysis.

Predicting Need for Escalation of Care or Death From Repeated Daily Clinical Observations and Laboratory Results in Patients With Severe Acute Respiratory Syndrome Coronavirus 2 (2022)
Journal Article
Crooks, C. J., West, J., Fogarty, A., Morling, J. R., Grainge, M. J., Gonem, S., …Card, T. R. (2022). Predicting Need for Escalation of Care or Death From Repeated Daily Clinical Observations and Laboratory Results in Patients With Severe Acute Respiratory Syndrome Coronavirus 2. American Journal of Epidemiology, 191(11), 1944-1953. https://doi.org/10.1093/aje/kwac126

We compared the performance of prognostic tools for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using parameters fitted either at the time of hospital admission or across all time points of an admission. This cohort study used clinic... Read More about Predicting Need for Escalation of Care or Death From Repeated Daily Clinical Observations and Laboratory Results in Patients With Severe Acute Respiratory Syndrome Coronavirus 2.

Incidence and pattern of mycophenolate discontinuation associated with abnormal monitoring blood-test results: cohort study using data from the Clinical Practice Research Datalink Aurum (2022)
Journal Article
Nakafero, G., Grainge, M. J., Card, T., Mallen, C. D., Riley, R., Van Der Windt, D., …Abhishek, A. (2022). Incidence and pattern of mycophenolate discontinuation associated with abnormal monitoring blood-test results: cohort study using data from the Clinical Practice Research Datalink Aurum. Rheumatology Advances in Practice, 6(2), Article rkac046. https://doi.org/10.1093/rap/rkac046

Objective: The aim was to examine the incidence and pattern of MMF discontinuation associated with abnormal monitoring blood-test results. Methods: Data from people prescribed MMF for common inflammatory conditions in the Clinical Practice Research D... Read More about Incidence and pattern of mycophenolate discontinuation associated with abnormal monitoring blood-test results: cohort study using data from the Clinical Practice Research Datalink Aurum.

The risk of unexpected hospital admissions and primary care visits after an elective day-case gastroscopy: A cohort study within England (2022)
Journal Article
Crooks, C. J., Card, T. R., & West, J. (2022). The risk of unexpected hospital admissions and primary care visits after an elective day-case gastroscopy: A cohort study within England. Alimentary Pharmacology and Therapeutics, 56(1), 56-66. https://doi.org/10.1111/apt.16946

Aim: To determine the excess of acute medical contacts following a day-case diagnostic gastroscopy. Methods: Cohort study using English linked primary, secondary care and death registry electronic health data. We included 277,535 diagnostic day-case... Read More about The risk of unexpected hospital admissions and primary care visits after an elective day-case gastroscopy: A cohort study within England.

Risk of mortality from suicide in patients with Huntington’s disease is increased compared to the general population in England (2022)
Journal Article
Alothman, D., Marshall, C. R., Tyrrell, E., Lewis, S., Card, T., & Fogarty, A. (2022). Risk of mortality from suicide in patients with Huntington’s disease is increased compared to the general population in England. Journal of Neurology, 269, 4436–4439. https://doi.org/10.1007/s00415-022-11085-z

Objective: To examine the relative risk of suicide mortality in patients with Huntington’s disease (HD). Methods: A case–control study design was used. We used linked electronic records from primary care, secondary care and Office for National Statis... Read More about Risk of mortality from suicide in patients with Huntington’s disease is increased compared to the general population in England.

Incidence and survival of haemophagocytic lymphohistiocytosis: A population‐based cohort study from England (2021)
Journal Article
West, J., Card, T. R., Bishton, M. J., Lanyon, P., Ban, L., Bythell, M., …Crooks, C. J. (2022). Incidence and survival of haemophagocytic lymphohistiocytosis: A population‐based cohort study from England. Journal of Internal Medicine, 291(4), 493-504. https://doi.org/10.1111/joim.13432

Background: Haemophagocytic lymphohistiocytosis (HLH) is a rare hyper-inflammatory condition with poor outcomes. Objectives: Few population-based estimates of the incidence and survival in adults exist. We aimed to provide these data for England. Met... Read More about Incidence and survival of haemophagocytic lymphohistiocytosis: A population‐based cohort study from England.

Ethnicity and suicide risk: A population-based study from England (2021)
Journal Article
Alothman, D., Fogarty, A., Tyrrell, E., Lewis, S., & Card, T. (2022). Ethnicity and suicide risk: A population-based study from England. Journal of Affective Disorders, 298(Part A), 555-557. https://doi.org/10.1016/j.jad.2021.11.044

Using multiple linked electronic health databases, we conducted a large case-control study in England from 2001 through 2019 to examine the association between ethnicity and suicide risk. Asian, Black and Other ethnic groups had a significantly lower... Read More about Ethnicity and suicide risk: A population-based study from England.

Development and validation of a prognostic model for leflunomide discontinuation with abnormal blood tests during long-term treatment: cohort study using data from the Clinical Practice Research Datalink Gold and Aurum (2021)
Journal Article
Nakafero, G., Grainge, M. J., Card, T., Taal, M. W., Aithal, G. P., Zhang, W., …Abhishek, A. (2022). Development and validation of a prognostic model for leflunomide discontinuation with abnormal blood tests during long-term treatment: cohort study using data from the Clinical Practice Research Datalink Gold and Aurum. Rheumatology, 61(7), 2783-2791. https://doi.org/10.1093/rheumatology/keab790

OBJECTIVE: To develop and validate a prognostic model for LEF discontinuation with abnormal blood test results. METHODS: Data from the Clinical Practice Research Datalink Gold and Aurum were used for model development and external validation, respect... Read More about Development and validation of a prognostic model for leflunomide discontinuation with abnormal blood tests during long-term treatment: cohort study using data from the Clinical Practice Research Datalink Gold and Aurum.

Chest Radiograph Scoring Alone or Combined with Other Risk Scores for Predicting Outcomes in COVID-19 (2021)
Journal Article
Au-Yong, I., Higashi, Y., Giannotti, E., Fogarty, A., Morling, J. R., Grainge, M., …Card, T. (2022). Chest Radiograph Scoring Alone or Combined with Other Risk Scores for Predicting Outcomes in COVID-19. Radiology, 302(2), 460-469. https://doi.org/10.1148/radiol.2021210986

Background Radiographic severity may help predict patient deterioration and outcomes from COVID-19 pneumonia. Purpose To assess the reliability and reproducibility of three chest radiograph reporting systems (radiographic assessment of lung edema [RA... Read More about Chest Radiograph Scoring Alone or Combined with Other Risk Scores for Predicting Outcomes in COVID-19.

Characterizing the risk interplay between alcohol intake and body mass index on cirrhosis morbidity (2021)
Journal Article
Innes, H., Crooks, C. J., Aspinall, E., Card, T. R., Hamill, V., Dillon, J., …Morling, J. R. (2022). Characterizing the risk interplay between alcohol intake and body mass index on cirrhosis morbidity. Hepatology, 75(2), 369-378. https://doi.org/10.1002/hep.32123

Background and Aims: It is thought that alcohol intake and body mass index (BMI) interact supra-additively to modulate the risk of cirrhosis, but evidence for this phenomenon is limited. We investigated the interrelationship between alcohol and BMI o... Read More about Characterizing the risk interplay between alcohol intake and body mass index on cirrhosis morbidity.

What is the incidence of methotrexate or leflunomide discontinuation related to cytopenia, liver enzyme elevation or kidney function decline? (2021)
Journal Article
Nakafero, G., Grainge, M. J., Card, T., Mallen, C. D., Zhang, W., Doherty, M., …Abhishek, A. (2021). What is the incidence of methotrexate or leflunomide discontinuation related to cytopenia, liver enzyme elevation or kidney function decline?. Rheumatology, 60(12), 5785-5794. https://doi.org/10.1093/rheumatology/keab254

Objectives: To examine incidence of treatment changes due to abnormal blood-test results and, to explore rates of treatment changes due to liver, kidney and haematological blood-test abnormalities in autoimmune rheumatic diseases (AIRD) treated with... Read More about What is the incidence of methotrexate or leflunomide discontinuation related to cytopenia, liver enzyme elevation or kidney function decline?.

Acceptability of chronic liver disease screening in a UK primary care setting: a qualitative evaluation (2020)
Journal Article
Knight, H., Harman, D., Morling, J. R., Aithal, G., Card, T., Guha, I. N., & Bains, M. (2020). Acceptability of chronic liver disease screening in a UK primary care setting: a qualitative evaluation. BMJ Open, 10(11), Article e041574. https://doi.org/10.1136/bmjopen-2020-041574

© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. OBJECTIVES: The increasing incidence of chronic liver disease (CLD) in the UK may be attributed to a rise in... Read More about Acceptability of chronic liver disease screening in a UK primary care setting: a qualitative evaluation.

Disease activity in inflammatory bowel disease is associated with arterial vascular disease (2020)
Journal Article
Card, T. R., Zittan, E., Nguyen, G. C., & Grainge, M. J. (2021). Disease activity in inflammatory bowel disease is associated with arterial vascular disease. Inflammatory Bowel Diseases, 27(5), 629–638. https://doi.org/10.1093/ibd/izaa156

Background and Aims: There is evidence that several inflammatory diseases are associated with increased cardiovascular risk. Whether this is true for inflammatory bowel diseases remains controversial. We aimed to assess this risk corrected for the ef... Read More about Disease activity in inflammatory bowel disease is associated with arterial vascular disease.

Incidence, prevalence and mortality of autoimmune hepatitis in England 1997-2015. A population-based cohort study (2020)
Journal Article
Grønbæk, L., Otete, H., Ban, L., Crooks, C., Card, T., Jepsen, P., & West, J. (2020). Incidence, prevalence and mortality of autoimmune hepatitis in England 1997-2015. A population-based cohort study. Liver International, 40(7), 1634-1644. https://doi.org/10.1111/liv.14480

© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd Background & Aims: There are few population-based studies of the incidence and mortality of autoimmune hepatitis. The burden of the disease and how it has changed over time have not... Read More about Incidence, prevalence and mortality of autoimmune hepatitis in England 1997-2015. A population-based cohort study.

Use of rapid reading software to reduce capsule endoscopy reading times while maintaining accuracy (2020)
Journal Article
Beg, S., Wronska, E., Araujo, I., González Suárez, B., Ivanova, E., Fedorov, E., …Ragunath, K. (2020). Use of rapid reading software to reduce capsule endoscopy reading times while maintaining accuracy. Gastrointestinal Endoscopy, 91(6), 1322-1327. https://doi.org/10.1016/j.gie.2020.01.026

Backgrounds and aims: A typical capsule endoscopy (CE) case generates tens of thousands of images, with abnormalities often confined to a just few frames. Omni Mode is a novel EndoCapsule software algorithm (Olympus, Tokyo, Japan) that proposes to... Read More about Use of rapid reading software to reduce capsule endoscopy reading times while maintaining accuracy.

Diagnosing dysplasia in Barrett’s oesophagus still requires Seattle protocol biopsy in the era of modern video endoscopy: results from a tertiary centre Barrett’s dysplasia database. (2019)
Journal Article
Nachiappan, A., Ragunath, K., Card, T., & Kaye, P. (2019). Diagnosing dysplasia in Barrett’s oesophagus still requires Seattle protocol biopsy in the era of modern video endoscopy: results from a tertiary centre Barrett’s dysplasia database. Scandinavian Journal of Gastroenterology, 55(1), 9-13. https://doi.org/10.1080/00365521.2019.1706762

Objectives: The role of random, four-quadrant biopsy (i.e. systematic biopsy) in Barrett’s oesophagus surveillance has been questioned given its drawbacks and the emergence of high-resolution endoscopy and advanced imaging modalities. Our study aims... Read More about Diagnosing dysplasia in Barrett’s oesophagus still requires Seattle protocol biopsy in the era of modern video endoscopy: results from a tertiary centre Barrett’s dysplasia database..

Vedolizumab use is not associated with increased malignancy incidence: GEMINI LTS study results and post-marketing data (2019)
Journal Article
Card, T., Ungaro, R., Bhayat, F., Blake, A., Hantsbarger, G., & Travis, S. (2020). Vedolizumab use is not associated with increased malignancy incidence: GEMINI LTS study results and post-marketing data. Alimentary Pharmacology and Therapeutics, 51(1), 149-157. https://doi.org/10.1111/apt.15538

© 2019 John Wiley & Sons Ltd Background: Vedolizumab is a gut-selective antibody to α4β7integrin approved to treat moderate-to-severe Crohn's disease and ulcerative colitis in adults. Inflammatory bowel disease (IBD) and immunosuppressant use are a... Read More about Vedolizumab use is not associated with increased malignancy incidence: GEMINI LTS study results and post-marketing data.

Diagnosis of Barrett’s esophagus and Esophageal Varices using a Magnetically Assisted Capsule Endoscopy system (2019)
Journal Article
Beg, S., Card, T., Warburton, S., Rahman, I., Wilkes, E., White, J., & Ragunath, K. (2020). Diagnosis of Barrett’s esophagus and Esophageal Varices using a Magnetically Assisted Capsule Endoscopy system. Gastrointestinal Endoscopy, 91(4), 773-781.e1. https://doi.org/10.1016/j.gie.2019.10.031

Background and Aims Magnetically assisted capsule endoscopy (MACE) potentially offers a comfortable, patient friendly, and community-based alternative to gastroscopy (EGD). This pilot study aims to explore whether this approach can be used to accura... Read More about Diagnosis of Barrett’s esophagus and Esophageal Varices using a Magnetically Assisted Capsule Endoscopy system.