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Recombinase-independent chromosomal rearrangements between dispersed inverted repeats in Saccharomyces cerevisiae meiosis (2023)
Journal Article
Allison, R. M., Johnson, D. J., Neale, M. J., & Gray, S. (2023). Recombinase-independent chromosomal rearrangements between dispersed inverted repeats in Saccharomyces cerevisiae meiosis. Nucleic Acids Research, 51(18), 9703-9715. https://doi.org/10.1093/nar/gkad650

DNA double-strand break (DSB) repair by homologous recombination (HR) uses a DNA template with similar sequence to restore genetic identity. Allelic DNA repair templates can be found on the sister chromatid or homologous chromosome. During meiotic re... Read More about Recombinase-independent chromosomal rearrangements between dispersed inverted repeats in Saccharomyces cerevisiae meiosis.

Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in Exo1 D173A mice (2022)
Journal Article
Wang, S., Lee, K., Gray, S., Zhang, Y., Tang, C., Morrish, R. B., …Chahwan, R. (2022). Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in Exo1 D173A mice. Nucleic Acids Research, 50(14), 8093-8106. https://doi.org/10.1093/nar/gkac616

DNA damage response pathways rely extensively on nuclease activity to process DNA intermediates. Exonuclease 1 (EXO1) is a pleiotropic evolutionary conserved DNA exonuclease involved in various DNA repair pathways, replication, antibody diversificati... Read More about Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in Exo1 D173A mice.

Cyclin N-Terminal Domain-Containing-1 Coordinates Meiotic Crossover Formation with Cell-Cycle Progression in a Cyclin-Independent Manner (2020)
Journal Article
Gray, S., Santiago, E. R., Chappie, J. S., & Cohen, P. E. (2020). Cyclin N-Terminal Domain-Containing-1 Coordinates Meiotic Crossover Formation with Cell-Cycle Progression in a Cyclin-Independent Manner. Cell Reports, 32(1), Article 107858. https://doi.org/10.1016/j.celrep.2020.107858

During mammalian meiotic prophase I, programmed DNA double-strand breaks are repaired by non-crossover or crossover events, the latter predominantly occurring via the class I crossover pathway and requiring the cyclin N-terminal domain-containing 1(C... Read More about Cyclin N-Terminal Domain-Containing-1 Coordinates Meiotic Crossover Formation with Cell-Cycle Progression in a Cyclin-Independent Manner.

A mutation in the endonuclease domain of mouse MLH3 reveals novel roles for MutLγ during crossover formation in meiotic prophase I (2019)
Journal Article
Toledo, M., Sun, X., Brieño-Enríquez, M. A., Raghavan, V., Gray, S., Pea, J., …Cohen, P. E. (2019). A mutation in the endonuclease domain of mouse MLH3 reveals novel roles for MutLγ during crossover formation in meiotic prophase I. PLoS Genetics, 15(6), 1-28. https://doi.org/10.1371/journal.pgen.1008177

During meiotic prophase I, double-strand breaks (DSBs) initiate homologous recombination leading to non-crossovers (NCOs) and crossovers (COs). In mouse, 10% of DSBs are designated to become COs, primarily through a pathway dependent on the MLH1-MLH3... Read More about A mutation in the endonuclease domain of mouse MLH3 reveals novel roles for MutLγ during crossover formation in meiotic prophase I.

Cohesin Removal along the Chromosome Arms during the First Meiotic Division Depends on a NEK1-PP1γ-WAPL Axis in the Mouse (2016)
Journal Article
Brieño-Enríquez, M. A., Moak, S. L., Toledo, M., Filter, J., Gray, S., Barbero, J., …Holloway, J. (2016). Cohesin Removal along the Chromosome Arms during the First Meiotic Division Depends on a NEK1-PP1γ-WAPL Axis in the Mouse. Cell Reports, 17(4), 977-986. https://doi.org/10.1016/j.celrep.2016.09.059

© 2016 The Author(s) Mammalian NIMA-like kinase-1 (NEK1) is a dual-specificity kinase highly expressed in mouse germ cells during prophase I of meiosis. Loss of NEK1 induces retention of cohesin on chromosomes at meiotic prophase I. Timely deposition... Read More about Cohesin Removal along the Chromosome Arms during the First Meiotic Division Depends on a NEK1-PP1γ-WAPL Axis in the Mouse.

Control of Meiotic Crossovers: From Double-Strand Break Formation to Designation (2016)
Journal Article
Gray, S., & Cohen, P. E. (2016). Control of Meiotic Crossovers: From Double-Strand Break Formation to Designation. Annual Review of Genetics, 50(1), 175-210. https://doi.org/10.1146/annurev-genet-120215-035111

© 2016 by Annual Reviews. All rights reserved. Meiosis, the mechanism of creating haploid gametes, is a complex cellular process observed across sexually reproducing organisms. Fundamental to meiosis is the process of homologous recombination, whereb... Read More about Control of Meiotic Crossovers: From Double-Strand Break Formation to Designation.

Tel1ATM-mediated interference suppresses clustered meiotic double-strand-break formation (2015)
Journal Article
Garcia, V., Gray, S., Allison, R. M., Cooper, T. J., & Neale, M. J. (2015). Tel1ATM-mediated interference suppresses clustered meiotic double-strand-break formation. Nature, 520(7545), 114-118. https://doi.org/10.1038/nature13993

©2015 Macmillan Publishers Limited. All rights reserved. Meiotic recombination is a critical step in gametogenesis for many organisms, enabling the creation of genetically diverse haploid gametes. In each meiotic cell, recombination is initiated by n... Read More about Tel1ATM-mediated interference suppresses clustered meiotic double-strand-break formation.

Smc5/6 Coordinates Formation and Resolution of Joint Molecules with Chromosome Morphology to Ensure Meiotic Divisions (2013)
Journal Article
Copsey, A., Tang, S., Jordan, P. W., Blitzblau, H. G., Newcombe, S., Chan, A. C.-H., …Hoffmann, E. (2013). Smc5/6 Coordinates Formation and Resolution of Joint Molecules with Chromosome Morphology to Ensure Meiotic Divisions. PLoS Genetics, 9(12), e1004071. https://doi.org/10.1371/journal.pgen.1004071

During meiosis, Structural Maintenance of Chromosome (SMC) complexes underpin two fundamental features of meiosis: homologous recombination and chromosome segregation. While meiotic functions of the cohesin and condensin complexes have been delineate... Read More about Smc5/6 Coordinates Formation and Resolution of Joint Molecules with Chromosome Morphology to Ensure Meiotic Divisions.

Positive regulation of meiotic DNA double-strand break formation by activation of the DNA damage checkpoint kinase Mec1(ATR) (2013)
Journal Article
Gray, S., Allison, R. M., Garcia, V., Goldman, A. S. H., & Neale, M. J. (2013). Positive regulation of meiotic DNA double-strand break formation by activation of the DNA damage checkpoint kinase Mec1(ATR). Open Biology, 3(7), 130019. https://doi.org/10.1098/rsob.130019

During meiosis, formation and repair of programmed DNA double-strand breaks (DSBs) create genetic exchange between homologous chromosomes-a process that is critical for reductional meiotic chromosome segregation andthe production of genetically diver... Read More about Positive regulation of meiotic DNA double-strand break formation by activation of the DNA damage checkpoint kinase Mec1(ATR).