All Outputs (2)

RadB acts in homologous recombination in the archaeon Haloferax volcanii, consistent with a role as recombination mediator (2017)
Journal Article
Wardell, K., Haldenby, S., Jones, N., Liddell, S., Ngo, G. H., & Allers, T. (2017). RadB acts in homologous recombination in the archaeon Haloferax volcanii, consistent with a role as recombination mediator. DNA Repair, 55, https://doi.org/10.1016/j.dnarep.2017.04.005

Homologous recombination plays a central role in the repair of double-strand DNA breaks, the restart of stalled replication forks and the generation of genetic diversity. Regulation of recombination is essential since defects can lead to genome insta... Read More about RadB acts in homologous recombination in the archaeon Haloferax volcanii, consistent with a role as recombination mediator.

High tolerance to self-targeting of the genome by the endogenous CRISPR-Cas system in an archaeon (2017)
Journal Article
Stachler, A.-E., Turgeman-Grott, I., Shtifman-Segal, E., Allers, T., Marchfelder, A., & Gophna, U. (2017). High tolerance to self-targeting of the genome by the endogenous CRISPR-Cas system in an archaeon. Nucleic Acids Research, 45(9), 5208-5216. https://doi.org/10.1093/nar/gkx150

CRISPR-Cas systems allow bacteria and archaea to acquire sequence-specific immunity against selfish genetic elements such as viruses and plasmids, by specific degradation of invader DNA or RNA. However, this involves the risk of autoimmunity if immun... Read More about High tolerance to self-targeting of the genome by the endogenous CRISPR-Cas system in an archaeon.