All Outputs (20)

The Impact of High BMI on Pregnancy Outcomes and Complications in Women with PCOS Undergoing IVF - A Systematic Review and Meta-Analysis (2024)
Journal Article
Alenezi, S. A., Khan, R., & Amer, S. (2024). The Impact of High BMI on Pregnancy Outcomes and Complications in Women with PCOS Undergoing IVF - A Systematic Review and Meta-Analysis. Journal of Clinical Medicine, 13(6), Article 1578. https://doi.org/10.3390/jcm13061578

(1) Background: Current evidence indicates that women with polycystic ovarian syndrome (PCOS) undergoing in vitro fertilization (IVF) have an increased likelihood of adverse pregnancy outcomes. The objective of this systematic review was to clarify t... Read More about The Impact of High BMI on Pregnancy Outcomes and Complications in Women with PCOS Undergoing IVF - A Systematic Review and Meta-Analysis.

Severe endosalpingiosis: Case reports and a literature review (2023)
Journal Article
Bazmi, S., & Amer, S. (2023). Severe endosalpingiosis: Case reports and a literature review. Journal of Endometriosis and Pelvic Pain Disorders, 15(3-4), 152-156. https://doi.org/10.1177/22840265231189914

Background: Endosalpingiosis is an understudied gynaecological condition with limited knowledge of its prevalence and clinical significance. Methods: We report two rare cases of severe endosalpingiosis aged 25 and 30 highlighting their clinical,... Read More about Severe endosalpingiosis: Case reports and a literature review.

The Role of NLRP3 Inflammasome in Obesity and PCOS — A Systematic Review and Meta-Analysis (2023)
Journal Article
Alenezi, S. A., Khan, R., Snell, L., Aboeldalyl, S., & Amer, S. (2023). The Role of NLRP3 Inflammasome in Obesity and PCOS — A Systematic Review and Meta-Analysis. International Journal of Molecular Sciences, 24(13), Article 10976. https://doi.org/10.3390/ijms241310976

Inflammasomes have recently been implicated in the pathogenesis of several chronic inflammatory disorders, such as diabetes and obesity. The aim of this meta-analysis was to investigate the possible role of the NLRP3 inflammasome in obesity and polyc... Read More about The Role of NLRP3 Inflammasome in Obesity and PCOS — A Systematic Review and Meta-Analysis.

HRT in Women Undergoing Pelvic Clearance for Endometriosis—A Case Report and a National Survey (2023)
Journal Article
Amer, S., & Bazmi, S. (2023). HRT in Women Undergoing Pelvic Clearance for Endometriosis—A Case Report and a National Survey. Journal of Clinical Medicine, 12(1), Article 336. https://doi.org/10.3390/jcm12010336

The optimal hormone replacement therapy (HRT) in women who have undergone pelvic clearance for endometriosis remains uncertain with insufficient evidence. The purpose of this case report and the national survey was to highlight the potential HRT-rela... Read More about HRT in Women Undergoing Pelvic Clearance for Endometriosis—A Case Report and a National Survey.

The Role of Chronic Inflammation in Polycystic Ovarian Syndrome—A Systematic Review and Meta-Analysis (2021)
Journal Article
Aboeldalyl, S., James, C., Seyam, E., Ibrahim, E. M., Shawki, H. E.-D., & Amer, S. (2021). The Role of Chronic Inflammation in Polycystic Ovarian Syndrome—A Systematic Review and Meta-Analysis. International Journal of Molecular Sciences, 22(5), Article 2734. https://doi.org/10.3390/ijms22052734

Although the current literature associates polycystic ovarian syndrome (PCOS) with chronic inflammation, the evidence for this link remains inconclusive and its causal nature remains unclear. The purpose of this systematic review was to assess the in... Read More about The Role of Chronic Inflammation in Polycystic Ovarian Syndrome—A Systematic Review and Meta-Analysis.

First-line ovulation induction for polycystic ovary syndrome: an individual participant data meta-analysis (2019)
Journal Article
Wang, R., Li, W., Bordewijk, E. M., Legro, R. S., Zhang, H., Wu, X., …the International Ovulation Induction IPDMA Collaboration. (2019). First-line ovulation induction for polycystic ovary syndrome: an individual participant data meta-analysis. Human Reproduction Update, 25(6), 717-732. https://doi.org/10.1093/humupd/dmz029

BACKGROUND: Polycystic ovary syndrome (PCOS) is the most frequent cause of anovulatory infertility. In women with PCOS, effective ovulation induction serves as an important first-line treatment for anovulatory infertility. Individual participant data... Read More about First-line ovulation induction for polycystic ovary syndrome: an individual participant data meta-analysis.

The impact of uterine artery embolization on ovarian reserve: A systematic review and meta-analysis (2019)
Journal Article
El Shamy, T., Amer, S. A., Mohamed, A., James, C., & Jayaprakasan, K. (2020). The impact of uterine artery embolization on ovarian reserve: A systematic review and meta-analysis. Acta Obstetricia et Gynecologica Scandinavica, 99(1), 16-23. https://doi.org/10.1111/aogs.13698

Introduction: Uterine artery embolization (UAE) has been gaining increasing popularity as an effective and minimally invasive treatment for uterine fibroids. However, there has been growing concern over the risk of unintended embolization of the uter... Read More about The impact of uterine artery embolization on ovarian reserve: A systematic review and meta-analysis.

The role of oxidative stress in ovarian toxicity induced by haloperidol and clozapine—a histological and biochemical study in albino rats (2019)
Journal Article
Khalaf, H. A., Elmorsy, E., Mahmoud, E. M., Aggour, A. M., & Amer, S. A. (2019). The role of oxidative stress in ovarian toxicity induced by haloperidol and clozapine—a histological and biochemical study in albino rats. Cell and Tissue Research, 378(2), 371-383. https://doi.org/10.1007/s00441-019-03067-x

Oxidative stress has been implicated in reproductive toxicity induced by antipsychotics (APs). This study aims to further investigate the role of AP-induced oxidative stress in reproductive dysfunction. Thirty adult female albino rats were divided in... Read More about The role of oxidative stress in ovarian toxicity induced by haloperidol and clozapine—a histological and biochemical study in albino rats.

Assessment of Circulating Anti-Müllerian Hormone in Women Using Hormonal Contraception: A Systematic Review (2019)
Journal Article
Amer, S. A., James, C., Al-Hussaini, T. K., & Mohamed, A. A. (2019). Assessment of Circulating Anti-Müllerian Hormone in Women Using Hormonal Contraception: A Systematic Review. Journal of Women's Health, 29(1), 100-110. https://doi.org/10.1089/jwh.2019.7733

Background: The status of ovarian reserve markers during hormonal contraception (HC) remains uncertain with conflicting literature data. The purpose of this study was to assess the impact of HC on circulating anti-Müllerian hormone (AMH) and other ov... Read More about Assessment of Circulating Anti-Müllerian Hormone in Women Using Hormonal Contraception: A Systematic Review.

Excess androgen production in subcutaneous adipose tissue of women with polycystic ovarian syndrome (2019)
Journal Article
Amer, S. A., Alzanati, N. G., Warren, A., Tarbox, R., & Khan, R. (2019). Excess androgen production in subcutaneous adipose tissue of women with polycystic ovarian syndrome. Journal of Endocrinology, 241(1), 99-109. https://doi.org/10.1530/JOE-18-0674

© 2019 Society for Endocrinology Published by Bioscientifica Ltd. The purpose of this study was to investigate androgen production and the role of insulin and LH in its regulation in subcutaneous adipose tissue (SAT) of women with polycystic ovarian... Read More about Excess androgen production in subcutaneous adipose tissue of women with polycystic ovarian syndrome.

The role of oxidative stress in antipsychotics induced ovarian toxicity (2017)
Journal Article
Elmorsy, E., Al-Ghafari, A., Aggour, A. M., Khan, R., & Amer, S. A. (2017). The role of oxidative stress in antipsychotics induced ovarian toxicity. Toxicology in Vitro, 44, https://doi.org/10.1016/j.tiv.2017.07.008

This study tested the hypothesis that oxidative stress could be an underlying mechanism for APs-induced ovarian cytotoxicity and reproductive dysfunction. Rat ovarian theca interstitial cells (TICs) were isolated and treated with four APs [chlorproma... Read More about The role of oxidative stress in antipsychotics induced ovarian toxicity.

Double-blind randomized controlled trial of letrozole versus clomiphene citrate in subfertile women with polycystic ovarian syndrome (2017)
Journal Article
Amer, S. A., Smith, J., Mahran, A., Fox, P., & Fakis, A. (2017). Double-blind randomized controlled trial of letrozole versus clomiphene citrate in subfertile women with polycystic ovarian syndrome. Human Reproduction, 32(8), https://doi.org/10.1093/humrep/dex227

STUDY QUESTION: Would letrozole as a primary ovulation induction agent generate better pregnancy rates than clomiphene citrate (CC) in subfertile women with anovulatory polycystic ovarian syndrome (PCOS)? SUMMARY ANSWER: Participants receiving letro... Read More about Double-blind randomized controlled trial of letrozole versus clomiphene citrate in subfertile women with polycystic ovarian syndrome.

The impact of laparoscopic ovarian drilling on AMH and ovarian reserve: a meta-analysis (2017)
Journal Article
Amer, S. A., Shamy, T. T. E., James, C., Yosef, A. H., & Mohamed, A. A. (2017). The impact of laparoscopic ovarian drilling on AMH and ovarian reserve: a meta-analysis. Reproduction, 154(1), R13-R21. https://doi.org/10.1530/REP-17-0063

Laparoscopic ovarian drilling (LOD) has been widely used as an effective treatment of anovulatory women with polycystic ovarian syndrome (PCOS). However, there has been a growing concern over a possible damaging effect of this procedure on ovarian re... Read More about The impact of laparoscopic ovarian drilling on AMH and ovarian reserve: a meta-analysis.

Gene expression of inflammatory markers in adipose tissue between obese women with polycystic ovary and normal obese women (2017)
Journal Article
Alshammari, G., Khan, R., Brameld, J. M., Amer, S. A., & Lomax, M. A. (2017). Gene expression of inflammatory markers in adipose tissue between obese women with polycystic ovary and normal obese women. European Review for Medical and Pharmacological Sciences, 21(5),

OBJECTIVE: The pathogenesis of polycystic ovary syndrome (PCOS), a common endocrine disease and metabolic disturbance, is still unknown. The aim of the study was to investigate whether patients with PCOS display increased expression of inflammatory m... Read More about Gene expression of inflammatory markers in adipose tissue between obese women with polycystic ovary and normal obese women.

Effect of antipsychotics on mitochondrial bioenergetics of rat ovarian theca cells (2017)
Journal Article
Elmorsy, E., Al-Ghafari, A., Aggour, A. M., Mosad, S. M., Khan, R., & Amer, S. (2017). Effect of antipsychotics on mitochondrial bioenergetics of rat ovarian theca cells. Toxicology Letters, 272, https://doi.org/10.1016/j.toxlet.2017.03.018

Background Antipsychotics (APs) are widely prescribed drugs, which are well known to cause reproductive adverse effects through mechanisms yet to be determined. The purpose of this study was to investigate the effect of antipsychotics on mitochond... Read More about Effect of antipsychotics on mitochondrial bioenergetics of rat ovarian theca cells.

Thecal cell sensitivity to luteinizing hormone and insulin in polycystic ovarian syndrome (2016)
Journal Article
Cadagan, D., Khan, R., & Amer, S. A. (2016). Thecal cell sensitivity to luteinizing hormone and insulin in polycystic ovarian syndrome. Reproductive Biology -Olsztyn-, 16(1), https://doi.org/10.1016/j.repbio.2015.12.006

This study examined whether a defect of steroid synthesis in ovarian theca cells may lead to the development of PCOS, through contributions to excess androgen secretion. Polycystic ovarian syndrome (PCOS) is one of the leading causes of infertilit... Read More about Thecal cell sensitivity to luteinizing hormone and insulin in polycystic ovarian syndrome.

Female adipocyte androgen synthesis and the effects of insulin (2014)
Journal Article
Cadagan, D., Khan, R., & Amer, S. (2014). Female adipocyte androgen synthesis and the effects of insulin. Molecular Genetics and Metabolism Reports, 1, 254-263. https://doi.org/10.1016/j.ymgmr.2014.05.002

The metabolic syndrome is a cluster of metabolic disorders characterized by insulin resistance and hyperinsulinaemia, and its presence can increase the risk of cardiovascular disease significantly. The metabolic syndrome is associated with increased... Read More about Female adipocyte androgen synthesis and the effects of insulin.

The influence of circulating anti-Müllerian hormone on ovarian responsiveness to ovulation induction with gonadotrophins in women with polycystic ovarian syndrome: a pilot study (2013)
Journal Article
Amer, S. A., Mahran, A., Abdelmaged, A., El-Adawy, A. R., Eissa, M. K., & Shaw, R. W. (2013). The influence of circulating anti-Müllerian hormone on ovarian responsiveness to ovulation induction with gonadotrophins in women with polycystic ovarian syndrome: a pilot study. Reproductive Biology and Endocrinology, 11(115), Article 115. https://doi.org/10.1186/1477-7827-11-115

Background Women with polycystic ovarian syndrome (PCOS) are known to have elevated circulating Anti-Müllerian hormone (AMH), which has been found to desensitize ovarian follicles to follicle stimulating hormone (FSH). The purpose of this study was... Read More about The influence of circulating anti-Müllerian hormone on ovarian responsiveness to ovulation induction with gonadotrophins in women with polycystic ovarian syndrome: a pilot study.

Long-term reproductive performance after surgery for ovarian endometrioma (2013)
Journal Article
Raffi, F., & Amer, S. A. (2014). Long-term reproductive performance after surgery for ovarian endometrioma. European Journal of Obstetrics and Gynecology and Reproductive Biology, 172(1), 80-84. https://doi.org/10.1016/j.ejogrb.2013.09.042

Objective To determine the long-term impact of different types of endometrioma surgery on reproductive performance and on age of menopause. Study design This was a longitudinal observational cohort study of 68 women with previous endometrioma surgery... Read More about Long-term reproductive performance after surgery for ovarian endometrioma.

The Predictive Value of Circulating Anti-Müllerian Hormone in Women With Polycystic Ovarian Syndrome Receiving Clomiphene Citrate: A Prospective Observational Study (2013)
Journal Article
Mahran, A., Abdelmeged, A., El-Adawy, A. R., Eissa, M. K., Shaw, R. W., & Amer, S. A. (2013). The Predictive Value of Circulating Anti-Müllerian Hormone in Women With Polycystic Ovarian Syndrome Receiving Clomiphene Citrate: A Prospective Observational Study. Journal of Clinical Endocrinology and Metabolism, 98(10), 4170-4175. https://doi.org/10.1210/jc.2013-2193

CONTEXT: Elevated serum anti-Müllerian hormone (AMH) concentration in women with polycystic ovarian syndrome (PCOS) is known to lower sensitivity of ovarian follicles to circulating FSH. This effect may compromise the outcome of clomiphene citrate (... Read More about The Predictive Value of Circulating Anti-Müllerian Hormone in Women With Polycystic Ovarian Syndrome Receiving Clomiphene Citrate: A Prospective Observational Study.