Intratumoural Cytochrome P450 Expression in Breast Cancer: Impact on Standard of Care Treatment and New Efforts to Develop Tumour-Selective Therapies

Sneha, Smarakan; Baker, Simon C.; Green, Andrew; Storr, Sarah; Aiyappa, Radhika; Martin, Stewart; Pors, Klaus

doi:10.3390/biomedicines9030290

All Outputs (3)

PP1, PKA and DARPP-32 in breast cancer: a retrospective assessment of protein and mRNA expression (2021)
Journal Article
Saidy, B., Kotecha, S., Butler, A., Rakha, E., Ellis, I., Green, A., …Storr, S. (2021). PP1, PKA and DARPP-32 in breast cancer: a retrospective assessment of protein and mRNA expression. Journal of Cellular and Molecular Medicine, 25(11), 5015-5024. https://doi.org/10.1111/jcmm.16447

Cyclic-AMP dependent protein kinase A (PKA) and protein phosphatase 1 (PP1) are proteins involved in numerous essential signalling pathways that modulate physiological and pathological functions. Both PP1 and PKA can be inhibited by dopamine and cAMP... Read More about PP1, PKA and DARPP-32 in breast cancer: a retrospective assessment of protein and mRNA expression.

Cytotoxic and radiosensitising effects of a novel thioredoxin reductase inhibitor in breast cancer (2021)
Journal Article
Abdullah, N. A., Inman, M., Moody, C. J., Storr, S. J., & Martin, S. G. (2021). Cytotoxic and radiosensitising effects of a novel thioredoxin reductase inhibitor in breast cancer. Investigational New Drugs, 39(5), 1232-1241. https://doi.org/10.1007/s10637-021-01106-5

Radiotherapy is an effective treatment modality for breast cancer but, unfortunately, not all patients respond fully with a significant number experiencing local recurrences. Overexpression of thioredoxin and thioredoxin reductase has been reported t... Read More about Cytotoxic and radiosensitising effects of a novel thioredoxin reductase inhibitor in breast cancer.

Intratumoural Cytochrome P450 Expression in Breast Cancer: Impact on Standard of Care Treatment and New Efforts to Develop Tumour-Selective Therapies (2021)
Journal Article
Sneha, S., Baker, S. C., Green, A., Storr, S., Aiyappa, R., Martin, S., & Pors, K. (2021). Intratumoural Cytochrome P450 Expression in Breast Cancer: Impact on Standard of Care Treatment and New Efforts to Develop Tumour-Selective Therapies. Biomedicines, 9(3), Article 290. https://doi.org/10.3390/biomedicines9030290