Cross talk between LAM cells and fibroblasts may influence alveolar epithelial cell behavior in lymphangioleiomyomatosis

Clements, Debbie; Miller, Suzanne; Babaei-Jadidi, Roya; Adam, Mike; Potter, S. Steven; Johnson, Simon R.

doi:10.1152/AJPLUNG.00351.2021

All Outputs (3)

Lysyl oxidase like 2 is increased in asthma and contributes to asthmatic airway remodelling (2022)
Journal Article
Ramis, J., Middlewick, R., Pappalardo, F., Cairns, J. T., Stewart, I. D., John, A. E., …Tatler, A. L. (2022). Lysyl oxidase like 2 is increased in asthma and contributes to asthmatic airway remodelling. European Respiratory Journal, 60(1), Article 2004361. https://doi.org/10.1183/13993003.04361-2020

BACKGROUND: Airway smooth muscle (ASM) cells are fundamental to asthma pathogenesis, influencing bronchoconstriction, airway hyperresponsiveness and airway remodelling. The extracellular matrix (ECM) can influence tissue remodelling pathways; however... Read More about Lysyl oxidase like 2 is increased in asthma and contributes to asthmatic airway remodelling.

Human bronchial epithelial cells from patients with asthma have an altered gene expression profile (2022)
Journal Article
Bhaker, S., Portelli, M. A., Rakkar, K., Shaw, D., Johnson, S., Brightling, C., & Sayers, I. (2022). Human bronchial epithelial cells from patients with asthma have an altered gene expression profile. ERJ Open Research, 8(1), Article 0625-2021. https://doi.org/10.1183/23120541.00625-2021Published21February2022

Cross talk between LAM cells and fibroblasts may influence alveolar epithelial cell behavior in lymphangioleiomyomatosis (2022)
Journal Article
Clements, D., Miller, S., Babaei-Jadidi, R., Adam, M., Potter, S. S., & Johnson, S. R. (2022). Cross talk between LAM cells and fibroblasts may influence alveolar epithelial cell behavior in lymphangioleiomyomatosis. AJP - Lung Cellular and Molecular Physiology, 322(2), L283-L293. https://doi.org/10.1152/AJPLUNG.00351.2021

Lymphangioleiomyomatosis (LAM) is a female-specific cystic lung disease in which tuberous sclerosis complex 2 (TSC2)-deficient LAM cells, LAM-associated fibroblasts (LAFs), and other cell types infiltrate the lungs. LAM lesions can be associated with... Read More about Cross talk between LAM cells and fibroblasts may influence alveolar epithelial cell behavior in lymphangioleiomyomatosis.