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All Outputs (42)

Proactive integrated consultation-liaison psychiatry and time spent in hospital by older medical inpatients in England (The HOME Study): a multicentre, parallel-group, randomised controlled trial (2024)
Journal Article
Sharpe, M., Walker, J., van Niekerk, M., Toynbee, M., Magill, N., Frost, C., White, I. R., Walker, S., Duarte, A., Owens, C., Dickens, C., Price, A., Sharpe, M., Walker, J., van Niekerk, M., Toynbee, M., Magill, N., Frost, C., White, I. R., Walker, S., …Yousif, M. (2024). Proactive integrated consultation-liaison psychiatry and time spent in hospital by older medical inpatients in England (The HOME Study): a multicentre, parallel-group, randomised controlled trial. Lancet Psychiatry, 11(9), 684-695. https://doi.org/10.1016/s2215-0366%2824%2900188-3

Background: Older people admitted to hospital in an emergency often have prolonged inpatient stays that worsen their outcomes, increase health-care costs, and reduce bed availability. Growing evidence suggests that the biopsychosocial complexity of t... Read More about Proactive integrated consultation-liaison psychiatry and time spent in hospital by older medical inpatients in England (The HOME Study): a multicentre, parallel-group, randomised controlled trial.

New horizons in clinical practice guidelines for use with older people (2024)
Journal Article
Martin, F. C., Quinn, T. J., Straus, S. E., Anand, S., van der Velde, N., & Harwood, R. H. (2024). New horizons in clinical practice guidelines for use with older people. Age and Ageing, 53(7), Article afae158. https://doi.org/10.1093/ageing/afae158

Globally, more people are living into advanced old age, with age-associated frailty, disability and multimorbidity. Achieving equity for all ages necessitates adapting healthcare systems. Clinical practice guidelines (CPGs) have an important place in... Read More about New horizons in clinical practice guidelines for use with older people.

Social participation in the promoting activity, independence and stability in early dementia (PrAISED), a home-based therapy intervention for people living with dementia: a realist evaluation (2024)
Journal Article
Lorito, C. D., Pollock, K., Booth, V., Howe, L., Goldberg, S., Godfrey, M., Dunlop, M., Harwood, R. H., Van Der Wardt, V., & Lorito, C. D. (2024). Social participation in the promoting activity, independence and stability in early dementia (PrAISED), a home-based therapy intervention for people living with dementia: a realist evaluation. BMC Geriatrics, 24(1), Article 615. https://doi.org/10.1186/s12877-024-05086-y

Background: Interventions promoting social activity may reduce behavioural psychological symptoms and improve quality of life in people living with dementia. This study aimed to identify social benefits for participants living with dementia in the co... Read More about Social participation in the promoting activity, independence and stability in early dementia (PrAISED), a home-based therapy intervention for people living with dementia: a realist evaluation.

Establishing a research partnership to investigate functional loss and rehabilitation towards the end of life (2024)
Journal Article
Maddocks, M., Brighton, L. J., Connell, L., Cowley, A., Laird, B., Peryer, G., …Harwood, R. (2024). Establishing a research partnership to investigate functional loss and rehabilitation towards the end of life. Health Technology Assessment, 1-12. https://doi.org/10.3310/pthc7598

Background
Functional loss, the inability to perform necessary or desired tasks, is a common consequence of life-limiting illnesses and associated symptoms (pain, fatigue, breathlessness, etc.) and causes suffering for patients and families. Rehabil... Read More about Establishing a research partnership to investigate functional loss and rehabilitation towards the end of life.

Adapted problem adaptation therapy for depression in mild to moderate Alzheimer's disease dementia: A randomized controlled trial (2024)
Journal Article
Howard, R., Cort, E., Rawlinson, C., Wiegand, M., Downey, A., Lawrence, V., …Gould, R. (2024). Adapted problem adaptation therapy for depression in mild to moderate Alzheimer's disease dementia: A randomized controlled trial. Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 20(4), 2990-2999. https://doi.org/10.1002/alz.13766

INTRODUCTION: Trials of effectiveness of treatment options for depression in dementia are an important priority. METHODS: Randomized controlled trial to assess adapted Problem Adaptation Therapy (PATH) for depression in mild/moderate dementia caused... Read More about Adapted problem adaptation therapy for depression in mild to moderate Alzheimer's disease dementia: A randomized controlled trial.

Whether from a position of strength or weakness, geriatric medicine has work to do to drive up standards in health care for older people (2023)
Journal Article
Gordon, A. L., Martin, F., Mistry, S., Harwood, R. H., & Dhesi, J. (2023). Whether from a position of strength or weakness, geriatric medicine has work to do to drive up standards in health care for older people. Age and Ageing, 52(11), Article afad208. https://doi.org/10.1093/ageing/afad208

• Geriatric medicine is the largest physicianly specialty in the UK, with high levels of competition for available training posts. • Improving care of older people has been the focus of multiple national policy initiatives in the UK over the past dec... Read More about Whether from a position of strength or weakness, geriatric medicine has work to do to drive up standards in health care for older people.

A rehabilitation intervention to improve recovery after an episode of delirium in adults over 65 years (RecoverED): study protocol for a multi-centre, single-arm feasibility study (2023)
Journal Article
Allan, L., O'Connell, A., Raghuraman, S., Bingham, A., Laverick, A., Chandler, K., …Clare, L. (2023). A rehabilitation intervention to improve recovery after an episode of delirium in adults over 65 years (RecoverED): study protocol for a multi-centre, single-arm feasibility study. Pilot and Feasibility Studies, 9, Article 162. https://doi.org/10.1186/s40814-023-01387-y

BackgroundDelirium affects over 20% of all hospitalised older adults. Delirium is associated with a number of adverse outcomes following hospital admission including cognitive decline, anxiety and depression, increased mortality and care needs. Previ... Read More about A rehabilitation intervention to improve recovery after an episode of delirium in adults over 65 years (RecoverED): study protocol for a multi-centre, single-arm feasibility study.

Promoting Activity, Independence, and Stability in Early Dementia and mild cognitive impairment (PrAISED): randomised controlled trial (2023)
Journal Article
Harwood, R. H., Goldberg, S. E., Brand, A., van Der Wardt, V., Booth, V., Di Lorito, C., Hoare, Z., Hancox, J., Bajwa, R., Burgon, C., Howe, L., Cowley, A., Bramley, T., Long, A., Lock, J., Tucker, R., Adams, E. J., O’Brien, R., Kearney, F., Kowalewska, K., …Masud, T. (2023). Promoting Activity, Independence, and Stability in Early Dementia and mild cognitive impairment (PrAISED): randomised controlled trial. BMJ, 382, Article e074787. https://doi.org/10.1136/bmj-2023-074787

Objective To determine the effectiveness of an exercise and functional activity therapy intervention in adults with early dementia or mild cognitive impairment compared with usual care.

Design Randomised controlled trial.

Setting Participants’... Read More about Promoting Activity, Independence, and Stability in Early Dementia and mild cognitive impairment (PrAISED): randomised controlled trial.

Promoting Activity, Independence and Stability in early dementia and mild cognitive impairment (PrAISED): randomised controlled trial (2023)
Journal Article
Harwood, R. H., Goldberg, S. E., Brand, A., van Der Wardt, V., Booth, V., Di Lorito, C., …Adams, E. (2023). Promoting Activity, Independence and Stability in early dementia and mild cognitive impairment (PrAISED): randomised controlled trial. BMJ, 382, Article e074787. https://doi.org/10.1136/bmj-2023-074787

Objective: To determine the effectiveness of an exercise and functional activity therapy intervention in adults with early dementia or mild cognitive impairment compared with usual care.

Design: Randomised controlled trial.

Setting: Participant... Read More about Promoting Activity, Independence and Stability in early dementia and mild cognitive impairment (PrAISED): randomised controlled trial.

Association between pain intensity and depressive symptoms in community-dwelling adults: longitudinal findings from the Survey of Health, Ageing and Retirement in Europe (SHARE) (2023)
Journal Article
Ogliari, G., Ryg, J., Andersen-Ranberg, K., Scheel-Hincke, L. L., Collins, J. T., Cowley, A., …Masud, T. (2023). Association between pain intensity and depressive symptoms in community-dwelling adults: longitudinal findings from the Survey of Health, Ageing and Retirement in Europe (SHARE). European Geriatric Medicine, 14(5), 1111-1124. https://doi.org/10.1007/s41999-023-00835-5

Purpose
To investigate the longitudinal associations between pain and depressive symptoms in adults.

Methods
Prospective cohort study on data from 28,515 community-dwelling adults ≥ 50 years, free from depression at baseline (Wave 5), with follo... Read More about Association between pain intensity and depressive symptoms in community-dwelling adults: longitudinal findings from the Survey of Health, Ageing and Retirement in Europe (SHARE).

Incidence of cognitive impairment and dementia after hospitalisation for pneumonia: a UK population-based matched cohort study (2023)
Journal Article
Chalitsios, C. V., Baskaran, V., Harwood, R. H., Lim, W. S., & McKeever, T. M. (2023). Incidence of cognitive impairment and dementia after hospitalisation for pneumonia: a UK population-based matched cohort study. ERJ Open Research, 9(3), Article 00328-2022. https://doi.org/10.1183/23120541.00328-2022

Background Survivors of common infections may develop cognitive impairment or dementia; however, the risk of these conditions in people hospitalised with pneumonia is not well established.

Methods A matched cohort study was conducted using Hospit... Read More about Incidence of cognitive impairment and dementia after hospitalisation for pneumonia: a UK population-based matched cohort study.

Promoting continence in older people (2022)
Journal Article
Schlögl, M., Umbehr, M. H., Habib, M. H., Wagg, A., Gordon, A. L., & Harwood, R. (2022). Promoting continence in older people. Age and Ageing, 51(9), Article afac199. https://doi.org/10.1093/ageing/afac199

The prevalence of urinary incontinence (UI) is strongly associated with increasing age. Twenty five percent of women over 80 years of age have clinically significant symptoms in population surveys, but prevalence is as high as 70% in older hospital i... Read More about Promoting continence in older people.

Impact of COVID-19 lockdown on physical exercise among participants receiving the Promoting Activity, Independence and Stability in Early Dementia (PrAISED) intervention: a repeated measure study (2022)
Journal Article
Di Lorito, C., van der Wardt, V., O'Brien, R., Gladman, J., Tahir, M., & Harwood, R. (2022). Impact of COVID-19 lockdown on physical exercise among participants receiving the Promoting Activity, Independence and Stability in Early Dementia (PrAISED) intervention: a repeated measure study. BMC Geriatrics, 22, Article 605. https://doi.org/10.1186/s12877-022-03239-5

Background
The potential decrease in daily physical activity associated with the COVID-19 pandemic lockdowns may have a negative impact on people living with dementia. Given the limited literature around the effects of home confinement in people liv... Read More about Impact of COVID-19 lockdown on physical exercise among participants receiving the Promoting Activity, Independence and Stability in Early Dementia (PrAISED) intervention: a repeated measure study.

Mixed-Methods Study on Caregiver Strain, Quality of Life, and Perceived Health (2021)
Journal Article
Di Lorito, C., Bosco, A., Godfrey, M., Dunlop, M., Lock, J., Pollock, K., Harwood, R. H., & van der Wardt, V. (2021). Mixed-Methods Study on Caregiver Strain, Quality of Life, and Perceived Health. Journal of Alzheimer's Disease, 80(2), 799-811. https://doi.org/10.3233/JAD-201257

Background:
Caring for someone with dementia is associated with negative and positive experiences. There is little evidence based on large datasets.

Objective:
To present data around the experience of caring for someone with dementia, to identif... Read More about Mixed-Methods Study on Caregiver Strain, Quality of Life, and Perceived Health.

The geriatrician’s role in end-of-life care (2020)
Journal Article
Ahmed, N., Ahmedzai, S. H., & Harwood, R. H. (2021). The geriatrician’s role in end-of-life care. Age and Ageing, 50(2), 366-369. https://doi.org/10.1093/ageing/afaa266

Healthcare aims to help older people to live well, but ultimately must also support them to die well. Most people die in old age, but predicting death in both short- and long-term is impossible for many, although not all, older people. Frail older pe... Read More about The geriatrician’s role in end-of-life care.

Association of frailty with mortality in older inpatients with Covid-19: a cohort study (2020)
Journal Article
Aw, D., Woodrow, L., Ogliari, G., & Harwood, R. (2020). Association of frailty with mortality in older inpatients with Covid-19: a cohort study. Age and Ageing, 49(6), 915-922. https://doi.org/10.1093/ageing/afaa184

Background: COVID-19 has disproportionately affected older people.
Objective: to investigate whether frailty is associated with all-cause mortality in older hospital inpatients, with COVID-19.
Design: cohort study
Setting: secondary care acute hos... Read More about Association of frailty with mortality in older inpatients with Covid-19: a cohort study.

Atypical presentation of COVID-19 in a frail older person (2020)
Journal Article
Tay, H. S., & Harwood, R. (2020). Atypical presentation of COVID-19 in a frail older person. Age and Ageing, 49(4), 523-524. https://doi.org/10.1093/ageing/afaa068

Common symptoms of pandemic coronavirus disease (COVID-19) include fever and cough.We describe a 94-year-old man
with well-controlled schizoaffective disorder, who presented with non-specific and atypical symptoms: delirium, low-grade
pyrexia and a... Read More about Atypical presentation of COVID-19 in a frail older person.