Fragment-Based Discovery of Subtype-Selective Adenosine Receptor Ligands from Homology Models
(2015)
Journal Article
Ranganathan, A., Stoddart, L. A., Hill, S. J., & Carlsson, J. (2015). Fragment-Based Discovery of Subtype-Selective Adenosine Receptor Ligands from Homology Models. Journal of Medicinal Chemistry, 58(24), 9578-9590. https://doi.org/10.1021/acs.jmedchem.5b01120
Fragment-based lead discovery (FBLD) holds great promise for drug discovery, but applications to G protein-coupled receptors (GPCRs) have been limited by a lack of sensitive screening techniques and scarce structural information. If virtual screening... Read More about Fragment-Based Discovery of Subtype-Selective Adenosine Receptor Ligands from Homology Models.