All Outputs (3)

Pharmacokinetics of inorganic cobalt and a vitamin B12 supplement in the thoroughbred horse: differentiating cobalt abuse from supplementation (2017)
Journal Article
Hillyer, L., Ridd, Z., Fenwick, S., Hincks, P., & Paine, S. (2018). Pharmacokinetics of inorganic cobalt and a vitamin B12 supplement in the thoroughbred horse: differentiating cobalt abuse from supplementation. Equine Veterinary Journal, 50(3), 343-349. https://doi.org/10.1111/evj.12774

Background

While cobalt is an essential micronutrient for vitamin B12 synthesis in the horse, at supraphysiological concentrations, it has been shown to enhance performance in human subjects and rats, and there is evidence that its administration... Read More about Pharmacokinetics of inorganic cobalt and a vitamin B12 supplement in the thoroughbred horse: differentiating cobalt abuse from supplementation.

A quantitative systems pharmacology approach, incorporating a novel liver model, for predicting pharmacokinetic drug-drug interactions (2017)
Journal Article
Cherkaoui-Rbati, M., Paine, S., Littlewood, P., & Rauch, C. (2017). A quantitative systems pharmacology approach, incorporating a novel liver model, for predicting pharmacokinetic drug-drug interactions. PLoS ONE, 12(9), Article e0183794. https://doi.org/10.1371/journal.pone.0183794

All pharmaceutical companies are required to assess pharmacokinetic drug-drug interactions (DDIs) of new chemical entities (NCEs) and mathematical prediction helps to select the best NCE candidate with regard to adverse effects resulting from a DDI b... Read More about A quantitative systems pharmacology approach, incorporating a novel liver model, for predicting pharmacokinetic drug-drug interactions.

A clinical evaluation of the pharmacokinetics and pharmacodynamics of intravenous alfaxalone in cyclodextrin in male and female rats following a loading dose and constant rate infusion (2017)
Journal Article
White, K. L., Paine, S., & Harris, J. (2017). A clinical evaluation of the pharmacokinetics and pharmacodynamics of intravenous alfaxalone in cyclodextrin in male and female rats following a loading dose and constant rate infusion. Veterinary Anaesthesia and Analgesia, 44(4), https://doi.org/10.1016/j.vaa.2017.01.001

Objective: To characterise, as a clinical study, the pharmacokinetics and pharmacodynamics and describe the hypnotic effect of the neurosteroid alfaxalone (3α-hydroxy-5 α-pregnane-11, 20-dione) formulated with 2-hydroxypropyl-β-cyclodextrin in male a... Read More about A clinical evaluation of the pharmacokinetics and pharmacodynamics of intravenous alfaxalone in cyclodextrin in male and female rats following a loading dose and constant rate infusion.