All Outputs (4)

Germ-line and somatic DICER1 mutations in pineoblastoma (2014)
Journal Article

Germ-line RB-1 mutations predispose to pineoblastoma (PinB), but other predisposing genetic factors are not well established. We recently identified a germ-line DICER1 mutation in a child with a PinB. This was accompanied by loss of heterozygosity (L... Read More about Germ-line and somatic DICER1 mutations in pineoblastoma.

Recommendations for assessing cognitive risks in young children treated for ependymoma for clinical and research protocols: evidence from a systematic literature review (2014)
Journal Article
Morrall, M. C., Pitchford, N. J., Waters, E. C., Ablett, K. L., Stocks, H., Walker, D., & Grundy, R. G. (2014). Recommendations for assessing cognitive risks in young children treated for ependymoma for clinical and research protocols: evidence from a systematic literature review. Journal of Pediatric Oncology Nursing, 2(1), https://doi.org/10.14205/2309-3021.2014.02.01.4

Background: Current treatment approaches for pediatric ependymoma differ between North American and European studies. Post-surgical adjuvant irradiation is used in children aged <36 months in North America, whilst European approaches use chemotherapy...

Processed pseudogenes acquired somatically during cancer development (2014)
Journal Article

Cancer evolves by mutation, with somatic reactivation of retrotransposons being one such mutational process. Germline retrotransposition can cause processed pseudogenes, but whether this occurs somatically has not been evaluated. Here we screen seque... Read More about Processed pseudogenes acquired somatically during cancer development.

RHPS4 G-quadruplex ligand induces anti-proliferative effects in brain tumor cells (2014)
Journal Article
Lagah, S., Tan, I.-L., Radhakrishnan, P., Hirst, R. A., Ward, J. H., O'Callaghan, C., …Rahman, R. (2014). RHPS4 G-quadruplex ligand induces anti-proliferative effects in brain tumor cells. PLoS ONE, 9(1), Article e86187. https://doi.org/10.1371/journal.pone.0086187

Background
Telomeric 3’ overhangs can fold into a four-stranded DNA structure termed G-quadruplex (G4), a formation which inhibits telomerase. As telomerase activation is crucial for telomere maintenance in most cancer cells, several classes of G4... Read More about RHPS4 G-quadruplex ligand induces anti-proliferative effects in brain tumor cells.