All Outputs (6)

Ondansetron for irritable bowel syndrome with diarrhoea: randomised controlled trial (2023)
Journal Article
Gunn, D., Topan, R., Fried, R., Holloway, I., Brindle, R., Hartley, S., …Spiller, R. (2023). Ondansetron for irritable bowel syndrome with diarrhoea: randomised controlled trial. Efficacy and Mechanism Evaluation, 10(9), 1-154. https://doi.org/10.3310/ytfw7874

Background: Irritable bowel syndrome with diarrhoea is characterised by frequent, loose or watery stools with associated urgency, resulting in marked reduction of quality of life. Ondansetron, a 5-hydroxytryptamine-3 receptor antagonist, has been sho... Read More about Ondansetron for irritable bowel syndrome with diarrhoea: randomised controlled trial.

Editorial: Interaction between fibre and colonic fermentation assessed with a novel gas‐sensing capsule (2023)
Journal Article
Spiller, R. (2023). Editorial: Interaction between fibre and colonic fermentation assessed with a novel gas‐sensing capsule. Alimentary Pharmacology and Therapeutics, 58(8), 828-829. https://doi.org/10.1111/apt.17687

In vivo observation of a stomach road or ‘Magenstrasse’ for gastric emptying using MRI imaging in healthy humans (2023)
Journal Article
Almutairi, F., Alyami, J., Pritchard, S., Alsharef, W., Spiller, R. C., Gowland, P. A., …Hoad, C. L. (2023). In vivo observation of a stomach road or ‘Magenstrasse’ for gastric emptying using MRI imaging in healthy humans. Clinical Nutrition Open Science, 51, 35-43. https://doi.org/10.1016/j.nutos.2023.08.002

The presence of a ‘magenstrasse’, a central ‘stomach road’ for flow and mixing of foods and drinks in the stomach had been predicted from hydrodynamic modelling. Here a magnetic resonance imaging (MRI) tagging technique was used to gain novel insight... Read More about In vivo observation of a stomach road or ‘Magenstrasse’ for gastric emptying using MRI imaging in healthy humans.

Thinking outside the box: a review of gastrointestinal symptoms and complications in cystic fibrosis (2023)
Journal Article
Yule, A., Sills, D., Smith, S., Spiller, R., & Smyth, A. R. (2023). Thinking outside the box: a review of gastrointestinal symptoms and complications in cystic fibrosis. Expert Review of Respiratory Medicine, 17(7), 547-561. https://doi.org/10.1080/17476348.2023.2228194

Introduction Gastrointestinal (GI)-related symptoms, complications, and comorbidities in cystic fibrosis (CF) are common and research to reduce their burden is a priority for the CF community. To enable future research, this review aimed to summariz... Read More about Thinking outside the box: a review of gastrointestinal symptoms and complications in cystic fibrosis.

Editorial: ondansetron for patients with IBS-D and bowel-predominant symptoms—authors' reply (2023)
Journal Article
Gunn, D., Ford, A., Farrin, A., & Spiller, R. (2023). Editorial: ondansetron for patients with IBS-D and bowel-predominant symptoms—authors' reply. Alimentary Pharmacology and Therapeutics, 57(11), 1337-1338. https://doi.org/10.1111/apt.17496

MRI tagging of colonic chyme mixing in healthy subjects: Inter‐observer variability and reliability of the measurement with time (2023)
Journal Article
Alshammari, M. T., Alyami, A. S., Wilkinson-Smith, V., Spiller, R. C., Gowland, P., Marciani, L., …Hoad, C. L. (2023). MRI tagging of colonic chyme mixing in healthy subjects: Inter‐observer variability and reliability of the measurement with time. Neurogastroenterology and Motility, 35(8), Article e14610. https://doi.org/10.1111/nmo.14610

Background: Magnetic resonance imaging (MRI) tagging techniques have been applied to the GI tract to assess bowel contractions and content mixing. We aimed to evaluate the dependence of a tagging measurement (for assessing chyme mixing) on inter-obse... Read More about MRI tagging of colonic chyme mixing in healthy subjects: Inter‐observer variability and reliability of the measurement with time.