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The Pseudomonas putida CsrA/RsmA homologues negatively affect c-di-GMP pools and biofilm formation through the GGDEF/EAL response regulator CfcR (2017)
Journal Article
Huertas-Rosales, Ó., Romero, M., Heeb, S., Espinosa-Urgel, M., Cámara, M., & Ramos-González, M. I. (in press). The Pseudomonas putida CsrA/RsmA homologues negatively affect c-di-GMP pools and biofilm formation through the GGDEF/EAL response regulator CfcR. Environmental Microbiology, 19(9), https://doi.org/10.1111/1462-2920.13848

Expression of cfcR, encoding the only GGDEF/EAL response regulator in Pseudomonas putida, is transcriptionally regulated by RpoS, ANR and FleQ, and the functionality of CfcR as a diguanylate cyclase requires the multisensor CHASE3/GAF hybrid histidin... Read More about The Pseudomonas putida CsrA/RsmA homologues negatively affect c-di-GMP pools and biofilm formation through the GGDEF/EAL response regulator CfcR.

Optimised chronic infection models demonstrate that siderophore 'cheating' in Pseudomonas aeruginosa is context specific (2017)
Journal Article
Diggle, S. P., da Silva, A. C., Harrison, F., McNally, A., Da Silva, A. C., Heeb, S., & Diggle, S. P. (2017). Optimised chronic infection models demonstrate that siderophore 'cheating' in Pseudomonas aeruginosa is context specific. ISME Journal, 11(11), 2492-2509. https://doi.org/10.1038/ismej.2017.103

© 2017 International Society for Microbial Ecology All rights reserved. The potential for siderophore mutants of Pseudomonas aeruginosa to attenuate virulence during infection, and the possibility of exploiting this for clinical ends, have attracted... Read More about Optimised chronic infection models demonstrate that siderophore 'cheating' in Pseudomonas aeruginosa is context specific.

Identification of a Pseudomonas aeruginosa PAO1 DNA methyltransferase, its Targets, and physiological roles (2017)
Journal Article
Doberenz, S., Eckweiler, D., Reichert, O., Jensen, V., Bunk, B., Spröer, C., …Häussler, S. (2017). Identification of a Pseudomonas aeruginosa PAO1 DNA methyltransferase, its Targets, and physiological roles. mBio, 8(1), Article e02312-16. https://doi.org/10.1128/mBio.02312-16

DNA methylation is widespread among prokaryotes, and most DNA methylation reactions are catalyzed by adenine DNA methyltransferases, which are part of restriction-modification (R-M) systems. R-M systems are known for their role in the defense against... Read More about Identification of a Pseudomonas aeruginosa PAO1 DNA methyltransferase, its Targets, and physiological roles.